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2020

Cardiac Dysfunction after Burn Injury: Role of the AMPK-SIRT1-PGC1α-NFE2L2-ARE Pathway

Wen, J., Cummins, C. B., Szczesny, B. & Radhakrishnan, R. S., Apr 2020, In : Journal of the American College of Surgeons. 230, 4, p. 562-571 10 p.

Research output: Contribution to journalArticle

3 Scopus citations

Epac1 inhibition ameliorates pathological angiogenesis through coordinated activation of Notch and suppression of VEGF signaling

Liu, H., Mei, F. C., Yang, W., Wang, H., Wong, E., Cai, J., Toth, E., Luo, P., Li, Y. M., Zhang, W. & Cheng, X., Jan 1 2020, In : Science Advances. 6, 1, eaay3566.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Neuronal Epac1 mediates retinal neurodegeneration in mouse models of ocular hypertension

Liu, W., Ha, Y., Xia, F., Zhu, S., Li, Y., Shi, S., Mei, F. C., Merkley, K., Vizzeri, G., Motamedi, M., Cheng, X., Liu, H. & Zhang, W., 2020, In : Journal of Experimental Medicine. 217, 4, e20190930.

Research output: Contribution to journalArticle

1 Scopus citations
2019

Adverse reactions to fluorescein angiography: A comprehensive review of the literature

Kornblau, I. S. & El-Annan, J., Jan 1 2019, In : Survey of Ophthalmology.

Research output: Contribution to journalArticle

5 Scopus citations

Curcumin protects against methylmercury-induced cytotoxicity in primary rat astrocytes by activating the Nrf2/ARE pathway independently of PKCδ

Yang, B., Yin, C., Zhou, Y., Wang, Q., Jiang, Y., Bai, Y., Qian, H., Xing, G., Wang, S., Li, F., Feng, Y., Zhang, Y., Cai, J., Aschner, M. & Lu, R., Sep 1 2019, In : Toxicology. 425, 152248.

Research output: Contribution to journalArticle

5 Scopus citations

Development of focal choroidal excavation in non-neovascular age related macular degeneration with pachy-choroid features

Banaee, T., Lyons, L. J. & El-Annan, J., Dec 2019, In : Journal of Current Ophthalmology. 31, 4, p. 454-457 4 p.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations
Open Access

Gender Differences in Case Volume among Ophthalmology Residents

Gong, D., Winn, B. J., Beal, C. J., Blomquist, P. H., Chen, R. W., Culican, S. M., Dagi Glass, L. R., Domeracki, G. F., Goshe, J. M., Jones, J. K., Khouri, A. S., Legault, G. L., Martin, T. J., Mitchell, K. T., Naseri, A., Oetting, T. A., Olson, J. H., Pettey, J. H., Reinoso, M. A., Reynolds, A. L. & 8 others, Siatkowski, R. M., Soohoo, J. R., Sun, G., Syed, M. F., Tao, J. P., Taravati, P., Wudunn, D. & Al-Aswad, L. A., Sep 2019, In : JAMA Ophthalmology. 137, 9, p. 1015-1020 6 p.

Research output: Contribution to journalArticle

4 Scopus citations

Knowledge and Use of Cosmetic Contact Lenses among Reproductive-Age Women

Berenson, A. B., Hirth, J. M., Chang, M. & Merkley, K. H., Mar 2019, In : Journal of Women's Health. 28, 3, p. 403-409 7 p.

Research output: Contribution to journalArticle

Neuroprotective effects of HSF1 in retinal ischemia-reperfusion injury

Liu, W., Xia, F., Ha, Y., Zhu, S., Li, Y., Folorunso, O., Pashaei-Marandi, A., Lin, P. Y., Tilton, R. G., Pierce, A., Liu, H. & Zhang, W., Mar 2019, In : Investigative Ophthalmology and Visual Science. 60, 4, p. 965-977 13 p.

Research output: Contribution to journalArticle

Open Access
6 Scopus citations

The PARP inhibitor olaparib exerts beneficial effects in mice subjected to cecal ligature and puncture and in cells subjected to oxidative stress without impairing DNA integrity: A potential opportunity for repurposing a clinically used oncological drug for the experimental therapy of sepsis

Ahmad, A., Vieira, J. D. C., de Mello, A. H., de Lima, T. M., Ariga, S. K., Barbeiro, D. F., Barbeiro, H. V., Szczesny, B., Törö, G., Druzhyna, N., Randi, E. B., Marcatti, M., Toliver-Kinsky, T., Kiss, A., Liaudet, L., Salomao, R., Soriano, F. G. & Szabo, C., Jul 2019, In : Pharmacological Research. 145, 104263.

Research output: Contribution to journalArticle

2 Scopus citations
2018

AAV2-mediated GRP78 transfer alleviates retinal neuronal injury by downregulating ER stress and Tau oligomer formation

Ha, Y., Liu, W., Liu, H., Zhu, S., Xia, F., Gerson, J. E., Azhar, N. A., Tilton, R., Motamedi, M., Kayed, R. & Zhang, W., Sep 1 2018, In : Investigative Ophthalmology and Visual Science. 59, 11, p. 4670-4682 13 p.

Research output: Contribution to journalArticle

5 Scopus citations

Amelioration of endotoxin-induced inflammatory toxic response by a metal chelator in rat eyes

Shoeb, M., Zhang, M., Xiao, T., Syed, M. & Ansari, N., Jan 1 2018, In : Investigative Ophthalmology and Visual Science. 59, 1, p. 31-38 8 p.

Research output: Contribution to journalArticle

1 Scopus citations

Enhancing TFEB-Mediated Cellular Degradation Pathways by the mTORC1 Inhibitor Quercetin

Huang, Y., Chen, Y., Shaw, A. M., Goldfine, H., Tian, J. & Cai, J., Jan 1 2018, In : Oxidative Medicine and Cellular Longevity. 2018, 1 p.

Research output: Contribution to journalArticle

3 Scopus citations

Evaluation of Notch3 deficiency in diabetes-induced pericyte loss in the Retina

Liu, H., Zhang, W. & Lilly, B., Nov 1 2018, In : Journal of Vascular Research. 55, 5, p. 308-318 11 p.

Research output: Contribution to journalArticle

5 Scopus citations

Formulation Stabilization and Disaggregation of Bevacizumab, Ranibizumab and Aflibercept in Dilute Solutions

Giannos, S. A., Kraft, E. R., Zhao, Z. Y., Merkley, K. & Cai, J., Apr 1 2018, In : Pharmaceutical Research. 35, 4, 78.

Research output: Contribution to journalArticle

7 Scopus citations

Low-dose rifampin as maintenance therapy in chronic central serous chorioretinopathy

Mattingly, J. J., Amram, A. L. & El-Annan, J., Jan 1 2018, (Accepted/In press) In : Canadian Journal of Ophthalmology.

Research output: Contribution to journalArticle

Mitochondrial DNA damage and subsequent activation of Z-DNA binding protein 1 links oxidative stress to inflammation in epithelial cells

Szczesny, B., Marcatti, M., Ahmad, A., Montalbano, M., Brunyánszki, A., Bibli, S. I., Papapetropoulos, A. & Szabo, C., Dec 1 2018, In : Scientific Reports. 8, 1, 914.

Research output: Contribution to journalArticle

21 Scopus citations

Neuron activity-induced Wnt signaling up-regulates expression of brain-derived neurotrophic factor in the pain neural circuit

Zhang, W., Shi, Y., Peng, Y., Zhong, L., Zhu, S., Zhang, W. & Tang, S. J., Oct 5 2018, In : Journal of Biological Chemistry. 293, 40, p. 15641-15651 11 p.

Research output: Contribution to journalArticle

6 Scopus citations

Optic Nerve Head Elevation in an Asymptomatic Child: Worry or Watch?

Nazari, H., Nakatsuka, A. S. & Soliman, M., May 1 2018, In : Pediatric Neurology. 82, p. 55-56 2 p.

Research output: Contribution to journalArticle

Oxandrolone protects against the development of multiorgan failure, modulates the systemic inflammatory response and promotes wound healing during burn injury

Ahmad, A., Herndon, D. & Szabo, C., Jan 1 2018, (Accepted/In press) In : Burns.

Research output: Contribution to journalArticle

1 Scopus citations

Peli1 facilitates virus replication and promotes neuroinflammation during West Nile virus infection

Luo, H., Winkelmann, E., Zhu, S., Ru, W., Mays, E., Silvas, J. A., Vollmer, L. L., Gao, J., Peng, B., Bopp, N. E., Cromer, C., Shan, C., Xie, G., Li, G., Tesh, R., Popov, V. L., Shi, P. Y., Sun, S. C., Wu, P., Klein, R. S. & 4 others, Tang, S. J., Zhang, W., Aguilar, P. V. & Wang, T., Nov 1 2018, In : The Journal of clinical investigation. 128, 11, p. 4980-4991 12 p.

Research output: Contribution to journalArticle

8 Scopus citations

Pentose phosphate shunt modulates reactive oxygen species and nitric oxide production controlling Trypanosoma cruzi in Macrophages

Koo, S. J., Szczesny, B., Wan, X., Putluri, N. & Garg, N. J., Feb 16 2018, In : Frontiers in immunology. 9, FEB, 202.

Research output: Contribution to journalArticle

10 Scopus citations

Phagocytosed photoreceptor outer segments activate mTORC1 in the retinal pigment epithelium

Yu, B., Egbejimi, A., Dharmat, R., Xu, P., Zhao, Z., Long, B., Miao, H., Chen, R., Wensel, T. G., Cai, J. & Chen, Y., May 29 2018, In : Science Signaling. 11, 532, eaag3315.

Research output: Contribution to journalArticle

9 Scopus citations

Photokinetic Drug Delivery: Near infrared (NIR) Induced Permeation Enhancement of Bevacizumab, Ranibizumab and Aflibercept through Human Sclera

Giannos, S. A., Kraft, E. R., Zhao, Z. Y., Merkley, K. & Cai, J., Jun 1 2018, In : Pharmaceutical Research. 35, 6, 110.

Research output: Contribution to journalArticle

2 Scopus citations

Retinal pigment epithelium tears in a 67-year-old man

Sultan, H., Kellogg, C. & El-Annan, J., May 1 2018, In : JAMA Ophthalmology. 136, 5, p. 583-584 2 p.

Research output: Contribution to journalArticle

Sirt6 deficiency impairs corneal epithelial wound healing

Hu, X., Zhu, S., Liu, R., Miller, J. D., Merkley, K., Tilton, R. & Liu, H., Aug 1 2018, In : Aging. 10, 8, p. 1932-1946 15 p.

Research output: Contribution to journalArticle

3 Scopus citations

The clinically used PARP inhibitor olaparib improves organ function, suppresses inflammatory responses and accelerates wound healing in a murine model of third-degree burn injury

Ahmad, A., Olah, G., Herndon, D. N. & Szabo, C., Jan 1 2018, In : British Journal of Pharmacology. 175, 2, p. 232-245 14 p.

Research output: Contribution to journalArticle

7 Scopus citations

The genetic dissection of Myo7a gene expression in the retinas of BXD mice

Lu, Y., Zhou, D., King, R., Zhu, S., Simpson, C. L., Jones, B. C., Zhang, W., Geisert, E. E. & Lu, L., Feb 3 2018, In : Molecular Vision. 24, p. 115-126 12 p.

Research output: Contribution to journalArticle

2017

A tightly regulated IL-22 response maintains immune functions and homeostasis in systemic viral infection

Yi, P., Liang, Y., Yuan, D. M. K., Jie, Z., Kwota, Z., Chen, Y., Cong, Y., Fan, X. & Sun, J., Dec 1 2017, In : Scientific reports. 7, 1, 3857.

Research output: Contribution to journalArticle

3 Scopus citations

Choroidal γδ T cells in protection against retinal pigment epithelium and retinal injury

Zhao, Z., Liang, Y., Liu, Y., Xu, P., Flamme-Wiese, M. J., Sun, D., Sun, J., Mullins, R. F., Chen, Y. & Cai, J., 2017, In : FASEB Journal. 31, 11, p. 4903-4916 14 p.

Research output: Contribution to journalArticle

8 Scopus citations
15 Scopus citations

Cystathionine-gamma-lyase deficient mice are protected against the development of multiorgan failure and exhibit reduced inflammatory response during burn

Ahmad, A., Druzhyna, N. & Szabo, C., 2017, (Accepted/In press) In : Burns.

Research output: Contribution to journalArticle

9 Scopus citations

Effects of short-term mild hypercapnia during head-down tilt on intracranial pressure and ocular structures in healthy human subjects

Laurie, S. S., Vizzeri, G., Taibbi, G., Ferguson, C. R., Hu, X., Lee, S. M. C., Ploutz-Snyder, R., Smith, S. M., Zwart, S. R. & Stenger, M. B., Jun 1 2017, In : Physiological Reports. 5, 11, e13302.

Research output: Contribution to journalArticle

17 Scopus citations

Effects of storage temperature on airway exosome integrity for diagnostic and functional analyses

Maroto, R., Zhao, Y., Jamaluddin, M., Popov, V., Wang, H., Kalubowilage, M., Zhang, Y., Luisi, J., Sun, H., Culbertson, C. T., Bossmann, S. H., Motamedi, M. & Brasier, A. R., Dec 1 2017, In : Journal of Extracellular Vesicles. 6, 1, 1359478.

Research output: Contribution to journalArticle

40 Scopus citations

Endothelial adenosine A2a receptor-mediated glycolysis is essential for pathological retinal angiogenesis

Liu, Z., Yan, S., Wang, J., Xu, Y., Wang, Y., Zhang, S., Xu, X., Yang, Q., Zeng, X., Zhou, Y., Gu, X., Lu, S., Fu, Z., Fulton, D. J., Weintraub, N. L., Caldwell, R. B., Zhang, W., Wu, C., Liu, X. L., Chen, J. F. & 10 others, Ahmad, A., Kaddour-Djebbar, I., Al-Shabrawey, M., Li, Q., Jiang, X., Sun, Y., Sodhi, A., Smith, L., Hong, M. & Huo, Y., Dec 1 2017, In : Nature communications. 8, 1, 584.

Research output: Contribution to journalArticle

21 Scopus citations

Five-year incidence and progression of diabetic retinopathy in patients with type II diabetes in a tertiary care center in Lebanon

Mehanna, C. J., Fattah, M. A., Tamim, H., Nasrallah, M. P., Zreik, R., Haddad, S. S., El-Annan, J., Raad, S., Haddad, R. S. & Salti, H. I. S., 2017, In : Journal of Ophthalmology. 2017, 9805145.

Research output: Contribution to journalArticle

1 Scopus citations

Neuro-ophthalmologic manifestations of cholangiocarcinoma: A case series

Rico, G., Smith, S. V., Siddiqui, Y., Whyte, A., Gombos, D. & Lee, A. G., Aug 1 2017, In : Eye (Basingstoke). 31, 8, p. 1245-1248 4 p.

Research output: Contribution to journalArticle

Open Access

New method of sudomotor function measurement to detect microvascular disease and sweat gland nerve or unmyelinated C fiber dysfunction in adults with retinopathy

Lewis, J. E., Atlas, S. E., Rasul, A., Farooqi, A., Lantigua, L., Higuera, O. L., Fiallo, A., Laria, L., Picciani, R., Wals, K., Yehoshua, Z., Mendez, A., Konefal, J., Goldberg, S. & Woolger, J., Jun 12 2017, In : Journal of Diabetes and Metabolic Disorders. 16, 1, 26.

Research output: Contribution to journalArticle

2 Scopus citations

Ophthalmological evaluation of integrated resistance and aerobic training during 70-day bed rest

Taibbi, G., Cromwell, R. L., Zanello, S. B., Yarbough, P. O., Ploutz-Snyder, R. J., Godley, B. F. & Vizzeri, G., Jul 1 2017, In : Aerospace medicine and human performance. 88, 7, p. 633-640 8 p.

Research output: Contribution to journalArticle

3 Scopus citations

Outcomes of Congenital Zika Disease Depend on Timing of Infection and Maternal-Fetal Interferon Action

Chen, J., Liang, Y., Yi, P., Xu, L., Hawkins, H. K., Rossi, S. L., Soong, L., Cai, J., Menon, R. & Sun, J., Nov 7 2017, In : Cell Reports. 21, 6, p. 1588-1599 12 p.

Research output: Contribution to journalArticle

40 Scopus citations

p38MAPK plays a critical role in induction of a pro-inflammatory phenotype of retinal Müller cells following Zika virus infection

Zhu, S., Luo, H., Liu, H., Ha, Y., Mays, E. R., Lawrence, R. E., Winkelmann, E., Barrett, A., Smith, S. B., Wang, M., Wang, T. & Zhang, W., Sep 1 2017, In : Antiviral Research. 145, p. 70-81 12 p.

Research output: Contribution to journalArticle

9 Scopus citations

PERK and XBP1 differentially regulate CXCL10 and CCL2 production

Zhu, S., Liu, H., Sha, H., Qi, L., Gao, D. S. & Zhang, W., Feb 1 2017, In : Experimental Eye Research. 155, p. 1-14 14 p.

Research output: Contribution to journalArticle

7 Scopus citations

Photodynamic therapy for choroidal carcinoid metastasis

Chu, C. K. & El-Annan, J., 2017, (Accepted/In press) In : Canadian Journal of Ophthalmology.

Research output: Contribution to journalArticle

3 Scopus citations

Retinal detachment and microangiopathy in mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes syndrome

Sultan, H., Kellogg, C. & El-Annan, J., 2017, (Accepted/In press) In : Canadian Journal of Ophthalmology.

Research output: Contribution to journalArticle

Sirt6 deficiency results in progression of glomerular injury in the kidney

Huang, W., Liu, H., Zhu, S., Woodson, M., Liu, R., Tilton, R. G., Miller, J. D. & Zhang, W., 2017, In : Aging. 9, 3, p. 1069-1083 15 p.

Research output: Contribution to journalArticle

16 Scopus citations

Smartphone Fundus Photography

Khanamiri, H. N., Nakatsuka, A. & El-Annan, J., Jul 6 2017, In : Journal of visualized experiments : JoVE. 125

Research output: Contribution to journalArticle

9 Scopus citations

Tau oligomers associate with inflammation in the brain and retina of tauopathy mice and in neurodegenerative diseases

Nilson, A. N., English, K. C., Gerson, J. E., Barton Whittle, T., Nicolas Crain, C., Xue, J., Sengupta, U., Castillo-Carranza, D. L., Zhang, W., Gupta, P. & Kayed, R., 2017, In : Journal of Alzheimer's Disease. 55, 3, p. 1083-1099 17 p.

Research output: Contribution to journalArticle

42 Scopus citations

Type 1-skewed neuroinflammation and vascular damage associated with Orientia tsutsugamushi infection in mice

Soong, L., Shelite, H. T. R., Xing, Y., Kodakandla, H., Liang, Y., Trent, B. J., Horton, P., Smith, K. C., Zhao, Z., Sun, J., Bouyer, D. H. & Cai, J., Jul 24 2017, In : PLoS neglected tropical diseases. 11, 7, e0005765.

Research output: Contribution to journalArticle

4 Scopus citations