Sealy Center for Environmental Health Medicine

Organization profile

Organization profile

Director:  Cornelis J. Elferink, PhD  

Deputy Director:  Lawrence C. Sowers, PhD

 

The mission of the Sealy Center for Environmental Health Medicine, AKA UTMB Center in Environmental Toxicology (UTMB-CET) is to explore the environmental basis of human diseases by fostering collaborative interactions amongst multidisciplinary basic and clinical investigators pursuing both fundamental and translational research pertinent to the effects of environmental factors on human health. The UTMB-CET is housed at the University of Texas Medical Branch in Galveston, and is the only NIEHS environmental health center located on the Gulf of Mexico coast, near the nation's busiest shipping port (Port of Houston) and an expansive petrochemical refining and manufacturing infrastructure. Our proximity to sources of many significant environmental problems makes UTMB a compelling site for such an environmental health sciences center. The underlying causes of these problems include the composition of the natural environment, meteorological conditions (namely hurricanes), population density, personal and commercial transportation patterns, and the endemic petrochemical industry. Some of the most serious environmental issues are ozone pollution, emissions of fine particulates, hazardous chemical releases, hazardous waste sites, and PCB/dioxin contamination of the marine biota. The UTMB-CET investigators concentrate their efforts in three disease categories: 1) asthma pathogenesis; 2) environmentally-linked carcinogenesis; and 3) disease states induced by reactive oxygen stress.

Organization profile

Director:  Cornelis J. Elferink, PhD  

Deputy Director:  Lawrence C. Sowers, PhD

 

The mission of the Sealy Center for Environmental Health Medicine, AKA UTMB Center in Environmental Toxicology (UTMB-CET) is to explore the environmental basis of human diseases by fostering collaborative interactions amongst multidisciplinary basic and clinical investigators pursuing both fundamental and translational research pertinent to the effects of environmental factors on human health. The UTMB-CET is housed at the University of Texas Medical Branch in Galveston, and is the only NIEHS environmental health center located on the Gulf of Mexico coast, near the nation's busiest shipping port (Port of Houston) and an expansive petrochemical refining and manufacturing infrastructure. Our proximity to sources of many significant environmental problems makes UTMB a compelling site for such an environmental health sciences center. The underlying causes of these problems include the composition of the natural environment, meteorological conditions (namely hurricanes), population density, personal and commercial transportation patterns, and the endemic petrochemical industry. Some of the most serious environmental issues are ozone pollution, emissions of fine particulates, hazardous chemical releases, hazardous waste sites, and PCB/dioxin contamination of the marine biota. The UTMB-CET investigators concentrate their efforts in three disease categories: 1) asthma pathogenesis; 2) environmentally-linked carcinogenesis; and 3) disease states induced by reactive oxygen stress.

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    Profiles

    Photo of Sherif Abdel-Rahman

    Sherif Abdel-Rahman, PhD

    Person: Academic

    19902018
    Photo of Bill Ameredes

    Bill Ameredes, PhD

    Person: Academic

    19842022
    Photo of Shakeel Ansari

    Shakeel Ansari, PhD

    Person: Academic

    19722019

    Projects

    A Randomized, Double-blind, Placebo-controlled, Parallel-group, 52-week Pivotal Study to Assess the Efficacy, Safety, and Tolerability of Dupilumab in Patients with Moderate-to-severe Chronic Obstructive Pulmonary Disease (COPD) with Type 2 inflammatio

    Calhoun, W.

    Sanofi US Services Inc

    11/7/19 → 11/6/22

    Project: Other project

    Study D3250C00059: A Phase 4, Multicenter, Randomized, Double-blind, Parallel Group, Placebo-controlled Study to Evaluate the Effect of Benralizumab on Structural and Lung Function Changes in Severe Eosinophilic Asthmatics (CHINOOK)

    Calhoun, W.

    AstraZeneca LP

    8/19/19 → 8/18/21

    Project: Other project

    A Long-term, Randomized, Double-blind, Multicenter, Parallel-group, Phase III Study Evaluating the Efficacy and Safety of PT027 Compared to PT007 Administered as Needed in Response to Symptoms in Symptomatic Adults and Children 4 Years of Age or Older

    Calhoun, W.

    Bond Avillion 2 Development LP

    7/22/19 → 7/21/21

    Project: Other project

    Research Output

    A polymorphism in the catalase gene promoter confers protection against severe RSV bronchiolitis

    Chambliss, J. M., Ansar, M., Kelley, J. P., Spratt, H., Garofalo, R. P. & Casola, A., Jan 3 2020, In : Viruses. 12, 1, , 57.

    Research output: Contribution to journal › Article

    Open Access

    • HSD3B1 genotype identifies glucocorticoid responsiveness in severe asthma

    Zein, J., Gaston, B., Bazeley, P., DeBoer, M. D., Igo, R. P., Bleecker, E. R., Meyers, D., Comhair, S., Marozkina, N. V., Cotton, C., Patel, M., Alyamani, M., Xu, W., Busse, W. W., Calhoun, W. J., Ortega, V., Hawkins, G. A., Castro, M., Chung, K. F., Fahy, J. V. & 12 others, Fitzpatrick, A. M., Israel, E., Jarjour, N. N., Levy, B., Mauger, D. T., Moore, W. C., Noel, P., Peters, S. P., Teague, W. G., Wenzel, S. E., Erzurum, S. C. & Sharifi, N., Jan 28 2020, In : Proceedings of the National Academy of Sciences of the United States of America. 117, 4, p. 2187-2193 7 p.

    Research output: Contribution to journal › Article

    Open Access

    • Management of Acute Asthma in Adults in 2020

    Zaidan, M. F., Ameredes, B. T. & Calhoun, W. J., Feb 11 2020, In : JAMA - Journal of the American Medical Association. 323, 6, p. 563-564 2 p.

    Research output: Contribution to journal › Short survey

    1 Scopus citations