Research Output

2020

Acute flaccid myelitis: Current status and diagnostic challenges

Fang, X. & Huda, R., Jul 2020, In : Journal of Clinical Neurology (Korea). 16, 3, p. 376-382 7 p.

Research output: Contribution to journalReview article

Open Access

Advances and considerations in AD tau-targeted immunotherapy

Bittar, A., Bhatt, N. & Kayed, R., Feb 2020, In : Neurobiology of Disease. 134, 104707.

Research output: Contribution to journalReview article

Open Access
6 Scopus citations

Amelioration of hippocampal dysfunction by adipose tissue-targeted stem cell transplantation in a mouse model of type 2 diabetes

Krishnan, B., Sallam, H. S., Tumurbataar, B., Saieva, S., Baymon, DM., Tuvdendorj, D., Micci, M. A., Abate, N. & Taglialatela, G., Apr 1 2020, In : Journal of neurochemistry. 153, 1, p. 51-62 12 p.

Research output: Contribution to journalArticle

1 Scopus citations

Deficiency in classical nonhomologous end-joining-mediated repair of transcribed genes is linked to SCA3 pathogenesis

Chakraborty, A., Tapryal, N., Venkova, T., Mitra, J., Vasquez, V., Sarker, A. H., Duarte-Silva, S., Huai, W., Ashizawa, T., Ghosh, G., MacIel, P., Sarkar, P. S., Hegde, M. L., Chen, X. & Hazra, T. K., Apr 7 2020, In : Proceedings of the National Academy of Sciences of the United States of America. 117, 14, p. 8154-8165 12 p.

Research output: Contribution to journalArticle

Fentanyl self-administration impacts brain immune responses in male Sprague-Dawley rats

Ezeomah, C., Cunningham, K. A., Stutz, S. J., Fox, R. G., Bukreyeva, N., Dineley, K. T., Paessler, S. & Cisneros, I. E., Jul 2020, In : Brain, Behavior, and Immunity. 87, p. 725-738 14 p.

Research output: Contribution to journalArticle

1 Scopus citations

Functional impairment of cortical AMPA receptors in schizophrenia

Zeppillo, T., Schulmann, A., Macciardi, F., Hjelm, B. E., Föcking, M., Sequeira, P. A., Guella, I., Cotter, D., Bunney, W. E., Limon, A. & Vawter, M. P., 2020, (Accepted/In press) In : Schizophrenia Research.

Research output: Contribution to journalArticle

Internalization mechanisms of brain-derived tau oligomers from patients with Alzheimer’s disease, progressive supranuclear palsy and dementia with Lewy bodies

Puangmalai, N., Bhatt, N., Montalbano, M., Sengupta, U., Gaikwad, S., Ventura, F., McAllen, S., Ellsworth, A., Garcia, S. & Kayed, R., May 1 2020, In : Cell Death and Disease. 11, 5, 314.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Polymorphic α-Synuclein Strains Modified by Dopamine and Docosahexaenoic Acid Interact Differentially with Tau Protein

Sengupta, U., Puangmalai, N., Bhatt, N., Garcia, S., Zhao, Y. & Kayed, R., Jun 1 2020, In : Molecular Neurobiology. 57, 6, p. 2741-2765 25 p.

Research output: Contribution to journalArticle

Open Access

Preservation of global synaptic excitatory to inhibitory ratio during long postmortem intervals

Scaduto, P., Sequeira, A., Vawter, M. P., Bunney, W. & Limon, A., Dec 1 2020, In : Scientific reports. 10, 1, 8626.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Regional transcriptome analysis of AMPA and GABAA receptor subunit expression generates E/I signatures of the human brain

Shen, K., Zeppillo, T. & Limon, A., Dec 1 2020, In : Scientific reports. 10, 1, 11352.

Research output: Contribution to journalArticle

Open Access

Revisiting the intersection of amyloid, pathologically modified tau and iron in Alzheimer's disease from a ferroptosis perspective

Derry, P. J., Hegde, M. L., Jackson, G. R., Kayed, R., Tour, J. M., Tsai, A. L. & Kent, T. A., Jan 2020, In : Progress in Neurobiology. 184, 101716.

Research output: Contribution to journalReview article

Open Access
7 Scopus citations

Selected microRNAs Increase Synaptic Resilience to the Damaging Binding of the Alzheimer’s Disease Amyloid Beta Oligomers

Zolochevska, O. & Taglialatela, G., May 1 2020, In : Molecular Neurobiology. 57, 5, p. 2232-2243 12 p.

Research output: Contribution to journalArticle

Open Access

Tonic Calcium-Activated Chloride Current Sustained by ATP Release and Highly Desensitizing Human P2X1 Receptors

Limon, A., Hagopian, G., Reyes-Ruiz, J. M. & Miledi, R., Jul 15 2020, In : Neuroscience. 439, p. 332-341 10 p.

Research output: Contribution to journalArticle

Tyrosine Kinase Inhibitors Reduce NMDA NR1 Subunit Expression, Nuclear Translocation, and Behavioral Pain Measures in Experimental Arthritis

Westlund, K. N., Lu, Y., Zhang, L., Pappas, T. C., Zhang, W. R., Taglialatela, G., McIlwrath, S. L. & McNearney, T. A., May 27 2020, In : Frontiers in Physiology. 11, 440.

Research output: Contribution to journalArticle

Open Access
2019

Ablation of amyloid precursor protein increases insulin-degrading enzyme levels and activity in brain and peripheral tissues

Kulas, J. A., Franklin, W. F., Smith, N. A., Manocha, G. D., Puig, K. L., Nagamoto-Combs, K., Hendrix, R. D., Taglialatela, G., Barger, S. W. & Combs, C. K., Jan 2019, In : American Journal of Physiology - Endocrinology and Metabolism. 316, 1, p. E106-E120

Research output: Contribution to journalArticle

5 Scopus citations

Amyloid oligomer interactions and polymorphisms: disease-relevant distinct assembly of α-synuclein and tau

Sengupta, U. & Kayed, R., Jan 1 2019, In : Neuropsychopharmacology. 44, 1, p. 222-223 2 p.

Research output: Contribution to journalComment/debate

1 Scopus citations
1 Scopus citations

Brachial Plexopathies: Update on Treatment

Shanina, E., Liao, B. & Smith, R. G., May 1 2019, In : Current Treatment Options in Neurology. 21, 5, 24.

Research output: Contribution to journalReview article

Chronic poly-drug administration damages adult mouse brain neural stem cells

McGrath, E. L., Schlagal, C. R., Cortez, I., Dunn, T. J., Gao, J., Fox, R. G., Stutz, S. J., Kuo, Y. F., Hommel, J., Dineley, K., Cunningham, K., Kaphalia, B. & Wu, P., Nov 15 2019, In : Brain Research. 1723, 146425.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Combinatory FK506 and minocycline treatment alleviates prion-induced neurodegenerative events via caspase-mediated MAPK-NRF2 pathway

Shah, S. Z. A., Zhao, D., Taglialatela, G., Hussain, T., Dong, H., Sabir, N., Mangi, M. H., Wu, W., Lai, M., Zhang, X., Duan, Y., Wang, L., Zhou, X. & Yang, L., Mar 1 2019, In : International journal of molecular sciences. 20, 5, 1144.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Co-occurrence of multiple sclerosis and myasthenia gravis: A case report and review of immunological theories

Dehbashi, S., Hamouda, D. & Shanina, E., Sep 1 2019, In : Multiple Sclerosis and Related Disorders. 34, p. 135-136 2 p.

Research output: Contribution to journalArticle

Open Access

Electrophysiological evaluation of extracellular spermine and alkaline pH on synaptic human GABAA receptors

Limon, A., Delbruck, E., Yassine, A., Pandya, D., Myers, R. M., Barchas, J. D., Lee, F., Schatzberg, Watson, S. J., Akil, H., Bunney, W. E., Vawter, M. P. & Sequeira, A., Dec 1 2019, In : Translational psychiatry. 9, 1, 218.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Hippocampal stem cells promotes synaptic resistance to the dysfunctional impact of amyloid beta oligomers via secreted exosomes

Micci, M. A., Krishnan, B., Bishop, E., Zhang, W. R., Guptarak, J., Grant, A., Zolochevska, O., Tumurbaatar, B., Franklin, W., Marino, C., Widen, S. G., Luthra, A., Kernie, S. G. & Taglialatela, G., Jun 14 2019, In : Molecular Neurodegeneration. 14, 1, 25.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

Hsp60 Protects against Amyloid β Oligomer Synaptic Toxicity via Modification of Toxic Oligomer Conformation

Marino, C., Krishnan, B., Cappello, F. & Taglialatela, G., Jun 19 2019, In : ACS chemical neuroscience. 10, 6, p. 2858-2867 10 p.

Research output: Contribution to journalArticle

2 Scopus citations

Human brain transcriptome analysis finds region- and subject-specific expression signatures of GABAAR subunits

Sequeira, A., Shen, K., Gottlieb, A. & Limon, A., Dec 1 2019, In : Communications Biology. 2, 1, 153.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

Hypermethylation of mitochondrial transcription factor A induced by cigarette smoke is associated with chronic obstructive pulmonary disease

Peng, H., Guo, T., Chen, Z., Zhang, H., Cai, S., Yang, M., Chen, P., Guan, C. & Fang, X., Apr 21 2019, In : Experimental Lung Research. 45, 3-4, p. 101-111 11 p.

Research output: Contribution to journalArticle

1 Scopus citations

Intraarterial Thrombolysis as Rescue Therapy for Large Vessel Occlusions: Analysis From the North American Solitaire Stent-Retriever Acute Stroke Registry

Zaidi, S. F., Castonguay, A. C., Jumaa, M. A., Malisch, T. W., Linfante, I., Marden, F. A., Abraham, M. G., Chebl, A. B., Novakovic, R., Taqi, M. A., Nogueira, R. G., Martin, C. O., Holloway, W. E., Mueller-Kronast, N., English, J. D., Dabus, G., Bozorgchami, H., Xavier, A., Rai, A. T., Froehler, M. T. & 11 others, Badruddin, A., Nguyen, T. N., Yoo, A. J., Shaltoni, H., Janardhan, V., Chen, P. R., Britz, G. W., Kaushal, R., Nanda, A., Gupta, R. & Zaidat, O. O., Apr 1 2019, In : Stroke. 50, 4, p. 1003-1006 4 p.

Research output: Contribution to journalArticle

8 Scopus citations

Is insulin resistance the cause of fibromyalgia? A preliminary report

Pappolla, M., Manchikanti, L., Andersen, C. R., Greig, N. H., Ahmed, F., Fang, X., Seffinger, M. A. & Trescot, A. M., Jan 1 2019, In : PloS one. 14, 5, p. e0216079

Research output: Contribution to journalArticle

Open Access

Mutant huntingtin impairs PNKP and ATXN3, disrupting DNA repair and transcription

Gao, R., Chakraborty, A., Geater, C., Pradhan, S., Gordon, K. L., Snowden, J., Yuan, S., Dickey, A. S., Choudhary, S., Ashizawa, T., Ellerby, L. M., La Spada, A. R., Thompson, L. M., Hazra, T. K. & Sarkar, P. S., Apr 2019, In : eLife. 8, e42988.

Research output: Contribution to journalArticle

Open Access
7 Scopus citations

Near Infrared Light Treatment Reduces Synaptic Levels of Toxic Tau Oligomers in Two Transgenic Mouse Models of Human Tauopathies

Comerota, M. M., Tumurbaatar, B., Krishnan, B., Kayed, R. & Taglialatela, G., May 1 2019, In : Molecular Neurobiology. 56, 5, p. 3341-3355 15 p.

Research output: Contribution to journalArticle

4 Scopus citations

NLRP3 inflammasome activation drives tau pathology

Ising, C., Venegas, C., Zhang, S., Scheiblich, H., Schmidt, S. V., Vieira-Saecker, A., Schwartz, S., Albasset, S., McManus, R. M., Tejera, D., Griep, A., Santarelli, F., Brosseron, F., Opitz, S., Stunden, J., Merten, M., Kayed, R., Golenbock, D. T., Blum, D., Latz, E. & 2 others, Buée, L. & Heneka, M. T., Nov 28 2019, In : Nature. 575, 7784, p. 669-673 5 p.

Research output: Contribution to journalArticle

56 Scopus citations

Suppressing aberrant phospholipase D1 signaling in 3xTg Alzheimer’s disease mouse model promotes synaptic resilience

Bourne, K. Z., Natarajan, C., Perez, C. X. M., Tumurbaatar, B., Taglialatela, G. & Krishnan, B., Dec 1 2019, In : Scientific reports. 9, 1, 18342.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Tau Interacts with the C-Terminal Region of α-Synuclein, Promoting Formation of Toxic Aggregates with Distinct Molecular Conformations

Dasari, A. K. R., Kayed, R., Wi, S. & Lim, K. H., Jun 25 2019, In : Biochemistry. 58, 25, p. 2814-2821 8 p.

Research output: Contribution to journalArticle

4 Scopus citations

Tau oligomers mediate aggregation of RNA-binding proteins Musashi1 and Musashi2 inducing Lamin alteration

Montalbano, M., McAllen, S., Sengupta, U., Puangmalai, N., Bhatt, N., Ellsworth, A. & Kayed, R., Dec 1 2019, In : Aging cell. 18, 6, e13035.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

Toxic Tau Oligomers Modulated by Novel Curcumin Derivatives

Lo Cascio, F., Puangmalai, N., Ellsworth, A., Bucchieri, F., Pace, A., Palumbo Piccionello, A. & Kayed, R., Dec 1 2019, In : Scientific reports. 9, 1, 19011.

Research output: Contribution to journalArticle

Open Access
6 Scopus citations

Use of noninvasive induction techniques in the diagnosis of PNES

Gogia, B., Rai, P. K., Matthys, S. A., Mong, E. R., Rodriguez, R., Yassin, A., Patel, K., Patel, C. & Todd, M., Oct 2019, In : Epilepsy and Behavior. 99, 106491.

Research output: Contribution to journalArticle

2 Scopus citations
2018

AAV2-mediated GRP78 transfer alleviates retinal neuronal injury by downregulating ER stress and Tau oligomer formation

Ha, Y., Liu, W., Liu, H., Zhu, S., Xia, F., Gerson, J. E., Azhar, N. A., Tilton, R. G., Motamedi, M., Kayed, R. & Zhang, W., Sep 2018, In : Investigative Ophthalmology and Visual Science. 59, 11, p. 4670-4682 13 p.

Research output: Contribution to journalArticle

5 Scopus citations

A protocol for measuring cue reactivity in a rat model of cocaine use disorder

Dimet, A. L., Cisneros, I. E., Fox, R. G., Stutz, S. J., Anastasio, N. C., Cunningham, K. A. & Dineley, K. T., Jun 20 2018, In : Journal of Visualized Experiments. 2018, 136, e55864.

Research output: Contribution to journalArticle

4 Scopus citations

Azure C Targets and Modulates Toxic Tau Oligomers

Lo Cascio, F. & Kayed, R., Jun 20 2018, In : ACS Chemical Neuroscience. 9, 6, p. 1317-1326 10 p.

Research output: Contribution to journalArticle

15 Scopus citations

Binding and neurotoxicity mitigation of toxic tau oligomers by synthetic heparin like oligosaccharides

Wang, P., Lo Cascio, F., Gao, J., Kayed, R. & Huang, X., 2018, In : Chemical Communications. 54, 72, p. 10120-10123 4 p.

Research output: Contribution to journalArticle

8 Scopus citations
6 Scopus citations

Do regenerative medicine therapies provide long-term relief in chronic low back pain: A systematic review and metaanalysis

Sanapati, J., Manchikanti, L., Atluri, S., Jordan, S., Albers, S. L., Pappolla, M. A., Kaye, A. D., Candido, K. D., Pampati, V. & Hirsch, J. A., Nov 2018, In : Pain physician. 21, 6, p. 515-540 26 p.

Research output: Contribution to journalReview article

35 Scopus citations
10 Scopus citations

Formation of Toxic Oligomeric Assemblies of RNA-binding Protein: Musashi in Alzheimer's disease

Sengupta, U., Montalbano, M., McAllen, S., Minuesa, G., Kharas, M. & Kayed, R., Oct 26 2018, In : Acta Neuropathologica Communications. 6, 1, p. 113 1 p.

Research output: Contribution to journalArticle

5 Scopus citations

Levels of Par-1 kinase determine the localization of Bruchpilot at the Drosophila neuromuscular junction synapses

Barber, K. R., Hruska, M., Bush, K. M., Martinez, J. A., Fei, H., Levitan, I. B., Dalva, M. B. & Wairkar, Y. P., Dec 1 2018, In : Scientific reports. 8, 1, 16099.

Research output: Contribution to journalArticle

1 Scopus citations

Melatonin treatment enhances Aβ lymphatic clearance in a transgenic mouse model of amyloidosis

Pappolla, M. A., Matsubara, E., Vidal, R., Pacheco-Quinto, J., Poeggeler, B., Zagorski, M. & Sambamurti, K., 2018, In : Current Alzheimer Research. 15, 7, p. 637-642 6 p.

Research output: Contribution to journalArticle

11 Scopus citations

Postsynaptic Proteome of Non-Demented Individuals with Alzheimer's Disease Neuropathology

Zolochevska, O., Bjorklund, N., Woltjer, R., Wiktorowicz, J. E. & Taglialatela, G., 2018, In : Journal of Alzheimer's disease : JAD. 65, 2, p. 659-682 24 p.

Research output: Contribution to journalArticle

8 Scopus citations