Bhupendra Kaphalia, PhD

Calculated based on number of publications stored in Pure and citations from Scopus
1981 …2024

Research activity per year

Personal profile

Research Strategic Pillar

Dr. Randall Urban, VP and Chief Research Officer, has determined that UTMB research should be prioritized into six health communities. This researcher has received the following badge(s):

Research Interests

Objectives: To understand the mechanisms of target organ toxicity of alcohol via lipid conjugation, hypomethylation and biomolecular modifications, and elucidation of the mechanisms involved in alcohol-induced target organ diseases.

Approach:?In general, I am working on formation, distribution, metabolism, disposition and toxicity evaluation of lipid conjugates of xenobiotic alcohols and develop analytical methods (HPLC, GC & TLC) involved in?in vitro?and?in vivo?metabolism of compounds of biological and environmental interest. I use state of art nuclear magnetic resonance spectroscopy and mass spectrometry for characterization of the metabolites. Currently, I am working Mechanism-based toxicity studies of ethanol and its metabolites to understand the mechanism(s) of alcoholic pancreatitis.

Research interests

Objectives: To understand the mechanisms of target organ toxicity of alcohol via lipid conjugation, hypomethylation and biomolecular modifications, and elucidation of the mechanisms involved in alcohol-induced target organ diseases. Approach: In general, I am working on formation, distribution, metabolism, disposition and toxicity evaluation of lipid conjugates of xenobiotic alcohols and develop analytical methods (HPLC, GC & TLC) involved in in vitro and in vivo metabolism of compounds of biological and environmental interest. I use state of art nuclear magnetic resonance spectroscopy and mass spectrometry for characterization of the metabolites. Currently, I am working Mechanism-based toxicity studies of ethanol and its metabolites to understand the mechanism(s) of alcoholic pancreatitis.

Education/Academic qualification

Chemistry (Toxicology), PhD, Kumaun University, Nainital, India

… → 1984

Chemistry, MS, Kumaun University, Nainital, India

… → 1975

Zoology, Botany, Chemistry, BS, Agra University, Agra, India

… → 1973

Research Strategic Pillar Keywords

  • Specialized Health

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