Alexander Bukreyev

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Alexander Bukreyev, PhD, MS

Calculated based on number of publications stored in Pure and citations from Scopus
1993 …2025

Research activity per year

Personal profile

Research Strategic Pillar

The Chief Research Officer, has determined that UTMB research should be prioritized into six health communities. This researcher has received the following badge(s):

Research interests

Our Lab focuses on investigation of the mechanisms of the high pathogenicity of viruses Ebola, Marburg and Lassa and development of vaccines and antibody treatments against these viruses. More recently we also started work with respiratory syncytial virus (RSV), Crimean-Congo hemorrhagic fever virus and hantaviruses Andes and Sin Nombre. Our research includes, but not limited to, the following specific topics:
  • Investigation of dysregulated immune response to Ebola virus at epigenetic level.
  • Development of vaccines and investigation of the mechanisms of their protective effects.
  • In-depth characterization of antibody responses to viral infections in humans.
  • Development of therapeutic human monoclonal antibody treatments and investigation of the mechanisms of their protective effects.
To get insight into these scientific topics, we are using molecular tools, including reverse genetics (i.e. development of genetically modified filoviruses from the DNA-copies of their genomes and use of mini-genomes), epigenetic methods (ATAC-seq, cut-and-run), single-cell sequencing, immunological tools such as multi-parameter flow cytometry, human immune cells and animal models. Our research includes experiments in BSL-2, BSL-3 and BSL-4 labs of the Galveston National Laboratory. Our research is supported by grants from NIH and DoD and by contracts.

Our collaborators include Dr. Mariano Garcia-Blanco (University of Virginia), Dr. James Crowe, Jr. (Vanderbilt University), Dr. Andrea Carfi (Moderna), Dr. Stuart Sealfon (Mount Sinai School of Medicine), Dr. Erica Ollmann Saphire (La Jolla Institute for Immunology), Dr. Thomas Geisbert (UTMB), and other groups.

Education/Academic qualification

Molecular Biology, PhD, State Research Center of Virology and Biotechnology "Vector", Koltsovo, Russia.

… → 1993

Pharmacy, MS, Pyatigorsk Pharmaceutical Institute, Pyatigorsk, Russia.

… → 1984

Research Strategic Pillar Keywords

  • Infectious/ Immunological Health

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Collaborations and top research areas from the last five years

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  • A global collaboration for systematic analysis of broad-ranging antibodies against the SARS-CoV-2 spike protein

    The CoVIC-DB Team & Coronavirus Immunotherapeutic Consortium, Apr 22 2025, In: Cell Reports. 44, 4, 115499.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    1 Scopus citations

  • Annual (2024) taxonomic update of RNA-directed RNA polymerase-encoding negative-sense RNA viruses (realm Riboviria: kingdom Orthornavirae: phylum Negarnaviricota)

    Kuhn, J. H., Adkins, S., Alkhovsky, S. V., An, W., Avšič-Županc, T., Ayllón, M. A., Bačnik, K., Bahl, J., Balkema-Buschmann, A., Ballinger, M. J., Beer, M., Bejerman, N., Bergeron, É., Biedenkopf, N., Blair, C. D., Blasdell, K. R., Bradfute, S. B., Briese, T., Brown, K. & Brown, P. A. & 168 others, Buchholz, U. J., Buchmeier, M. J., Bukreyev, A., Burt, F., Calisher, C. H., Calvelage, S., Cao, M., Casas, I., Chabi-Jesus, C., Chandran, K., Charrel, R. N., Crane, A., Cuypers, L. N., Bó, E. D., de la Torre, J. C., de Souza, W. M., de Swart, R. L., Debat, H. J., Dheilly, N. M., Paola, N. D., Serio, F. D., Dietzgen, R. G., Digiaro, M., Felix Drexler, J., Paul Duprex, W., Dürrwald, R., Easton, A. J., Elbeaino, T., Ergünay, K., Eshak, M. I. Y., Feng, G., Firth, A. E., Fooks, A. R., Formenty, P. B. H., Freitas-Astúa, J., Freuling, C. M., Gadd, T., Gago-Zachert, S., García, M. L., García-Sastre, A., Garrison, A. R., Goldberg, T. L., Gonzalez, J. P. J., de Bellocq, J. G., Griffiths, A., Groschup, M. H., Gryseels, S., Gutiérrez-Aguirre, I., Günther, S., Hammond, J., Hepojoki, J., Horie, M., Hume, A. J., Hyndman, T. H., Höper, D., Jiāng, D., Junglen, S., Klempa, B., Klingström, J., Kondō, H., Koonin, E. V., Krupovic, M., Kubota, K., Kurath, G., Kutnjak, D., Laenen, L., Lambert, A. J., Lee, B., Li, C., Lǐ, J., Li, J. M., Lukashevich, I. S., Maes, P., Marklewitz, M., Marshall, S. H., Marzano, S. Y. L., McCauley, J. W., Mehle, N., Mirazimi, A., Morikawa, T., Mühlberger, E., Müller, T., Naidu, R., Natsuaki, T., Navarro, B., Navarro, J. A., Neriya, Y., Netesov, S. V., Nicoloso, V. M., Neumann, G., Nokireki, T., Nowotny, N., Nunes, M. R. T., Ochoa-Corona, F. M., Palacios, G., Pallás, V., Papa, A., Paraskevopoulou, S., Parrish, C. R., Pauvolid-Corrêa, A., Pecman, A., Pérez, D. R., Pfaff, F., Plemper, R. K., Postler, T. S., Radoshitzky, S. R., Ramos-González, P. L., Ravnikar, M., Resende, R. O., Reuter, G., Reyes, C. A., Rivarez, M. P. S., Romanowski, V., Rubbenstroth, D., Rubino, L., Runstadler, J. A., Ruiz-Padilla, A., Sabanadzovic, S., Salvato, M. S., Sasaya, T., Schmaljohn, C. S., Schmidt-Posthaus, H., Schwemmle, M., Seljak, G., Seuberlich, T., Shi, M., Shimomoto, Y., Simmonds, P., Sironi, M., Smith, D. B., Smither, S., Song, J. W., Spann, K. M., Spengler, J. R., Stenglein, M. D., Takada, A., Takemura, C., Tammiranta, N., Tesh, R. B., Thornburg, N. J., Tischler, N. D., Tomitaka, Y., Tomonaga, K., Tordo, N., Turina, M., Tzanetakis, I. E., Vaira, A. M., van den Hoogen, B., Vanmechelen, B., Vasilakis, N., Verbeek, M., von Bargen, S., Vučurović, A., Wada, J., Wahl, V., Walker, P. J., Wang, F., Whitfield, A. E., Williams, J. V., Wolf, Y. I., Yanagisawa, H., Yang, C., Ye, G., Yu, M. C., Zerbini, F. M., Zhang, S., Økland, A. L. & Hughes, H. R., 2025, In: Journal of General Virology. 106, 6, 002077.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    4 Scopus citations

  • Distinct immune properties of the N- and C-termini of the immunosuppressive domain of Ebola virus glycoprotein

    Iampietro, M., Periasamy, S., Ilinykh, P. A., Qiu, Y., Liu, Y., Nagar, A., Gong, B. & Bukreyev, A., Nov 12 2025, In: mBio. 16, 11, p. 1-22 22 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access

  • Divergent antibody recognition profiles are generated by protective mRNA vaccines against Marburg and Ravn viruses

    Meyer, M., Gunn, B. M., Pietzsch, C., Subramani, C., Kedarinath, K., Villarreal, P. P., Hyde, M. A., Saphire, E. O., Crowe, J. E., Alter, G., Himansu, S., Carfi, A. & Bukreyev, A., Dec 2025, In: Nature communications. 16, 1, 5702.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    1 Scopus citations

  • Ebola virus nucleoprotein interaction with host protein phosphatase-1 regulates its dimerization and capsid formation

    Ahmad, A., Tigabu, B., Ivanov, A., Jerebtsova, M., Ammosova, T., Ramanathan, P., Kumari, N., Brantner, C. A., Pietzsch, C. A., Simhadri, J., Abdullah, G., Uversky, V. N., Paromov, V., Popratiloff, A., Widen, S., Bukreyev, A. & Nekhai, S., Jun 2025, In: Journal of Biological Chemistry. 301, 6, 108541.

    Research output: Contribution to journal › Article › peer-review

    1 Scopus citations
View all 189 Research outputs