Alexander Freiberg

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Alexander Freiberg, PhD

Director, Robert E. Shope Biosafety Level 4 Laboratory (BSL4)

Calculated based on number of publications stored in Pure and citations from Scopus
20032025

Research activity per year

Personal profile

Research Strategic Pillar

The Chief Research Officer, has determined that UTMB research should be prioritized into six health communities. This researcher has received the following badge(s):

Research interests

One main research interest is in understanding the molecular mechanisms by which emerging RNA viruses cause encephalitis and hemorrhagic fever diseases. We are characterizing the host innate immune response and activation of cellular signaling pathways following viral infection, with a major interest on infections caused by Nipah and Hendra viruses, Tick-borne encephalitis viruses, as well as Rift Valley fever virus. The goal is to better understand the role that the host cell-mediated immune response may play in development of encephalitis and hemorrhagic fever diseases. These studies are being performed in BSL-2, BSL-3E and BSL-4 containment facilities. In addition, another project focuses on understanding the structure and assembly of high-containment classified viruses, with a major focus on bunyaviruses using cryo-electron microscopy and biophysical techniques. We have determined the three-dimensional structure of Rift Valley fever virus, and are analyzing the arrangement and interaction of the two viral glycoproteins within the virus particle. This information can be utilized to develop structure-based vaccines and antivirals. In collaboration with partners in academia and in biotechnology, we are also working on the identification and characterization of broad spectrum antivirals and on testing novel vaccine platforms against Filo-, Bunya-, Henipa-, Arena- and Flaviviruses.

Education/Academic qualification

Arbovirology, Structural Virology, Postdoctoral Fellowship, University of Texas Medical Branch, Galveston, TX

2005 → 2009

Physical Biochemistry, PhD, University of Potsdam, Germany

… → 2005

Biochemistry, Diploma, University of Potsdam, Germany

… → 2000

Research Strategic Pillar Keywords

  • Infectious/ Immunological Health

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Collaborations and top research areas from the last five years

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View all 33 projects/grants

  • AI is a viable alternative to high throughput screening: a 318-target study

    Wallach, I., Bernard, D., Nguyen, K., Ho, G., Morrison, A., Stecula, A., Rosnik, A., O’Sullivan, A. M., Davtyan, A., Samudio, B., Thomas, B., Worley, B., Butler, B., Laggner, C., Thayer, D., Moharreri, E., Friedland, G., Truong, H., van den Bedem, H. & Ng, H. L. & 667 others, Stafford, K., Sarangapani, K., Giesler, K., Ngo, L., Mysinger, M., Ahmed, M., Anthis, N. J., Henriksen, N., Gniewek, P., Eckert, S., de Oliveira, S., Suterwala, S., PrasadPrasad, S. V. K., Shek, S., Contreras, S., Hare, S., Palazzo, T., O’Brien, T. E., Van Grack, T., Williams, T., Chern, T. R., Kenyon, V., Lee, A. H., Cann, A. B., Bergman, B., Anderson, B. M., Cox, B. D., Warrington, J. M., Sorenson, J. M., Goldenberg, J. M., Young, M. A., DeHaan, N., Pemberton, R. P., Schroedl, S., Abramyan, T. M., Gupta, T., Mysore, V., Presser, A. G., Ferrando, A. A., Andricopulo, A. D., Ghosh, A., Ayachi, A. G., Mushtaq, A., Shaqra, A. M., Toh, A. K. L., Smrcka, A. V., Ciccia, A., de Oliveira, A. S., Sverzhinsky, A., de Sousa, A. M., Agoulnik, A. I., Kushnir, A., Freiberg, A. N., Statsyuk, A. V., Gingras, A. R., Degterev, A., Tomilov, A., Vrielink, A., Garaeva, A. A., Bryant-Friedrich, A., Caflisch, A., Patel, A. K., Rangarajan, A. V., Matheeussen, A., Battistoni, A., Caporali, A., Chini, A., Ilari, A., Mattevi, A., Foote, A. T., Trabocchi, A., Stahl, A., Herr, A. B., Berti, A., Freywald, A., Reidenbach, A. G., Lam, A., Cuddihy, A. R., White, A., Taglialatela, A., Ojha, A. K., Cathcart, A. M., Motyl, A. A. L., Borowska, A., D’Antuono, A., Hirsch, A. K. H., Porcelli, A. M., Minakova, A., Montanaro, A., Müller, A., Fiorillo, A., Virtanen, A., O’Donoghue, A. J., Del Rio Flores, A., Garmendia, A. E., Pineda-Lucena, A., Panganiban, A. T., Samantha, A., Chatterjee, A. K., Haas, A. L., Paparella, A. S., John, A. L. S., Prince, A., ElSheikh, A., Apfel, A. M., Colomba, A., O’Dea, A., Diallo, B. N., Ribeiro, B. M. R. M., Bailey-Elkin, B. A., Edelman, B. L., Liou, B., Perry, B., Chua, B. S. K., Kováts, B., Englinger, B., Balakrishnan, B., Gong, B., Agianian, B., Pressly, B., Salas, B. P. M., Duggan, B. M., Geisbrecht, B. V., Dymock, B. W., Morten, B. C., Hammock, B. D., Mota, B. E. F., Dickinson, B. C., Fraser, C., Lempicki, C., Novina, C. D., Torner, C., Ballatore, C., Bon, C., Chapman, C. J., Partch, C. L., Chaton, C. T., Huang, C., Yang, C. Y., Kahler, C. M., Karan, C., Keller, C., Dieck, C. L., Huimei, C., Liu, C., Peltier, C., Mantri, C. K., Kemet, C. M., Müller, C. E., Weber, C., Zeina, C. M., Muli, C. S., Morisseau, C., Alkan, C., Reglero, C., Loy, C. A., Wilson, C. M., Myhr, C., Arrigoni, C., Paulino, C., Santiago, C., Luo, D., Tumes, D. J., Keedy, D. A., Lawrence, D. A., Chen, D., Manor, D., Trader, D. J., Hildeman, D. A., Drewry, D. H., Dowling, D. J., Hosfield, D. J., Smith, D. M., Moreira, D., Siderovski, D. P., Shum, D., Krist, D. T., Riches, D. W. H., Ferraris, D. M., Anderson, D. H., Coombe, D. R., Welsbie, D. S., Hu, D., Ortiz, D., Alramadhani, D., Zhang, D., Chaudhuri, D., Slotboom, D. J., Ronning, D. R., Lee, D., Dirksen, D., Shoue, D. A., Zochodne, D. W., Krishnamurthy, D., Duncan, D., Glubb, D. M., Gelardi, E. L. M., Hsiao, E. C., Lynn, E. G., Silva, E. B., Aguilera, E., Lenci, E., Abraham, E. T., Lama, E., Mameli, E., Leung, E., Christensen, E. M., Mason, E. R., Petretto, E., Trakhtenberg, E. F., Rubin, E. J., Strauss, E., Thompson, E. W., Cione, E., Lisabeth, E. M., Fan, E., Kroon, E. G., Jo, E., García-Cuesta, E. M., Glukhov, E., Gavathiotis, E., Yu, F., Xiang, F., Leng, F., Wang, F., Ingoglia, F., van den Akker, F., Borriello, F., Vizeacoumar, F. J., Luh, F., Buckner, F. S., Vizeacoumar, F. S., Bdira, F. B., Svensson, F., Rodriguez, G. M., Bognár, G., Lembo, G., Zhang, G., Dempsey, G., Eitzen, G., Mayer, G., Greene, G. L., Garcia, G. A., Lukacs, G. L., Prikler, G., Parico, G. C. G., Colotti, G., De Keulenaer, G., Cortopassi, G., Roti, G., Girolimetti, G., Fiermonte, G., Gasparre, G., Leuzzi, G., Dahal, G., Michlewski, G., Conn, G. L., Stuchbury, G. D., Bowman, G. R., Popowicz, G. M., Veit, G., de Souza, G. E., Akk, G., Caljon, G., Alvarez, G., Rucinski, G., Lee, G., Cildir, G., Li, H., Breton, H. E., Jafar-Nejad, H., Zhou, H., Moore, H. P., Tilford, H., Yuan, H., Shim, H., Wulff, H., Hoppe, H., Chaytow, H., Tam, H. K., Van Remmen, H., Xu, H., Debonsi, H. M., Lieberman, H. B., Jung, H., Fan, H. Y., Feng, H., Zhou, H., Kim, H. J., Greig, I. R., Caliandro, I., Corvo, I., Arozarena, I., Mungrue, I. N., Verhamme, I. M., Qureshi, I. A., Lotsaris, I., Cakir, I., Perry, J. J. P., Kwiatkowski, J., Boorman, J., Ferreira, J., Fries, J., Kratz, J. M., Miner, J., Siqueira-Neto, J. L., Granneman, J. G., Ng, J., Shorter, J., Voss, J. H., Gebauer, J. M., Chuah, J., Mousa, J. J., Maynes, J. T., Evans, J. D., Dickhout, J., MacKeigan, J. P., Jossart, J. N., Zhou, J., Lin, J., Xu, J., Wang, J., Zhu, J., Liao, J., Xu, J., Zhao, J., Lin, J., Lee, J., Reis, J., Stetefeld, J., Bruning, J. B., Bruning, J. B., Coles, J. G., Tanner, J. J., Pascal, J. M., So, J., Pederick, J. L., Costoya, J. A., Rayman, J. B., Maciag, J. J., Nasburg, J. A., Gruber, J. J., Finkelstein, J. M., Watkins, J., Rodríguez-Frade, J. M., Arias, J. A. S., Lasarte, J. J., Oyarzabal, J., Milosavljevic, J., Cools, J., Lescar, J., Bogomolovas, J., Wang, J., Kee, J. M., Liao, J., Sistla, J. C., Abrahão, J. S., Sishtla, K., Francisco, K. R., Hansen, K. B., Molyneaux, K. A., Cunningham, K. A., Martin, K. R., Gadar, K., Ojo, K. K., Wong, K. S., Wentworth, K. L., Lai, K., Lobb, K. A., Hopkins, K. M., Parang, K., Machaca, K., Pham, K., Ghilarducci, K., Sugamori, K. S., McManus, K. J., Musta, K., Faller, K. M. E., Nagamori, K., Mostert, K. J., Korotkov, K. V., Liu, K., Smith, K. S., Sarosiek, K., Rohde, K. H., Kim, K. K., Lee, K. H., Pusztai, L., Lehtiö, L., Haupt, L. M., Cowen, L. E., Byrne, L. J., Su, L., Wert-Lamas, L., Puchades-Carrasco, L., Chen, L., Malkas, L. H., Zhuo, L., Hedstrom, L., Hedstrom, L., Walensky, L. D., Antonelli, L., Iommarini, L., Whitesell, L., Randall, L. M., Fathallah, M. D., Nagai, M. H., Kilkenny, M. L., Ben-Johny, M., Lussier, M. P., Windisch, M. P., Lolicato, M., Lolli, M. L., Vleminckx, M., Caroleo, M. C., Macias, M. J., Valli, M., Barghash, M. M., Mellado, M., Tye, M. A., Wilson, M. A., Hannink, M., Ashton, M. R., Cerna, M. V. C. D., Giorgis, M., Safo, M. K., Maurice, M. S., McDowell, M. A., Pasquali, M., Mehedi, M., Serafim, M. S. M., Soellner, M. B., Alteen, M. G., Champion, M. M., Skorodinsky, M., O’Mara, M. L., Bedi, M., Rizzi, M., Levin, M., Mowat, M., Jackson, M. R., Paige, M., Al-Yozbaki, M., Giardini, M. A., Maksimainen, M. M., De Luise, M., Hussain, M. S., Christodoulides, M., Stec, N., Zelinskaya, N., Van Pelt, N., Merrill, N. M., Singh, N., Kootstra, N. A., Singh, N., Gandhi, N. S., Chan, N. L., Trinh, N. M., Schneider, N. O., Matovic, N., Horstmann, N., Longo, N., Bharambe, N., Rouzbeh, N., Mahmoodi, N., Gumede, N. J., Anastasio, N. C., Khalaf, N. B., Rabal, O., Kandror, O., Escaffre, O., Silvennoinen, O., Bishop, O. T., Iglesias, P., Sobrado, P., Chuong, P., O’Connell, P., Martin-Malpartida, P., Mellor, P., Fish, P. V., Moreira, P. O. L., Zhou, P., Liu, P., Liu, P., Wu, P., Agogo-Mawuli, P., Jones, P. L., Ngoi, P., Toogood, P., Ip, P., von Hundelshausen, P., Lee, P. H., Rowswell-Turner, R. B., Balaña-Fouce, R., Rocha, R. E. O., Guido, R. V. C., Ferreira, R. S., Agrawal, R. K., Harijan, R. K., Ramachandran, R., Verma, R., Singh, R. K., Tiwari, R. K., Mazitschek, R., Koppisetti, R. K., Dame, R. T., Douville, R. N., Austin, R. C., Taylor, R. E., Moore, R. G., Ebright, R. H., Angell, R. M., Yan, R., Kejriwal, R., Batey, R. A., Blelloch, R., Vandenberg, R. J., Hickey, R. J., Kelm, R. J., Lake, R. J., Bradley, R. K., Blumenthal, R. M., Solano, R., Gierse, R. M., Viola, R. E., McCarthy, R. R., Reguera, R. M., Uribe, R. V., do Monte-Neto, R. L., Gorgoglione, R., Cullinane, R. T., Katyal, S., Hossain, S., Phadke, S., Shelburne, S. A., Geden, S. E., Johannsen, S., Wazir, S., Legare, S., Landfear, S. M., Radhakrishnan, S. K., Ammendola, S., Dzhumaev, S., Seo, S. Y., Li, S., Zhou, S., Chu, S., Chauhan, S., Maruta, S., Ashkar, S. R., Shyng, S. L., Conticello, S. G., Buroni, S., Garavaglia, S., White, S. J., Zhu, S., Tsimbalyuk, S., Chadni, S. H., Byun, S. Y., Park, S., Xu, S. Q., Banerjee, S., Zahler, S., Espinoza, S., Gustincich, S., Sainas, S., Celano, S. L., Capuzzi, S. J., Waggoner, S. N., Poirier, S., Olson, S. H., Marx, S. O., Van Doren, S. R., Sarilla, S., Brady-Kalnay, S. M., Dallman, S., Azeem, S. M., Teramoto, T., Mehlman, T., Swart, T., Abaffy, T., Akopian, T., Haikarainen, T., Moreda, T. L., Ikegami, T., Teixeira, T. R., Jayasinghe, T. D., Gillingwater, T. H., Kampourakis, T., Richardson, T. I., Herdendorf, T. J., Kotzé, T. J., O’Meara, T. R., Corson, T. W., Hermle, T., Ogunwa, T. H., Lan, T., Su, T., Banjo, T., O’Mara, T. A., Chou, T., Chou, T. F., Baumann, U., Desai, U. R., Pai, V. P., Thai, V. C., Tandon, V., Banerji, V., Robinson, V. L., Gunasekharan, V., Namasivayam, V., Segers, V. F. M., Maranda, V., Dolce, V., Maltarollo, V. G., Scoffone, V. C., Woods, V. A., Ronchi, V. P., Van Hung Le, V., Clayton, W. B., Lowther, W. T., Houry, W. A., Li, W., Tang, W., Zhang, W., Van Voorhis, W. C., Donaldson, W. A., Hahn, W. C., Kerr, W. G., Gerwick, W. H., Bradshaw, W. J., Foong, W. E., Blanchet, X., Wu, X., Lu, X., Qi, X., Xu, X., Yu, X., Qin, X., Wang, X., Yuan, X., Zhang, X., Zhang, Y. J., Hu, Y., Aldhamen, Y. A., Chen, Y., Li, Y., Sun, Y., Zhu, Y., Gupta, Y. K., Pérez-Pertejo, Y., Li, Y., Tang, Y., He, Y., Tse-Dinh, Y. C., Sidorova, Y. A., Yen, Y., Li, Y., Frangos, Z. J., Chung, Z., Su, Z., Wang, Z., Zhang, Z., Liu, Z., Inde, Z., Artía, Z. & Heifets, A., Dec 2024, In: Scientific reports. 14, 1, 7526.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    32 Scopus citations

  • Comparison of Routes of Administration, Frequency, and Duration of Favipiravir Treatment in Mouse and Guinea Pig Models of Ebola Virus Disease

    Johnson, D., Juelich, T., Zhang, L., Smith, J. K., Kalveram, B., Perez, D., Smith, J., Grimes, M. R., Garron, T., Torres, M., Massey, S., Brasel, T., Beasley, D. W. C., Freiberg, A. N. & Comer, J., Jul 2024, In: Viruses. 16, 7, 1101.

    Research output: Contribution to journal › Article › peer-review

    Open Access

  • Ebola virus VP35 interacts non-covalently with ubiquitin chains to promote viral replication

    Rodríguez-Salazar, C. A., van Tol, S., Mailhot, O., Gonzalez-Orozco, M., Galdino, G. T., Warren, A. N., Teruel, N., Behera, P., Afreen, K. S., Zhang, L., Juelich, T. L., Smith, J. K., Zylber, M. I., Freiberg, A. N., Najmanovich, R. J., Giraldo, M. I. & Rajsbaum, R., Feb 2024, In: PLoS Biology. 22, 2, e3002544.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    3 Scopus citations

  • Efficacy and Immunogenicity of a Recombinant Vesicular Stomatitis Virus-Vectored Marburg Vaccine in Cynomolgus Macaques

    Camargos, V. N., Rossi, S. L., Juelich, T. L., Smith, J. K., Vasilakis, N., Freiberg, A. N., Nichols, R. & Fusco, J., Aug 2024, In: Viruses. 16, 8, 1181.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    1 Scopus citations

  • Efficacy of Polyphenylene Carboxymethylene (PPCM) Gel at Protecting Type I Interferon Receptors Knockout Mice from Intravaginal Ebola Virus Challenge

    Escaffre, O., Juelich, T. L., Smith, J. K., Zhang, L., Pearson, M., Bourne, N. & Freiberg, A. N., Nov 2024, In: Viruses. 16, 11, 1693.

    Research output: Contribution to journal › Article › peer-review

    Open Access
View all 119 Research outputs