Andrew Routh, PhD

  • 1377 Citations
  • 13 h-Index
20072020
If you made any changes in Pure, your changes will be visible here soon.

Research Output 2007 2020

  • 1377 Citations
  • 13 h-Index
  • 23 Article
  • 1 Chapter
  • 1 Short survey
2020
Open Access
Ribonucleosides
Capsid
Virion
RNA
Virus Replication
2019
1 Citation (Scopus)

Dengue NS2A Protein Orchestrates Virus Assembly

Xie, X., Zou, J., Zhang, X., Zhou, Y., Routh, A. L., Kang, C., Popov, V. L., Chen, X., Wang, Q. Y., Dong, H. & Shi, P. Y., Nov 13 2019, In : Cell Host and Microbe. 26, 5, p. 606-622.e8

Research output: Contribution to journalArticle

Virus Assembly
Dengue
Virion
Polyproteins
Nucleocapsid
1 Citation (Scopus)

Development of Poly(A)-ClickSeq as a tool enabling simultaneous genome-wide poly(A)-site identification and differential expression analysis

Elrod, N. D., Jaworski, E. A., Ji, P., Wagner, E. & Routh, A., Jan 1 2019, (Accepted/In press) In : Methods.

Research output: Contribution to journalArticle

Poly A
Genes
Genome
RNA
Gene Expression

DPAC: A tool for differential poly(A)-cluster usage from poly(A)-targeted RNAseq data

Routh, A., Jan 1 2019, In : G3: Genes, Genomes, Genetics. 9, 6, p. 1825-1830 6 p.

Research output: Contribution to journalArticle

Open Access
Poly A
Cluster Analysis
Messenger RNA
Gene Expression
Polyadenylation
1 Citation (Scopus)

Mosquito cells persistently infected with dengue virus produce viral particles with host-dependent replication

Reyes-Ruiz, J. M., Osuna-Ramos, J. F., Bautista-Carbajal, P., Jaworski, E., Soto-Acosta, R., Cervantes-Salazar, M., Angel-Ambrocio, A. H., Castillo-Munguía, J. P., Chávez-Munguía, B., De Nova-Ocampo, M., Routh, A., del Ángel, R. M. & Salas-Benito, J. S., May 1 2019, In : Virology. 531, p. 1-18 18 p.

Research output: Contribution to journalArticle

Dengue Virus
Culicidae
Virion
Vertebrates
Arboviruses
3 Citations (Scopus)

Nudt21 regulates the alternative polyadenylation of Pak1 and is predictive in the prognosis of glioblastoma patients

Chu, Y., Elrod, N., Wang, C., Li, L., Chen, T., Routh, A., Xia, Z., Li, W., Wagner, E. & Ji, P., Jan 1 2019, In : Oncogene.

Research output: Contribution to journalArticle

Polyadenylation
Glioblastoma
3' Untranslated Regions
Glioma
Genes

Whole-genome sequence of rickettsia parkeri strain atlantic rainforest, isolated from a colombian tick

Londoño, A. F., Mendell, N. L., Valbuena, G. A., Routh, A. L., Wood, T. G., Widen, S. G., Rodas, J. D., Walker, D. H. & Bouyer, D. H., Sep 26 2019, In : Microbiology Resource Announcements. 8, 39, e00684-19.

Research output: Contribution to journalArticle

Open Access
Rickettsia
Ticks
Genome
Colombia
Rainforest
2018

Better Safe than Sorry: A Dual-Function Viral Protein Inhibiting Host Defense

Lechtenberg, B. C. & Routh, A., Oct 10 2018, In : Cell Host and Microbe. 24, 4, p. 467-469 3 p.

Research output: Contribution to journalShort survey

Viral Proteins
Gryllidae
Viruses
Paralysis
Immune System
4 Citations (Scopus)

ClickSeq: Replacing fragmentation and enzymatic ligation with click-chemistry to prevent sequence chimeras

Jaworski, E. & Routh, A., Jan 1 2018, Methods in Molecular Biology. Humana Press Inc., Vol. 1712. p. 71-85 15 p. (Methods in Molecular Biology; vol. 1712).

Research output: Chapter in Book/Report/Conference proceedingChapter

Click Chemistry
Biological Phenomena
Viral RNA
Genetic Recombination
Libraries
2017
47 Citations (Scopus)

High-fidelity mass analysis unveils heterogeneity in intact ribosomal particles

Van De Waterbeemd, M., Fort, K. L., Boll, D., Reinhardt-Szyba, M., Routh, A., Makarov, A. & Heck, A. J. R., Feb 28 2017, In : Nature Methods. 14, 3, p. 283-286 4 p.

Research output: Contribution to journalArticle

Ribosomes
Mass spectrometers
Viruses
Nucleic Acids
Molecular Biology
19 Citations (Scopus)

Parallel ClickSeq and Nanopore sequencing elucidates the rapid evolution of defective-interfering RNAs in Flock House virus

Jaworski, E. & Routh, A., May 1 2017, In : PLoS Pathogens. 13, 5, e1006365.

Research output: Contribution to journalArticle

Nanopores
RNA
Viruses
Genetic Recombination
Cell Culture Techniques
13 Citations (Scopus)

Poly(A)-ClickSeq: Click-chemistry for next-generation 3'-end sequencing without RNA enrichment or fragmentation

Routh, A., Ji, P., Jaworski, E., Xia, Z., Li, W. & Wagner, E., Jul 1 2017, In : Nucleic Acids Research. 45, 12, e112.

Research output: Contribution to journalArticle

Click Chemistry
RNA Sequence Analysis
Poly A
Polyadenylation
RNA
2016
174 Citations (Scopus)

A Screen of FDA-Approved Drugs for Inhibitors of Zika Virus Infection

Barrows, N. J., Kroon Campos, R., Powell, S. T., Prasanth, K. R., Schott-Lerner, G., Soto-Acosta, R., Galarza-Munoz, G., McGrath, E. L., Urrabaz-Garza, R., Gao, J., Wu, P., Menon, R., Saade, G., Fernandez-Salas, I., Rossi, S., Vasilakis, N., Routh, A., Bradrick, S. & Garcia-Blanco, M., May 15 2016, (Accepted/In press) In : Cell Host and Microbe.

Research output: Contribution to journalArticle

Pharmaceutical Preparations
Amnion
Neural Stem Cells
Daptomycin
Mycophenolic Acid
2015
15 Citations (Scopus)

ClickSeq: Fragmentation-Free Next-Generation Sequencing via Click Ligation of Adaptors to Stochastically Terminated 3′-Azido cDNAs

Routh, A., Head, S. R., Ordoukhanian, P. & Johnson, J. E., Aug 14 2015, In : Journal of Molecular Biology. 427, 16, p. 2610-2616 7 p.

Research output: Contribution to journalArticle

Ligation
Alkynes
Complementary DNA
DNA
Dideoxynucleotides
5 Citations (Scopus)

CoVaMa: Co-Variation Mapper for disequilibrium analysis of mutant loci in viral populations using next-generation sequence data

Routh, A., Chang, M. W., Okulicz, J. F., Johnson, J. E. & Torbett, B. E., 2015, In : Methods. 91, p. 40-47 8 p.

Research output: Contribution to journalArticle

Viruses
Genes
Boidae
HIV Protease
Amino Acids
2014
17 Citations (Scopus)
Genetic Recombination
Viruses
Nucleotides
Viral Genome
Genome
2012
71 Citations (Scopus)

Host RNAs, including transposons, are encapsidated by a eukaryotic single-stranded RNA virus

Routh, A., Domitrovic, T. & Johnson, J. E., Feb 7 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 6, p. 1907-1912 6 p.

Research output: Contribution to journalArticle

RNA Viruses
Virion
RNA
Viruses
DNA Transposable Elements
13 Citations (Scopus)

Nucleotide-resolution profiling of RNA recombination in the encapsidated genome of a eukaryotic RNA virus by next-generation sequencing

Routh, A., Ordoukhanian, P. & Johnson, J. E., Dec 14 2012, In : Journal of Molecular Biology. 424, 5, p. 257-269 13 p.

Research output: Contribution to journalArticle

RNA Viruses
Genetic Recombination
Nucleotides
Genome
RNA
9 Citations (Scopus)

Packaging host RNAs in small RNA viruses: An inevitable consequence of an error-prone polymerase?

Routh, A., Domitrovic, T. & Johnson, J. E., Oct 15 2012, In : Cell Cycle. 11, 20, p. 3713-3714 2 p.

Research output: Contribution to journalArticle

RNA Viruses
Product Packaging
RNA
2009
306 Citations (Scopus)

A Method for Genetically Installing Site-Specific Acetylation in Recombinant Histones Defines the Effects of H3 K56 Acetylation

Neumann, H., Hancock, S. M., Buning, R., Routh, A., Chapman, L., Somers, J., Owen-Hughes, T., van Noort, J., Rhodes, D. & Chin, J. W., Oct 9 2009, In : Molecular Cell. 36, 1, p. 153-163 11 p.

Research output: Contribution to journalArticle

Acetylation
Histones
Lysine
Nucleosomes
DNA Replication
172 Citations (Scopus)

Single-molecule force spectroscopy reveals a highly compliant helical folding for the 30-nm chromatin fiber

Kruithof, M., Chien, F. T., Routh, A., Logie, C., Rhodes, D. & Van Noort, J., May 2009, In : Nature Structural and Molecular Biology. 16, 5, p. 534-540 7 p.

Research output: Contribution to journalArticle

Nucleosomes
Chromatin
DNA
Histones
Compliance
2008
210 Citations (Scopus)

30 nm Chromatin Fibre Decompaction Requires both H4-K16 Acetylation and Linker Histone Eviction

Robinson, P. J. J., An, W., Routh, A., Martino, F., Chapman, L., Roeder, R. G. & Rhodes, D., Sep 12 2008, In : Journal of Molecular Biology. 381, 4, p. 816-825 10 p.

Research output: Contribution to journalArticle

Acetylation
Histones
Chromatin
Nucleosomes
DNA
45 Citations (Scopus)

Biophysical characterization of Vpu from HIV-1 suggests a channel-pore dualism

Mehnert, T., Routh, A., Judge, P. J., Lam, Y. H., Fischer, D., Watts, A. & Fischer, W. B., Mar 2008, In : Proteins: Structure, Function and Genetics. 70, 4, p. 1488-1497 10 p.

Research output: Contribution to journalArticle

HIV-1
Peptides
Flickering
Artificial Membranes
Membranes
227 Citations (Scopus)

Nucleosome repeat length and linker histone stoichiometry determine chromatin fiber structure

Routh, A., Sandin, S. & Rhodes, D., Jul 1 2008, In : Proceedings of the National Academy of Sciences of the United States of America. 105, 26, p. 8872-8877 6 p.

Research output: Contribution to journalArticle

Nucleosomes
Histones
Chromatin
DNA
2007
24 Citations (Scopus)

Towards a mechanism of function of the viral ion channel Vpu from HIV-1

Mehnert, T., Lam, Y. H., Judge, P. J., Routh, A., Fischer, D., Watts, A. & Fischer, W. B., Jun 2007, In : Journal of Biomolecular Structure and Dynamics. 24, 6, p. 589-596 8 p.

Research output: Contribution to journalArticle

Ion Channels
Virion
HIV-1
Membrane Proteins
Peptides