Research Output

2020

Annexin a2 depletion exacerbates the intracerebral microhemorrhage induced by acute rickettsia and ebola virus infections

Su, Z., Chang, Q., Drelich, A., Shelite, T., Judy, B., Liu, Y., Xiao, J., Zhou, C., He, X., Jin, Y., Saito, T., Tang, S., Soong, L., Wakamiya, M., Fang, X., Bukreyev, A., Ksiazek, T., Russell, W. K. & Gong, B., Jul 2020, In : PLoS neglected tropical diseases. 14, 7, p. 1-30 30 p., e0007960.

Research output: Contribution to journalArticle

Open Access

A Region of UNC-89 (Obscurin) Lying between Two Protein Kinase Domains Is a Highly Elastic Spring Required for Proper Sarcomere Organization

Qadota, H., Moody, J. C., Lesanpezeshki, L., Moncrief, T., Kitzler, D., Bhat, P. D., Vanapalli, S. A., Oberhauser, A. F. & Benian, G. M., Aug 7 2020, In : Journal of Molecular Biology. 432, 17, p. 4799-4814 16 p.

Research output: Contribution to journalArticle

Burn-Induced Impairment of Ileal Muscle Contractility Is Associated with Increased Extracellular Matrix Components

Cummins, C. B., Gu, Y., Wang, X., Lin, Y. M., Shi, X. Z. & Radhakrishnan, R. S., Jan 1 2020, In : Journal of Gastrointestinal Surgery. 24, 1, p. 188-197 10 p.

Research output: Contribution to journalArticle

Circadian regulation of chemotherapy-induced peripheral neuropathic pain and the underlying transcriptomic landscape

Kim, H. K., Lee, S. Y., Koike, N., Kim, E., Wirianto, M., Burish, M. J., Yagita, K., Lee, H. K., Chen, Z., Chung, J. M., Abdi, S. & Yoo, S. H., Dec 1 2020, In : Scientific reports. 10, 1, 13844.

Research output: Contribution to journalArticle

Open Access

Circulating levels of ATP is a biomarker of HIV cognitive impairment

Velasquez, S., Prevedel, L., Valdebenito, S., Gorska, A. M., Golovko, M., Khan, N., Geiger, J. & Eugenin, E. A., Jan 2020, In : EBioMedicine. 51, 102503.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Enhancing KCNQ channel activity improves neurobehavioral recovery after spinal cord injury

Wu, Z., Li, L., Xie, F., Xu, G., Dang, D. & Yang, Q., Apr 1 2020, In : Journal of Pharmacology and Experimental Therapeutics. 373, 1, p. 72-80 9 p.

Research output: Contribution to journalArticle

1 Scopus citations

HIV-1 Tat: Role in Bystander Toxicity

Ajasin, D. & Eugenin, E. A., Feb 25 2020, In : Frontiers in Cellular and Infection Microbiology. 10, 61.

Research output: Contribution to journalReview article

Open Access
1 Scopus citations

HIV GP120 protein increases the function of connexin 43 hemichannels and pannexin-1 channels in astrocytes: Repercussions on astroglial function

Gajardo-Gómez, R., Santibañez, C. A., Labra, V. C., Gómez, G. I., Eugenin, E. A. & Orellana, J. A., Apr 2020, In : International journal of molecular sciences. 21, 7, 2503.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

HIV infects astrocytes in vivo and egresses from the brain to the periphery

Lutgen, V., Narasipura, S. D., Barbian, H. J., Richards, M., Wallace, J., Razmpour, R., Buzhdygan, T., Ramirez, S. H., Prevedel, L., Eugenin, E. A. & Al-Harthi, L., Jun 2020, In : PLoS pathogens. 16, 6, e1008381.

Research output: Contribution to journalArticle

Open Access

Increased talin–vinculin spatial proximities in livers in response to spotted fever group rickettsial and Ebola virus infections

Liu, Y., Xiao, J., Zhang, B., Shelite, T. R., Su, Z., Chang, Q., Judy, B., Li, X., Drelich, A., Bei, J., Zhou, Y., Zheng, J., Jin, Y., Rossi, S. L., Tang, S. J., Wakamiya, M., Saito, T., Ksiazek, T., Kaphalia, B. & Gong, B., Aug 1 2020, In : Laboratory Investigation. 100, 8, p. 1030-1041 12 p.

Research output: Contribution to journalArticle

Open Access

In Vivo Epithelial Metabolic Imaging Using a Topical Fluorescent Glucose Analog

Villarreal, P., Pal, R. & Vargas, G., 2020, Methods in Molecular Biology. Humana Press Inc., p. 21-31 11 p. (Methods in Molecular Biology; vol. 2126).

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Low-intensity, Kilohertz Frequency Spinal Cord Stimulation Differently Affects Excitatory and Inhibitory Neurons in the Rodent Superficial Dorsal Horn

Lee, K. Y., Bae, C., Lee, D., Kagan, Z., Bradley, K., Chung, J. M. & La, J. H., Jan 21 2020, In : Neuroscience. 428, p. 132-139 8 p.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Nucleolin mediates the binding of cancer cells to L-selectin under conditions of lymphodynamic shear stress

Goldson, T. M., Turner, K. L., Huang, Y., Carlson, G. E., Caggiano, E. G., Oberhauser, A. F., Fennewald, S., Burdick, M. M. & Resto, V. A., Jan 1 2020, In : American Journal of Physiology - Cell Physiology. 318, 1, p. C83-C93

Research output: Contribution to journalArticle

1 Scopus citations

Peli1 signaling blockade attenuates congenital zika syndrome

Luo, H., Li, G., Wang, B., Tian, B., Gao, J., Zou, J., Shi, S., Zhu, S., Peng, B. H., Adam, A., Martinez, A., Hein, K., Winkelmann, E. R., Mahmoud, Y., Zhou, X., Shan, C., Rossi, S., Weaver, S., Barrett, A. D. T., Sun, S. C. & 4 others, Zhang, W., Shi, P. Y., Wu, P. & Wang, T., Jun 2020, In : PLoS pathogens. 16, 6, e1008538.

Research output: Contribution to journalArticle

Open Access

Penetration of ibrexafungerp (formerly SCY-078) at the site of infection in an intra-abdominal candidiasis mouse model

Lee, A., Prideaux, B., Zimmerman, M., Carter, C., Barat, S., Angulo, D., Dartois, V., Perlin, D. S. & Zhao, Y., 2020, In : Antimicrobial agents and chemotherapy. 64, 3, e02268.

Research output: Contribution to journalArticle

Platelets from HIV-infected individuals on antiretroviral drug therapy with poor CD4+ T cell recovery can harbor replication-competent HIV despite viral suppression

Real, F., Capron, C., Sennepin, A., Arrigucci, R., Zhu, A., Sannier, G., Zheng, J., Xu, L., Massé, J. M., Greffe, S., Cazabat, M., Donoso, M., Delobel, P., Izopet, J., Eugenin, E., Gennaro, M. L., Rouveix, E., Bordé, E. C. & Bomsel, M., Mar 18 2020, In : Science Translational Medicine. 12, 535, eaat6263.

Research output: Contribution to journalArticle

3 Scopus citations

Reactive Oxygen Species (ROS) are Critical for Morphine Exacerbation of HIV-1 gp120-Induced Pain

Shi, Y., Yuan, S. & Tang, S. J., 2020, (Accepted/In press) In : Journal of Neuroimmune Pharmacology.

Research output: Contribution to journalArticle

Open Access

Role of microglia in the dissemination of zika virus from mother to fetal brain

Xu, P., Shan, C., Dunn, T. J., Xie, X., Xia, H., Gao, J., Labastida, J. A., Zou, J., Villarreal, P. P., Schlagal, C. R., Yu, Y., Vargas, G., Rossi, S. L., Vasilakis, N., Shi, P. Y., Weaver, S. C. & Wu, P., Jul 2020, In : PLoS neglected tropical diseases. 14, 7, p. 1-21 21 p., e0008413.

Research output: Contribution to journalArticle

Open Access

Scattering angle resolved optical coherence tomography detects early changes in 3xTg Alzheimer’s disease mouse model

Gardner, M. R., Baruah, V., Vargas, G., Motamedi, M., Milner, T. E. & Rylander, H. G., Apr 2020, In : Translational Vision Science and Technology. 9, 5, p. 1-14 14 p., 18.

Research output: Contribution to journalArticle

Open Access

The Glutamate System as a Crucial Regulator of CNS Toxicity and Survival of HIV Reservoirs

Gorska, A. M. & Eugenin, E. A., Jun 24 2020, In : Frontiers in Cellular and Infection Microbiology. 10, 261.

Research output: Contribution to journalReview article

Open Access
2019

Activation of KCNQ Channels Prevents Paclitaxel-Induced Peripheral Neuropathy and Associated Neuropathic Pain

Li, L., Li, J., Zuo, Y., Dang, D., Frost, J. A. & Yang, Q., May 2019, In : Journal of Pain. 20, 5, p. 528-539 12 p.

Research output: Contribution to journalArticle

4 Scopus citations

A Highly Immunogenic, Protective, and Safe Adenovirus-Based Vaccine Expressing Middle East Respiratory Syndrome Coronavirus S1-CD40L Fusion Protein in a Transgenic Human Dipeptidyl Peptidase 4 Mouse Model

Hashem, A. M., Algaissi, A., Agrawal, A. S., Al-Amri, S. S., Alhabbab, R. Y., Sohrab, S. S., Almasoud, A. S., Alharbi, N. K., Peng, B. H., Russell, M., Li, X. & Tseng, C. T. K., Oct 8 2019, In : Journal of Infectious Diseases. 220, 10, p. 1558-1567 10 p.

Research output: Contribution to journalArticle

26 Scopus citations

A Naturally Occurring Polymorphism in the HIV-1 Tat Basic Domain Inhibits Uptake by Bystander Cells and Leads to Reduced Neuroinflammation

Ruiz, A. P., Ajasin, D. O., Ramasamy, S., DesMarais, V., Eugenin, E. A. & Prasad, V. R., Dec 1 2019, In : Scientific reports. 9, 1, 3308.

Research output: Contribution to journalArticle

3 Scopus citations

Beyond tissue concentrations: Antifungal penetration at the site of infection

Zhao, Y., Prideaux, B., Baistrocchi, S., Sheppard, D. C. & Perlin, D. S., Apr 1 2019, In : Medical Mycology. 57, p. S161-S167

Research output: Contribution to journalReview article

3 Scopus citations

Chronic poly-drug administration damages adult mouse brain neural stem cells

McGrath, E. L., Schlagal, C. R., Cortez, I., Dunn, T. J., Gao, J., Fox, R. G., Stutz, S. J., Kuo, Y. F., Hommel, J., Dineley, K., Cunningham, K., Kaphalia, B. & Wu, P., Nov 15 2019, In : Brain Research. 1723, 146425.

Research output: Contribution to journalArticle

Distinct roles of histamine H1-and H2-receptor signaling pathways in inflammation-associated colonic tumorigenesis

Shi, Z., Fultz, R. S., Engevik, M. A., Gao, C., Hall, A., Major, A., Mori-Akiyama, Y. & Versalovic, J., Jan 2019, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 316, 1, p. G205-G216

Research output: Contribution to journalArticle

2 Scopus citations

Effect of N-(2-aminoethyl) ethanolamine on hypertrophic scarring changes in vitro: Finding novel anti-fibrotic therapies

Chen, Z., Gu, J., El Ayadi, A., Oberhauser, A. F., Zhou, J., Sousse, L. E., Finnerty, C. C., Herndon, D. N. & Boor, P. J., Jan 1 2019, In : Toxicology and Applied Pharmacology. 362, p. 9-19 11 p.

Research output: Contribution to journalArticle

2 Scopus citations

Efficacy of novel highly specific bromodomain-containing protein 4 inhibitors in innate inflammation–driven airway remodeling

Tian, B., Liu, Z., Litvinov, J., Maroto, R., Jamaluddin, M., Rytting, E., Patrikeev, I., Ochoa, L., Vargas, G., Motamedi, M., Ameredes, B. T., Zhou, J. & Brasier, A. R., Jan 2019, In : American journal of respiratory cell and molecular biology. 60, 1, p. 68-83 16 p.

Research output: Contribution to journalArticle

11 Scopus citations

Electroacupuncture downregulates P2X3 receptor expression in dorsal root ganglia of the spinal nerve-ligated rat

Liang, Y., Gu, Y., Shi, R., Li, G., Chen, Y. & Huang, L. Y. M., May 1 2019, In : Molecular pain. 15

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Elevated human dipeptidyl peptidase 4 expression reduces the susceptibility of hDPP4 transgenic mice to middle east respiratory syndrome coronavirus infection and disease

Algaissi, A., Agrawal, A. S., Han, S., Peng, B. H., Luo, C., Li, F., Chan, T. S., Couch, R. B. & Tseng, C. T. K., Feb 15 2019, In : Journal of Infectious Diseases. 219, 5, p. 829-835 7 p.

Research output: Contribution to journalArticle

5 Scopus citations

Erratum: Determination of [11C]Rifampin Pharmacokinetics within Mycobacterium tuberculosis-Infected Mice by Using Dynamic Positron Emission Tomography Bioimaging (Antimicrobial Agents and Chemotherapy (2015) 59:9 (5768-5774) 10.1128/AAC.01146-15)

DeMarco, V. P., Ordonez, A. A., Klunk, M., Prideaux, B., Wang, H., Zhang, Z., Tonge, P. J., Dannals, R. F., Holt, D. P., Lee, C. K. K., Weinstein, E. A., Dartois, V., Dooley, K. E. & Jain, S. K., 2019, In : Antimicrobial agents and chemotherapy. 63, 9, e01368-19.

Research output: Contribution to journalComment/debate

Open Access

Exchange protein directly activated by cAMP plays a critical role in regulation of vascular fibrinolysis

He, X., Drelich, A., Yu, S., Chang, Q., Gong, D., Zhou, Y., Qu, Y., Yuan, Y., Su, Z., Qiu, Y., Tang, S. J., Gaitas, A., Ksiazek, T., Xu, Z., Zhou, J., Feng, Z., Wakamiya, M., Lu, F. & Gong, B., Mar 15 2019, In : Life Sciences. 221, p. 1-12 12 p.

Research output: Contribution to journalArticle

2 Scopus citations

Ferroptosis inhibitor SRS 16-86 attenuates ferroptosis and promotes functional recovery in contusion spinal cord injury

Zhang, Y., Sun, C., Zhao, C., Hao, J., Zhang, Y., Fan, B., Li, B., Duan, H., Liu, C., Kong, X., Wu, P., Yao, X. & Feng, S., Mar 1 2019, In : Brain Research. 1706, p. 48-57 10 p.

Research output: Contribution to journalArticle

12 Scopus citations

Fine-Tuning of GPCR-Chemokine Interactions. Design and Identification of Chemokine Analogues as Receptor Agonists, Biased Agonists, and Antagonists

Navarro, J., Mar 12 2019, In : Biochemistry. 58, 10, p. 1432-1439 8 p.

Research output: Contribution to journalArticle

Fluoroquinolone efficacy against tuberculosis is driven by penetration into lesions and activity against resident bacterial populations

Sarathy, J., Blanc, L., Alvarez-Cabrera, N., O’Brien, P., Dias-Freedman, I., Mina, M., Zimmerman, M., Kaya, F., Liang, H. P. H., Prideaux, B., Dietzold, J., Salgame, P., Savic, R. M., Linderman, J., Kirschner, D., Pienaar, E. & Dartois, V., May 2019, In : Antimicrobial agents and chemotherapy. 63, 5, e02516-18.

Research output: Contribution to journalArticle

7 Scopus citations

Gap junctions coordinate the propagation of glycogenolysis induced by norepinephrine in the pineal gland

Eugenin, E. A., Valdebenito, S., Gorska, A. M., Martínez, A. D., Bitran, M. & Sáez, J. C., Dec 1 2019, In : Journal of neurochemistry. 151, 5, p. 558-569 12 p.

Research output: Contribution to journalArticle

HIV-1 reservoirs in urethral macrophages of patients under suppressive antiretroviral therapy

Ganor, Y., Real, F., Sennepin, A., Dutertre, C. A., Prevedel, L., Xu, L., Tudor, D., Charmeteau, B., Couedel-Courteille, A., Marion, S., Zenak, A. R., Jourdain, J. P., Zhou, Z., Schmitt, A., Capron, C., Eugenin, E. A., Cheynier, R., Revol, M., Cristofari, S., Hosmalin, A. & 1 others, Bomsel, M., Apr 1 2019, In : Nature Microbiology. 4, 4, p. 633-644 12 p.

Research output: Contribution to journalArticle

62 Scopus citations

HIV infection and latency induce a unique metabolic signature in human macrophages

Castellano, P., Prevedel, L., Valdebenito, S. & Eugenin, E. A., Dec 1 2019, In : Scientific reports. 9, 1, 3941.

Research output: Contribution to journalArticle

Open Access
11 Scopus citations

Identification, Localization, and Quantification of HIV Reservoirs Using Microscopy

Prevedel, L., Ruel, N., Castellano, P., Smith, C., Malik, S., Villeux, C., Bomsel, M., Morgello, S. & Eugenin, E. A., Mar 2019, In : Current Protocols in Cell Biology. 82, 1, e64.

Research output: Contribution to journalArticle

7 Scopus citations

Inhibition of LEF1-mediated DCLK1 by niclosamide attenuates colorectal cancer stemness

Park, S. Y., Kim, J. Y., Choi, J. H., Kim, J. H., Lee, C. J., Singh, P., Sarkar, S., Baek, J. H. & Nam, J. S., Feb 15 2019, In : Clinical Cancer Research. 25, 4, p. 1415-1429 15 p.

Research output: Contribution to journalArticle

10 Scopus citations

Inhibition of Upf2-Dependent Nonsense-Mediated Decay Leads to Behavioral and Neurophysiological Abnormalities by Activating the Immune Response

Johnson, J. L., Stoica, L., Liu, Y., Zhu, P. J., Bhattacharya, A., Buffington, S. A., Huq, R., Eissa, N. T., Larsson, O., Porse, B. T., Domingo, D., Nawaz, U., Carroll, R., Jolly, L., Scerri, T. S., Kim, H. G., Brignell, A., Coleman, M. J., Braden, R., Kini, U. & 11 others, Jackson, V., Baxter, A., Bahlo, M., Scheffer, I. E., Amor, D. J., Hildebrand, M. S., Bonnen, P. E., Beeton, C., Gecz, J., Morgan, A. T. & Costa-Mattioli, M., Nov 20 2019, In : Neuron. 104, 4, p. 665-679.e8

Research output: Contribution to journalArticle

7 Scopus citations

Mass spectrometry imaging to detect lipid biomarkers and disease signatures in cancer

Holzlechner, M., Eugenin, E. & Prideaux, B., Dec 1 2019, In : Cancer Reports. 2, 6, e1229.

Research output: Contribution to journalReview article

Open Access

Maternal vaccination and protective immunity against Zika virus vertical transmission

Shan, C., Xie, X., Luo, H., Muruato, A. E., Liu, Y., Wakamiya, M., La, J. H., Chung, J. M., Weaver, S. C., Wang, T. & Shi, P. Y., Dec 1 2019, In : Nature communications. 10, 1, 5677.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

Mechanical unfolding of spectrin reveals a super-exponential dependence of unfolding rate on force

Renn, J. P., Bhattacharyya, S., Bai, H., He, C., Li, H., Oberhauser, A. F., Marko, J. F., Makarov, D. E. & Matouschek, A., Jul 31 2019, In : Scientific reports. 9, 1, p. 11101 1 p., 11101.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Mechanisms Underlying Microbial-Mediated Changes in Social Behavior in Mouse Models of Autism Spectrum Disorder

Sgritta, M., Dooling, S. W., Buffington, S. A., Momin, E. N., Francis, M. B., Britton, R. A. & Costa-Mattioli, M., Jan 16 2019, In : Neuron. 101, 2, p. 246-259.e6

Research output: Contribution to journalArticle

78 Scopus citations

Microglia Mediate HIV-1 gp120-Induced Synaptic Degeneration in Spinal Pain Neural Circuits

Ru, W., Liu, X., Bae, C., Shi, Y., Walikonis, R., Mo Chung, J. & Tang, S. J., Oct 16 2019, In : The Journal of neuroscience : the official journal of the Society for Neuroscience. 39, 42, p. 8408-8421 14 p.

Research output: Contribution to journalArticle

5 Scopus citations

Morphine and HIV-1 gp120 cooperatively promote pathogenesis in the spinal pain neural circuit

Shi, Y., Yuan, S. & Tang, S. J., Jul 1 2019, In : Molecular pain. 15

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Motor neuron disease-associated loss of nuclear TDP-43 is linked to DNA double-strand break repair defects

Mitra, J., Guerrero, E. N., Hegde, P. M., Liachko, N. F., Wang, H., Vasquez, V., Gao, J., Pandey, A., Paul Taylor, J., Kraemer, B. C., Wu, P., Boldogh, I., Garruto, R. M., Mitra, S., Rao, K. S. & Hegde, M. L., 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 10, p. 4696-4705 10 p.

Research output: Contribution to journalArticle

37 Scopus citations

Novel approaches for glioblastoma treatment: Focus on tumor heterogeneity, treatment resistance, and computational tools

Valdebenito, S., D'Amico, D. & Eugenin, E., Dec 1 2019, In : Cancer Reports. 2, 6, e1220.

Research output: Contribution to journalReview article

Open Access
1 Scopus citations

Peripheral and central oxidative stress in chemotherapy-induced neuropathic pain

Shim, H. S., Bae, C., Wang, J., Lee, K. H., Hankerd, K. M., Kim, H. K., Chung, J. M. & La, J. H., Apr 1 2019, In : Molecular pain. 15

Research output: Contribution to journalArticle

Open Access
12 Scopus citations