Research Output

2015

Inactivation of PNKP by Mutant ATXN3 Triggers Apoptosis by Activating the DNA Damage-Response Pathway in SCA3

Gao, R., Liu, Y., Silva-Fernandes, A., Fang, X., Paulucci-Holthauzen, A., Chatterjee, A., Zhang, H. L., Matsuura, T., Choudhary, S., Ashizawa, T., Koeppen, A. H., Maciel, P., Hazra, T. K. & Sarkar, P. S., Jan 1 2015, In : PLoS genetics. 11, 1, e1004834.

Research output: Contribution to journalArticle

28 Scopus citations

NFκB-Activated Astroglial Release of Complement C3 Compromises Neuronal Morphology and Function Associated with Alzheimer's Disease

Lian, H., Yang, L., Cole, A., Sun, L., Chiang, A. C. A., Fowler, S. W., Shim, D. J., Rodriguez-Rivera, J., Taglialatela, G., Jankowsky, J. L., Lu, H. C. & Zheng, H., Jan 7 2015, In : Neuron. 85, 1, p. 101-115 15 p.

Research output: Contribution to journalArticle

139 Scopus citations

Nicotinic ACh receptors as therapeutic targets in CNS disorders

Dineley, K. T., Pandya, A. A. & Yakel, J. L., Feb 2015, In : Trends in Pharmacological Sciences. 36, 2, p. 96-108 13 p.

Research output: Contribution to journalReview article

211 Scopus citations

Oxidative stress events and neuronal dysfunction in alzheimer’s disease: Focus on APE1/ref-1-mediated survival strategies

Kaur, N., Sarkar, B., Mittal, S., Dhiman, M., Taglialatela, G., Perez-Polo, R. J. & Mantha, A. K., Jan 1 2015, Free Radicals in Human Health and Disease. Springer India, p. 175-207 33 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

4 Scopus citations

Peripheral adipose tissue insulin resistance alters lipid composition and function of hippocampal synapses

Sallam, H. S., Tumurbaatar, B., Zhang, W. R., Tuvdendorj, D., Chandalia, M., Tempia, F., Laezza, F., Taglialatela, G. & Abate, N., Apr 2015, In : Journal of neurochemistry. 133, 1, p. 125-133 9 p.

Research output: Contribution to journalArticle

11 Scopus citations

Tau immunotherapy modulates both pathological tau and upstream amyloid pathology in an alzheimer’s disease mouse model

Castillo-Carranza, D. L., Guerrero-Muñoz, M. J., Sengupta, U., Hernandez, C., Barrett, A. D. T., Dineley, K. & Kayed, R., Jan 1 2015, In : Journal of Neuroscience. 35, 12, p. 4857-4868 12 p.

Research output: Contribution to journalArticle

76 Scopus citations

The Role of the Mammalian DNA End-processing Enzyme Polynucleotide Kinase 3’-Phosphatase in Spinocerebellar Ataxia Type 3 Pathogenesis

Chatterjee, A., Saha, S., Chakraborty, A., Silva-Fernandes, A., Mandal, S. M., Neves-Carvalho, A., Liu, Y., Pandita, R. K., Hegde, M. L., Hegde, P. M., Boldogh, I., Ashizawa, T., Koeppen, A. H., Pandita, T. K., Maciel, P., Sarkar, P. S. & Hazra, T. K., Jan 1 2015, In : PLoS genetics. 11, 1, e1004749.

Research output: Contribution to journalArticle

37 Scopus citations
2014

Acute peripheral vestibulopathy in a cocaine addict: Cracking the vestibular nucleus

Feyissa, A. M., Masel, T. & Busby, S. P., Jan 1 2014, In : Neurology: Clinical Practice. 4, 6, p. 532-533 2 p.

Research output: Contribution to journalComment/debate

Advances in therapeutics for neurodegenerative tauopathies: Moving toward the specific targeting of the most toxic tau species

Gerson, J. E., Castillo-Carranza, D. L. & Kayed, R., Sep 17 2014, In : ACS chemical neuroscience. 5, 9, p. 752-769 18 p.

Research output: Contribution to journalReview article

31 Scopus citations

Amyloid-β oligomers as a template for secondary amyloidosis in Alzheimer's disease

Guerrero-Muñoz, M. J., Castillo-Carranza, D. L., Krishnamurthy, S., Paulucci-Holthauzen, A. A., Sengupta, U., Lasagna-Reeves, C. A., Ahmad, Y., Jackson, G. R. & Kayed, R., Nov 2014, In : Neurobiology of Disease. 71, p. 14-23 10 p.

Research output: Contribution to journalArticle

26 Scopus citations

Characterization of tau oligomeric seeds in progressive supranuclear palsy

Gerson, J. E., Sengupta, U., Lasagna-Reeves, C. A., Guerrero-Muñoz, M. J., Troncoso, J. & Kayed, R., Jan 27 2014, In : Acta Neuropathologica Communications. 2, 1, 73.

Research output: Contribution to journalArticle

39 Scopus citations

Chronic traumatic encephalopathy: A critical appraisal

Levin, B. & Bhardwaj, A., Apr 2014, In : Neurocritical Care. 20, 2, p. 334-344 11 p.

Research output: Contribution to journalReview article

13 Scopus citations

Cognitive enhancing treatment with a PPARγ agonist normalizes dentate granule cell presynaptic function in Tg2576 APP mice

Nenov, M. N., Laezza, F., Haidacher, S. J., Zhao, Y., Sadygov, R. G., Starkey, J. M., Spratt, H., Luxon, B. A., Dineley, K. T. & Denner, L., Jan 20 2014, In : Journal of Neuroscience. 34, 3, p. 1028-1036 9 p.

Research output: Contribution to journalArticle

39 Scopus citations

Ethanol suppresses PGC-1α expression by interfering with the cAMP-CREB pathway in neuronal cells

Liu, Z., Liu, Y., Gao, R., Li, H., Dunn, T., Wu, P., Smith, R. G., Sarkar, P. S. & Fang, X., Aug 6 2014, In : PloS one. 9, 8, e104247.

Research output: Contribution to journalArticle

14 Scopus citations

Evidence for lymphatic Aβ clearance in Alzheimer's transgenic mice

Pappolla, M., Sambamurti, K., Vidal, R., Pacheco-Quinto, J., Poeggeler, B. & Matsubara, E., Nov 2014, In : Neurobiology of Disease. 71, p. 215-219 5 p.

Research output: Contribution to journalArticle

27 Scopus citations

Evidence of a novel mechanism for partial γ-secretase inhibition induced paradoxical increase in secreted amyloid β protein

Barnwell, E., Padmaraju, V., Baranello, R., Pacheco-Quinto, J., Crosson, C., Ablonczy, Z., Eckman, E., Eckman, C. B., Ramakrishnan, V., Greig, N. H., Pappolla, M. A. & Sambamurti, K., Mar 21 2014, In : PloS one. 9, 3, e91531.

Research output: Contribution to journalArticle

13 Scopus citations

Hypertrophic spinal pachymeningitis: Idiopathic vs. IgG4-related

Ezzeldin, M., Shawagfeh, A., Schnadig, V., Smith, R. G. & Fang, X., Dec 15 2014, In : Journal of the Neurological Sciences. 347, 1-2, p. 398-400 3 p.

Research output: Contribution to journalLetter

15 Scopus citations

Insulin resistance in Alzheimer's disease

Dineley, K. T., Jahrling, J. B. & Denner, L., Dec 1 2014, In : Neurobiology of Disease. 72, Part A, p. 92-103 12 p.

Research output: Contribution to journalReview article

54 Scopus citations

Islet amyloid polypeptide (iapp): A second amyloid in alzheimer’s disease

Fawver, J. N., Ghiwot, Y., Koola, C., Carrera, W., Rodriguez-Rivera, J., Hernandez, C., Dineley, K. T., Kong, Y., Li, J., Jhamandas, J., Perry, G. & Murray, I. V. J., Dec 1 2014, In : Current Alzheimer Research. 11, 10, p. 928-940 13 p.

Research output: Contribution to journalArticle

33 Scopus citations

Passive immunization with tau oligomer monoclonal antibody reverses tauopathy phenotypes without affecting hyperphosphorylated neurofibrillary tangles

Castillo-Carranza, D. L., Sengupta, U., Guerrero-Muñoz, M. J., Lasagna-Reeves, C. A., Gerson, J. E., Singh, G., Mark Estes, D., Barrett, A. D. T., Dineley, K. T., Jackson, G. R. & Kayed, R., Jan 1 2014, In : Journal of Neuroscience. 34, 12, p. 4260-4272 13 p.

Research output: Contribution to journalArticle

146 Scopus citations

PPARγ recruitment to active ERK during memory consolidation is required for alzheimer's disease-related cognitive enhancement

Jahrling, J. B., Hernandez, C. M., Denner, L. & Dineley, K. T., Jan 1 2014, In : Journal of Neuroscience. 34, 11, p. 4054-4063 10 p.

Research output: Contribution to journalArticle

39 Scopus citations

Research tool: Validation of floxed α7 nicotinic acetylcholine receptor conditional knockout mice using in vitro and in vivo approaches

Hernandez, C. M., Cortez, I., Gu, Z., Colón-Sáez, J. O., Lamb, P. W., Wakamiya, M., Yakel, J. L. & Dineley, K. T., Aug 1 2014, In : Journal of Physiology. 592, 15, p. 3201-3214 14 p.

Research output: Contribution to journalArticle

14 Scopus citations

Specific targeting of tau oligomers in Htau mice prevents cognitive impairment and tau toxicity following injection with brain-derived tau oligomeric seeds

Castillo-Carranza, D. L., Gerson, J. E., Sengupta, U., Guerrero-Muñoz, M. J., Lasagna-Reeves, C. A. & Kayed, R., 2014, In : Journal of Alzheimer's Disease. 40, S1, p. S97-S111

Research output: Contribution to journalArticle

82 Scopus citations

Structure of the myotonic dystrophy type 2 RNA and designed small molecules that reduce toxicity

Childs-Disney, J. L., Yildirim, I., Park, H., Lohman, J. R., Guan, L., Tran, T., Sarkar, P., Schatz, G. C. & Disney, M. D., Feb 21 2014, In : ACS Chemical Biology. 9, 2, p. 538-550 13 p.

Research output: Contribution to journalArticle

39 Scopus citations

TDP-43 phosphorylation by casein kinase iε promotes oligomerization and enhances toxicity in vivo

Choksi, D. K., Roy, B., Chatterjee, S., Yusuff, T., Bakhoum, M. F., Sengupta, U., Ambegaokar, S., Kayed, R. & Jackson, G. R., Feb 1 2014, In : Human Molecular Genetics. 23, 4, p. 1025-1035 11 p., ddt498.

Research output: Contribution to journalArticle

47 Scopus citations

The formation of tau pore-like structures is prevalent and cell specific: Possible implications for the disease phenotypes

Lasagna-Reeves, C. A., Sengupta, U., Castillo-Carranza, D., Gerson, J. E., Guerrero-Munoz, M., Troncoso, J. C., Jackson, G. R. & Kayed, R., Jan 27 2014, In : Acta Neuropathologica Communications. 2, 1, 56.

Research output: Contribution to journalArticle

31 Scopus citations

Therapeutic approaches against common structural features of toxic oligomers shared by multiple amyloidogenic proteins

Guerrero-Muñoz, M. J., Castillo-Carranza, D. L. & Kayed, R., Apr 15 2014, In : Biochemical Pharmacology. 88, 4, p. 468-478 11 p.

Research output: Contribution to journalReview article

71 Scopus citations
2013

Accelerated neurodegeneration through chaperone-mediated oligomerization of tau

Blair, L. J., Nordhues, B. A., Hill, S. E., Scaglione, K. M., O'Leary, J. C., Fontaine, S. N., Breydo, L., Zhang, B., Li, P., Wang, L., Cotman, C., Paulson, H. L., Muschol, M., Uversky, V. N., Klengel, T., Binder, E. B., Kayed, R., Golde, T. E., Berchtold, N. & Dickey, C. A., Oct 1 2013, In : Journal of Clinical Investigation. 123, 10, p. 4158-4169 12 p.

Research output: Contribution to journalArticle

114 Scopus citations

CK2α regulates the transcription of BRP in Drosophila

Wairkar, Y. P., Trivedi, D., Natarajan, R., Barnes, K., Dolores, L. & Cho, P., Dec 1 2013, In : Developmental Biology. 384, 1, p. 53-64 12 p.

Research output: Contribution to journalArticle

5 Scopus citations

Design of metastable β-sheet oligomers from natively unstructured peptide

Guerrero-Muñoz, M. J., Castillo-Carranza, D. L., Sengupta, U., White, M. A. & Kayed, R., Dec 18 2013, In : ACS chemical neuroscience. 4, 12, p. 1520-1523 4 p.

Research output: Contribution to journalArticle

8 Scopus citations

Dual role of p53 amyloid formation in cancer; loss of function and gain of toxicity

Lasagna-Reeves, C. A., Clos, A. L., Castillo-Carranza, D., Sengupta, U., Guerrero-Muñoz, M., Kelly, B., Wagner, R. & Kayed, R., Jan 18 2013, In : Biochemical and Biophysical Research Communications. 430, 3, p. 963-968 6 p.

Research output: Contribution to journalArticle

44 Scopus citations

Enhanced leptin sensitivity, reduced adiposity, and improved glucose homeostasis in mice lacking exchange protein directly activated by cyclic AMP Isoform 1

Yan, J., Mei, F. C., Cheng, H., Lao, D. H., Hu, Y., Wei, J., Patrikeev, I., Hao, D., Stutz, S. J., Dineley, K. T., Motamedi, M., Hommel, J. D., Cunningham, K. A., Chen, J. & Cheng, X., Mar 1 2013, In : Molecular and cellular biology. 33, 5, p. 918-926 9 p.

Research output: Contribution to journalArticle

54 Scopus citations

Expression and methylation of mitochondrial transcription factor a in chronic obstructive pulmonary disease patients with lung cancer

Peng, H., Yang, M., Chen, Z. Y., Chen, P., Guan, C. X., Xiang, X. D., Cai, S., Chen, Y. & Fang, X., Dec 18 2013, In : PloS one. 8, 12, e82739.

Research output: Contribution to journalArticle

15 Scopus citations

Formation and propagation of tau oligomeric seeds

Gerson, J. E. & Kayed, R., Sep 11 2013, In : Frontiers in Neurology. 4 JUL, Article 93.

Research output: Contribution to journalReview article

61 Scopus citations

Klotho ameliorates chemically induced endoplasmic reticulum (ER) stress signaling

Banerjee, S., Zhao, Y., Sarkar, P. S., Rosenblatt, K. P., Tilton, R. G. & Choudhary, S., May 2013, In : Cellular Physiology and Biochemistry. 31, 4-5, p. 659-672 14 p.

Research output: Contribution to journalArticle

22 Scopus citations

Major carboxyl terminal fragments generated by γ-secretase processing of the alzheimer amyloid precursor Are 50 and 51 amino acids long

Pinnix, I., Ghiso, J. A., Pappolla, M. A. & Sambamurti, K., May 2013, In : American Journal of Geriatric Psychiatry. 21, 5, p. 474-483 10 p.

Research output: Contribution to journalArticle

7 Scopus citations

Molecular mechanisms of amyloid oligomers toxicity

Kayed, R. & Lasagna-Reeves, C. A., Jan 1 2013, In : Journal of Alzheimer's Disease. 33, SUPPL. 1, p. S67-S78

Research output: Contribution to journalReview article

182 Scopus citations

Paradoxical effects of repeat interruptions on spinocerebellar ataxia type 10 expansions and repeat instability

McFarland, K. N., Liu, J., Landrian, I., Gao, R., Sarkar, P. S., Raskin, S., Moscovich, M., Gatto, E. M., Teive, H. A. G., Ochoa, A., Rasmussen, A. & Ashizawa, T., Nov 1 2013, In : European Journal of Human Genetics. 21, 11, p. 1272-1276 5 p.

Research output: Contribution to journalArticle

19 Scopus citations

Purkinje cell loss is the major brain pathology of spinocerebellar ataxia type 10

Xia, G., McFarland, K. N., Wang, K., Sarkar, P. S., Yachnis, A. T. & Ashizawa, T., Dec 2013, In : Journal of Neurology, Neurosurgery and Psychiatry. 84, 12, p. 1409-1411 3 p.

Research output: Contribution to journalLetter

10 Scopus citations

Rapid accumulation of endogenous Tau oligomers in a rat model of traumatic brain injury: Possible link between traumatic brain injury and sporadic tauopathies

Hawkins, B. E., Krishnamurthy, S., Castillo-Carranza, D. L., Sengupta, U., Prough, D. S., Jackson, G. R., DeWitt, D. S. & Kayed, R., Jun 7 2013, In : Journal of Biological Chemistry. 288, 23, p. 17042-17050 9 p.

Research output: Contribution to journalArticle

84 Scopus citations

Ruthenium red colorimetric and birefringent staining of amyloid-β aggregates in vitro and in Tg2576 mice

Cook, N. P., Archer, C. M., Fawver, J. N., Schall, H. E., Rodriguez-Rivera, J., Dineley, K. T., Martí, A. A. & Murray, I. V. J., Mar 20 2013, In : ACS chemical neuroscience. 4, 3, p. 379-384 6 p.

Research output: Contribution to journalArticle

6 Scopus citations

Small misfolded tau species are internalized via bulk endocytosis and anterogradely and retrogradely transported in neurons

Wu, J. W., Herman, M., Liu, L., Simoes, S., Acker, C. M., Figueroa, H., Steinberg, J. I., Margittai, M., Kayed, R., Zurzolo, C., Di Paolo, G. & Duff, K. E., Jan 18 2013, In : Journal of Biological Chemistry. 288, 3, p. 1856-1870 15 p.

Research output: Contribution to journalArticle

240 Scopus citations

Tau aggregates as immunotherapeutic targets

Castillo-Carranza, D. L., Lasagna-Reeves, C. A. & Kayed, R., Jan 1 2013, In : Frontiers in Bioscience - Scholar. 5 S, 2, p. 426-438 13 p.

Research output: Contribution to journalArticle

30 Scopus citations

Tuberous sclerosis complex regulates drosophila neuromuscular junction growth via the TORC2/Akt pathway

Natarajan, R., Trivedi-vyas, D. & Wairkar, Y. P., May 1 2013, In : Human Molecular Genetics. 22, 10, p. 2010-2023 14 p., ddt053.

Research output: Contribution to journalArticle

21 Scopus citations

α7 nicotinic receptor-mediated astrocytic gliotransmitter release: Aβ effects in a preclinical Alzheimer's mouse model

Pirttimaki, T. M., Codadu, N. K., Awni, A., Pratik, P., Nagel, D. A., Hill, E. J., Dineley, K. T. & Parri, H. R., Nov 28 2013, In : PloS one. 8, 11, e81828.

Research output: Contribution to journalArticle

52 Scopus citations
2012

Alzheimer brain-derived tau oligomers propagate pathology from endogenous tau

Lasagna-Reeves, C. A., Castillo-Carranza, D. L., Sengupta, U., Guerrero-Munoz, M. J., Kiritoshi, T., Neugebauer, V., Jackson, G. R. & Kayed, R., Nov 7 2012, In : Scientific reports. 2, 700.

Research output: Contribution to journalArticle

227 Scopus citations

Association of skin with the pathogenesis and treatment of neurodegenerative amyloidosis

Clos, A. L., Kayed, R. & Lasagna-Reeves, C. A., Sep 12 2012, In : Frontiers in Neurology. JAN, Article 5.

Research output: Contribution to journalArticle

10 Scopus citations

Brain serum amyloid P levels are reduced in individuals that lack Dementia while having Alzheimer's disease neuropathology

Crawford, J. R., Gomer, R. H., Bjorklund, N. L. & Taglialatela, G., Apr 1 2012, In : Neurochemical Research. 37, 4, p. 795-801 7 p.

Research output: Contribution to journalArticle

13 Scopus citations

Cognitive enhancement with rosiglitazone links the hippocampal PPARγ and ERK MAPK signaling pathways

Denner, L. A., Rodriguez-Rivera, J., Haidacher, S. J., Jahrling, J. B., Carmical, J. R., Hernandez, C. M., Zhao, Y., Sadygov, R. G., Starkey, J. M., Spratt, H., Luxon, B. A., Wood, T. G. & Dineley, K. T., Nov 21 2012, In : Journal of Neuroscience. 32, 47, p. 16725-16735 11 p.

Research output: Contribution to journalArticle

77 Scopus citations

Differential activation of the ER stress factor XBP1 by oligomeric assemblies

Castillo-Carranza, D. L., Zhang, Y., Guerrero-Muñoz, M. J., Kayed, R., Rincon-Limas, D. E. & Fernandez-Funez, P., Aug 1 2012, In : Neurochemical Research. 37, 8, p. 1707-1717 11 p.

Research output: Contribution to journalArticle

23 Scopus citations