Sciex TripleTOF 5600+ System

Typically used for proteomics, the Sciex TripleTOF 5600+ System is a hybrid quadrupole TOF platform, accurate mass (<3ppm), high-resolution (30,000) system than can operate by means of information-dependent acquisition (IDA) with speed (up to 50Hz) and sensitivity of a TOF MS and quantification capabilities similar to a triple quadrupole MS. When operated in a data-independent acquisition (DIA) mode, termed SWATH-MS by Sciex, the 5600 offers quantitative accuracy comparable to Selected Reaction Monitoring (SRM), and multiplexing capabilities comparable to DDA proteomics. In SWATH-MS, peptide precursors are sequentially selected in defined precursor ion mass windows for concurrent fragmentation, and the resulting fragment ion spectra are recorded in recursive cycles over the chromatography time.