Pharmacology & Toxicology

Projects

Projects per year 2010 2018 2019 2020 2023 2029

• 27 Active
• 73 Completed

Projects per year

Search results

• Active

  NLM Training Program in Biomedical Informatics & Data Science

  Golovko, G. (PI)

  Rice University ( Award #5T15LM00709333)

  1/1/25 → 12/31/25

  Project: Research project

• VGLUT3 Synergy in the Raphe-Accumbal Circuit Upon Vulnerability to Cocaine Use Disorder

  Anastasio, N. (PI)

  Peter F. McManus Charitable Trust ( Award # )

  1/1/25 → 12/31/25

  Project: Research project

• Small Compound Inhibitors Targeting HPV Genome Replication

  Zhou, J. (PI)

  University of Texas SouthWestern Med Cen ( Award #1R01CA28874301A1)

  12/1/24 → 11/30/25

  Project: Research project

  • HPV Genome 100%
  • Bromodomain-containing Protein 4 (BRD4) 100%
  • Medicinal Chemistry 100%
  • Small Molecule Compounds 100%
  • Structure-activity 100%

• SIRTUIN-DEPENDENT REGULATION OF TUBERCULOSIS AND HIV INTERACTIONS IN MACROPHAGES

  Zhang, K. (PI)

  Houston Methodist Research Institute ( Award #1R01AI18455101)

  8/1/24 → 7/31/25

  Project: Research project

  • Sirtuins 100%
  • SIRT2 100%
  • Tuberculosis 100%
  • Macrophages 100%
  • Macrophage 100%

• Frustration effects on drug taking

  Green, T. (PI)

  National Institute on Drug Abuse ( Award #1R01DA06022101)

  4/15/24 → 3/31/29

  Project: Research project

  • Frustration Effect 100%
  • Motivation 100%
  • Drug Taking 100%
  • Behavior (Neuroscience) 100%
  • Nucleus Accumbens 66%

• Synaptic Organizers: Dynamic Regulation of Trans-synaptic Bridges

  Rudenko, G. (PI)

  National Institute of Mental Health ( Award #5R01MH07730318)

  12/15/23 → 10/31/28

  Project: Research project

  • Dynamic Regulation 100%
  • Transsynaptic 100%
  • Synaptic Organizer 100%
  • Neurexin 100%
  • Synapse 100%

• DNA Microbial Screening of Air Filters Using Next-generation Sequencing

  Golovko, G. (PI)

  Texas A&M AgriLife Research ( Award #70RSAT21G00000001)

  9/26/23 → 3/28/25

  Project: Research project

  • Microbial Screening 100%
  • Next-generation Sequencing 100%
  • DNA Isolation 100%
  • Air Filter 100%
  • Sequencing Depth 100%

• Galveston Safety against Fentanyl Emergency (G-SAFE) Program

  Houghton, D. (PI) & Cunningham, K. (PI)

  Sealy and Smith Foundation ( Award # )

  9/1/23 → 8/31/25

  Project: Research project

• Brain derived extracellular vesicles-mediated neurotoxicity of deltamethrin

  Laezza, F. (PI)

  National Institute of Environmental Health Sciences ( Award #1R21ES03495601A1)

  8/1/23 → 7/31/25

  Project: Research project

  • Neurotoxicity 100%
  • Brain-inspired 100%
  • Extracellular Vesicles 100%
  • Deltamethrin 100%
  • Attention Deficit Hyperactivity Disorder 100%

• Development of novel BTK-MALT1 dual inhibitors to treat MCL

  Zhou, J. (PI)

  University of Texas MD Anderson Cancer Center ( Award # )

  7/1/23 → 6/30/25

  Project: Research project

• Translational Explorations in Substance Use Disorders

  Cunningham, K. (PI)

  National Institute on Drug Abuse ( Award #5T32DA00728727)

  7/1/23 → 6/30/28

  Project: Research project

• Targeting serine and one-carbon metabolism for the treatment of RB-deficient aggressive variant prostate cancer

  Zhang, K. (PI)

  University of Texas MD Anderson Cancer Center ( Award #HT94252310424)

  5/15/23 → 5/14/25

  Project: Research project

  • Prostate Cancer 100%
  • Aggressive Variant Prostate Cancer 100%
  • Epigenetic Modification 100%
  • One-carbon Metabolism 100%
  • Carbon Metabolism 100%

• Probing brain circuit and behavior with protein: protein interaction modulators

  Laezza, F. (PI)

  National Institute of Mental Health ( Award #5R01MH13222602)

  2/1/23 → 11/30/26

  Project: Research project

• Hepatic Aryl Hydrocarbon Receptor Regulation of Obesity: Mechanisms of Action

  Elferink, C. (PI) & Wright, C. (PI)

  National Institute of Environmental Health Sciences ( Award #5R01ES03368203)

  9/9/22 → 6/30/27

  Project: Research project

• GPR52 - MapLight Project

  Allen, J. (PI)

  MapLight Therapeutics ( Award # )

  9/1/22 → 8/31/25

  Project: Research project

• 5-HT2 Receptor Allosterism in Cocaine Use Disorder

  Zhou, J. (PI)

  National Institute on Drug Abuse ( Award #5R01DA03844608)

  8/1/22 → 4/30/27

  Project: Research project

• Targeting chemoresistant prostate cancer with novel EED inhibitors

  Zhou, J. (PI)

  Clark Atlanta University ( Award #5R01CA25605803)

  4/1/22 → 3/31/25

  Project: Research project

• Novel Addiction Neurocircuits in Cocaine Taking

  Hommel, J. (PI)

  National Institute on Drug Abuse ( Award #5R01DA05347204)

  4/1/22 → 1/31/27

  Project: Research project

• Small molecule modulators of FosB

  Rudenko, G. (PI)

  National Institute on Drug Abuse ( Award #5R01DA04062109)

  7/1/21 → 3/31/26

  Project: Research project

• High throughput screening assays to identify chemical probes targeting Hectd3, an E3 ubiquitin ligase implicated in multiple sclerosis

  Zhou, J. (PI)

  University of Arizona ( Award #5R01AI16184504)

  4/15/21 → 3/31/25

  Project: Research project

• Neurotoxicology of deltamethrin in the developing brain

  Laezza, F. (PI)

  National Institute of Environmental Health Sciences ( Award #5R01ES03182305)

  9/28/20 → 6/30/25

  Project: Research project

  • Deltamethrin 100%
  • Brain Development 100%
  • Neurotoxicology 100%
  • Protocerebrum 100%

• NOP Receptor Antagonist for OUD Pharmacotherapy

  Cunningham, K. (PI)

  National Institute on Drug Abuse ( Award #1UG3DA05228201)

  9/1/20 → 8/31/25

  Project: Research project

• Neurotrophin-dependent regulation of voltage-gated sodium channels

  Laezza, F. (PI)

  National Institute of Mental Health ( Award #5R01MH12435105)

  7/1/20 → 4/30/25

  Project: Research project

• CTSA Institutional Career Development Core

  Ameredes, B. (PI)

  National Center for Advancing Translational Sciences ( Award #5KL2TR00144110)

  4/8/20 → 3/31/26

  Project: Research project

• CTSA NRSA Training Core

  Hommel, J. (PI)

  National Center for Advancing Translational Sciences ( Award #5TL1TR00144010)

  4/8/20 → 3/31/26

  Project: Research project

• Chemoprevention of breast cancer by targeting glucose metabolism with HJC0152

  Zhou, J. (PI)

  Louisiana State University Health Science Center ( Award #5R01CA22600106)

  4/1/20 → 3/31/25

  Project: Research project

• Targeting Glucose Metabolism with HJC0152 for Treating Metastatic Breast Cancer

  Zhou, J. (PI)

  Louisiana State University Health Science Center ( Award #5R01CA23115006)

  9/1/19 → 6/30/25

  Project: Research project

• Completed

  Investigation of KB-128 on Methamphetamine-Induced Hyperactivity

  Cunningham, K. (PI)

  Kuleon, LLC ( Award # )

  3/15/24 → 6/15/24

  Project: Research project

  • Hyperactivity 100%
  • Methamphetamine 100%
  • Locomotor Activity 66%
  • Serotonin 2A Receptor (5-HT2AR) 66%
  • Sprague-Dawley Rats 66%

• Investigation of Low Dose Naltrexol (LD-6BN) for the Treatment of Opioid Drug-Taking, Hyperaigesia, and Dependence

  Cunningham, K. (PI)

  Aether Therpeutics ( Award # )

  2/1/24 → 6/1/24

  Project: Research project

  • Opioid Drugs 100%
  • Hyperalgesia 100%
  • Drug Taking 100%
  • Naltrexol 100%
  • Receptor 66%

• Investigation of the Peripherally Selective Opioid Antagonist 68-Naltrexol {68N) for Treatment of Opioid Use Disorder

  Cunningham, K. (PI)

  Aether Therpeutics ( Award # )

  8/1/23 → 11/30/23

  Project: Research project

• Chronic alcohol regulates circuitry structure and demand for alcohol

  Hommel, J. (PI)

  National Institute on Alcohol Abuse and Alcoholism ( Award #5R03AA02916402)

  8/15/22 → 7/31/24

  Project: Research project

• Acquisition of an automated crystal imager

  Rudenko, G. (PI)

  Office of the Director - National Institutes of Health

  4/15/22 → 4/14/23

  Project: Research project

• Protein Degradation of CDK9 for Treatment of Drug-Resistant Mantle Cell Lymphoma

  Zhou, J. (PI)

  Cancer Prevention and Research Institute ( Award #RP210062)

  8/31/21 → 2/29/24

  Project: Research project

• Novel Molecular Therapeutics to Modulate Serotonin 5-HT2A Receptor Function

  Cunningham, K. (PI)

  VidaLibreBio, Inc ( Award # )

  4/1/21 → 3/11/22

  Project: Research project

• High throughput screening of the Prp8 intein splicing inhibitors for pathogenic fungi

  Zhou, J. (PI)

  University of Arizona ( Award #5R01AI14072604)

  2/26/21 → 11/30/24

  Project: Research project

• High throughput screening of orthosteric inhibitors of flavivirus protease

  Zhou, J. (PI)

  University of Arizona ( Award #5R01AI13166905)

  1/30/21 → 1/31/25

  Project: Research project

• Screening Ligands at Serotonin and Dopamine Receptors

  Allen, J. (PI)

  New Atlas Biotechnologies, LLC ( Award # )

  1/25/21 → 12/31/22

  Project: Research project

• Cortical GluN2B NMDA Receptor Role in Cocaine Relapse-Like Behaviors

  Anastasio, N. (PI)

  Peter F. McManus Charitable Trust ( Award # )

  12/1/20 → 12/31/22

  Project: Research project

• Discovery of therapeutics against Cryptococcosis by Repurposing Pharmaceutical Libraries

  Zhou, J. (PI)

  University of Arizona ( Award #7R21AI14117803)

  12/1/20 → 1/31/22

  Project: Research project

• Preclinical evaluation of the efficacy of a novel 5-HT2CR agonist to reduce binge-eating behavior

  Cunningham, K. (PI)

  Bright Minds Biosciences ( Award # )

  10/15/20 → 3/31/22

  Project: Research project

• Preclinical evaluation of the efficacy of a novel 5-HT2CR agonist to reduce binge-eating behavior

  Cunningham, K. (PI)

  Bright Minds Biosciences ( Award # )

  10/15/20 → 5/31/22

  Project: Research project

• Validation of GPR52 agonists as a therapeutic approach for stimulant use disorders

  Allen, J. (PI)

  National Institute on Drug Abuse ( Award #1U18DA05254301)

  9/30/20 → 9/29/23

  Project: Research project

• AMPAkines for Novel Opioid Use Disorder Pharmacotherapy

  Anastasio, N. (PI)

  National Institute on Drug Abuse ( Award #1U18DA05254501)

  9/30/20 → 9/29/23

  Project: Research project

• FGF13: a novel druggable target for treating substance abuse disorders

  Laezza, F. (PI)

  National Institute on Drug Abuse ( Award #1U18DA05250401)

  9/30/20 → 9/29/22

  Project: Research project

• BRD4 Inhibition for Opioid Pharmacotherapy

  Cunningham, K. (PI)

  National Institute on Drug Abuse ( Award #1U18DA05254601)

  9/30/20 → 9/29/22

  Project: Research project

  • Opioid Pharmacotherapy 100%
  • BRD4 Inhibition 100%
  • Pharmacotherapy 100%

• Elucidating the Structual Constituents of Fibroblast Growth Factor 14 that Confer its Modulatory Effects on the Voltage-Gated Na+ Channel 1.6

  Laezza, F. (PI)

  Baylor College of Medicine ( Award #5T32GM00828034)

  9/1/20 → 8/31/23

  Project: Research project

• Causal Role for Bromodomain-Containing Protein 4 in Opioid Use Disorder

  Cunningham, K. (PI)

  Peter F. McManus Charitable Trust ( Award # )

  12/31/19 → 12/31/21

  Project: Research project

• Long-Term Activation of Spinal Opioid Analgesia after Inflammation - Supplement

  Zhou, J. (PI)

  University of Pittsburgh ( Award #3R01DA03762105S1)

  9/30/19 → 6/30/22

  Project: Research project

• Targeting the Ghrelin System for Novel Opioid Use Disorder Therapeutics

  Cunningham, K. (PI)

  National Institute on Drug Abuse ( Award #1UG3DA05031701)

  9/30/19 → 8/31/24

  Project: Research project

• Targeting the Gherlin System for Novel Opioid Use Disorder therapeutics

  Cunningham, K. (PI)

  National Institute on Drug Abuse ( Award #3UG3DA05031701S1)

  9/30/19 → 8/31/24

  Project: Research project