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2019

Amelioration of hippocampal dysfunction by adipose tissue-targeted stem cell transplantation in a mouse model of type 2 diabetes

Krishnan, B., Sallam, H. S., Tumurbataar, B., Saieva, S., Baymon, DM., Tuvdendorj, D., Micci, M. A., Abate, N. & Taglialatela, G., Jan 1 2019, (Accepted/In press) In : Journal of neurochemistry. e14915.

Research output: Contribution to journalArticle

Chronic poly-drug administration damages adult mouse brain neural stem cells

McGrath, E. L., Schlagal, C. R., Cortez, I., Dunn, T. J., Gao, J., Fox, R. G., Stutz, S. J., Kuo, Y. F., Hommel, J., Dineley, K., Cunningham, K., Kaphalia, B. & Wu, P., Nov 15 2019, In : Brain Research. 1723, 146425.

Research output: Contribution to journalArticle

Open Access

Combinatory FK506 and Minocycline Treatment Alleviates Prion-Induced Neurodegenerative Events via Caspase-Mediated MAPK-NRF2 Pathway

Shah, S. Z. A., Zhao, D., Taglialatela, G., Hussain, T., Dong, H., Sabir, N., Mangi, M. H., Wu, W., Lai, M., Zhang, X., Duan, Y., Wang, L., Zhou, X. & Yang, L., Mar 6 2019, In : International journal of molecular sciences. 20, 5

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Co-occurrence of multiple sclerosis and myasthenia gravis: A case report and review of immunological theories

Dehbashi, S., Hamouda, D. & Shanina, E., Sep 1 2019, In : Multiple Sclerosis and Related Disorders. 34, p. 135-136 2 p.

Research output: Contribution to journalArticle

Open Access

Electrophysiological evaluation of extracellular spermine and alkaline pH on synaptic human GABAA receptors

Limon-Ruiz, A., Delbruck, E., Yassine, A., Pandya, D., Myers, R. M., Barchas, J. D., Lee, F., Schatzberg, Watson, S. J., Akil, H., Bunney, W. E., Vawter, M. P. & Sequeira, A., Dec 1 2019, In : Translational psychiatry. 9, 1, 218.

Research output: Contribution to journalArticle

Open Access

Hippocampal stem cells promotes synaptic resistance to the dysfunctional impact of amyloid beta oligomers via secreted exosomes

Micci, M., Krishnan, B., Bishop, E., Zhang, W. R., Guptarak, J., Grant, A., Cain, O., Tumurbaatar, B., Franklin, W., Marino, C., Widen, S., Luthra, A., Kernie, S. G. & Taglialatela, G., Jun 14 2019, In : Molecular Neurodegeneration. 14, 1, 25.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations
1 Scopus citations

Human brain transcriptome analysis finds region- and subject-specific expression signatures of GABAAR subunits

Sequeira, A., Shen, K., Gottlieb, A. & Limon-Ruiz, A., Dec 1 2019, In : Communications Biology. 2, 1, 153.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Hypermethylation of mitochondrial transcription factor A induced by cigarette smoke is associated with chronic obstructive pulmonary disease

Peng, H., Guo, T., Chen, Z., Zhang, H., Cai, S., Yang, M., Chen, P., Guan, C. & Fang, X., Apr 21 2019, In : Experimental Lung Research. 45, 3-4, p. 101-111 11 p.

Research output: Contribution to journalArticle

Intraarterial Thrombolysis as Rescue Therapy for Large Vessel Occlusions

Zaidi, S. F., Castonguay, A. C., Jumaa, M. A., Malisch, T. W., Linfante, I., Marden, F. A., Abraham, M. G., Chebl, A. B., Novakovic, R., Taqi, M. A., Nogueira, R. G., Martin, C. O., Holloway, W. E., Mueller-Kronast, N., English, J. D., Dabus, G., Bozorgchami, H., Xavier, A., Rai, A. T., Froehler, M. T. & 11 others, Badruddin, A., Nguyen, T. N., Yoo, A. J., Shaltoni, H., Janardhan, V., Chen, P. R., Britz, G. W., Kaushal, R., Nanda, A., Gupta, R. & Zaidat, O. O., Apr 1 2019, In : Stroke. 50, 4, p. 1003-1006 4 p.

Research output: Contribution to journalArticle

7 Scopus citations

Is insulin resistance the cause of fibromyalgia? A preliminary report

Pappolla, M., Manchikanti, L., Andersen, C. R., Greig, N. H., Ahmed, F., Fang, X., Seffinger, M. A. & Trescot, A. M., Jan 1 2019, In : PloS one. 14, 5, p. e0216079

Research output: Contribution to journalArticle

Open Access

Mutant huntingtin impairs PNKP and ATXN3, disrupting DNA repair and transcription

Gao, R., Chakraborty, A., Geater, C., Pradhan, S., Gordon, K. L., Snowden, J., Yuan, S., Dickey, A. S., Choudhary, S., Ashizawa, T., Ellerby, L. M., La Spada, A. R., Thompson, L. M., Hazra, T. & Sarkar, P., Apr 17 2019, In : eLife. 8

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

NLRP3 inflammasome activation drives tau pathology

Ising, C., Venegas, C., Zhang, S., Scheiblich, H., Schmidt, S. V., Vieira-Saecker, A., Schwartz, S., Albasset, S., McManus, R. M., Tejera, D., Griep, A., Santarelli, F., Brosseron, F., Opitz, S., Stunden, J., Merten, M., Kayed, R., Golenbock, D. T., Blum, D., Latz, E. & 2 others, Buée, L. & Heneka, M. T., Nov 28 2019, In : Nature. 575, 7784, p. 669-673 5 p.

Research output: Contribution to journalArticle

10 Scopus citations

Responsible, Safe, and Effective Use of Biologics in the Management of Low Back Pain: American Society of Interventional Pain Physicians (ASIPP) Guidelines

Navani, A., Manchikanti, L., Albers, S. L., Latchaw, R. E., Sanapati, J., Kaye, A. D., Atluri, S., Jordan, S., Gupta, A., Cedeno, D., Vallejo, A., Fellows, B., Knezevic, N. N., Pappolla, M., Diwan, S., Trescot, A. M., Soin, A., Kaye, A. M., Aydin, S. M., Calodney, A. K. & 10 others, Candido, K. D., Bakshi, S., Benyamin, R. M., Vallejo, R., Watanabe, A., Beall, D., Stitik, T. P., Foye, P. M., Helander, E. M. & Hirsch, J. A., Jan 1 2019, In : Pain physician. 22, 1, p. S1-S74

Research output: Contribution to journalArticle

8 Scopus citations

Suppressing aberrant phospholipase D1 signaling in 3xTg Alzheimer’s disease mouse model promotes synaptic resilience

Bourne, K. Z., Natarajan, C., Perez, C. X. M., Tumurbaatar, B., Taglialatela, G. & Krishnan, B., Dec 1 2019, In : Scientific reports. 9, 1, 18342.

Research output: Contribution to journalArticle

Open Access

Tau Interacts with the C-Terminal Region of α-Synuclein, Promoting Formation of Toxic Aggregates with Distinct Molecular Conformations

Dasari, A. K. R., Kayed, R., Wi, S. & Lim, K. H., Jun 25 2019, In : Biochemistry. 58, 25, p. 2814-2821 8 p.

Research output: Contribution to journalArticle

1 Scopus citations

Tau oligomers mediate aggregation of RNA-binding proteins Musashi1 and Musashi2 inducing Lamin alteration

Montalbano, M., McAllen, S., Sengupta, U., Puangmalai, N., Bhatt, N., Ellsworth, A. & Kayed, R., Dec 1 2019, In : Aging Cell. 18, 6, e13035.

Research output: Contribution to journalArticle

Open Access

Tonic Calcium-Activated Chloride Current Sustained by ATP Release and Highly Desensitizing Human P2X1 Receptors

Limon-Ruiz, A., Hagopian, G., Reyes-Ruiz, J. M. & Miledi, R., Jan 1 2019, In : Neuroscience.

Research output: Contribution to journalArticle

Use of noninvasive induction techniques in the diagnosis of PNES

Gogia, B., Rai, P. K., Matthys, S. A., Mong, E. R., Rodriguez, R., Yassin, A., Patel, K., Patel, C. & Todd, M., Oct 2019, In : Epilepsy and Behavior. 99, 106491.

Research output: Contribution to journalArticle

2018

AAV2-mediated GRP78 transfer alleviates retinal neuronal injury by downregulating ER stress and Tau oligomer formation

Ha, Y., Liu, W., Liu, H., Zhu, S., Xia, F., Gerson, J. E., Azhar, N. A., Tilton, R., Motamedi, M., Kayed, R. & Zhang, W., Sep 1 2018, In : Investigative Ophthalmology and Visual Science. 59, 11, p. 4670-4682 13 p.

Research output: Contribution to journalArticle

2 Scopus citations

Azure C Targets and Modulates Toxic Tau Oligomers

Lo Cascio, F. & Kayed, R., Jun 20 2018, In : ACS Chemical Neuroscience. 9, 6, p. 1317-1326 10 p.

Research output: Contribution to journalArticle

11 Scopus citations

Binding and neurotoxicity mitigation of toxic tau oligomers by synthetic heparin like oligosaccharides

Wang, P., Lo Cascio, F., Gao, J., Kayed, R. & Huang, X., Jan 1 2018, In : Chemical Communications. 54, 72, p. 10120-10123 4 p.

Research output: Contribution to journalArticle

6 Scopus citations

Postsynaptic Proteome of Non-Demented Individuals with Alzheimer's Disease Neuropathology

Cain, O., Bjorklund, N., Woltjer, R., Wiktorowicz, J. E. & Taglialatela, G., Jan 1 2018, In : Journal of Alzheimer's disease : JAD. 65, 2, p. 659-682 24 p.

Research output: Contribution to journalArticle

7 Scopus citations
2017
1 Scopus citations
2016

Pre-amyloid oligomers budding: A metastatic mechanism of proteotoxicity

Bernini, F., Malferrari, D., Pignataro, M., Bortolotti, C. A., Di Rocco, G., Lancellotti, L., Brigatti, M. F., Kayed, R., Borsari, M., Del Monte, F. & Castellini, E., Oct 24 2016, In : Scientific Reports. 6, 35865.

Research output: Contribution to journalArticle

4 Scopus citations

Preserved neurogenesis in non-demented individuals with AD neuropathology

Briley, D., Ghirardi, V., Woltjer, R., Renck, A., Cain, O., Taglialatela, G. & Micci, M., Jun 14 2016, In : Scientific Reports. 6, 27812.

Research output: Contribution to journalArticle

20 Scopus citations
2015

Amyloid-beta protein clearance and degradation (ABCD) pathways and their role in Alzheimer’s disease

Baranello, R. J., Bharani, K. L., Padmaraju, V., Chopra, N., Lahiri, D. K., Greig, N. H., Pappolla, M. A. & Sambamurti, K., Oct 1 2015, In : Current Alzheimer Research. 12, 1, p. 32-46 15 p.

Research output: Contribution to journalArticle

107 Scopus citations

Compression of lateral antebrachial cutaneous nerve in waitresses

Patel, C. & Vishnubhakat, S., Mar 6 2015, In : Journal of Clinical Neuromuscular Disease. 16, 3, p. 121-124 4 p.

Research output: Contribution to journalArticle

Inactivation of PNKP by Mutant ATXN3 Triggers Apoptosis by Activating the DNA Damage-Response Pathway in SCA3

Gao, R., Liu, Y., Silva-Fernandes, A., Fang, X., Paulucci-Holthauzen, A., Chatterjee, A., Zhang, H. L., Matsuura, T., Choudhary, S., Ashizawa, T., Koeppen, A. H., Maciel, P., Hazra, T. K. & Sarkar, P. S., Jan 1 2015, In : PLoS genetics. 11, 1, e1004834.

Research output: Contribution to journalArticle

27 Scopus citations

NFκB-Activated Astroglial Release of Complement C3 Compromises Neuronal Morphology and Function Associated with Alzheimer's Disease

Lian, H., Yang, L., Cole, A., Sun, L., Chiang, A. C. A., Fowler, S. W., Shim, D. J., Rodriguez-Rivera, J., Taglialatela, G., Jankowsky, J. L., Lu, H. C. & Zheng, H., Jan 7 2015, In : Neuron. 85, 1, p. 101-115 15 p.

Research output: Contribution to journalArticle

134 Scopus citations

Peripheral adipose tissue insulin resistance alters lipid composition and function of hippocampal synapses

Sallam, H. S., Tumurbaatar, B., Zhang, W. R., Tuvdendorj, D., Chandalia, M., Tempia, F., Laezza, F., Taglialatela, G. & Abate, N., Apr 2015, In : Journal of neurochemistry. 133, 1, p. 125-133 9 p.

Research output: Contribution to journalArticle

11 Scopus citations

Tau immunotherapy modulates both pathological tau and upstream amyloid pathology in an alzheimer’s disease mouse model

Castillo-Carranza, D. L., Guerrero-Muñoz, M. J., Sengupta, U., Hernandez, C., Barrett, A. D. T., Dineley, K. & Kayed, R., Jan 1 2015, In : Journal of Neuroscience. 35, 12, p. 4857-4868 12 p.

Research output: Contribution to journalArticle

73 Scopus citations

The Role of the Mammalian DNA End-processing Enzyme Polynucleotide Kinase 3’-Phosphatase in Spinocerebellar Ataxia Type 3 Pathogenesis

Chatterjee, A., Saha, S., Chakraborty, A., Silva-Fernandes, A., Mandal, S. M., Neves-Carvalho, A., Liu, Y., Pandita, R. K., Hegde, M. L., Hegde, P. M., Boldogh, I., Ashizawa, T., Koeppen, A. H., Pandita, T. K., Maciel, P., Sarkar, P. S. & Hazra, T. K., Jan 1 2015, In : PLoS genetics. 11, 1, e1004749.

Research output: Contribution to journalArticle

35 Scopus citations
2014

Amyloid-β oligomers as a template for secondary amyloidosis in Alzheimer's disease

Guerrero-Muñoz, M. J., Castillo-Carranza, D. L., Krishnamurthy, S., Paulucci-Holthauzen, A. A., Sengupta, U., Lasagna-Reeves, C. A., Ahmad, Y., Jackson, G. R. & Kayed, R., Nov 2014, In : Neurobiology of Disease. 71, p. 14-23 10 p.

Research output: Contribution to journalArticle

26 Scopus citations

Characterization of tau oligomeric seeds in progressive supranuclear palsy

Gerson, J. E., Sengupta, U., Lasagna-Reeves, C. A., Guerrero-Muñoz, M. J., Troncoso, J. & Kayed, R., Jan 27 2014, In : Acta Neuropathologica Communications. 2, 1, 73.

Research output: Contribution to journalArticle

37 Scopus citations

Cognitive enhancing treatment with a PPARγ agonist normalizes dentate granule cell presynaptic function in Tg2576 APP mice

Nenov, M. N., Laezza, F., Haidacher, S. J., Zhao, Y., Sadygov, R. G., Starkey, J. M., Spratt, H., Luxon, B. A., Dineley, K. T. & Denner, L., Jan 20 2014, In : Journal of Neuroscience. 34, 3, p. 1028-1036 9 p.

Research output: Contribution to journalArticle

39 Scopus citations

Ethanol suppresses PGC-1α expression by interfering with the cAMP-CREB pathway in neuronal cells

Liu, Z., Liu, Y., Gao, R., Li, H., Dunn, T., Wu, P., Smith, R. G., Sarkar, P. S. & Fang, X., Aug 6 2014, In : PloS one. 9, 8, e104247.

Research output: Contribution to journalArticle

14 Scopus citations

Evidence for lymphatic Aβ clearance in Alzheimer's transgenic mice

Pappolla, M., Sambamurti, K., Vidal, R., Pacheco-Quinto, J., Poeggeler, B. & Matsubara, E., Nov 2014, In : Neurobiology of Disease. 71, p. 215-219 5 p.

Research output: Contribution to journalArticle

26 Scopus citations

Evidence of a novel mechanism for partial γ-secretase inhibition induced paradoxical increase in secreted amyloid β protein

Barnwell, E., Padmaraju, V., Baranello, R., Pacheco-Quinto, J., Crosson, C., Ablonczy, Z., Eckman, E., Eckman, C. B., Ramakrishnan, V., Greig, N. H., Pappolla, M. A. & Sambamurti, K., Mar 21 2014, In : PloS one. 9, 3, e91531.

Research output: Contribution to journalArticle

13 Scopus citations

Islet amyloid polypeptide (iapp): A second amyloid in alzheimer’s disease

Fawver, J. N., Ghiwot, Y., Koola, C., Carrera, W., Rodriguez-Rivera, J., Hernandez, C., Dineley, K. T., Kong, Y., Li, J., Jhamandas, J., Perry, G. & Murray, I. V. J., Dec 1 2014, In : Current Alzheimer Research. 11, 10, p. 928-940 13 p.

Research output: Contribution to journalArticle

30 Scopus citations

Long-term efficacy and safety of fluphenazine in patients with Tourette syndrome

Wijemanne, S., Wu, L. J. C. & Jankovic, J., Jan 1 2014, In : Movement Disorders. 29, 1, p. 126-130 5 p.

Research output: Contribution to journalArticle

26 Scopus citations

Passive immunization with tau oligomer monoclonal antibody reverses tauopathy phenotypes without affecting hyperphosphorylated neurofibrillary tangles

Castillo-Carranza, D. L., Sengupta, U., Guerrero-Muñoz, M. J., Lasagna-Reeves, C. A., Gerson, J. E., Singh, G., Mark Estes, D., Barrett, A. D. T., Dineley, K. T., Jackson, G. R. & Kayed, R., Jan 1 2014, In : Journal of Neuroscience. 34, 12, p. 4260-4272 13 p.

Research output: Contribution to journalArticle

141 Scopus citations

PPARγ recruitment to active ERK during memory consolidation is required for alzheimer's disease-related cognitive enhancement

Jahrling, J. B., Hernandez, C. M., Denner, L. & Dineley, K. T., Jan 1 2014, In : Journal of Neuroscience. 34, 11, p. 4054-4063 10 p.

Research output: Contribution to journalArticle

39 Scopus citations

Research tool: Validation of floxed α7 nicotinic acetylcholine receptor conditional knockout mice using in vitro and in vivo approaches

Hernandez, C. M., Cortez, I., Gu, Z., Colón-Sáez, J. O., Lamb, P. W., Wakamiya, M., Yakel, J. L. & Dineley, K. T., Aug 1 2014, In : Journal of Physiology. 592, 15, p. 3201-3214 14 p.

Research output: Contribution to journalArticle

12 Scopus citations

Specific targeting of tau oligomers in Htau mice prevents cognitive impairment and tau toxicity following injection with brain-derived tau oligomeric seeds

Castillo-Carranza, D. L., Gerson, J. E., Sengupta, U., Guerrero-Muñoz, M. J., Lasagna-Reeves, C. A. & Kayed, R., 2014, In : Journal of Alzheimer's Disease. 40, S1, p. S97-S111

Research output: Contribution to journalArticle

76 Scopus citations

Structure of the myotonic dystrophy type 2 RNA and designed small molecules that reduce toxicity

Childs-Disney, J. L., Yildirim, I., Park, H., Lohman, J. R., Guan, L., Tran, T., Sarkar, P., Schatz, G. C. & Disney, M. D., Feb 21 2014, In : ACS Chemical Biology. 9, 2, p. 538-550 13 p.

Research output: Contribution to journalArticle

39 Scopus citations

TDP-43 phosphorylation by casein kinase iε promotes oligomerization and enhances toxicity in vivo

Choksi, D. K., Roy, B., Chatterjee, S., Yusuff, T., Bakhoum, M. F., Sengupta, U., Ambegaokar, S., Kayed, R. & Jackson, G. R., Feb 1 2014, In : Human Molecular Genetics. 23, 4, p. 1025-1035 11 p., ddt498.

Research output: Contribution to journalArticle

46 Scopus citations