Alan Barrett

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Alan Barrett, PhD

Director, The Sealy Institute of Vaccine Sciences

Calculated based on number of publications stored in Pure and citations from Scopus
1979 …2024

Research activity per year

Personal profile

Research Strategic Pillar

The Chief Research Officer, has determined that UTMB research should be prioritized into six health communities. This researcher has received the following badge(s):

Research interests

Our laboratory is undertaking basic research on the development of vaccines against the flavivirus diseases. This includes West Nile, Japanese encephalitis, yellow fever and dengue. We undertake studies on the excellent yellow fever 17D vaccine as a model to understand the molecular basis of attenuation of this vaccine. This is of major importance as the 17D vaccine virus is being used as an attenuated backbone to generate chimeric vaccine viruses against other flavivirus diseases, including dengue and Japanese encephalitis. In addition, recombinant DNA technology and infectious clone technology/reverse genetics are being used to identify molecular determinants of virulence of yellow fever, West Nile and Japanese encephalitis viruses with the aim of mutating these virulence determinants to develop candidate attenuated vaccine strains. We also investigate the molecular epidemiology of various flaviviruses (yellow fever, West Nile, Japanese encephalitis, and St Louis encephalitis viruses).

Education/Academic qualification

Virology, PhD, University of Warwick, Coventry, U.K

… → 1983

Virology, MS, University of Warwick, Coventry, U.K

… → 1980

Microbiology & Virology, BS, University of Warwick, Coventry, U.K

… → 1978

Virology, Post-Doctoral Fellow, Arbovirus Research Unit, London School of Hygiene and Tropical Medicine, UK

Research Strategic Pillar Keywords

  • Infectious/ Immunological Health

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Collaborations and top research areas from the last five years

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  • Lassa fever research priorities: towards effective medical countermeasures by the end of the decade

    Moore, K. A., Ostrowsky, J. T., Mehr, A. J., Johnson, R. A., Ulrich, A. K., Moua, N. M., Fay, P. C., Hart, P. J., Golding, J. P., Benassi, V., Preziosi, M. P., Adetifa, I. M., Akpede, G. O., Ampofo, W. K., Asogun, D. A., Barrett, A. D. T., Bausch, D. G., de Coster, I., Emperador, D. M. & Feldmann, H. & 12 others, Fichet-Calvet, E., Formenty, P. B. H., Garry, R. F., Grant, D. S., Günther, S., Gupta, S. B., Jaspard, M., Mazzola, L. T., Okogbenin, S. A., Roth, C., Schmaljohn, C. S. & Osterholm, M. T., 2024, (Accepted/In press) In: The Lancet Infectious Diseases.

    Research output: Contribution to journal › Review article › peer-review

    1 Scopus citations

  • Progress with COVID vaccine development and implementation

    Titball, R. W., Bernstein, D. I., Fanget, N. V. J., Hall, R. A., Longet, S., MacAry, P. A., Rupp, R. E., van Gils, M., von Messling, V., Walker, D. H. & Barrett, A. D. T., Apr 1 2024, In: npj Vaccines. 9, 1, p. 69 69.

    Research output: Contribution to journal › Editorial › peer-review

    Open Access
    1 Scopus citations

  • Vaccine value profile for Chikungunya

    Flandes, X., Hansen, C. A., Palani, S., Abbas, K., Bennett, C., Caro, W. P., Hutubessy, R., Khazhidinov, K., Lambach, P., Maure, C., Marshall, C., Rojas, D. P., Rosewell, A., Sahastrabuddhe, S., Tufet, M., Wilder-Smith, A., Beasley, D. W. C., Bourne, N. & Barrett, A. D. T., Jul 25 2024, In: Vaccine. 42, 19S1, p. S9-S24

    Research output: Contribution to journal › Article › peer-review

    Open Access
    9 Scopus citations

  • A Prototype-Pathogen Approach for the Development of Flavivirus Countermeasures

    Kuhn, R. J., Barrett, A. D. T., Desilva, A. M., Harris, E., Kramer, L. D., Montgomery, R. R., Pierson, T. C., Sette, A. & Diamond, M. S., Oct 15 2023, In: Journal of Infectious Diseases. 228, p. S398-S413

    Research output: Contribution to journal › Article › peer-review

    2 Scopus citations

  • Blocking NS3–NS4B interaction inhibits dengue virus in non-human primates

    Goethals, O., Kaptein, S. J. F., Kesteleyn, B., Bonfanti, J. F., Van Wesenbeeck, L., Bardiot, D., Verschoor, E. J., Verstrepen, B. E., Fagrouch, Z., Putnak, J. R., Kiemel, D., Ackaert, O., Straetemans, R., Lachau-Durand, S., Geluykens, P., Crabbe, M., Thys, K., Stoops, B., Lenz, O. & Tambuyzer, L. & 24 others, De Meyer, S., Dallmeier, K., McCracken, M. K., Gromowski, G. D., Rutvisuttinunt, W., Jarman, R. G., Karasavvas, N., Touret, F., Querat, G., de Lamballerie, X., Chatel-Chaix, L., Milligan, G. N., Beasley, D. W. C., Bourne, N., Barrett, A. D. T., Marchand, A., Jonckers, T. H. M., Raboisson, P., Simmen, K., Chaltin, P., Bartenschlager, R., Bogers, W. M., Neyts, J. & Van Loock, M., Mar 23 2023, In: Nature. 615, 7953, p. 678-686 9 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    40 Scopus citations
View all 361 Research outputs