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2014

Cognitive enhancing treatment with a PPARγ agonist normalizes dentate granule cell presynaptic function in Tg2576 APP mice

Nenov, M. N., Laezza, F., Haidacher, S. J., Zhao, Y., Sadygov, R. G., Starkey, J. M., Spratt, H., Luxon, B. A., Dineley, K. T. & Denner, L., Jan 20 2014, In : Journal of Neuroscience. 34, 3, p. 1028-1036 9 p.

Research output: Contribution to journalArticle

39 Scopus citations

Ethanol suppresses PGC-1α expression by interfering with the cAMP-CREB pathway in neuronal cells

Liu, Z., Liu, Y., Gao, R., Li, H., Dunn, T., Wu, P., Smith, R. G., Sarkar, P. S. & Fang, X., Aug 6 2014, In : PloS one. 9, 8, e104247.

Research output: Contribution to journalArticle

14 Scopus citations

Evidence for lymphatic Aβ clearance in Alzheimer's transgenic mice

Pappolla, M., Sambamurti, K., Vidal, R., Pacheco-Quinto, J., Poeggeler, B. & Matsubara, E., Nov 2014, In : Neurobiology of Disease. 71, p. 215-219 5 p.

Research output: Contribution to journalArticle

27 Scopus citations

Evidence of a novel mechanism for partial γ-secretase inhibition induced paradoxical increase in secreted amyloid β protein

Barnwell, E., Padmaraju, V., Baranello, R., Pacheco-Quinto, J., Crosson, C., Ablonczy, Z., Eckman, E., Eckman, C. B., Ramakrishnan, V., Greig, N. H., Pappolla, M. A. & Sambamurti, K., Mar 21 2014, In : PloS one. 9, 3, e91531.

Research output: Contribution to journalArticle

13 Scopus citations

Islet amyloid polypeptide (iapp): A second amyloid in alzheimer’s disease

Fawver, J. N., Ghiwot, Y., Koola, C., Carrera, W., Rodriguez-Rivera, J., Hernandez, C., Dineley, K. T., Kong, Y., Li, J., Jhamandas, J., Perry, G. & Murray, I. V. J., Dec 1 2014, In : Current Alzheimer Research. 11, 10, p. 928-940 13 p.

Research output: Contribution to journalArticle

33 Scopus citations

Passive immunization with tau oligomer monoclonal antibody reverses tauopathy phenotypes without affecting hyperphosphorylated neurofibrillary tangles

Castillo-Carranza, D. L., Sengupta, U., Guerrero-Muñoz, M. J., Lasagna-Reeves, C. A., Gerson, J. E., Singh, G., Mark Estes, D., Barrett, A. D. T., Dineley, K. T., Jackson, G. R. & Kayed, R., Jan 1 2014, In : Journal of Neuroscience. 34, 12, p. 4260-4272 13 p.

Research output: Contribution to journalArticle

146 Scopus citations

PPARγ recruitment to active ERK during memory consolidation is required for alzheimer's disease-related cognitive enhancement

Jahrling, J. B., Hernandez, C. M., Denner, L. & Dineley, K. T., Jan 1 2014, In : Journal of Neuroscience. 34, 11, p. 4054-4063 10 p.

Research output: Contribution to journalArticle

39 Scopus citations

Research tool: Validation of floxed α7 nicotinic acetylcholine receptor conditional knockout mice using in vitro and in vivo approaches

Hernandez, C. M., Cortez, I., Gu, Z., Colón-Sáez, J. O., Lamb, P. W., Wakamiya, M., Yakel, J. L. & Dineley, K. T., Aug 1 2014, In : Journal of Physiology. 592, 15, p. 3201-3214 14 p.

Research output: Contribution to journalArticle

14 Scopus citations

Specific targeting of tau oligomers in Htau mice prevents cognitive impairment and tau toxicity following injection with brain-derived tau oligomeric seeds

Castillo-Carranza, D. L., Gerson, J. E., Sengupta, U., Guerrero-Muñoz, M. J., Lasagna-Reeves, C. A. & Kayed, R., 2014, In : Journal of Alzheimer's Disease. 40, S1, p. S97-S111

Research output: Contribution to journalArticle

82 Scopus citations

Structure of the myotonic dystrophy type 2 RNA and designed small molecules that reduce toxicity

Childs-Disney, J. L., Yildirim, I., Park, H., Lohman, J. R., Guan, L., Tran, T., Sarkar, P., Schatz, G. C. & Disney, M. D., Feb 21 2014, In : ACS Chemical Biology. 9, 2, p. 538-550 13 p.

Research output: Contribution to journalArticle

39 Scopus citations

TDP-43 phosphorylation by casein kinase iε promotes oligomerization and enhances toxicity in vivo

Choksi, D. K., Roy, B., Chatterjee, S., Yusuff, T., Bakhoum, M. F., Sengupta, U., Ambegaokar, S., Kayed, R. & Jackson, G. R., Feb 1 2014, In : Human Molecular Genetics. 23, 4, p. 1025-1035 11 p., ddt498.

Research output: Contribution to journalArticle

47 Scopus citations

The formation of tau pore-like structures is prevalent and cell specific: Possible implications for the disease phenotypes

Lasagna-Reeves, C. A., Sengupta, U., Castillo-Carranza, D., Gerson, J. E., Guerrero-Munoz, M., Troncoso, J. C., Jackson, G. R. & Kayed, R., Jan 27 2014, In : Acta Neuropathologica Communications. 2, 1, 56.

Research output: Contribution to journalArticle

31 Scopus citations
2013

Accelerated neurodegeneration through chaperone-mediated oligomerization of tau

Blair, L. J., Nordhues, B. A., Hill, S. E., Scaglione, K. M., O'Leary, J. C., Fontaine, S. N., Breydo, L., Zhang, B., Li, P., Wang, L., Cotman, C., Paulson, H. L., Muschol, M., Uversky, V. N., Klengel, T., Binder, E. B., Kayed, R., Golde, T. E., Berchtold, N. & Dickey, C. A., Oct 1 2013, In : Journal of Clinical Investigation. 123, 10, p. 4158-4169 12 p.

Research output: Contribution to journalArticle

114 Scopus citations

CK2α regulates the transcription of BRP in Drosophila

Wairkar, Y. P., Trivedi, D., Natarajan, R., Barnes, K., Dolores, L. & Cho, P., Dec 1 2013, In : Developmental Biology. 384, 1, p. 53-64 12 p.

Research output: Contribution to journalArticle

5 Scopus citations

Design of metastable β-sheet oligomers from natively unstructured peptide

Guerrero-Muñoz, M. J., Castillo-Carranza, D. L., Sengupta, U., White, M. A. & Kayed, R., Dec 18 2013, In : ACS chemical neuroscience. 4, 12, p. 1520-1523 4 p.

Research output: Contribution to journalArticle

8 Scopus citations

Dual role of p53 amyloid formation in cancer; loss of function and gain of toxicity

Lasagna-Reeves, C. A., Clos, A. L., Castillo-Carranza, D., Sengupta, U., Guerrero-Muñoz, M., Kelly, B., Wagner, R. & Kayed, R., Jan 18 2013, In : Biochemical and Biophysical Research Communications. 430, 3, p. 963-968 6 p.

Research output: Contribution to journalArticle

44 Scopus citations

Enhanced leptin sensitivity, reduced adiposity, and improved glucose homeostasis in mice lacking exchange protein directly activated by cyclic AMP Isoform 1

Yan, J., Mei, F. C., Cheng, H., Lao, D. H., Hu, Y., Wei, J., Patrikeev, I., Hao, D., Stutz, S. J., Dineley, K. T., Motamedi, M., Hommel, J. D., Cunningham, K. A., Chen, J. & Cheng, X., Mar 1 2013, In : Molecular and cellular biology. 33, 5, p. 918-926 9 p.

Research output: Contribution to journalArticle

54 Scopus citations

Expression and methylation of mitochondrial transcription factor a in chronic obstructive pulmonary disease patients with lung cancer

Peng, H., Yang, M., Chen, Z. Y., Chen, P., Guan, C. X., Xiang, X. D., Cai, S., Chen, Y. & Fang, X., Dec 18 2013, In : PloS one. 8, 12, e82739.

Research output: Contribution to journalArticle

15 Scopus citations

Klotho ameliorates chemically induced endoplasmic reticulum (ER) stress signaling

Banerjee, S., Zhao, Y., Sarkar, P. S., Rosenblatt, K. P., Tilton, R. G. & Choudhary, S., May 2013, In : Cellular Physiology and Biochemistry. 31, 4-5, p. 659-672 14 p.

Research output: Contribution to journalArticle

22 Scopus citations

Major carboxyl terminal fragments generated by γ-secretase processing of the alzheimer amyloid precursor Are 50 and 51 amino acids long

Pinnix, I., Ghiso, J. A., Pappolla, M. A. & Sambamurti, K., May 2013, In : American Journal of Geriatric Psychiatry. 21, 5, p. 474-483 10 p.

Research output: Contribution to journalArticle

7 Scopus citations

Paradoxical effects of repeat interruptions on spinocerebellar ataxia type 10 expansions and repeat instability

McFarland, K. N., Liu, J., Landrian, I., Gao, R., Sarkar, P. S., Raskin, S., Moscovich, M., Gatto, E. M., Teive, H. A. G., Ochoa, A., Rasmussen, A. & Ashizawa, T., Nov 1 2013, In : European Journal of Human Genetics. 21, 11, p. 1272-1276 5 p.

Research output: Contribution to journalArticle

19 Scopus citations

Rapid accumulation of endogenous Tau oligomers in a rat model of traumatic brain injury: Possible link between traumatic brain injury and sporadic tauopathies

Hawkins, B. E., Krishnamurthy, S., Castillo-Carranza, D. L., Sengupta, U., Prough, D. S., Jackson, G. R., DeWitt, D. S. & Kayed, R., Jun 7 2013, In : Journal of Biological Chemistry. 288, 23, p. 17042-17050 9 p.

Research output: Contribution to journalArticle

84 Scopus citations

Ruthenium red colorimetric and birefringent staining of amyloid-β aggregates in vitro and in Tg2576 mice

Cook, N. P., Archer, C. M., Fawver, J. N., Schall, H. E., Rodriguez-Rivera, J., Dineley, K. T., Martí, A. A. & Murray, I. V. J., Mar 20 2013, In : ACS chemical neuroscience. 4, 3, p. 379-384 6 p.

Research output: Contribution to journalArticle

6 Scopus citations

Small misfolded tau species are internalized via bulk endocytosis and anterogradely and retrogradely transported in neurons

Wu, J. W., Herman, M., Liu, L., Simoes, S., Acker, C. M., Figueroa, H., Steinberg, J. I., Margittai, M., Kayed, R., Zurzolo, C., Di Paolo, G. & Duff, K. E., Jan 18 2013, In : Journal of Biological Chemistry. 288, 3, p. 1856-1870 15 p.

Research output: Contribution to journalArticle

240 Scopus citations

Tau aggregates as immunotherapeutic targets

Castillo-Carranza, D. L., Lasagna-Reeves, C. A. & Kayed, R., Jan 1 2013, In : Frontiers in Bioscience - Scholar. 5 S, 2, p. 426-438 13 p.

Research output: Contribution to journalArticle

30 Scopus citations

Tuberous sclerosis complex regulates drosophila neuromuscular junction growth via the TORC2/Akt pathway

Natarajan, R., Trivedi-vyas, D. & Wairkar, Y. P., May 1 2013, In : Human Molecular Genetics. 22, 10, p. 2010-2023 14 p., ddt053.

Research output: Contribution to journalArticle

21 Scopus citations

α7 nicotinic receptor-mediated astrocytic gliotransmitter release: Aβ effects in a preclinical Alzheimer's mouse model

Pirttimaki, T. M., Codadu, N. K., Awni, A., Pratik, P., Nagel, D. A., Hill, E. J., Dineley, K. T. & Parri, H. R., Nov 28 2013, In : PloS one. 8, 11, e81828.

Research output: Contribution to journalArticle

52 Scopus citations
2012

Alzheimer brain-derived tau oligomers propagate pathology from endogenous tau

Lasagna-Reeves, C. A., Castillo-Carranza, D. L., Sengupta, U., Guerrero-Munoz, M. J., Kiritoshi, T., Neugebauer, V., Jackson, G. R. & Kayed, R., Nov 7 2012, In : Scientific reports. 2, 700.

Research output: Contribution to journalArticle

227 Scopus citations

Association of skin with the pathogenesis and treatment of neurodegenerative amyloidosis

Clos, A. L., Kayed, R. & Lasagna-Reeves, C. A., Sep 12 2012, In : Frontiers in Neurology. JAN, Article 5.

Research output: Contribution to journalArticle

10 Scopus citations

Brain serum amyloid P levels are reduced in individuals that lack Dementia while having Alzheimer's disease neuropathology

Crawford, J. R., Gomer, R. H., Bjorklund, N. L. & Taglialatela, G., Apr 1 2012, In : Neurochemical Research. 37, 4, p. 795-801 7 p.

Research output: Contribution to journalArticle

13 Scopus citations

Cognitive enhancement with rosiglitazone links the hippocampal PPARγ and ERK MAPK signaling pathways

Denner, L. A., Rodriguez-Rivera, J., Haidacher, S. J., Jahrling, J. B., Carmical, J. R., Hernandez, C. M., Zhao, Y., Sadygov, R. G., Starkey, J. M., Spratt, H., Luxon, B. A., Wood, T. G. & Dineley, K. T., Nov 21 2012, In : Journal of Neuroscience. 32, 47, p. 16725-16735 11 p.

Research output: Contribution to journalArticle

77 Scopus citations

Differential activation of the ER stress factor XBP1 by oligomeric assemblies

Castillo-Carranza, D. L., Zhang, Y., Guerrero-Muñoz, M. J., Kayed, R., Rincon-Limas, D. E. & Fernandez-Funez, P., Aug 1 2012, In : Neurochemical Research. 37, 8, p. 1707-1717 11 p.

Research output: Contribution to journalArticle

23 Scopus citations

Gastrointestinal prophylaxis in neurocritical care

Schirmer, C. M., Kornbluth, J., Heilman, C. B. & Bhardwaj, A., Feb 1 2012, In : Neurocritical Care. 16, 1, p. 184-193 10 p.

Research output: Contribution to journalArticle

17 Scopus citations

Identification of oligomers at early stages of tau aggregation in Alzheimer's disease

Lasagna-Reeves, C. A., Castillo-Carranza, D. L., Sengupta, U., Sarmiento, J., Troncoso, J., Jackson, G. R. & Kayed, R., May 1 2012, In : FASEB Journal. 26, 5, p. 1946-1959 14 p.

Research output: Contribution to journalArticle

208 Scopus citations

Identification of potential mediators of retinotopic mapping: A comparative proteomic analysis of optic nerve from WT and Phr1 retinal knockout mice

Lee, A. R., Lamb, R. R., Chang, J. H., Erdmann-Gilmore, P., Lichti, C. F., Rohrs, H. W., Malone, J. P., Wairkar, Y. P., Diantonio, A., Townsend, R. R. & Culican, S. M., Nov 2 2012, In : Journal of Proteome Research. 11, 11, p. 5515-5526 12 p.

Research output: Contribution to journalArticle

1 Scopus citations

Increased risk of lung cancer associated with a functionally impaired polymorphic variant of the human DNA glycosylase NEIL2

Dey, S., Maiti, A. K., Hegde, M. L., Hegde, P. M., Boldogh, I., Sarkar, P. S., Abdel-Rahman, S. Z., Sarker, A. H., Hang, B., Xie, J., Tomkinson, A. E., Zhou, M., Shen, B., Wang, G., Wu, C., Yu, D., Lin, D., Cardenas, V. & Hazra, T. K., Jun 1 2012, In : DNA Repair. 11, 6, p. 570-578 9 p.

Research output: Contribution to journalArticle

26 Scopus citations

Intra-arterial vasodilator use during endovascular therapy for acute ischemic stroke might improve reperfusion rate

El-Zammar, Z. M. K., Latorre, J. G. S., Wang, D., Satyan, S., Elnour, E., Kamel, A., Devasenapathy, A. & Lodi, Y. M., Sep 2012, In : Annals of the New York Academy of Sciences. 1268, 1, p. 134-140 7 p.

Research output: Contribution to journalArticle

6 Scopus citations

Potential role of α-synuclein in neurodegeneration: Studies in a rat animal model

Stoica, G., Lungu, G., Bjorklund, N. L., Taglialatela, G., Zhang, X., Chiu, V., Hill, H. H., Schenk, J. O. & Murray, I., Aug 1 2012, In : Journal of neurochemistry. 122, 4, p. 812-822 11 p.

Research output: Contribution to journalArticle

16 Scopus citations

Proteomic study of amyloid beta (25-35) peptide exposure to neuronal cells: Impact on APE1/Ref-1's protein-protein interaction

Mantha, A. K., Dhiman, M., Taglialatela, G., Perez-Polo, R. J. & Mitra, S., Jun 1 2012, In : Journal of Neuroscience Research. 90, 6, p. 1230-1239 10 p.

Research output: Contribution to journalArticle

25 Scopus citations

Role of human DNA glycosylase Nei-like 2 (NEIL2) and single strand break repair protein polynucleotide kinase 3′-phosphatase in maintenance of mitochondrial genome

Mandal, S. M., Hegde, M. L., Chatterjee, A., Hegde, P. M., Szczesny, B., Banerjee, D., Boldogh, I., Gao, R., Falkenberg, M., Gustafsson, C. M., Sarkar, P. S. & Hazra, T. K., Jan 20 2012, In : Journal of Biological Chemistry. 287, 4, p. 2819-2829 11 p.

Research output: Contribution to journalArticle

54 Scopus citations
28 Scopus citations

Surgical treatment of patients with Lennox-Gastaut syndrome phenotype

Liu, S. Y., An, N., Fang, X., Singh, P., Oommen, J., Yin, Q., Yang, M. H., Liu, Y., Liao, W., Gao, C. Q. & Yang, H., Jun 21 2012, In : The Scientific World Journal. 2012, 614263.

Research output: Contribution to journalArticle

10 Scopus citations

Transgenic mice with SCA10 pentanucleotide repeats show motor phenotype and susceptibility to seizure: A toxic RNA gain-of-function model

White, M., Xia, G., Gao, R., Wakamiya, M., Sarkar, P. S., McFarland, K. & Ashizawa, T., Mar 1 2012, In : Journal of Neuroscience Research. 90, 3, p. 706-714 9 p.

Research output: Contribution to journalArticle

31 Scopus citations

Vaccination with a non-human random sequence amyloid oligomer mimic results in improved cognitive function and reduced plaque deposition and micro hemorrhage in Tg2576 mice

Rasool, S., Albay, R., Martinez-Coria, H., Breydo, L., Wu, J., Milton, S., Misra, S., Tran, A., Pensalfini, A., Laferla, F., Kayed, R. & Glabe, C. G., Aug 8 2012, In : Molecular Neurodegeneration. 7, 1, 37.

Research output: Contribution to journalArticle

28 Scopus citations

α7 nicotinic acetylcholine receptors in Alzheimer's disease: Neuroprotective, neurotrophic or both?

Hernandez, C. M. & Dineley, K. T., May 2012, In : Current Drug Targets. 13, 5, p. 613-622 10 p.

Research output: Contribution to journalArticle

54 Scopus citations

α-Synuclein oligomers oppose long-term potentiation and impair memory through a calcineurin-dependent mechanism: Relevance to human synucleopathic diseases

Martin, Z. S., Neugebauer, V., Dineley, K. T., Kayed, R., Zhang, W., Reese, L. C. & Taglialatela, G., Feb 1 2012, In : Journal of neurochemistry. 120, 3, p. 440-452 13 p.

Research output: Contribution to journalArticle

56 Scopus citations
2011

Amyloid-β annular protofibrils evade fibrillar fate in Alzheimer disease brain

Lasagna-Reeves, C. A., Glabe, C. G. & Kayed, R., Jun 24 2011, In : Journal of Biological Chemistry. 286, 25, p. 22122-22130 9 p.

Research output: Contribution to journalArticle

96 Scopus citations

ApoE4-driven accumulation of intraneuronal oligomerized Aß42 following activation of the amyloid cascade in vivo is mediated by a gain of function

Zepa, L., Frenkel, M., Belinson, H., Kariv-Inbal, Z., Kayed, R., Masliah, E. & Michaelson, D. M., Apr 6 2011, In : International Journal of Alzheimer's Disease. 792070.

Research output: Contribution to journalArticle

21 Scopus citations

Astrocytes contain amyloid-β annular protofibrils in Alzheimer's disease brains

Lasagna-Reeves, C. A. & Kayed, R., Oct 3 2011, In : FEBS Letters. 585, 19, p. 3052-3057 6 p.

Research output: Contribution to journalArticle

27 Scopus citations

Cocaine withdrawal reduces group I mGluR-mediated long-term potentiation via decreased GABAergic transmission in the amygdala

Schmidt, K., Krishnan, B., Xia, Y., Sun, A., Orozco-Cabal, L., Pollandt, S., Centeno, M., Genzer, K., Gallagher, J. P., Shinnick-Gallagher, P. & Liu, J., Jul 1 2011, In : European Journal of Neuroscience. 34, 2, p. 177-189 13 p.

Research output: Contribution to journalArticle

7 Scopus citations