• 4659 Citations
  • 42 h-Index
1995 …2021
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Personal profile

Personal profile

Member, Institute for Human Infections & Immunity

Dr. Casola is a physician-scientist specialized in pediatric infectious diseases, with research expertise in the area of respiratory viral pathogens, lung inflammation, and cell signaling. Her research is focused on the investigation of viral- and host-specific mechanisms that contribute to the pathogenesis of respiratory viral infections. Over the past several years, she has identified several inducible intracellular signaling pathways activated by respiratory syncytial virus (RSV) in airway epithelial cells with particular emphasis on the role of reactive oxygen species in RSV induced lung inflammation both in vitro and in vivo, using a mouse model of RSV infection. Her research efforts include investigating the pathogenesis of respiratory diseases caused by human metapneumovirus (hMPV). Her laboratory uses recombinant hMPV viruses to investigate specific viral protein functions, with the ultimate goal to understand disease pathogenesis and design effective vaccines.

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Projects 2010 2021

Research Output 1995 2019

  • 4659 Citations
  • 42 h-Index
  • 87 Article
  • 3 Review article
Cystathionine
Lyases
Virus Diseases
Smoke
Tobacco

Human metapneumovirus infection of airway epithelial cells is associated with changes in core metabolic pathways

Zhao, Y., Chahar, H. S., Komaravelli, N., Dossumekova, A. & Casola, A., May 1 2019, In : Virology. 531, p. 183-191 9 p.

Research output: Contribution to journalArticle

Metapneumovirus
Metabolic Networks and Pathways
Epithelial Cells
Infection
Hexokinase
1 Citation (Scopus)

Human metapneumovirus small hydrophobic protein inhibits interferon induction in plasmacytoid dendritic cells

Bao, X., Kolli, D., Esham, D., Velayutham, T. S. & Casola, A., Jun 1 2018, In : Viruses. 10, 6, 278.

Research output: Contribution to journalArticle

Metapneumovirus
Dendritic Cells
Interferons
TNF Receptor-Associated Factor 6
Interferon Type I
1 Citation (Scopus)
Metapneumovirus
Respiratory Syncytial Viruses
Antioxidants
Airway Obstruction
Enzymes
6 Citations (Scopus)

Respiratory Syncytial Virus Infection Changes Cargo Composition of Exosome Released from Airway Epithelial Cells

Chahar, H. S., Gorgun, T., Kudlicki, A. S., Komaravelli, N. & Casola, A., Dec 1 2018, In : Scientific Reports. 8, 1, 387.

Research output: Contribution to journalArticle

Exosomes
Respiratory Syncytial Virus Infections
Epithelial Cells
Respiratory Syncytial Viruses
RNA