Alexander Bukreyev, PhD, MS

  • 4730 Citations
  • 40 h-Index
1993 …2023

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2020

Analysis of a Therapeutic Antibody Cocktail Reveals Determinants for Cooperative and Broad Ebolavirus Neutralization

Gilchuk, P., Murin, C. D., Milligan, J. C., Cross, R. W., Mire, C. E., Ilinykh, P. A., Huang, K., Kuzmina, N., Altman, P. X., Hui, S., Gunn, B. M., Bryan, A. L., Davidson, E., Doranz, B. J., Turner, H. L., Alkutkar, T., Flinko, R., Orlandi, C., Carnahan, R., Nargi, R. & 13 others, Bombardi, R. G., Vodzak, M. E., Li, S., Okoli, A., Ibeawuchi, M., Ohiaeri, B., Lewis, G. K., Alter, G., Bukreyev, A., Saphire, E. O., Geisbert, T. W., Ward, A. B. & Crowe, J. E., Feb 18 2020, In : Immunity. 52, 2, p. 388-403.e12

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Ebola virus produces discrete small noncoding RNAs independently of the host MicroRNA pathway which lack RNA interference activity in bat and human cells

Prasad, A. N., Ronk, A. J., Widen, S. G., Wood, T. G., Basler, C. F. & Bukreyev, A., Mar 1 2020, In : Journal of virology. 94, 6, e01441-19.

Research output: Contribution to journalArticle

Small Molecule Compounds That Inhibit Antioxidant Response Gene Expression in an Inducer-Dependent Manner

Edwards, M. R., Liu, G., De, S., Sourimant, J., Pietzsch, C., Johnson, B., Amarasinghe, G. K., Leung, D. W., Bukreyev, A., Plemper, R. K., Aron, Z., Bowlin, T. L., Moir, D. T. & Basler, C. F., Mar 13 2020, In : ACS Infectious Diseases. 6, 3, p. 489-502 14 p.

Research output: Contribution to journalArticle

2019

Antibody-mediated protective mechanisms induced by a trivalent parainfluenza virus-vectored ebolavirus vaccine

Brian Kimble, J., Malherbe, D. C., Meyer, M., Gunn, B. M., Karim, M. M., Ilinykh, P. A., Iampietro, M., Mohamed, K. S., Negi, S., Gilchuk, P., Huang, K., Wolf, Y. I., Braun, W., Crowe, J. E., Alter, G. & Bukreyev, A., Feb 1 2019, In : Journal of virology. 93, 4, e0184518.

Research output: Contribution to journalArticle

1 Scopus citations

Cross-reactive neutralizing human survivor monoclonal antibody BDBV223 targets the ebolavirus stalk

King, L. B., West, B. R., Moyer, C. L., Gilchuk, P., Flyak, A., Ilinykh, P. A., Bombardi, R., Hui, S., Huang, K., Bukreyev, A., Crowe, J. E. & Saphire, E. O., Dec 1 2019, In : Nature communications. 10, 1, 1788.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Ebola virus-mediated T-lymphocyte depletion is the result of an abortive infection

Younan, P., Santos, R. I., Ramanathan, P., Iampietro, M., Nishida, A., Dutta, M., Ammosova, T., Meyer, M., Katze, M. G., Popov, V. L., Nekhai, S. & Bukreyev, A., Jan 1 2019, In : PLoS pathogens. 15, 10, e1008068.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Global phosphoproteomic analysis of Ebola virions reveals a novel role for VP35 phosphorylation-dependent regulation of genome transcription

Ivanov, A., Ramanathan, P., Parry, C., Ilinykh, P. A., Lin, X., Petukhov, M., Obukhov, Y., Ammosova, T., Amarasinghe, G. K., Bukreyev, A. & Nekhai, S., Jan 1 2019, (Accepted/In press) In : Cellular and Molecular Life Sciences.

Research output: Contribution to journalArticle

ICTV virus taxonomy profile: Filoviridae

ICTV Report Consortium, Jun 2019, In : Journal of General Virology. 100, 6, p. 911-912 2 p.

Research output: Contribution to journalArticle

5 Scopus citations

Structural basis of broad ebolavirus neutralization by a human survivor antibody

West, B. R., Wec, A. Z., Moyer, C. L., Fusco, M. L., Ilinykh, P. A., Huang, K., Wirchnianski, A. S., James, R. M., Herbert, A. S., Hui, S., Goodwin, E., Howell, K. A., Kailasan, S., Aman, M. J., Walker, L. M., Dye, J. M., Bukreyev, A., Chandran, K. & Saphire, E. O., Mar 1 2019, In : Nature Structural and Molecular Biology. 26, 3, p. 204-212 9 p.

Research output: Contribution to journalArticle

6 Scopus citations

Targeting the Non-catalytic RVxF Site of Protein Phosphatase-1 With Small Molecules for Ebola Virus Inhibition

Lin, X., Ammosova, T., Choy, M. S., Pietzsch, C. A., Ivanov, A., Ahmad, A., Saygideğer, Y., Kumari, N., Kovalskyy, D., Üren, A., Peti, W., Bukreyev, A. & Nekhai, S., Sep 13 2019, In : Frontiers in Microbiology. 10, 2145.

Research output: Contribution to journalArticle

Open Access

Taxonomy of the order Mononegavirales: update 2019

Amarasinghe, G. K., Ayllón, M. A., Bào, Y., Basler, C. F., Bavari, S., Blasdell, K. R., Briese, T., Brown, P. A., Bukreyev, A., Balkema-Buschmann, A., Buchholz, U. J., Chabi-Jesus, C., Chandran, K., Chiapponi, C., Crozier, I., de Swart, R. L., Dietzgen, R. G., Dolnik, O., Drexler, J. F., Dürrwald, R. & 64 others, Dundon, W. G., Duprex, W. P., Dye, J. M., Easton, A. J., Fooks, A. R., Formenty, P. B. H., Fouchier, R. A. M., Freitas-Astúa, J., Griffiths, A., Hewson, R., Horie, M., Hyndman, T. H., Jiāng, D., Kitajima, E. W., Kobinger, G. P., Kondō, H., Kurath, G., Kuzmin, I. V., Lamb, R. A., Lavazza, A., Lee, B., Lelli, D., Leroy, E. M., Lǐ, J., Maes, P., Marzano, S. Y. L., Moreno, A., Mühlberger, E., Netesov, S. V., Nowotny, N., Nylund, A., Økland, A. L., Palacios, G., Pályi, B., Pawęska, J. T., Payne, S. L., Prosperi, A., Ramos-González, P. L., Rima, B. K., Rota, P., Rubbenstroth, D., Shī, M., Simmonds, P., Smither, S. J., Sozzi, E., Spann, K., Stenglein, M. D., Stone, D. M., Takada, A., Tesh, R. B., Tomonaga, K., Tordo, N., Towner, J. S., van den Hoogen, B., Vasilakis, N., Wahl, V., Walker, P. J., Wang, L. F., Whitfield, A. E., Williams, J. V., Zerbini, F. M., Zhāng, T., Zhang, Y. Z. & Kuhn, J. H., Jul 1 2019, In : Archives of virology. 164, 7, p. 1967-1980 14 p.

Research output: Contribution to journalArticle

Open Access
31 Scopus citations

Taxonomy of the order Mononegavirales: second update 2018

Maes, P., Amarasinghe, G. K., Ayllón, M. A., Basler, C. F., Bavari, S., Blasdell, K. R., Briese, T., Brown, P. A., Bukreyev, A., Balkema-Buschmann, A., Buchholz, U. J., Chandran, K., Crozier, I., de Swart, R. L., Dietzgen, R. G., Dolnik, O., Domier, L. L., Drexler, J. F., Dürrwald, R., Dundon, W. G. & 57 others, Duprex, W. P., Dye, J. M., Easton, A. J., Fooks, A. R., Formenty, P. B. H., Fouchier, R. A. M., Freitas-Astúa, J., Ghedin, E., Griffiths, A., Hewson, R., Horie, M., Hurwitz, J. L., Hyndman, T. H., Jiāng, D., Kobinger, G. P., Kondō, H., Kurath, G., Kuzmin, I. V., Lamb, R. A., Lee, B., Leroy, E. M., Lǐ, J., Marzano, S. Y. L., Mühlberger, E., Netesov, S. V., Nowotny, N., Palacios, G., Pályi, B., Pawęska, J. T., Payne, S. L., Rima, B. K., Rota, P., Rubbenstroth, D., Simmonds, P., Smither, S. J., Song, Q., Song, T., Spann, K., Stenglein, M. D., Stone, D. M., Takada, A., Tesh, R. B., Tomonaga, K., Tordo, N., Towner, J. S., van den Hoogen, B., Vasilakis, N., Wahl, V., Walker, P. J., Wang, D., Wang, L. F., Whitfield, A. E., Williams, J. V., Yè, G., Zerbini, F. M., Zhang, Y. Z. & Kuhn, J. H., Apr 3 2019, In : Archives of virology. 164, 4, p. 1233-1244 12 p.

Research output: Contribution to journalArticle

Open Access
25 Scopus citations
2018

A high throughput screen identifies benzoquinoline compounds as inhibitors of Ebola virus replication

Luthra, P., Liang, J., Pietzsch, C. A., Khadka, S., Edwards, M. R., Wei, S., De, S., Posner, B., Bukreyev, A., Ready, J. M. & Basler, C. F., Feb 1 2018, In : Antiviral Research. 150, p. 193-201 9 p.

Research output: Contribution to journalArticle

16 Scopus citations

Antibody-Dependent Enhancement of Ebola Virus Infection by Human Antibodies Isolated from Survivors

Kuzmina, N. A., Younan, P., Gilchuk, P., Santos, R. I., Flyak, A. I., Ilinykh, P. A., Huang, K., Lubaki, N. M., Ramanathan, P., Crowe, J. E. & Bukreyev, A., Aug 14 2018, In : Cell Reports. 24, 7, p. 1802-1815.e5

Research output: Contribution to journalArticle

6 Scopus citations

Antibody Repertoires to the Same Ebola Vaccine Antigen Are Differentially Affected by Vaccine Vectors

Meyer, M., Yoshida, A., Ramanathan, P., Saphire, E. O., Collins, P. L., Crowe, J. E., Samal, S. & Bukreyev, A., Aug 14 2018, In : Cell Reports. 24, 7, p. 1816-1829 14 p.

Research output: Contribution to journalArticle

2 Scopus citations

Asymmetric antiviral effects of ebolavirus antibodies targeting glycoprotein stem and glycan cap

Ilinykh, P. A., Santos, R. I., Gunn, B. M., Kuzmina, N. A., Shen, X., Huang, K., Gilchuk, P., Flyak, A. I., Younan, P., Alter, G., Crowe, J. E. & Bukreyev, A., Aug 1 2018, In : PLoS Pathogens. 14, 8, e1007204.

Research output: Contribution to journalArticle

4 Scopus citations

Broadly neutralizing antibodies from human survivors target a conserved site in the ebola virus glycoprotein hr2-mper region

Flyak, A. I., Kuzmina, N., Murin, C. D., Bryan, C., Davidson, E., Gilchuk, P., Gulka, C. P., Ilinykh, P. A., Shen, X., Huang, K., Ramanathan, P., Turner, H., Fusco, M. L., Lampley, R., Kose, N., King, H., Sapparapu, G., Doranz, B. J., Ksiazek, T. G., Wright, D. W. & 4 others, Saphire, E. O., Ward, A. B., Bukreyev, A. & Crowe, J. E., Jun 1 2018, In : Nature Microbiology. 3, 6, p. 670-677 8 p.

Research output: Contribution to journalArticle

23 Scopus citations

Can Ebola Virus Vaccines Have Universal Immune Correlates of protection?

Meyer, M., Malherbe, D. C. & Bukreyev, A., Jan 1 2018, (Accepted/In press) In : Trends in Microbiology.

Research output: Contribution to journalArticle

5 Scopus citations

Disabling of lymphocyte immune response by Ebola virus

Younan, P., Iampietro, M. & Bukreyev, A., Apr 1 2018, In : PLoS Pathogens. 14, 4, e1006932.

Research output: Contribution to journalArticle

7 Scopus citations

Disruption of Phosphatidylserine Synthesis or Trafficking Reduces Infectivity of Ebola Virus

Younan, P., Iampietro, M., Santos, R. I., Ramanathan, P., Popov, V. & Bukreyev, A., Nov 22 2018, In : The Journal of infectious diseases. 218, 5, p. S475-S485

Research output: Contribution to journalArticle

2 Scopus citations

Ebolavirus Chimerization for the Development of a Mouse Model for Screening of Bundibugyo-Specific Antibodies

Ilinykh, P. A., Graber, J., Kuzmina, N. A., Huang, K., Ksiazek, T., Crowe, J. E. & Bukreyev, A., Nov 22 2018, In : The Journal of infectious diseases. 218, 5, p. S418-S422

Research output: Contribution to journalArticle

Ebola Virus Shed Glycoprotein Triggers Differentiation, Infection, and Death of Monocytes Through Toll-Like Receptor 4 Activation

Iampietro, M., Santos, R. I., Lubaki, N. M. & Bukreyev, A., Nov 22 2018, In : The Journal of infectious diseases. 218, 5, p. S327-S334

Research output: Contribution to journalArticle

2 Scopus citations

Inhibiting pyrimidine biosynthesis impairs Ebola virus replication through depletion of nucleoside pools and activation of innate immune responses

Luthra, P., Naidoo, J., Pietzsch, C. A., De, S., Khadka, S., Anantpadma, M., Williams, C. G., Edwards, M. R., Davey, R. A., Bukreyev, A., Ready, J. M. & Basler, C. F., Oct 1 2018, In : Antiviral Research. 158, p. 288-302 15 p.

Research output: Contribution to journalArticle

14 Scopus citations

Modified mRNA-Based Vaccines Elicit Robust Immune Responses and Protect Guinea Pigs from Ebola Virus Disease

Meyer, M., Huang, E., Yuzhakov, O., Ramanathan, P., Ciaramella, G. & Bukreyev, A., Jan 17 2018, In : Journal of Infectious Diseases. 217, 3, p. 451-455 5 p.

Research output: Contribution to journalArticle

15 Scopus citations

Multifunctional Pan-ebolavirus Antibody Recognizes a Site of Broad Vulnerability on the Ebolavirus Glycoprotein

Gilchuk, P., Kuzmina, N., Ilinykh, P. A., Huang, K., Gunn, B. M., Bryan, A., Davidson, E., Doranz, B. J., Turner, H. L., Fusco, M. L., Bramble, M. S., Hoff, N. A., Binshtein, E., Kose, N., Flyak, A. I., Flinko, R., Orlandi, C., Carnahan, R., Parrish, E. H., Sevy, A. M. & 12 others, Bombardi, R. G., Singh, P. K., Mukadi, P., Muyembe-Tamfum, J. J., Ohi, M. D., Saphire, E. O., Lewis, G. K., Alter, G., Ward, A. B., Rimoin, A. W., Bukreyev, A. & Crowe, J. E., Aug 21 2018, In : Immunity. 49, 2, p. 363-374.e10

Research output: Contribution to journalArticle

16 Scopus citations

Phosphorylated VP30 of marburg virus is a repressor of transcription

Tigabu, B., Ramanathan, P., Ivanov, A., Lin, X., Ilinykh, P. A., Parry, C. S., Freiberg, A., Nekhai, S. & Bukreyev, A., Nov 1 2018, In : Journal of Virology. 92, 21, e00426.

Research output: Contribution to journalArticle

6 Scopus citations

Protein Phosphatase 1-Targeting Small-Molecule C31 Inhibits Ebola Virus Replication

Ammosova, T., Pietzsch, C. A., Saygideger, Y., Ilatovsky, A., Lin, X., Ivanov, A., Kumari, N., Jerebtsova, M., Kulkarni, A., Petukhov, M., Üren, A., Bukreyev, A. & Nekhai, S., Nov 22 2018, In : The Journal of infectious diseases. 218, 5, p. S627-S635

Research output: Contribution to journalArticle

2 Scopus citations

Role of Transmembrane Protein 16F in the Incorporation of Phosphatidylserine Into Budding Ebola Virus Virions

Younan, P., Iampietro, M., Santos, R. I., Ramanathan, P., Popov, V. & Bukreyev, A., Nov 22 2018, In : The Journal of infectious diseases. 218, 5, p. S335-S345

Research output: Contribution to journalArticle

2 Scopus citations

Staufen1 interacts with multiple components of the ebola virus ribonucleoprotein and enhances viral RNA synthesis

Fang, J., Pietzsch, C., Ramanathan, P., Santos, R. I., Ilinykh, P. A., Garcia-Blanco, M., Bukreyev, A. & Bradrick, S., Sep 1 2018, In : mBio. 9, 5, e01771-18.

Research output: Contribution to journalArticle

3 Scopus citations

Systematic Analysis of Monoclonal Antibodies against Ebola Virus GP Defines Features that Contribute to Protection

the Viral Hemorrhagic Fever Immunotherapeutic Consortium, Aug 9 2018, In : Cell. 174, 4, p. 938-952.e13

Research output: Contribution to journalArticle

45 Scopus citations

Taxonomy of the order Mononegavirales: update 2018

Amarasinghe, G. K., Aréchiga Ceballos, N. G., Banyard, A. C., Basler, C. F., Bavari, S., Bennett, A. J., Blasdell, K. R., Briese, T., Bukreyev, A., Caì, Y., Calisher, C. H., Campos Lawson, C., Chandran, K., Chapman, C. A., Chiu, C. Y., Choi, K. S., Collins, P. L., Dietzgen, R. G., Dolja, V. V., Dolnik, O. & 71 others, Domier, L. L., Dürrwald, R., Dye, J. M., Easton, A. J., Ebihara, H., Echevarría, J. E., Fooks, A. R., Formenty, P. B. H., Fouchier, R. A. M., Freuling, C. M., Ghedin, E., Goldberg, T. L., Hewson, R., Horie, M., Hyndman, T. H., Jiāng, D., Kityo, R., Kobinger, G. P., Kondō, H., Koonin, E. V., Krupovic, M., Kurath, G., Lamb, R. A., Lee, B., Leroy, E. M., Maes, P., Maisner, A., Marston, D. A., Mor, S. K., Müller, T., Mühlberger, E., Ramírez, V. M. N., Netesov, S. V., Ng, T. F. F., Nowotny, N., Palacios, G., Patterson, J. L., Pawęska, J. T., Payne, S. L., Prieto, K., Rima, B. K., Rota, P., Rubbenstroth, D., Schwemmle, M., Siddell, S., Smither, S. J., Song, Q., Song, T., Stenglein, M. D., Stone, D. M., Takada, A., Tesh, R. B., Thomazelli, L. M., Tomonaga, K., Tordo, N., Towner, J. S., Vasilakis, N., Vázquez-Morón, S., Verdugo, C., Volchkov, V. E., Wahl, V., Walker, P. J., Wang, D., Wang, L. F., Wellehan, J. F. X., Wiley, M. R., Whitfield, A. E., Wolf, Y. I., Yè, G., Zhāng, Y. Z. & Kuhn, J. H., Aug 1 2018, In : Archives of virology. 163, 8, p. 2283-2294 12 p.

Research output: Contribution to journalArticle

72 Scopus citations

The Marburgvirus-Neutralizing Human Monoclonal Antibody MR191 Targets a Conserved Site to Block Virus Receptor Binding

King, L. B., Fusco, M. L., Flyak, A. I., Ilinykh, P. A., Huang, K., Gunn, B., Kirchdoerfer, R. N., Hastie, K. M., Sangha, A. K., Meiler, J., Alter, G., Bukreyev, A., Crowe, J. E. & Saphire, E. O., Jan 10 2018, In : Cell Host and Microbe. 23, 1, p. 101-109.e4

Research output: Contribution to journalArticle

9 Scopus citations
2017

A Sensitive in Vitro High-Throughput Screen to Identify Pan-filoviral Replication Inhibitors Targeting the VP35-NP Interface

Liu, G., Nash, P. J., Johnson, B., Pietzsch, C., Ilagan, M. X. G., Bukreyev, A., Basler, C. F., Bowlin, T. L., Moir, D. T., Leung, D. W. & Amarasinghe, G. K., Mar 10 2017, In : ACS Infectious Diseases. 3, 3, p. 190-198 9 p.

Research output: Contribution to journalArticle

9 Scopus citations

Ebola virus binding to Tim-1 on T lymphocytes induces a cytokine storm

Younan, P., Iampietro, M., Nishida, A., Ramanathan, P., Santos, R. I., Dutta, M., Lubaki, N. M., Koup, R. A., Katze, M. G. & Bukreyev, A., Sep 1 2017, In : mBio. 8, 5, e00845-17.

Research output: Contribution to journalArticle

24 Scopus citations

Ebola virus glycoprotein directly triggers T lymphocyte death despite of the lack of infection

Iampietro, M., Younan, P., Nishida, A., Dutta, M., Lubaki, N. M., Santos, R. I., Koup, R. A., Katze, M. G. & Bukreyev, A., May 1 2017, In : PLoS Pathogens. 13, 5, e1006397.

Research output: Contribution to journalArticle

18 Scopus citations

Innate immune responses of bat and human cells to filoviruses: Commonalities and distinctions

Kuzmin, I. V., Schwarz, T. M., Ilinykh, P. A., Jordan, I., Ksiazek, T., Sachidanandam, R., Basler, C. F. & Bukreyev, A., Apr 1 2017, In : Journal of Virology. 91, 8, e02471-16.

Research output: Contribution to journalArticle

19 Scopus citations

Possibility and challenges of conversion of current virus species names to Linnaean binomials

Postler, T. S., Clawson, A. N., Amarasinghe, G. K., Basler, C. F., Bavari, S., Benko, M., Blasdell, K. R., Briese, T., Buchmeier, M. J., Bukreyev, A., Calisher, C. H., Chandran, K., Charrel, R., Clegg, C. S., Collins, P. L., De La Torre, J. C., DeRisi, J. L., Dietzgen, R. G., Dolnik, O., Dürrwald, R. & 52 others, Dye, J. M., Easton, A. J., Emonet, S., Formenty, P., Fouchier, R. A. M., Ghedin, E., Gonzalez, J. P., Harrach, B., Hewson, R., Horie, M., Jiāng, D., Kobinger, G., Kondo, H., Kropinski, A. M., Krupovic, M., Kurath, G., Lamb, R. A., Leroy, E. M., Lukashevich, I. S., Maisner, A., Mushegian, A. R., Netesov, S. V., Nowotny, N., Patterson, J. L., Payne, S. L., Paweska, J. T., Peters, C. J., Radoshitzky, S. R., Rima, B. K., Romanowski, V., Rubbenstroth, D., Sabanadzovic, S., Sanfaçon, H., Salvato, M. S., Schwemmle, M., Smither, S. J., Stenglein, M. D., Stone, D. M., Takada, A., Tesh, R. B., Tomonaga, K., Tordo, N., Towner, J. S., Vasilakis, N., Volchkov, V. E., Wahl-Jensen, V., Walker, P. J., Wang, L. F., Varsani, A., Whitfield, A. E., Murilo Zerbini, F. & Kuhn, J. H., May 1 2017, In : Systematic Biology. 66, 3, p. 463-473 11 p.

Research output: Contribution to journalArticle

8 Scopus citations

Taxonomy of the order Mononegavirales: update 2017

Amarasinghe, G. K., Bào, Y., Basler, C. F., Bavari, S., Beer, M., Bejerman, N., Blasdell, K. R., Bochnowski, A., Briese, T., Bukreyev, A., Calisher, C. H., Chandran, K., Collins, P. L., Dietzgen, R. G., Dolnik, O., Dürrwald, R., Dye, J. M., Easton, A. J., Ebihara, H., Fang, Q. & 53 others, Formenty, P., Fouchier, R. A. M., Ghedin, E., Harding, R. M., Hewson, R., Higgins, C. M., Hong, J., Horie, M., James, A. P., Jiāng, D., Kobinger, G. P., Kondo, H., Kurath, G., Lamb, R. A., Lee, B., Leroy, E. M., Li, M., Maisner, A., Mühlberger, E., Netesov, S. V., Nowotny, N., Patterson, J. L., Payne, S. L., Paweska, J. T., Pearson, M. N., Randall, R. E., Revill, P. A., Rima, B. K., Rota, P., Rubbenstroth, D., Schwemmle, M., Smither, S. J., Song, Q., Stone, D. M., Takada, A., Terregino, C., Tesh, R. B., Tomonaga, K., Tordo, N., Towner, J. S., Vasilakis, N., Volchkov, V. E., Wahl-Jensen, V., Walker, P. J., Wang, B., Wang, D., Wang, F., Wang, L. F., Werren, J. H., Whitfield, A. E., Yan, Z., Ye, G. & Kuhn, J. H., Aug 1 2017, In : Archives of virology. 162, 8, p. 2493-2504 12 p.

Research output: Contribution to journalArticle

113 Scopus citations

Topoisomerase II inhibitors induce DNA damage-dependent interferon responses circumventing ebola virus immune evasion

Luthra, P., Aguirre, S., Yen, B. C., Pietzsch, C. A., Sanchez-Aparicio, M. T., Tigabu, B., Morlock, L. K., García-Sastre, A., Leung, D. W., Williams, N. S., Fernandez-Sesma, A., Bukreyev, A. & Basler, C. F., Mar 1 2017, In : mBio. 8, 2, e00368-17.

Research output: Contribution to journalArticle

28 Scopus citations
2016

Chimeric filoviruses for identification and characterization of monoclonal antibodies

Ilinykh, P. A., Shen, X., Flyak, A. I., Kuzmina, N., Ksiazek, T. G., Crowe, J. E. & Bukreyev, A., Apr 1 2016, In : Journal of virology. 90, 8, p. 3890-3901 12 p.

Research output: Contribution to journalArticle

18 Scopus citations

Cross-Reactive and Potent Neutralizing Antibody Responses in Human Survivors of Natural Ebolavirus Infection

Flyak, A. I., Shen, X., Murin, C. D., Turner, H. L., David, J. A., Fusco, M. L., Lampley, R., Kose, N., Ilinykh, P. A., Kuzmina, N., Branchizio, A., King, H., Brown, L., Bryan, C., Davidson, E., Doranz, B. J., Slaughter, J. C., Sapparapu, G., Klages, C., Ksiazek, T. G. & 4 others, Saphire, E. O., Ward, A. B., Bukreyev, A. & Crowe, J. E., Jan 28 2016, In : Cell. 164, 3, p. 392-405 14 p.

Research output: Contribution to journalArticle

91 Scopus citations

High-Throughput Minigenome System for Identifying Small-Molecule Inhibitors of Ebola Virus Replication

Edwards, M. R., Pietzsch, C., Vausselin, T., Shaw, M. L., Bukreyev, A. & Basler, C. F., Jan 8 2016, In : ACS Infectious Diseases. 1, 8, p. 380-387 8 p.

Research output: Contribution to journalArticle

36 Scopus citations

Proteoform-specific insights into cellular proteome regulation

Norris, E. L., Headlam, M. J., Dave, K. A., Smith, D. D., Bukreyev, A., Singh, T., Jayakody, B. A., Chappell, K. J., Collins, P. L. & Gorman, J. J., Oct 2016, In : Molecular and Cellular Proteomics. 15, 10, p. 3297-3320 24 p.

Research output: Contribution to journalArticle

1 Scopus citations

Taxonomy of the order Mononegavirales: update 2016

Afonso, C. L., Amarasinghe, G. K., Bányai, K., Bào, Y., Basler, C. F., Bavari, S., Bejerman, N., Blasdell, K. R., Briand, F. X., Briese, T., Bukreyev, A., Calisher, C. H., Chandran, K., Chéng, J., Clawson, A. N., Collins, P. L., Dietzgen, R. G., Dolnik, O., Domier, L. L., Dürrwald, R. & 63 others, Dye, J. M., Easton, A. J., Ebihara, H., Farkas, S. L., Freitas-Astúa, J., Formenty, P., Fouchier, R. A. M., Fù, Y., Ghedin, E., Goodin, M. M., Hewson, R., Horie, M., Hyndman, T. H., Jiāng, D., Kitajima, E. W., Kobinger, G. P., Kondo, H., Kurath, G., Lamb, R. A., Lenardon, S., Leroy, E. M., Li, C. X., Lin, X. D., Liú, L., Longdon, B., Marton, S., Maisner, A., Mühlberger, E., Netesov, S. V., Nowotny, N., Patterson, J. L., Payne, S. L., Paweska, J. T., Randall, R. E., Rima, B. K., Rota, P., Rubbenstroth, D., Schwemmle, M., Shi, M., Smither, S. J., Stenglein, M. D., Stone, D. M., Takada, A., Terregino, C., Tesh, R. B., Tian, J. H., Tomonaga, K., Tordo, N., Towner, J. S., Vasilakis, N., Verbeek, M., Volchkov, V. E., Wahl-Jensen, V., Walsh, J. A., Walker, P. J., Wang, D., Wang, L. F., Wetzel, T., Whitfield, A. E., Xiè, J., Yuen, K. Y., Zhang, Y. Z. & Kuhn, J. H., Aug 1 2016, In : Archives of virology. 161, 8, p. 2351-2360 10 p.

Research output: Contribution to journalArticle

238 Scopus citations

The Ebola Interferon Inhibiting Domains Attenuate and Dysregulate Cell-Mediated Immune Responses

Lubaki, N. M., Younan, P., Santos, R. I., Meyer, M., Iampietro, M., Koup, R. A. & Bukreyev, A., Dec 8 2016, In : PLoS Pathogens. 12, 12, e1006031.

Research output: Contribution to journalArticle

17 Scopus citations

Topoisomerase 1 inhibition suppresses inflammatory genes and protects from death by inflammation

Rialdi, A., Campisi, L., Zhao, N., Lagda, A. C., Pietzsch, C., Ho, J. S. Y., Martinez-Gil, L., Fenouil, R., Chen, X., Edwards, M., Metreveli, G., Jordan, S., Peralta, Z., Munoz-Fontela, C., Bouvier, N., Merad, M., Jin, J., Weirauch, M., Heinz, S., Benner, C. & 5 others, Van Bakel, H., Basler, C., García-Sastre, A., Bukreyev, A. & Marazzi, I., May 27 2016, In : Science. 352, 6289, 7993.

Research output: Contribution to journalArticle

59 Scopus citations
2015

Adapting high-throughput screening methods and assays for biocontainment laboratories

Rasmussen, L., Tigabu, B., White, E. L., Bostwick, R., Tower, N., Bukreyev, A., Rockx, B., Leduc, J. W. & Noah, J. W., Feb 1 2015, In : Assay and Drug Development Technologies. 13, 1, p. 44-54 11 p.

Research output: Contribution to journalArticle

4 Scopus citations

Aerosolized Ebola vaccine protects primates and elicits lung-resident T cell responses

Meyer, M., Garron, T., Lubaki, N. M., Mire, C., Fenton, K. A., Klages, C., Olinger, G. G., Geisbert, T., Collins, P. L. & Bukreyev, A., Aug 3 2015, In : Journal of Clinical Investigation. 125, 8, p. 3241-3255 15 p.

Research output: Contribution to journalArticle

42 Scopus citations

Different temporal effects of Ebola virus VP35 and VP24 proteins on global gene expression in human dendritic cells

Ilinykh, P. A., Lubaki, N. M., Widen, S., Renn, L. A., Theisen, T. C., Rabin, R. L., Wood, T. & Bukreyev, A., 2015, In : Journal of Virology. 89, 15, p. 7567-7583 17 p.

Research output: Contribution to journalArticle

31 Scopus citations

Mechanism of Human Antibody-Mediated Neutralization of Marburg Virus

Flyak, A. I., Ilinykh, P. A., Murin, C. D., Garron, T., Shen, X., Fusco, M. L., Hashiguchi, T., Bornholdt, Z. A., Slaughter, J. C., Sapparapu, G., Klages, C., Ksiazek, T. G., Ward, A. B., Saphire, E. O., Bukreyev, A. & Crowe, J. E., Feb 26 2015, In : Cell. 160, 5, p. 893-903 11 p.

Research output: Contribution to journalArticle

71 Scopus citations