• 8396 Citations
  • 37 h-Index
1988 …2020

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Article
1988

Activation by divalent cations of a Ca2+-activated K+ channel from skeletal muscle membrane

Oberhauser, A., Alvarez, O. & Latorre, R., Jul 1 1988, In : Journal of General Physiology. 92, 1, p. 67-86 20 p.

Research output: Contribution to journalArticle

Open Access
104 Scopus citations

Inositol (1,4,5)-trisphosphate activates a calcium channel in isolated sarcoplasmic reticulum membranes

Suárez-Isla, B. A., Irribarra, V., Oberhauser, A., Larralde, L., Bull, R., Hidalgo, C. & Jaimovich, E., 1988, In : Biophysical journal. 54, 4, p. 737-741 5 p.

Research output: Contribution to journalArticle

Open Access
52 Scopus citations

Probing a Ca2+-activated K+ channel with quaternary ammonium ions

Villarroel, A., Alvarez, O., Oberhauser, A. & Latorre, R., Dec 1 1988, In : Pflügers Archiv European Journal of Physiology. 413, 2, p. 118-126 9 p.

Research output: Contribution to journalArticle

108 Scopus citations
1989

Batrachotoxin-modified sodium channels from squid optic nerve in planar bilayers: Ion conduction and gating properties

Behrens, M. I., Oberhauser, A., Bezanilla, F. & Latorre, R., Jan 1 1989, In : Journal of General Physiology. 93, 1, p. 23-41 19 p.

Research output: Contribution to journalArticle

Open Access
31 Scopus citations
1991

Is swelling of the secretory granule matrix the force that dilates the exocytotic fusion pore?

Monck, J. R., Oberhauser, A. F., Alvarez de Toledo, G. & Fernandez, J. M., 1991, In : Biophysical journal. 59, 1, p. 39-47 9 p.

Research output: Contribution to journalArticle

Open Access
64 Scopus citations
1992
Open Access
49 Scopus citations

Exocytotic fusion is activated by Rab3a peptides

Oberhauser, A. F., Monck, J. R., Balch, W. E. & Fernandez, J. M., Jan 1 1992, In : Nature. 360, 6401, p. 270-273 4 p.

Research output: Contribution to journalArticle

144 Scopus citations

The exocytotic fusion pore modeled as a lipidic pore

Nanavati, C., Markin, V. S., Oberhauser, A. F. & Fernandez, J. M., 1992, In : Biophysical journal. 63, 4, p. 1118-1132 15 p.

Research output: Contribution to journalArticle

Open Access
90 Scopus citations

Thin-section ratiometric Ca2+ images obtained by optical sectioning of fura-2 loaded mast cells

Monck, J. R., Oberhauser, A. F., Keating, T. J. & Fernandez, J. M., Feb 1992, In : Journal of Cell Biology. 116, 3, p. 745-759 15 p.

Research output: Contribution to journalArticle

Open Access
62 Scopus citations
1993

Patch clamp studies of single intact secretory granules

Oberhauser, A. F. & Fernandez, J. M., 1993, In : Biophysical journal. 65, 5, p. 1844-1852 9 p.

Research output: Contribution to journalArticle

Open Access
17 Scopus citations
1994

Is the Activity of the Fusion Pore Scaffold Regulated by a Coincidence Detector?

ROBINSON, IAIN. M., OBERHAUSER, ANDRES. F. & FERNANDEZ, JULIO. M., Mar 1994, In : Annals of the New York Academy of Sciences. 710, 1, p. 168-178 11 p.

Research output: Contribution to journalArticle

4 Scopus citations

Neurotransmitter release through the exocytotic fusion pore

Monck, J. R., Oberhauser, A. F., Robinson, I. M. & Fernandez, J. M., Jun 1994, In : Seminars in Neuroscience. 6, 3, p. 177-185 9 p.

Research output: Contribution to journalArticle

3 Scopus citations

RT-PCR cloning of Rab3 isoforms expressed in peritoneal mast cells

Oberhauser, A. F., Balan, V., Fernandez-Badilla, C. L. & Fernandez, J. M., Feb 14 1994, In : FEBS Letters. 339, 1-2, p. 171-174 4 p.

Research output: Contribution to journalArticle

35 Scopus citations
1995

Do caged-Ca2+ compounds mimic the physiological stimulus for secretion?

Oberhauser, A. F., Robinson, I. M. & Fernandez, J. M., 1995, In : Journal of Physiology - Paris. 89, 2, p. 71-75 5 p.

Research output: Contribution to journalArticle

9 Scopus citations

Hydrophobic ions amplify the capacitive currents used to measure exocytotic fusion

Oberhauser, A. F. & Fernandez, J. M., 1995, In : Biophysical journal. 69, 2, p. 451-459 9 p.

Research output: Contribution to journalArticle

Open Access
22 Scopus citations

The exocytotic fusion pore interface: A model of the site of neurotransmitter release

Monck, J. R., Oberhauser, A. F. & Fernandez, J. M., Jan 1 1995, In : Molecular membrane biology. 12, 1, p. 151-156 6 p.

Research output: Contribution to journalArticle

36 Scopus citations
1996

A fusion pore phenotype in mast cells of the ruby-eye mouse

Oberhauser, A. F. & Fernandez, J. M., Dec 10 1996, In : Proceedings of the National Academy of Sciences of the United States of America. 93, 25, p. 14349-14354 6 p.

Research output: Contribution to journalArticle

35 Scopus citations

Simultaneous capacitance and amperometric measurements of exocytosis: A comparison

Oberhauser, A. F., Robinson, I. M. & Fernandez, J. M., Aug 1996, In : Biophysical journal. 71, 2, p. 1131-1139 9 p.

Research output: Contribution to journalArticle

Open Access
63 Scopus citations
1998

Polysaccharide elasticity governed by chair-boat transitions of the glucopyranose ring

Marszalek, P. E., Oberhauser, A. F., Pang, Y. P. & Fernandez, J. M., Dec 17 1998, In : Nature. 396, 6712, p. 661-664 4 p.

Research output: Contribution to journalArticle

370 Scopus citations

The molecular elasticity of the extracellular matrix protein tenascin

Oberhauser, A. F., Marszalek, P. E., Erickson, H. P. & Fernandez, J. M., May 14 1998, In : Nature. 393, 6681, p. 181-185 5 p.

Research output: Contribution to journalArticle

699 Scopus citations
1999

Atomic force microscopy captures length phenotypes in single proteins

Carrion-Vazquez, M., Marszalek, P. E., Oberhauser, A. F. & Fernandez, J. M., Sep 28 1999, In : Proceedings of the National Academy of Sciences of the United States of America. 96, 20, p. 11288-11292 5 p.

Research output: Contribution to journalArticle

154 Scopus citations

Atomic levers control pyranose ring conformations

Marszalek, P. E., Pang, Y. P., Li, H., El Yazal, J., Oberhauser, A. F. & Fernandez, J. M., Jul 6 1999, In : Proceedings of the National Academy of Sciences of the United States of America. 96, 14, p. 7894-7898 5 p.

Research output: Contribution to journalArticle

130 Scopus citations

Mechanical and chemical unfolding of a single protein: A comparison

Carrion-Vazquez, M., Oberhauser, A. F., Fowler, S. B., Marszalek, P. E., Broedel, S. E., Clarke, J. & Fernandez, J. M., Mar 30 1999, In : Proceedings of the National Academy of Sciences of the United States of America. 96, 7, p. 3694-3699 6 p.

Research output: Contribution to journalArticle

825 Scopus citations

Mechanical unfolding intermediates in titin modules

Marszalek, P. E., Lu, H., Li, H., Carrion-Vazquez, M., Oberhauser, A. F., Schulten, K. & Fernandez, J. M., Nov 4 1999, In : Nature. 402, 6757, p. 100-103 4 p.

Research output: Contribution to journalArticle

652 Scopus citations

Single protein misfolding events captured by atomic force microscopy

Oberhauser, A. F., Marszalek, P. E., Carrion-Vazquez, M. & Fernandez, J. M., Nov 17 1999, In : Nature Structural Biology. 6, 11, p. 1025-1028 4 p.

Research output: Contribution to journalArticle

163 Scopus citations
2000

Atomic force microscopy captures quantized plastic deformation in gold nanowires

Marszalek, P. E., Greenleaf, W. J., Li, H., Oberhauser, A. F. & Fernandez, J. M., Jun 6 2000, In : Proceedings of the National Academy of Sciences of the United States of America. 97, 12, p. 6282-6286 5 p.

Research output: Contribution to journalArticle

104 Scopus citations

Atomic force microscopy reveals the mechanical design of a modular protein

Li, H., Oberhauser, A. F., Fowler, S. B., Clarke, J. & Fernandez, J. M., Jun 6 2000, In : Proceedings of the National Academy of Sciences of the United States of America. 97, 12, p. 6527-6531 5 p.

Research output: Contribution to journalArticle

238 Scopus citations

Point mutations alter the mechanical stability of immunoglobulin modules

Li, H., Carrion-Vazquez, M., Oberhauser, A. F., Marszalek, P. E. & Fernandez, J. M., Dec 23 2000, In : Nature Structural Biology. 7, 12, p. 1117-1120 4 p.

Research output: Contribution to journalArticle

171 Scopus citations
2001

Multiple conformations of PEVK proteins detected by single-molecule techniques

Li, H., Oberhauser, A. F., Redick, S. D., Carrion-Vazquez, M., Erickson, H. P. & Fernandez, J. M., Sep 11 2001, In : Proceedings of the National Academy of Sciences of the United States of America. 98, 19, p. 10682-10686 5 p.

Research output: Contribution to journalArticle

139 Scopus citations

Stepwise unfolding of titin under force-clamp atomic force microscopy

Oberhauser, A. F., Hansma, P. K., Carrion-Vazquez, M. & Fernandez, J. M., Jan 16 2001, In : Proceedings of the National Academy of Sciences of the United States of America. 98, 2, p. 468-472 5 p.

Research output: Contribution to journalArticle

Open Access
330 Scopus citations
2002

Chair-boat transitions in single polysaccharide molecules observed with force-ramp AFM

Marszalek, P. E., Li, H., Oberhauser, A. F. & Fernandez, J. M., Apr 2 2002, In : Proceedings of the National Academy of Sciences of the United States of America. 99, 7, p. 4278-4283 6 p.

Research output: Contribution to journalArticle

120 Scopus citations

Reverse engineering of the giant muscle protein titin

Li, H., Linke, W. A., Oberhauser, A. F., Carrion-Vazquez, M., Kerkvliet, J. G., Lu, H., Marszalek, P. E. & Fernandez, J. M., Aug 29 2002, In : Nature. 418, 6901, p. 998-1002 5 p.

Research output: Contribution to journalArticle

382 Scopus citations

The mechanical hierarchies of fibronectin observed with single-molecule AFM

Oberhauser, A. F., Badilla-Fernandez, C., Carrion-Vazquez, M. & Fernandez, J. M., Jan 1 2002, In : Journal of Molecular Biology. 319, 2, p. 433-447 15 p.

Research output: Contribution to journalArticle

302 Scopus citations
2003

The force-driven conformations of heparin studied with single molecule force microscopy

Marszalek, P. E., Oberhauser, A. F., Li, H. & Fernandez, J. M., Oct 1 2003, In : Biophysical journal. 85, 4, p. 2696-2704 9 p.

Research output: Contribution to journalArticle

Open Access
36 Scopus citations

The mechanical stability of ubiquitin is linkage dependent

Carrion-Vazquez, M., Li, H., Lu, H., Marszalek, P. E., Oberhauser, A. F. & Fernandez, J. M., Sep 1 2003, In : Nature Structural Biology. 10, 9, p. 738-743 6 p.

Research output: Contribution to journalArticle

350 Scopus citations
2005

The nanomechanics of polycystin-1 extracellular region

Qian, F., Wei, W., Germino, G. & Oberhauser, A., Dec 9 2005, In : Journal of Biological Chemistry. 280, 49, p. 40723-40730 8 p.

Research output: Contribution to journalArticle

59 Scopus citations
2006

The mechanical properties of E. coli type 1 pili measured by atomic force microscopy techniques

Miller, E., Garcia, T., Hultgren, S. & Oberhauser, A. F., Nov 2006, In : Biophysical journal. 91, 10, p. 3848-3856 9 p.

Research output: Contribution to journalArticle

105 Scopus citations

The molecular elasticity of the insect flight muscle proteins projectin and kettin

Bullard, B., Garcia, T., Benes, V., Leake, M. C., Linke, W. A. & Oberhauser, A. F., Mar 21 2006, In : Proceedings of the National Academy of Sciences of the United States of America. 103, 12, p. 4451-4456 6 p.

Research output: Contribution to journalArticle

75 Scopus citations
2009

A LIM-9 (FHL) / SCPL-1 (SCP) Complex Interacts with the C-terminal Protein Kinase Regions of UNC-89 (Obscurin) in Caenorhabditis elegans Muscle

Xiong, G., Qadota, H., Mercer, K. B., McGaha, L. A., Oberhauser, A. F. & Benian, G. M., Mar 6 2009, In : Journal of Molecular Biology. 386, 4, p. 976-988 13 p.

Research output: Contribution to journalArticle

27 Scopus citations
17 Scopus citations

Naturally occurring mutations alter the stability of polycystin-1 polycystic kidney disease (PKD) domains

Ma, L., Xu, M., Forman, J. R., Clarke, J. & Oberhauser, A. F., Nov 20 2009, In : Journal of Biological Chemistry. 284, 47, p. 32942-32949 8 p.

Research output: Contribution to journalArticle

18 Scopus citations

The C2 domains of human synaptotagmin 1 have distinct mechanical properties

Fuson, K. L., Liang, M., Sutton, R. B. & Oberhauser, A. F., Feb 4 2009, In : Biophysical journal. 96, 3, p. 1083-1090 8 p.

Research output: Contribution to journalArticle

18 Scopus citations
2010

Naturally occurring osmolytes modulate the nanomechanical properties of polycystic kidney disease domains

Ma, L., Xu, M. & Oberhauser, A. F., Dec 3 2010, In : Journal of Biological Chemistry. 285, 49, p. 38438-38443 6 p.

Research output: Contribution to journalArticle

19 Scopus citations

Substrate elasticity provides mechanical signals for the expansion of hemopoietic stem and progenitor cells

Holst, J., Watson, S., Lord, M. S., Eamegdool, S. S., Bax, D. V., Nivison-Smith, L. B., Kondyurin, A., Ma, L., Oberhauser, A. F., Weiss, A. S. & Rasko, J. E. J., Oct 1 2010, In : Nature Biotechnology. 28, 10, p. 1123-1128 6 p.

Research output: Contribution to journalArticle

186 Scopus citations
2011

Shape of tropoelastin, the highly extensible protein that controls human tissue elasticity

Baldock, C., Oberhauser, A. F., Ma, L., Lammie, D., Siegler, V., Mithieux, S. M., Tu, Y., Chow, J. Y. H., Suleman, F., Malfois, M., Rogers, S., Guo, L., Irving, T. C., Wess, T. J. & Weiss, A. S., Mar 15 2011, In : Proceedings of the National Academy of Sciences of the United States of America. 108, 11, p. 4322-4327 6 p.

Research output: Contribution to journalArticle

116 Scopus citations

Ubiquilin-1 is a molecular chaperone for the amyloid precursor protein

Stieren, E. S., El Ayadi, A., Xiao, Y., Siller, E., Landsverk, M. L., Oberhauser, A. F., Barral, J. M. & Boehning, D., Oct 14 2011, In : Journal of Biological Chemistry. 286, 41, p. 35689-35698 10 p.

Research output: Contribution to journalArticle

62 Scopus citations
2012

Engineering proteins with enhanced mechanical stability by force-specific sequence motifs

Lu, W., Negi, S. S., Oberhauser, A. F. & Braun, W., May 2012, In : Proteins: Structure, Function and Bioinformatics. 80, 5, p. 1308-1315 8 p.

Research output: Contribution to journalArticle

6 Scopus citations

Purification and aggregation of the amyloid precursor protein intracellular domain

El Ayadi, A., Stieren, E. S., Barral, J. M., Oberhauser, A. F. & Boehning, D., Aug 28 2012, In : Journal of Visualized Experiments. 66

Research output: Contribution to journalArticle

Rickettsiae induce microvascular hyperpermeability via phosphorylation of ve-cadherins: Evidence from atomic force microscopy and biochemical studies

Gong, B., Ma, L., Liu, Y., Gong, Q., Shelite, T., Bouyer, D., Boor, P. J., Lee, Y. S. & Oberhauser, A., Jun 2012, In : PLoS neglected tropical diseases. 6, 6, e1699.

Research output: Contribution to journalArticle

12 Scopus citations

Tracking UNC-45 chaperone-myosin interaction with a titin mechanical reporter

Kaiser, C. M., Bujalowski, P. J., Ma, L., Anderson, J., Epstein, H. F. & Oberhauser, A. F., May 2 2012, In : Biophysical journal. 102, 9, p. 2212-2219 8 p.

Research output: Contribution to journalArticle

18 Scopus citations