Bing Tian, PhD

  • 2384 Citations
  • 26 h-Index
19992020

Research output per year

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Research Output

2020

Bisphenol A Activates an Innate Viral Immune Response Pathway

Sowers, M. L., Tang, H., Tian, B., Goldblum, R., Midoro-Horiuti, T. & Zhang, K., Feb 7 2020, In : Journal of Proteome Research. 19, 2, p. 644-654 11 p.

Research output: Contribution to journalArticle

Discovery of Orally Bioavailable Chromone Derivatives as Potent and Selective BRD4 Inhibitors: Scaffold Hopping, Optimization, and Pharmacological Evaluation

Liu, Z., Chen, H., Wang, P., Li, Y., Wold, E. A., Leonard, P. G., Joseph, S., Brasier, A., Tian, B., Tian, B., Zhou, J., Zhou, J. & Zhou, J., May 28 2020, In : Journal of medicinal chemistry. 63, 10, p. 5242-5256 15 p.

Research output: Contribution to journalArticle

Peli1 signaling blockade attenuates congenital zika syndrome

Luo, H., Li, G., Wang, B., Tian, B., Gao, J., Zou, J., Shi, S., Zhu, S., Peng, B. H., Adam, A., Martinez, A., Hein, K., Winkelmann, E. R., Mahmoud, Y., Zhou, X., Shan, C., Rossi, S., Weaver, S., Barrett, A. D. T., Sun, S. C. & 4 others, Zhang, W., Shi, P. Y., Wu, P. & Wang, T., Jun 1 2020, In : PLoS pathogens. 16, 6, p. e1008538

Research output: Contribution to journalArticle

Open Access
2019

Efficacy of novel highly specific bromodomain-containing protein 4 inhibitors in innate inflammation–driven airway remodeling

Tian, B., Liu, Z., Litvinov, J., Maroto, R., Jamaluddin, M., Rytting, E., Patrikeev, I., Ochoa, L., Vargas, G., Motamedi, M., Ameredes, B. T., Zhou, J. & Brasier, A. R., Jan 2019, In : American journal of respiratory cell and molecular biology. 60, 1, p. 68-83 16 p.

Research output: Contribution to journalArticle

8 Scopus citations

Mucosal bromodomain-containing protein 4 mediates aeroallergen-induced inflammation and remodeling

Tian, B., Hosoki, K., Liu, Z., Yang, J., Zhao, Y., Sun, H., Zhou, J., Rytting, E., Kaphalia, L., Calhoun, W. J., Sur, S. & Brasier, A. R., Apr 2019, In : Journal of Allergy and Clinical Immunology. 143, 4, p. 1380-1394.e9

Research output: Contribution to journalArticle

8 Scopus citations

Pharmacoproteomics reveal novel protective activity of bromodomain containing 4 inhibitors on vascular homeostasis in TLR3-mediated airway remodeling

Zhao, Y., Tian, B., Sun, H., Zhang, J., Zhang, Y., Ivannikov, M., Motamedi, M., Liu, Z., Zhou, J., Kaphalia, L., Calhoun, W. J., Maroto, R. & Brasier, A. R., Aug 15 2019, In : Journal of Proteomics. 205, 103415.

Research output: Contribution to journalArticle

4 Scopus citations

Structure-guided drug design identifies a BRD4-selective small molecule that suppresses HIV

Niu, Q., Liu, Z., Alamer, E., Fan, X., Chen, H., Endsley, J., Gelman, B. B., Tian, B., Kim, J. H., Michael, N. L., Robb, M. L., Ananworanich, J., Zhou, J. & Hu, H., Aug 1 2019, In : Journal of Clinical Investigation. 129, 8, p. 3361-3373 13 p.

Research output: Contribution to journalArticle

Open Access
7 Scopus citations
2018

Central role of the NF-κB pathway in the Scgb1a1-expressing epithelium in mediating respiratory syncytial virus-induced airway inflammation

Tian, B., Yang, J., Zhao, Y., Ivanciuc, T., Sun, H., Wakamiya, M., Garofalo, R. & Brasier, A. R., Jun 1 2018, In : Journal of Virology. 92, 11, e00441-18.

Research output: Contribution to journalArticle

10 Scopus citations

Discovery of potent and selective BRD4 inhibitors capable of blocking TLR3-induced acute airway inflammation

Liu, Z., Tian, B., Chen, H., Wang, P., Brasier, A. & Zhou, J., May 10 2018, In : European Journal of Medicinal Chemistry. 151, p. 450-461 12 p.

Research output: Contribution to journalArticle

16 Scopus citations

Imaging of Murine Whole Lung Fibrosis by Large Scale 3D Microscopy aided by Tissue Optical Clearing

Ochoa, L. F., Kholodnykh, A., Villarreal, P., Tian, B., Pal, R., Freiberg, A. N., Brasier, A. R., Motamedi, M. & Vargas, G., Dec 1 2018, In : Scientific reports. 8, 1, 13348.

Research output: Contribution to journalArticle

5 Scopus citations

Repetitive TLR3 activation in the lung induces skeletal muscle adaptations and cachexia

Graber, T., Rawls, B. L., Tian, B., Durham, W. J., Brightwell, C. R., Brasier, A. R., Rasmussen, B. & Fry, C., Jun 1 2018, In : Experimental Gerontology. 106, p. 88-100 13 p.

Research output: Contribution to journalArticle

3 Scopus citations

Selective Antagonists of the Bronchiolar Epithelial NF-κB-Bromodomain-Containing Protein 4 Pathway in Viral-Induced Airway Inflammation

Tian, B., Liu, Z., Yang, J., Sun, H., Zhao, Y., Wakamiya, M., Chen, H., Rytting, E., Zhou, J. & Brasier, A. R., Apr 24 2018, In : Cell Reports. 23, 4, p. 1138-1151 14 p.

Research output: Contribution to journalArticle

13 Scopus citations

The NFκB subunit RELA is a master transcriptional regulator of the committed epithelial-mesenchymal transition in airway epithelial cells

Tian, B., Widen, S. G., Yang, J., Wood, T. G., Kudlicki, A., Zhao, Y. & Brasier, A. R., Oct 19 2018, In : Journal of Biological Chemistry. 293, 42, p. 16528-16545 18 p.

Research output: Contribution to journalArticle

9 Scopus citations
2017

BRD4 couples NF-κB/RelA with airway inflammation and the IRF-RIG-I amplification loop in respiratory syncytial virus infection

Tian, B., Yang, J., Zhao, Y., Ivanciuc, T., Sun, H., Garofalo, R. & Brasier, A. R., 2017, In : Journal of Virology. 91, 6, e00007-17.

Research output: Contribution to journalArticle

24 Scopus citations

Drug Discovery Targeting Bromodomain-Containing Protein 4

Liu, Z., Wang, P., Chen, H., Wold, E. A., Tian, B., Brasier, A. R. & Zhou, J., Jun 8 2017, In : Journal of Medicinal Chemistry. 60, 11, p. 4533-4558 26 p.

Research output: Contribution to journalReview article

83 Scopus citations
11 Scopus citations

NF-κB mediates mesenchymal transition, remodeling, and pulmonary fibrosis in response to chronic inflammation by viral RNA patterns

Tian, B., Patrikeev, I., Ochoa, L., Vargas, G., Belanger, K. A. K., Litvinov, J., Boldogh, I., Ameredes, B., Motamedi, M. & Brasier, A. R., Apr 1 2017, In : American Journal of Respiratory Cell and Molecular Biology. 56, 4, p. 506-520 15 p.

Research output: Contribution to journalArticle

18 Scopus citations

Proteome analysis of hypoxic glioblastoma cells reveals sequential metabolic adaptation of one-carbon metabolic pathways

Zhang, K., Xu, P., Sowers, J. L., Machuca, D. F., Mirfattah, B., Herring, J., Tang, H., Chen, Y., Tian, B., Brasier, A. R. & Sowers, L., Nov 1 2017, In : Molecular and Cellular Proteomics. 16, 11, p. 1906-1921 16 p.

Research output: Contribution to journalArticle

5 Scopus citations
2016
32 Scopus citations

Integrative proteomic analysis reveals reprograming tumor necrosis factor signaling in epithelial mesenchymal transition

Zhao, Y., Tian, B., Sadygov, R., Zhang, Y. & Brasier, A. R., Oct 4 2016, In : Journal of Proteomics. 148, p. 126-138 13 p.

Research output: Contribution to journalArticle

13 Scopus citations
3 Scopus citations

Targeting Chromatin Remodeling in Inflammation and Fibrosis

Yang, J., Tian, B. & Brasier, A. R., 2016, (Accepted/In press) In : Advances in Protein Chemistry and Structural Biology.

Research output: Contribution to journalArticle

8 Scopus citations
2015

Analysis of the TGFβ-induced program in primary airway epithelial cells shows essential role of NF-ΚB/RelA signaling network in type II epithelial mesenchymal transition

Tian, B., Li, X., Kalita, M., Widen, S., Yang, J., Bhavnani, S., Dang, B., Kudlicki, A., Sinha, M., Kong, F., Wood, T., Luxon, B. A. & Brasier, A. R., Jul 18 2015, In : BMC Genomics. 16, 1, 529.

Research output: Contribution to journalArticle

39 Scopus citations

Ataxia telangiectasia mutated kinase mediates NF-κB serine 276 phosphorylation and interferon expression via the IRF7-RIG-I amplification loop in paramyxovirus infection

Fang, L., Choudhary, S., Tian, B., Boldogh, I., Yang, C., Ivanciuc, T., Ma, Y., Garofalo, R. P. & Brasier, A. R., Jan 1 2015, In : Journal of virology. 89, 5, p. 2628-2642 15 p.

Research output: Contribution to journalArticle

18 Scopus citations

A West Nile virus NS4B-P38G mutant strain induces cell intrinsic innate cytokine responses in human monocytic and macrophage cells

Xie, G., Luo, H., Tian, B., Mann, B., Bao, X., McBride, J., Tesh, R., Barrett, A. D. & Wang, T., Feb 11 2015, In : Vaccine. 33, 7, p. 869-878 10 p.

Research output: Contribution to journalArticle

4 Scopus citations

Mixed-effects model of epithelial-mesenchymal transition reveals rewiring of signaling networks

Desai, P., Yang, J., Tian, B., Sun, H., Kalita, M., Ju, H., Paulucci-Holthauzen, A., Zhao, Y., Brasier, A. R. & Sadygov, R. G., Jul 1 2015, In : Cellular Signalling. 27, 7, p. 1413-1425 13 p.

Research output: Contribution to journalArticle

16 Scopus citations

Respiratory syncytial virus infection down-regulates antioxidant enzyme expression by triggering deacetylation-proteasomal degradation of Nrf2

Komaravelli, N., Tian, B., Ivanciuc, T., Mautemps, N., Brasier, A. R., Garofalo, R. & Casola, A., 2015, In : Free Radical Biology and Medicine. 88, Part B, p. 391-403 13 p.

Research output: Contribution to journalArticle

30 Scopus citations

Systematic determination of human cyclin dependent kinase (CDK)-9 interactome identifies novel functions in RNA splicing mediated by the DEAD Box (DDX)-5/17 RNA helicases

Yang, J., Zhao, Y., Kalita, M., Li, X., Jamaluddin, M., Tian, B., Edeh, C. B., Wiktorowicz, J. E., Kudlicki, A. & Brasier, A. R., Oct 1 2015, In : Molecular and Cellular Proteomics. 14, 10, p. 2701-2721 21 p.

Research output: Contribution to journalArticle

18 Scopus citations

Whole transcriptome analysis reveals a role for OGG1-initiated DNA repair signaling in airway remodeling

Aguilera-Aguirre, L., Hosoki, K., Bacsi, A., Radák, Z., Sur, S., Hegde, M. L., Tian, B., Saavedra-Molina, A., Brasier, A. R., Ba, X. & Boldogh, I., Dec 1 2015, In : Free Radical Biology and Medicine. 89, p. 20-33 14 p.

Research output: Contribution to journalArticle

21 Scopus citations
2014

Dynamic cross talk model of the epithelial innate immune response to double-stranded RNA stimulation: Coordinated dynamics emerging from cell-level noise

Bertolusso, R., Tian, B., Zhao, Y., Vergara, L., Sabree, A., Iwanaszko, M., Lipniacki, T., Brasier, A. R. & Kimmel, M., Apr 7 2014, In : PloS one. 9, 4, e93396.

Research output: Contribution to journalArticle

22 Scopus citations

Modulation of gene expression regulated by the transcription factor nf-κb/rela

Li, X., Zhao, Y., Tian, B., Jamaluddin, M., Mitra, A., Yang, J., Rowicka, M., Brasier, A. R. & Kudlicki, A., Apr 25 2014, In : Journal of Biological Chemistry. 289, 17, p. 11927-11944 18 p.

Research output: Contribution to journalArticle

20 Scopus citations

RIG-I enhanced interferon independent apoptosis upon Junin virus infection

Kolokoltsova, O. A., Grant, A. M., Huang, C., Smith, J. K., Poussard, A. L., Tian, B., Brasier, A. R., Peters, C. J., Tseng, C. T. K., De La Torre, J. C. & Paessler, S., Jun 11 2014, In : PloS one. 9, 6, e99610.

Research output: Contribution to journalArticle

14 Scopus citations

Systems biology approaches to understanding epithelial mesenchymal transition (EMT) in mucosal remodeling and signaling in asthma

Ijaz, T., Pazdrak, K., Kalita, M., Konig, R., Choudhary, S., Tian, B., Boldogh, I. & Brasier, A. R., Jun 2 2014, In : World Allergy Organization Journal. 7, 1, 13.

Research output: Contribution to journalReview article

47 Scopus citations
2013

CDK9-dependent transcriptional elongation in the innate interferon-stimulated gene response to respiratory syncytial virus infection in airway epithelial cells

Tian, B., Zhao, Y., Kalita, M., Edeh, C. B., Paessler, S., Casola, A., Teng, M. N., Garofalo, R. P. & Brasier, A. R., Jun 1 2013, In : Journal of virology. 87, 12, p. 7075-7092 18 p.

Research output: Contribution to journalArticle

39 Scopus citations

Inducible Tumor Necrosis Factor (TNF) receptor-associated factor-1 expression couples the canonical to the non-canonical NF-κB pathway in TNF stimulation

Choudhary, S., Kalita, M., Fang, L., Patel, K. V., Tian, B., Zhao, Y., Edeh, C. B. & Brasier, A. R., May 17 2013, In : Journal of Biological Chemistry. 288, 20, p. 14612-14623 12 p.

Research output: Contribution to journalArticle

27 Scopus citations

Quantitation of the dynamic profiles of the innate immune response using multiplex selected reaction monitoring-mass spectrometry

Zhao, Y., Tian, B., Edeh, C. B. & Brasier, A. R., Jun 1 2013, In : Molecular and Cellular Proteomics. 12, 6, p. 1513-1529 17 p.

Research output: Contribution to journalArticle

29 Scopus citations

Systems approaches to modeling chronic mucosal inflammation

Kalita, M., Tian, B., Gao, B., Choudhary, S., Wood, T. G., Carmical, J. R., Boldogh, I., Mitra, S., Minna, J. D. & Brasier, A. R., Nov 18 2013, In : BioMed Research International. 2013, 505864.

Research output: Contribution to journalArticle

27 Scopus citations
2012

Junín virus infection activates the type I interferon pathway in a RIG-I-dependent manner

Huang, C., Kolokoltsova, O. A., Yun, N. E., Seregin, A. V., Poussard, A. L., Walker, A. G., Brasier, A. R., Zhao, Y., Tian, B., de la Torre, J. C. & Paessler, S., May 2012, In : PLoS neglected tropical diseases. 6, 5, e1659.

Research output: Contribution to journalArticle

40 Scopus citations

Two-step cross-linking for analysis of protein-chromatin interactions

Tian, B., Yang, J. & Brasier, A. R., Jan 2 2012, Transcriptional Regulation: Methods and Protocols. Vancura, A. (ed.). p. 105-120 16 p. (Methods in Molecular Biology; vol. 809).

Research output: Chapter in Book/Report/Conference proceedingChapter

57 Scopus citations
2011

High throughput short interfering RNA (siRNA) screening of the human kinome identifies novel kinases controlling the canonical nuclear factor-κB (NF-κB) activation pathway

Choudhary, S., Rosenblatt, K. P., Fang, L., Tian, B., Wu, Z. H. & Brasier, A. R., Oct 28 2011, In : Journal of Biological Chemistry. 286, 43, p. 37187-37195 9 p.

Research output: Contribution to journalArticle

19 Scopus citations
36 Scopus citations

RelA Ser276 phosphorylation-coupled Lys310 acetylation controls transcriptional elongation of inflammatory cytokines in respiratory syncytial virus infection

Brasier, A. R., Tian, B., Jamaluddin, M., Kalita, M. K., Garofalo, R. P. & Lu, M., Nov 1 2011, In : Journal of virology. 85, 22, p. 11752-11769 18 p.

Research output: Contribution to journalArticle

60 Scopus citations

Sources of cell-to-cell variability in canonical nuclear factor-κB (NF-κB) signaling pathway inferred from single cell dynamic images

Kalita, M. K., Sargsyan, K., Tian, B., Paulucci-Holthauzen, A., Najm, H. N., Debusschere, B. J. & Brasier, A. R., Oct 28 2011, In : Journal of Biological Chemistry. 286, 43, p. 37741-37757 17 p.

Research output: Contribution to journalArticle

34 Scopus citations
2010

IKKε modulates RSV-induced NF-?B-dependent gene transcription

Bao, X., Indukuri, H., Liu, T., Liao, S. L., Tian, B., Brasier, A. R., Garofalo, R. P. & Casola, A., Dec 20 2010, In : Virology. 408, 2, p. 224-231 8 p.

Research output: Contribution to journalArticle

16 Scopus citations
2009

Expression of an IKKγ Splice Variant Determines IRF3 and Canonical NF-κB Pathway Utilization in ssRNA Virus Infection

Liu, P., Lu, M., Tian, B., Li, K., Garofalo, R. P., Prusak, D., Wood, T. G. & Brasier, A. R., Dec 1 2009, In : PloS one. 4, 11, e0008079.

Research output: Contribution to journalArticle

20 Scopus citations

Respiratory syncytial virus infection induces a reactive oxygen species-MSK1-phospho-Ser-276 RelA pathway required for cytokine expression

Jamaluddin, M., Tian, B., Boldogh, I., Garofalo, R. P. & Brasier, A. R., Oct 1 2009, In : Journal of virology. 83, 20, p. 10605-10615 11 p.

Research output: Contribution to journalArticle

64 Scopus citations

Signaling pathways in the host cell response to RSV infection

Brasier, A. R., Liu, P., Tian, B. & Choudhary, S., Jan 1 2009, RNA Viruses: Host Gene Responses to Infections. World Scientific Publishing Co., p. 157-184 28 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations
2008

RelA Ser276 phosphorylation is required for activation of a subset of NF-κB-dependent genes by recruiting cyclin-dependent kinase 9/cyclin t1 complexes

Nowak, D. E., Tian, B., Jamaluddin, M., Boldogh, I., Vergara, L. A., Choudhary, S. & Brasier, A. R., Jun 1 2008, In : Molecular and cellular biology. 28, 11, p. 3623-3638 16 p.

Research output: Contribution to journalArticle

121 Scopus citations
2007

Hyperspectral confocal fluorescence imaging of cells

Haaland, D. M., Jones, H. D. T., Sinclair, M. B., Carson, B., Branda, C., Poschet, J. F., Rebeil, R., Tian, B., Liu, P. & Brasier, A. R., Dec 1 2007, Next-Generation Spectroscopic Technologies. 676509. (Proceedings of SPIE - The International Society for Optical Engineering; vol. 6765).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

6 Scopus citations