Alexander Freiberg

2024

AI is a viable alternative to high throughput screening: a 318-target study

Wallach, I., Bernard, D., Nguyen, K., Ho, G., Morrison, A., Stecula, A., Rosnik, A., O’Sullivan, A. M., Davtyan, A., Samudio, B., Thomas, B., Worley, B., Butler, B., Laggner, C., Thayer, D., Moharreri, E., Friedland, G., Truong, H., van den Bedem, H. & Ng, H. L. & 667 others, Stafford, K., Sarangapani, K., Giesler, K., Ngo, L., Mysinger, M., Ahmed, M., Anthis, N. J., Henriksen, N., Gniewek, P., Eckert, S., de Oliveira, S., Suterwala, S., PrasadPrasad, S. V. K., Shek, S., Contreras, S., Hare, S., Palazzo, T., O’Brien, T. E., Van Grack, T., Williams, T., Chern, T. R., Kenyon, V., Lee, A. H., Cann, A. B., Bergman, B., Anderson, B. M., Cox, B. D., Warrington, J. M., Sorenson, J. M., Goldenberg, J. M., Young, M. A., DeHaan, N., Pemberton, R. P., Schroedl, S., Abramyan, T. M., Gupta, T., Mysore, V., Presser, A. G., Ferrando, A. A., Andricopulo, A. D., Ghosh, A., Ayachi, A. G., Mushtaq, A., Shaqra, A. M., Toh, A. K. L., Smrcka, A. V., Ciccia, A., de Oliveira, A. S., Sverzhinsky, A., de Sousa, A. M., Agoulnik, A. I., Kushnir, A., Freiberg, A. N., Statsyuk, A. V., Gingras, A. R., Degterev, A., Tomilov, A., Vrielink, A., Garaeva, A. A., Bryant-Friedrich, A., Caflisch, A., Patel, A. K., Rangarajan, A. V., Matheeussen, A., Battistoni, A., Caporali, A., Chini, A., Ilari, A., Mattevi, A., Foote, A. T., Trabocchi, A., Stahl, A., Herr, A. B., Berti, A., Freywald, A., Reidenbach, A. G., Lam, A., Cuddihy, A. R., White, A., Taglialatela, A., Ojha, A. K., Cathcart, A. M., Motyl, A. A. L., Borowska, A., D’Antuono, A., Hirsch, A. K. H., Porcelli, A. M., Minakova, A., Montanaro, A., Müller, A., Fiorillo, A., Virtanen, A., O’Donoghue, A. J., Del Rio Flores, A., Garmendia, A. E., Pineda-Lucena, A., Panganiban, A. T., Samantha, A., Chatterjee, A. K., Haas, A. L., Paparella, A. S., John, A. L. S., Prince, A., ElSheikh, A., Apfel, A. M., Colomba, A., O’Dea, A., Diallo, B. N., Ribeiro, B. M. R. M., Bailey-Elkin, B. A., Edelman, B. L., Liou, B., Perry, B., Chua, B. S. K., Kováts, B., Englinger, B., Balakrishnan, B., Gong, B., Agianian, B., Pressly, B., Salas, B. P. M., Duggan, B. M., Geisbrecht, B. V., Dymock, B. W., Morten, B. C., Hammock, B. D., Mota, B. E. F., Dickinson, B. C., Fraser, C., Lempicki, C., Novina, C. D., Torner, C., Ballatore, C., Bon, C., Chapman, C. J., Partch, C. L., Chaton, C. T., Huang, C., Yang, C. Y., Kahler, C. M., Karan, C., Keller, C., Dieck, C. L., Huimei, C., Liu, C., Peltier, C., Mantri, C. K., Kemet, C. M., Müller, C. E., Weber, C., Zeina, C. M., Muli, C. S., Morisseau, C., Alkan, C., Reglero, C., Loy, C. A., Wilson, C. M., Myhr, C., Arrigoni, C., Paulino, C., Santiago, C., Luo, D., Tumes, D. J., Keedy, D. A., Lawrence, D. A., Chen, D., Manor, D., Trader, D. J., Hildeman, D. A., Drewry, D. H., Dowling, D. J., Hosfield, D. J., Smith, D. M., Moreira, D., Siderovski, D. P., Shum, D., Krist, D. T., Riches, D. W. H., Ferraris, D. M., Anderson, D. H., Coombe, D. R., Welsbie, D. S., Hu, D., Ortiz, D., Alramadhani, D., Zhang, D., Chaudhuri, D., Slotboom, D. J., Ronning, D. R., Lee, D., Dirksen, D., Shoue, D. A., Zochodne, D. W., Krishnamurthy, D., Duncan, D., Glubb, D. M., Gelardi, E. L. M., Hsiao, E. C., Lynn, E. G., Silva, E. B., Aguilera, E., Lenci, E., Abraham, E. T., Lama, E., Mameli, E., Leung, E., Christensen, E. M., Mason, E. R., Petretto, E., Trakhtenberg, E. F., Rubin, E. J., Strauss, E., Thompson, E. W., Cione, E., Lisabeth, E. M., Fan, E., Kroon, E. G., Jo, E., García-Cuesta, E. M., Glukhov, E., Gavathiotis, E., Yu, F., Xiang, F., Leng, F., Wang, F., Ingoglia, F., van den Akker, F., Borriello, F., Vizeacoumar, F. J., Luh, F., Buckner, F. S., Vizeacoumar, F. S., Bdira, F. B., Svensson, F., Rodriguez, G. M., Bognár, G., Lembo, G., Zhang, G., Dempsey, G., Eitzen, G., Mayer, G., Greene, G. L., Garcia, G. A., Lukacs, G. L., Prikler, G., Parico, G. C. G., Colotti, G., De Keulenaer, G., Cortopassi, G., Roti, G., Girolimetti, G., Fiermonte, G., Gasparre, G., Leuzzi, G., Dahal, G., Michlewski, G., Conn, G. L., Stuchbury, G. D., Bowman, G. R., Popowicz, G. M., Veit, G., de Souza, G. E., Akk, G., Caljon, G., Alvarez, G., Rucinski, G., Lee, G., Cildir, G., Li, H., Breton, H. E., Jafar-Nejad, H., Zhou, H., Moore, H. P., Tilford, H., Yuan, H., Shim, H., Wulff, H., Hoppe, H., Chaytow, H., Tam, H. K., Van Remmen, H., Xu, H., Debonsi, H. M., Lieberman, H. B., Jung, H., Fan, H. Y., Feng, H., Zhou, H., Kim, H. J., Greig, I. R., Caliandro, I., Corvo, I., Arozarena, I., Mungrue, I. N., Verhamme, I. M., Qureshi, I. A., Lotsaris, I., Cakir, I., Perry, J. J. P., Kwiatkowski, J., Boorman, J., Ferreira, J., Fries, J., Kratz, J. M., Miner, J., Siqueira-Neto, J. L., Granneman, J. G., Ng, J., Shorter, J., Voss, J. H., Gebauer, J. M., Chuah, J., Mousa, J. J., Maynes, J. T., Evans, J. D., Dickhout, J., MacKeigan, J. P., Jossart, J. N., Zhou, J., Lin, J., Xu, J., Wang, J., Zhu, J., Liao, J., Xu, J., Zhao, J., Lin, J., Lee, J., Reis, J., Stetefeld, J., Bruning, J. B., Bruning, J. B., Coles, J. G., Tanner, J. J., Pascal, J. M., So, J., Pederick, J. L., Costoya, J. A., Rayman, J. B., Maciag, J. J., Nasburg, J. A., Gruber, J. J., Finkelstein, J. M., Watkins, J., Rodríguez-Frade, J. M., Arias, J. A. S., Lasarte, J. J., Oyarzabal, J., Milosavljevic, J., Cools, J., Lescar, J., Bogomolovas, J., Wang, J., Kee, J. M., Liao, J., Sistla, J. C., Abrahão, J. S., Sishtla, K., Francisco, K. R., Hansen, K. B., Molyneaux, K. A., Cunningham, K. A., Martin, K. R., Gadar, K., Ojo, K. K., Wong, K. S., Wentworth, K. L., Lai, K., Lobb, K. A., Hopkins, K. M., Parang, K., Machaca, K., Pham, K., Ghilarducci, K., Sugamori, K. S., McManus, K. J., Musta, K., Faller, K. M. E., Nagamori, K., Mostert, K. J., Korotkov, K. V., Liu, K., Smith, K. S., Sarosiek, K., Rohde, K. H., Kim, K. K., Lee, K. H., Pusztai, L., Lehtiö, L., Haupt, L. M., Cowen, L. E., Byrne, L. J., Su, L., Wert-Lamas, L., Puchades-Carrasco, L., Chen, L., Malkas, L. H., Zhuo, L., Hedstrom, L., Hedstrom, L., Walensky, L. D., Antonelli, L., Iommarini, L., Whitesell, L., Randall, L. M., Fathallah, M. D., Nagai, M. H., Kilkenny, M. L., Ben-Johny, M., Lussier, M. P., Windisch, M. P., Lolicato, M., Lolli, M. L., Vleminckx, M., Caroleo, M. C., Macias, M. J., Valli, M., Barghash, M. M., Mellado, M., Tye, M. A., Wilson, M. A., Hannink, M., Ashton, M. R., Cerna, M. V. C. D., Giorgis, M., Safo, M. K., Maurice, M. S., McDowell, M. A., Pasquali, M., Mehedi, M., Serafim, M. S. M., Soellner, M. B., Alteen, M. G., Champion, M. M., Skorodinsky, M., O’Mara, M. L., Bedi, M., Rizzi, M., Levin, M., Mowat, M., Jackson, M. R., Paige, M., Al-Yozbaki, M., Giardini, M. A., Maksimainen, M. M., De Luise, M., Hussain, M. S., Christodoulides, M., Stec, N., Zelinskaya, N., Van Pelt, N., Merrill, N. M., Singh, N., Kootstra, N. A., Singh, N., Gandhi, N. S., Chan, N. L., Trinh, N. M., Schneider, N. O., Matovic, N., Horstmann, N., Longo, N., Bharambe, N., Rouzbeh, N., Mahmoodi, N., Gumede, N. J., Anastasio, N. C., Khalaf, N. B., Rabal, O., Kandror, O., Escaffre, O., Silvennoinen, O., Bishop, O. T., Iglesias, P., Sobrado, P., Chuong, P., O’Connell, P., Martin-Malpartida, P., Mellor, P., Fish, P. V., Moreira, P. O. L., Zhou, P., Liu, P., Liu, P., Wu, P., Agogo-Mawuli, P., Jones, P. L., Ngoi, P., Toogood, P., Ip, P., von Hundelshausen, P., Lee, P. H., Rowswell-Turner, R. B., Balaña-Fouce, R., Rocha, R. E. O., Guido, R. V. C., Ferreira, R. S., Agrawal, R. K., Harijan, R. K., Ramachandran, R., Verma, R., Singh, R. K., Tiwari, R. K., Mazitschek, R., Koppisetti, R. K., Dame, R. T., Douville, R. N., Austin, R. C., Taylor, R. E., Moore, R. G., Ebright, R. H., Angell, R. M., Yan, R., Kejriwal, R., Batey, R. A., Blelloch, R., Vandenberg, R. J., Hickey, R. J., Kelm, R. J., Lake, R. J., Bradley, R. K., Blumenthal, R. M., Solano, R., Gierse, R. M., Viola, R. E., McCarthy, R. R., Reguera, R. M., Uribe, R. V., do Monte-Neto, R. L., Gorgoglione, R., Cullinane, R. T., Katyal, S., Hossain, S., Phadke, S., Shelburne, S. A., Geden, S. E., Johannsen, S., Wazir, S., Legare, S., Landfear, S. M., Radhakrishnan, S. K., Ammendola, S., Dzhumaev, S., Seo, S. Y., Li, S., Zhou, S., Chu, S., Chauhan, S., Maruta, S., Ashkar, S. R., Shyng, S. L., Conticello, S. G., Buroni, S., Garavaglia, S., White, S. J., Zhu, S., Tsimbalyuk, S., Chadni, S. H., Byun, S. Y., Park, S., Xu, S. Q., Banerjee, S., Zahler, S., Espinoza, S., Gustincich, S., Sainas, S., Celano, S. L., Capuzzi, S. J., Waggoner, S. N., Poirier, S., Olson, S. H., Marx, S. O., Van Doren, S. R., Sarilla, S., Brady-Kalnay, S. M., Dallman, S., Azeem, S. M., Teramoto, T., Mehlman, T., Swart, T., Abaffy, T., Akopian, T., Haikarainen, T., Moreda, T. L., Ikegami, T., Teixeira, T. R., Jayasinghe, T. D., Gillingwater, T. H., Kampourakis, T., Richardson, T. I., Herdendorf, T. J., Kotzé, T. J., O’Meara, T. R., Corson, T. W., Hermle, T., Ogunwa, T. H., Lan, T., Su, T., Banjo, T., O’Mara, T. A., Chou, T., Chou, T. F., Baumann, U., Desai, U. R., Pai, V. P., Thai, V. C., Tandon, V., Banerji, V., Robinson, V. L., Gunasekharan, V., Namasivayam, V., Segers, V. F. M., Maranda, V., Dolce, V., Maltarollo, V. G., Scoffone, V. C., Woods, V. A., Ronchi, V. P., Van Hung Le, V., Clayton, W. B., Lowther, W. T., Houry, W. A., Li, W., Tang, W., Zhang, W., Van Voorhis, W. C., Donaldson, W. A., Hahn, W. C., Kerr, W. G., Gerwick, W. H., Bradshaw, W. J., Foong, W. E., Blanchet, X., Wu, X., Lu, X., Qi, X., Xu, X., Yu, X., Qin, X., Wang, X., Yuan, X., Zhang, X., Zhang, Y. J., Hu, Y., Aldhamen, Y. A., Chen, Y., Li, Y., Sun, Y., Zhu, Y., Gupta, Y. K., Pérez-Pertejo, Y., Li, Y., Tang, Y., He, Y., Tse-Dinh, Y. C., Sidorova, Y. A., Yen, Y., Li, Y., Frangos, Z. J., Chung, Z., Su, Z., Wang, Z., Zhang, Z., Liu, Z., Inde, Z., Artía, Z. & Heifets, A., Dec 2024, In: Scientific reports. 14, 1, 7526.

Research output: Contribution to journal › Article › peer-review

33 Scopus citations

Comparison of Routes of Administration, Frequency, and Duration of Favipiravir Treatment in Mouse and Guinea Pig Models of Ebola Virus Disease

Johnson, D., Juelich, T., Zhang, L., Smith, J. K., Kalveram, B., Perez, D., Smith, J., Grimes, M. R., Garron, T., Torres, M., Massey, S., Brasel, T., Beasley, D. W. C., Freiberg, A. N. & Comer, J., Jul 2024, In: Viruses. 16, 7, 1101.

Research output: Contribution to journal › Article › peer-review

Open Access

Ebola virus VP35 interacts non-covalently with ubiquitin chains to promote viral replication

Rodríguez-Salazar, C. A., van Tol, S., Mailhot, O., Gonzalez-Orozco, M., Galdino, G. T., Warren, A. N., Teruel, N., Behera, P., Afreen, K. S., Zhang, L., Juelich, T. L., Smith, J. K., Zylber, M. I., Freiberg, A. N., Najmanovich, R. J., Giraldo, M. I. & Rajsbaum, R., Feb 2024, In: PLoS Biology. 22, 2, e3002544.

Research output: Contribution to journal › Article › peer-review

Open Access

3 Scopus citations

Efficacy and Immunogenicity of a Recombinant Vesicular Stomatitis Virus-Vectored Marburg Vaccine in Cynomolgus Macaques

Camargos, V. N., Rossi, S. L., Juelich, T. L., Smith, J. K., Vasilakis, N., Freiberg, A. N., Nichols, R. & Fusco, J., Aug 2024, In: Viruses. 16, 8, 1181.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Scopus citations

Efficacy of Polyphenylene Carboxymethylene (PPCM) Gel at Protecting Type I Interferon Receptors Knockout Mice from Intravaginal Ebola Virus Challenge

Escaffre, O., Juelich, T. L., Smith, J. K., Zhang, L., Pearson, M., Bourne, N. & Freiberg, A. N., Nov 2024, In: Viruses. 16, 11, 1693.

Research output: Contribution to journal › Article › peer-review

Open Access

Structure-guided mutagenesis of Henipavirus receptor-binding proteins reveals molecular determinants of receptor usage and antibody-binding epitopes

Oguntuyo, K. Y., Haas, G. D., Azarm, K. D., Stevens, C. S., Brambilla, L., Kowdle, S. S., Avanzato, V. A., Pryce, R., Freiberg, A. N., Bowden, T. A. & Lee, B., Mar 2024, In: Journal of virology. 98, 3

Research output: Contribution to journal › Article › peer-review

Open Access

3 Scopus citations

Tetracistronic minigenomes elucidate a functional promoter for Ghana virus and unveils Cedar virus replicase promiscuity for all henipaviruses

Haas, G. D., Kowdle, S., Schmitz, K. S., Azarm, K. D., Johnson, K. N., Klain, W. R., Freiberg, A. N., Cox, R. M., Plemper, R. K. & Lee, B., Oct 2024, In: Journal of virology. 98, 10, e00806-24.

Research output: Contribution to journal › Article › peer-review

Open Access

2 Scopus citations

TRIM7 ubiquitinates SARS-CoV-2 membrane protein to limit apoptosis and viral replication

Gonzalez-Orozco, M., Tseng, H. C., Hage, A., Xia, H., Behera, P., Afreen, K., Peñaflor-Tellez, Y., Giraldo, M. I., Huante, M., Puebla-Clark, L., van Tol, S., Odle, A., Crown, M., Teruel, N., Shelite, T. R., Moreno-Contreras, J., Terasaki, K., Makino, S., Menachery, V. & Endsley, M. & 8 others, Endsley, J. J., Najmanovich, R. J., Bashton, M., Stephens, R., Shi, P.-Y., Xie, X., Freiberg, A. N. & Rajsbaum Gorodezky, R., Dec 2024, In: Nature communications. 15, 1, 10438.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Scopus citations

2023

Characterization of an air-liquid interface primary human vaginal epithelium to study Ebola virus infection and testing of antivirals

Escaffre, O., Popov, V., Hager, E. & Freiberg, A. N., Mar 2023, In: Antiviral research. 211, 105551.

Research output: Contribution to journal › Article › peer-review

Open Access

7 Scopus citations

Differences in Genetic Diversity of Mammalian Tick-Borne Flaviviruses

Carpio, K. L., Thompson, J. K., Widen, S. G., Smith, J. K., Juelich, T. L., Clements, D. E., Freiberg, A. N. & Barrett, A. D. T., Feb 2023, In: Viruses. 15, 2, 281.

Research output: Contribution to journal › Article › peer-review

Open Access

5 Scopus citations

Hydrogen Sulfide Ameliorates SARS-CoV-2-Associated Lung Endothelial Barrier Disruption

Escaffre, O., Szaniszlo, P., Törő, G., Vilas, C. L., Servantes, B. J., Lopez, E., Juelich, T. L., Levine, C. B., McLellan, S. L. F., Cardenas, J. C., Freiberg, A. N. & Módis, K., Jul 2023, In: Biomedicines. 11, 7, 1790.

Research output: Contribution to journal › Article › peer-review

Open Access

2 Scopus citations

Nipah Virus Bangladesh Infection Elicits Organ-Specific Innate and Inflammatory Responses in the Marmoset Model

Stevens, C. S., Lowry, J., Juelich, T., Atkins, C., Johnson, K., Smith, J. K., Panis, M., Ikegami, T., Tenoever, B., Freiberg, A. N. & Lee, B., Sep 1 2023, In: Journal of Infectious Diseases. 228, 5, p. 604-614 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

4 Scopus citations

Pteropus vampyrus TRIM40 Is an Interferon-Stimulated Gene That Antagonizes RIG-I-like Receptors

van Tol, S., Hage, A., Rajsbaum, R. & Freiberg, A. N., Nov 2023, In: Viruses. 15, 11, 2147.

Research output: Contribution to journal › Article › peer-review

Open Access

2 Scopus citations

The prophylactic and therapeutic efficacy of the broadly active antiviral ribonucleoside N⁴-Hydroxycytidine (EIDD-1931) in a mouse model of lethal Ebola virus infection

Bluemling, G. R., Mao, S., Natchus, M. G., Painter, W., Mulangu, S., Lockwood, M., De La Rosa, A., Brasel, T., Comer, J. E., Freiberg, A. N., Kolykhalov, A. A. & Painter, G. R., Jan 2023, In: Antiviral research. 209, 105453.

Research output: Contribution to journal › Article › peer-review

Open Access

9 Scopus citations

The Susceptibility of BALB/c Mice to a Mouse-Adapted Ebola Virus Intravaginal Infection

Escaffre, O., Juelich, T. L., Smith, J. K., Zhang, L., Bourne, N. & Freiberg, A. N., Jul 2023, In: Viruses. 15, 7, 1590.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Scopus citations

2022

Evaluations of rationally designed rift valley fever vaccine candidate RVax-1 in mosquito and rodent models

Ikegami, T., Jurado-Cobena, E., Alkan, C., Smith, J. K., Zhang, L., Kalveram, B., Juelich, T. L., Esterly, A. T., Bhaskar, J. R., Thangamani, S. & Freiberg, A. N., Dec 2022, In: npj Vaccines. 7, 1, 109.

Research output: Contribution to journal › Article › peer-review

Open Access

6 Scopus citations

Powassan Virus Induces Structural Changes in Human Neuronal Cells In Vitro and Murine Neurons In Vivo

Nelson, J., Ochoa, L., Villareal, P., Dunn, T., Wu, P., Vargas, G. & Freiberg, A. N., Oct 2022, In: Pathogens. 11, 10, 1218.

Research output: Contribution to journal › Article › peer-review

Open Access

5 Scopus citations

The RNA helicase DHX16 recognizes specific viral RNA to trigger RIG-I-dependent innate antiviral immunity

Hage, A., Bharaj, P., van Tol, S., Giraldo, M. I., Gonzalez-Orozco, M., Valerdi, K. M., Warren, A. N., Aguilera-Aguirre, L., Xie, X., Widen, S., Moulton, H. M., Lee, B., Johnson, J. R., Krogan, N. J., García-Sastre, A., Shi, P.-Y., Freiberg, A. N. & Rajsbaum Gorodezky, R., Mar 8 2022, In: Cell Reports. 38, 10, 110434.

Research output: Contribution to journal › Article › peer-review

Open Access

30 Scopus citations

Tilorone-dihydrochloride protects against rift valley fever virus infection and disease in the mouse model

Johnson, K. N., Kalveram, B., Smith, J. K., Zhang, L., Juelich, T., Atkins, C., Ikegami, T. & Freiberg, A. N., Jan 2022, In: Microorganisms. 10, 1, 92.

Research output: Contribution to journal › Article › peer-review

Open Access

3 Scopus citations

Ubiquitination of Ebola virus VP35 at lysine 309 regulates viral transcription and assembly

van Tol, S., Kalveram, B., Ilinykh, P. A., Ronk, A., Huang, K., Aguilera-Aguirre, L., Bharaj, P., Hage, A., Atkins, C., Giraldo, M. I., Wakamiya, M., Gonzalez-Orozco, M., Warren, A. N., Bukreyev, A., Freiberg, A. N. & Rajsbaum, R., May 2022, In: PLoS pathogens. 18, 5, e1010532.

Research output: Contribution to journal › Article › peer-review

Open Access

12 Scopus citations

2021

Discovery of a novel highly potent broad-spectrum heterocyclic chemical series of arenavirus cell entry inhibitors

Plewe, M. B., Gantla, V. R., Sokolova, N. V., Shin, Y. J., Naik, S., Brown, E. R., Fetsko, A., Zhang, L., Kalveram, B., Freiberg, A. N., Henkel, G. & McCormack, K., Jun 1 2021, In: Bioorganic and Medicinal Chemistry Letters. 41, 127983.

Research output: Contribution to journal › Article › peer-review

Open Access

12 Scopus citations

Inhibition of innate immune response ameliorates zika virus-induced neurogenesis deficit in human neural stem cells

Xu, P., Gao, J., Shan, C., Dunn, T. J., Xie, X., Xia, H., Zou, J., Thames, B. H., Sajja, A., Yu, Y., Freiberg, A. N., Vasilakis, N., Shi, P.-Y., Weaver, S. C. & Wu, P., Mar 2021, In: PLoS neglected tropical diseases. 15, 3, e0009183.

Research output: Contribution to journal › Article › peer-review

Open Access

10 Scopus citations

Loss of furin cleavage site attenuates SARS-CoV-2 pathogenesis

Johnson, B. A., Xie, X., Bailey, A. L., Kalveram, B., Lokugamage, K. G., Muruato, A., Zou, J., Zhang, X., Juelich, T., Smith, J. K., Zhang, L., Bopp, N., Schindewolf, C., Vu, M., Vanderheiden, A., Winkler, E. S., Swetnam, D., Plante, J. A., Aguilar, P. & Plante, K. S. & 13 others, Popov, V., Lee, B., Weaver, S. C., Suthar, M. S., Routh, A. L., Ren, P., Ku, Z., An, Z., Debbink, K., Diamond, M. S., Shi, P. Y., Freiberg, A. N. & Menachery, V. D., Mar 11 2021, In: Nature. 591, 7849, p. 293-299 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

463 Scopus citations

Polyphenylene carboxymethylene (PPCM) microbicide repurposed as antiviral against SARS-CoV-2. Proof of concept in primary human undifferentiated epithelial cells

Escaffre, O. & Freiberg, A. N., Oct 2021, In: Antiviral research. 194, 105162.

Research output: Contribution to journal › Article › peer-review

Open Access

7 Scopus citations

Potent neutralization of Rift Valley fever virus by human monoclonal antibodies through fusion inhibition

Chapman, N. S., Zhao, H., Kose, N., Westover, J. B., Kalveram, B., Bombardi, R., Rodriguez, J., Sutton, R., Genualdi, J., LaBeaud, A. D., Mutuku, F. M., Pittman, P. R., Freiberg, A. N., Gowen, B. B., Fremont, D. H. & Crowe, J. E., Apr 6 2021, In: Proceedings of the National Academy of Sciences of the United States of America. 118, 14, e2025642118.

Research output: Contribution to journal › Article › peer-review

Open Access

25 Scopus citations

Rift valley fever virus 78kda envelope protein attenuates virus replication in macrophage-derived cell lines and viral virulence in mice

Terasaki, K., Kalveram, B., Johnson, K. N., Juelich, T., Smith, J. K., Zhang, L., Freiberg, A. N. & Makino, S., Sep 2021, In: PLoS neglected tropical diseases. 15, 9, e0009785.

Research output: Contribution to journal › Article › peer-review

Open Access

10 Scopus citations

SARS-CoV-2 proteases PLpro and 3CLpro cleave IRF3 and critical modulators of inflammatory pathways (NLRP12 and TAB1): implications for disease presentation across species

Moustaqil, M., Ollivier, E., Chiu, H. P., Van Tol, S., Rudolffi-Soto, P., Stevens, C., Bhumkar, A., Hunter, D. J. B., Freiberg, A. N., Jacques, D., Lee, B., Sierecki, E. & Gambin, Y., 2021, In: Emerging Microbes and Infections. 10, 1, p. 178-195 18 p.

Research output: Contribution to journal › Article › peer-review

Open Access

181 Scopus citations

Spike mutation D614G alters SARS-CoV-2 fitness

Plante, J. A., Liu, Y., Liu, J., Xia, H., Johnson, B. A., Lokugamage, K. G., Zhang, X., Muruato, A. E., Zou, J., Fontes-Garfias, C. R., Mirchandani, D., Scharton, D., Bilello, J. P., Ku, Z., An, Z., Kalveram, B., Freiberg, A. N., Menachery, V. D., Xie, X. & Plante, K. S. & 2 others, Weaver, S. C. & Shi, P. Y., Apr 1 2021, In: Nature. 592, 7852, p. 116-121 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

1081 Scopus citations

Stat-1 knockout mice as a model for wild-type sudan virus (Sudv)

Escaffre, O., Juelich, T. L., Neef, N., Massey, S., Smith, J., Brasel, T., Smith, J. K., Kalveram, B., Zhang, L., Perez, D., Ikegami, T., Freiberg, A. N. & Comer, J. E., Jul 2021, In: Viruses. 13, 7, 1388.

Research output: Contribution to journal › Article › peer-review

Open Access

10 Scopus citations

Targeted disruption of pi–pi stacking in Malaysian banana lectin reduces mitogenicity while preserving antiviral activity

Covés-Datson, E. M., King, S. R., Legendre, M., Swanson, M. D., Gupta, A., Claes, S., Meagher, J. L., Boonen, A., Zhang, L., Kalveram, B., Raglow, Z., Freiberg, A. N., Prichard, M., Stuckey, J. A., Schols, D. & Markovitz, D. M., Dec 2021, In: Scientific reports. 11, 1, 656.

Research output: Contribution to journal › Article › peer-review

Open Access

19 Scopus citations

2020

Discovery of Adamantane Carboxamides as Ebola Virus Cell Entry and Glycoprotein Inhibitors

Plewe, M. B., Sokolova, N. V., Gantla, V. R., Brown, E. R., Naik, S., Fetsko, A., Lorimer, D. D., Lorimer, D. D., Dranow, D. M., Dranow, D. M., Smutney, H., Smutney, H., Bullen, J., Bullen, J., Sidhu, R., Sidhu, R., Master, A., Master, A., Wang, J. & Wang, J. & 6 others, Kallel, E. A., Zhang, L., Kalveram, B., Freiberg, A. N., Henkel, G. & McCormack, K., Jun 11 2020, In: ACS Medicinal Chemistry Letters. 11, 6, p. 1160-1167 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

14 Scopus citations

Niemann-Pick C1 Heterogeneity of Bat Cells Controls Filovirus Tropism

Takadate, Y., Kondoh, T., Igarashi, M., Maruyama, J., Manzoor, R., Ogawa, H., Kajihara, M., Furuyama, W., Sato, M., Miyamoto, H., Yoshida, R., Hill, T. E., Freiberg, A. N., Feldmann, H., Marzi, A. & Takada, A., Jan 14 2020, In: Cell Reports. 30, 2, p. 308-319.e5

Research output: Contribution to journal › Article › peer-review

Open Access

21 Scopus citations

Pyronaridine tetraphosphate efficacy against Ebola virus infection in guinea pig

Lane, T. R., Massey, C., Comer, J. E., Freiberg, A. N., Zhou, H., Dyall, J., Holbrook, M. R., Anantpadma, M., Davey, R. A., Madrid, P. B. & Ekins, S., Sep 2020, In: Antiviral research. 181, 104863.

Research output: Contribution to journal › Article › peer-review

Open Access

16 Scopus citations

VAMP8 contributes to the TRIM6-mediated type I interferon antiviral response during West Nile virus infection

Van Tol, S., Atkins, C., Bharaj, P., Johnson, K. N., Hage, A., Freiberg, A. N. & Rajsbaum, R., Jan 1 2020, In: Journal of virology. 94, 2, e01454-19.

Research output: Contribution to journal › Article › peer-review

Open Access

26 Scopus citations

2019

Filovirus virulence in interferon α/β and γ double knockout mice, and treatment with favipiravir

Comer, J. E., Escaffre, O., Neef, N., Brasel, T., Juelich, T. L., Smith, J. K., Smith, J., Kalveram, B., Perez, D. D., Massey, S., Zhang, L. & Freiberg, A. N., Feb 2019, In: Viruses. 11, 2, 137.

Research output: Contribution to journal › Article › peer-review

Open Access

15 Scopus citations

Henipavirus infection of the central nervous system

Dawes, B. E. & Freiberg, A. N., Mar 1 2019, In: Pathogens and disease. 77, 2, ftz023.

Research output: Contribution to journal › Article › peer-review

Open Access

19 Scopus citations

Peptidoglycan-associated cyclic lipopeptide disrupts viral infectivity

Johnson, B. A., Hage, A., Kalveram, B., Mears, M., Plante, J., Rodriguez, S., Ding, Z., Luo, X., Bente, D., Bradrick, S., Freiberg, A. N., Popov, V., Rajsbaum Gorodezky, R., Rossi, S., Russell, W. K. & Menachery, V. D., Nov 1 2019, In: Journal of virology. 93, 22, e01282-19.

Research output: Contribution to journal › Article › peer-review

Open Access

51 Scopus citations

Polyphenylene carboxymethylene (PPCM) in vitro antiviral efficacy against Ebola virus in the context of a sexually transmitted infection

Escaffre, O., Juelich, T. L. & Freiberg, A. N., Oct 2019, In: Antiviral research. 170, 104567.

Research output: Contribution to journal › Article › peer-review

Open Access

10 Scopus citations

Repurposing quinacrine against Ebola virus infection in vivo

Lane, T. R., Comer, J. E., Freiberg, A. N., Madrid, P. B. & Ekins, S., 2019, In: Antimicrobial agents and chemotherapy. 63, 9, e01142-19.

Research output: Contribution to journal › Article › peer-review

Open Access

27 Scopus citations

SAR studies of 4-acyl-1,6-dialkylpiperazin-2-one arenavirus cell entry inhibitors

Plewe, M. B., Whitby, L. R., Naik, S., Brown, E. R., Sokolova, N. V., Gantla, V. R., York, J., Nunberg, J. H., Zhang, L., Kalveram, B., Freiberg, A. N., Boger, D. L., Henkel, G. & McCormack, K., Nov 15 2019, In: Bioorganic and Medicinal Chemistry Letters. 29, 22, 126620.

Research output: Contribution to journal › Article › peer-review

Open Access

7 Scopus citations

2018

A single-cycle replicable Rift Valley fever phlebovirus vaccine carrying a mutated NSs confers full protection from lethal challenge in mice

Terasaki, K., Juelich, T. L., Smith, J. K., Kalveram, B., Perez, D. D., Freiberg, A. N. & Makino, S., Dec 1 2018, In: Scientific reports. 8, 1, 17097.

Research output: Contribution to journal › Article › peer-review

Open Access

8 Scopus citations

Efficacy of tilorone dihydrochloride against ebola virus infection

Ekins, S., Lingerfelt, M. A., Comer, J. E., Freiberg, A. N., Mirsalis, J. C., O’Loughlin, K., Harutyunyan, A., McFarlane, C., Green, C. E. & Madrid, P. B., Feb 2018, In: Antimicrobial agents and chemotherapy. 62, 2, e01711-17.

Research output: Contribution to journal › Article › peer-review

Open Access

49 Scopus citations

Experimental Infection of Syrian Hamsters with Aerosolized Nipah Virus

Escaffre, O., Hill, T., Ikegami, T., Juelich, T. L., Smith, J. K., Zhang, L., Perez, D. E., Atkins, C., Park, A., Lawrence, W. S., Sivasubramani, S. K., Peel, J. E., Peterson, J., Lee, B. & Freiberg, A. N., Oct 5 2018, In: Journal of Infectious Diseases. 218, 10, p. 1602-1610 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

24 Scopus citations

Favipiravir (T-705) protects against Nipah virus infection in the hamster model /631/326/22/1295 /631/326/596/1296 /13/106 /14/35 /38/77 /82/51 /96/63 article

Dawes, B. E., Kalveram, B., Ikegami, T., Juelich, T., Smith, J. K., Zhang, L., Park, A., Lee, B., Komeno, T., Furuta, Y. & Freiberg, A. N., Dec 1 2018, In: Scientific reports. 8, 1, 7604.

Research output: Contribution to journal › Article › peer-review

Open Access

93 Scopus citations

Human neural stem cell-derived neuron/astrocyte co-cultures respond to la Crosse virus infection with proinflammatory cytokines and chemokines

Dawes, B. E., Gao, J., Atkins, C., Nelson, J. T., Johnson, K., Wu, P. & Freiberg, A. N., Nov 15 2018, In: Journal of neuroinflammation. 15, 1, 315.

Research output: Contribution to journal › Article › peer-review

Open Access

18 Scopus citations

Imaging of Murine Whole Lung Fibrosis by Large Scale 3D Microscopy aided by Tissue Optical Clearing

Ochoa, L. F., Kholodnykh, A., Villarreal, P., Tian, B., Pal, R., Freiberg, A. N., Brasier, A. R., Motamedi, M. & Vargas, G., Dec 1 2018, In: Scientific reports. 8, 1, 13348.

Research output: Contribution to journal › Article › peer-review

Open Access

36 Scopus citations

Natural History and Pathogenesis of Wild-Type Marburg Virus Infection in STAT2 Knockout Hamsters

Atkins, C., Miao, J., Kalveram, B., Juelich, T., Smith, J. K., Perez, D., Zhang, L., Westover, J. L. B., Van Wettere, A. J., Gowen, B. B., Wang, Z. & Freiberg, A. N., Nov 22 2018, In: Journal of Infectious Diseases. 218, p. S438-S447

Research output: Contribution to journal › Article › peer-review

Open Access

13 Scopus citations

Phosphorylated VP30 of marburg virus is a repressor of transcription

Tigabu, B., Ramanathan, P., Ivanov, A., Lin, X., Ilinykh, P. A., Parry, C. S., Freiberg, A. N., Nekhai, S. & Bukreyev, A., Nov 1 2018, In: Journal of virology. 92, 21, e00426.

Research output: Contribution to journal › Article › peer-review

Open Access

24 Scopus citations

2017

Attenuation and protective efficacy of Rift Valley fever phlebovirus rMP12-GM50 strain

Ly, H. J., Nishiyama, S., Lokugamage, N., Smith, J. K., Zhang, L., Perez, D., Juelich, T. L., Freiberg, A. N. & Ikegami, T., Dec 4 2017, In: Vaccine. 35, 48, p. 6634-6642 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

13 Scopus citations

Broad-Range Antiviral Activity of Hydrogen Sulfide Against Highly Pathogenic RNA Viruses

Bazhanov, N., Escaffre, O., Freiberg, A. N., Garofalo, R. P. & Casola, A., Jan 20 2017, In: Scientific reports. 7, 41029.

Research output: Contribution to journal › Article › peer-review

Open Access

57 Scopus citations

Alexander Freiberg, PhD

Research output

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