Cornelis "Kees" Elferink, PhD

Director, Sealy Center for Environmental Health & Medicine

  • 1824 Citations
  • 24 h-Index
1987 …2019

Research output per year

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Research Output

  • 1824 Citations
  • 24 h-Index
  • 40 Article
  • 2 Comment/debate
  • 2 Review article
  • 1 Short survey
2019

Distribution of petrogenic polycyclic aromatic hydrocarbons (PAHs) in seafood following Deepwater Horizon oil spill

Fernando, H., Ju, H., Kakumanu, R., Bhopale, K. K., Croisant, S., Elferink, C., Kaphalia, B. & Ansari, G., Aug 1 2019, In : Marine Pollution Bulletin. 145, p. 200-207 8 p.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

Using Precision Environmental Health Principles in Risk Evaluation and Communication of the Deepwater Horizon Oil Spill

Jackson, D., Huang, M., Fernando, H., Ansari, G., Howarth, M., Mesaros, C., Penning, T. & Elferink, C., Feb 1 2019, In : New Solutions. 28, 4, p. 599-616 18 p.

Research output: Contribution to journalArticle

1 Scopus citations
2018

Building and Maintaining a Citizen Science Network With Fishermen and Fishing Communities Post Deepwater Horizon Oil Disaster Using a CBPR Approach

Center for Environmental & Economic Justice, Alabama Fisheries Cooperative, Louisiana Environmental Action Network, United Houma Nation, Bayou Interfaith Shared Community Organizing & Dustin Nguyen-Vietnamese Community Partner, Nov 1 2018, In : New Solutions. 28, 3, p. 416-447 32 p.

Research output: Contribution to journalArticle

10 Scopus citations

Implications of the GC-HARMS Fishermen’s Citizen Science Network: Issues Raised, Lessons Learned, and Next Steps for the Network and Citizen Science

Sullivan, J., Croisant, S., Howarth, M., Subra, W., Orr, M. & Elferink, C., Jan 1 2018, (Accepted/In press) In : New Solutions.

Research output: Contribution to journalArticle

1 Scopus citations
2017

Canonical and non-canonical aryl hydrocarbon receptor signaling pathways

Wright, E. J., Pereira De Castro, K., Joshi, A. D. & Elferink, C. J., Jan 1 2017, In : Current Opinion in Toxicology. 2, p. 87-92 6 p.

Research output: Contribution to journalReview article

14 Scopus citations
3 Scopus citations

The gulf coast health Alliance: health risks related to the macondo spill (GC-HARMS) study: Self-reported health effects

Croisant, S. A., Lin, Y. L., Shearer, J. J., Prochaska, J., Phillips-Savoy, A., Gee, J., Jackson, D., Panettieri, R. A., Howarth, M., Sullivan, J., Black, B. J., Tate, J., Nguyen, D., Anthony, A., Khan, A., Fernando, H., Shakeel Ansari, G. A., Rowe, G., Howrey, B., Singleton, C. & 1 others, Elferink, C., Nov 2017, In : International Journal of Environmental Research and Public Health. 14, 11, 1328.

Research output: Contribution to journalArticle

5 Scopus citations
2016

The MET Receptor Tyrosine Kinase Confers Repair of Murine Pancreatic Acinar Cells following Acute and Chronic Injury

Gaziova, I., Jackson, D., Boor, P. J., Carter, D., Cruz-Monserrate, Z., Elferink, C. J., Joshi, A. D., Kaphalia, B., Logsdon, C. D., De Castro, K. P., Soong, L., Tao, X., Qiu, S. & Elferink, L. A., Oct 1 2016, In : PLoS One. 11, 10, 0165485.

Research output: Contribution to journalArticle

1 Scopus citations
2015

Ah receptor pathway intricacies; signaling through diverse protein partners and DNA-motifs

Jackson, D. P., Joshi, A. D. & Elferink, C. J., Feb 18 2015, In : Toxicology Research. 4, 5, p. 1143-1158 16 p.

Research output: Contribution to journalArticle

23 Scopus citations
12 Scopus citations

Homocitrullination is a novel histone H1 epigenetic mark dependent on aryl hydrocarbon receptor recruitment of carbamoyl phosphate synthase

Joshi, A. D., Mustafa, M. G., Lichti, C. F. & Elferink, C. J., Nov 13 2015, In : Journal of Biological Chemistry. 290, 46, p. 27767-27778 12 p.

Research output: Contribution to journalArticle

10 Scopus citations

Targeted proteomics for biomarker discovery and validation of hepatocellular carcinoma in hepatitis C infected patients

Mustafa, G. M., Denner, L., Petersen, J. R. & Elferink, C., 2015, In : World Journal of Hepatology. 7, 10, p. 1312-1324 13 p.

Research output: Contribution to journalArticle

14 Scopus citations
2014

Ah receptor-mediated suppression of liver regeneration through NC-XRE-driven p21Cip1 expression

Jackson, D. P., Li, H., Mitchell, K. A., Joshi, A. D. & Elferink, C. J., Apr 1 2014, In : Molecular pharmacology. 85, 4, p. 533-541 9 p.

Research output: Contribution to journalArticle

25 Scopus citations

Evaluation of polycyclic aromatic hydrocarbons using analytical methods, toxicology, and risk assessment research: Seafood safety after a petroleum spill as an example

Wickliffe, J., Overton, E., Frickel, S., Howard, J., Wilson, M., Simon, B., Echsner, S., Nguyen, D., Gauthe, D., Blake, D., Miller, C., Elferink, C., Ansari, S., Fernando, H., Trapido, E. & Kane, A., Jan 1 2014, In : Environmental health perspectives. 122, 1, p. 6-9 4 p.

Research output: Contribution to journalComment/debate

32 Scopus citations
2013

Biomarker discovery for early detection of hepatocellular carcinoma in hepatitis C-Infected patients

Mustafa, M. G., Petersen, J. R., Ju, H., Cicalese, L., Snyder, N., Haidacher, S. J., Denner, L. & Elferink, C., Dec 1 2013, In : Molecular and Cellular Proteomics. 12, 12, p. 3640-3652 13 p.

Research output: Contribution to journalArticle

31 Scopus citations

Identification of stanniocalcin 2 as a novel aryl hydrocarbon receptor target genes

Harper, T. A., Joshi, A. D. & Elferink, C. J., Mar 1 2013, In : Journal of Pharmacology and Experimental Therapeutics. 344, 3, p. 579-588 10 p.

Research output: Contribution to journalArticle

15 Scopus citations
39 Scopus citations
2012

A novel nonconsensus xenobiotic response element capable of mediating aryl hydrocarbon receptor-dependent gene expression

Huang, G. & Elferink, C. J., Mar 1 2012, In : Molecular pharmacology. 81, 3, p. 338-347 10 p.

Research output: Contribution to journalArticle

57 Scopus citations
2010

The activated aryl hydrocarbon receptor synergizes mitogen-induced murine liver hyperplasia

Mitchell, K. A., Wilson, S. R. & Elferink, C. J., Oct 1 2010, In : Toxicology. 276, 2, p. 103-109 7 p.

Research output: Contribution to journalArticle

10 Scopus citations
2009

Timing is everything: Consequences of transient and sustained AhR activity

Mitchell, K. A. & Elferink, C. J., Mar 15 2009, In : Biochemical Pharmacology. 77, 6, p. 947-956 10 p.

Research output: Contribution to journalComment/debate

70 Scopus citations
2006

Requirement of biphasic calcium release from the endoplasmic reticulum for Fas-mediated apoptosis

Wozniak, A. L., Wang, X., Stieren, E. S., Scarbrough, S. G., Elferink, C. J. & Boehning, D., Dec 2006, In : Journal of Cell Biology. 175, 5, p. 709-714 6 p.

Research output: Contribution to journalArticle

56 Scopus citations

Scanning cytometry with a LEAP: Laser-enabled analysis and processing of live cells in situ

Szaniszlo, P., Rose, W. A., Wang, N., Reece, L. M., Tsulaia, T. V., Hanania, E. G., Elferink, C. J. & Leary, J. F., Jul 1 2006, In : Cytometry Part A. 69, 7, p. 641-651 11 p.

Research output: Contribution to journalArticle

21 Scopus citations

Sustained aryl hydrocarbon receptor activity attenuates liver regeneration

Mitchell, K. A., Lockhart, C. A., Huang, G. & Elferink, C. J., Jun 27 2006, In : Molecular pharmacology. 70, 1, p. 163-170 8 p.

Research output: Contribution to journalArticle

60 Scopus citations
2005

Multiple mechanisms are involved in Ah receptor-mediated cell cycle arrest

Huang, G. & Elferink, C. J., Jan 1 2005, In : Molecular pharmacology. 67, 1, p. 88-96 9 p.

Research output: Contribution to journalArticle

81 Scopus citations

The aryl hydrocarbon receptor predisposes hepatocytes to Fas-mediated apoptosis

Park, K. T., Mitchell, K. A., Huang, G. & Elferink, C. J., Mar 2005, In : Molecular pharmacology. 67, 3, p. 612-622 11 p.

Research output: Contribution to journalArticle

48 Scopus citations
2004

Cytochrome P4501A1 Promotes G1 Phase Cell Cycle Progression by Controlling Aryl Hydrocarbon Receptor Activity

Levine-Fridman, A., Chen, L. & Elferink, C. J., Feb 1 2004, In : Molecular pharmacology. 65, 2, p. 461-469 9 p.

Research output: Contribution to journalArticle

71 Scopus citations
2003

Aryl hydrocarbon receptor-mediated cell cycle control.

Elferink, C. J., 2003, In : Progress in cell cycle research. 5, p. 261-267 7 p.

Research output: Contribution to journalReview article

52 Scopus citations
2002

Role of the aryl hydrocarbon receptor in cell cycle regulation

Puga, A., Xia, Y. & Elferink, C., Sep 20 2002, In : Chemico-Biological Interactions. 141, 1-2, p. 117-130 14 p.

Research output: Contribution to journalArticle

131 Scopus citations
2001

Maximal aryl hydrocarbon receptor activity depends on an interaction with the retinoblastoma protein

Elferink, C. J., Ge, N. L. & Levine, A., Jan 1 2001, In : Molecular pharmacology. 59, 4, p. 664-673 10 p.

Research output: Contribution to journalArticle

101 Scopus citations

Molecular regulation of genes encoding xenobiotic-metabolizing enzymes: Mechanisms involving endogenous factors

Hines, R. N., Luo, Z., Cresteil, T., Ding, X., Prough, R. A., Fitzpatrick, J. L., Ripp, S. L., Falkner, K. C., Ge, N. L., Levine, A. & Elferink, C. J., May 7 2001, In : Drug Metabolism and Disposition. 29, 5, p. 623-633 11 p.

Research output: Contribution to journalShort survey

24 Scopus citations

Progressive resistance to apoptosis in a cell lineage model of human proliferative breast disease

Starcevic, S. L., Elferink, C. & Novak, R. F., May 16 2001, In : Journal of the National Cancer Institute. 93, 10, p. 776-782 7 p.

Research output: Contribution to journalArticle

Open Access
25 Scopus citations

Regulation of Cyp1a1 induction by dioxin as a function of cell cycle phase

Santini, R. P., Myrand, S., Elferink, C. & Reiners, J. J., Oct 30 2001, In : Journal of Pharmacology and Experimental Therapeutics. 299, 2, p. 718-728 11 p.

Research output: Contribution to journalArticle

36 Scopus citations
1998
211 Scopus citations
1997

Downregulation of aryl hydrocarbon receptor function and cytochrome p450 1A1 induction by expression of Ha-ras oncogenes

Reiners, J. J., Jones, C. L., Hong, N., Clift, R. E. & Elferink, C., Jul 28 1997, In : Molecular Carcinogenesis. 19, 2, p. 91-100 10 p.

Research output: Contribution to journalArticle

42 Scopus citations
1996

Quantitative RT-PCR on CYP1A1 heterogeneous nuclear RNA: A surrogate for the in vitro transcription run-on assay

Elferink, C. J. & Reiners, J. J., Mar 1 1996, In : BioTechniques. 20, 3, p. 470-477 8 p.

Research output: Contribution to journalArticle

134 Scopus citations
1994

Dioxin-dependent, DNA sequence-specific binding of a multiprotein complex containing the Ah receptor.

Elferink, C. J. & Whitlock, J. P., Jan 1 1994, In : Receptor. 4, 3, p. 157-173 17 p.

Research output: Contribution to journalArticle

30 Scopus citations
1991

2,3,7,8-tetrachlorodibenzo-P-dioxin induces cytochrome P450IA1 enzyme activity by activating transcription of the corresponding gene

Lusska, A. E., Jones, K. W., Elferink, C. J., Wu, L., Shen, E. S., Wen, L. P. & Whitlock, J. P., 1991, In : Advances in Enzyme Regulation. 31, C, p. 307-317 11 p.

Research output: Contribution to journalArticle

4 Scopus citations

Characterization of Multiple Forms of the Ah Receptor: Recognition of a Dioxin-Responsive Enhancer Involves Heteromer Formation

Gasiewicz, T. A., Elferink, C. J. & Henry, E. C., Mar 1 1991, In : Biochemistry. 30, 11, p. 2909-2916 8 p.

Research output: Contribution to journalArticle

50 Scopus citations

Use of gel retardation to analyze protein-DNA interactions upstream of CYPIA1 gene

Shen, E. S., Elferink, C. J. & Whitlock, J. P., Jan 1 1991, In : Methods in enzymology. 206, C, p. 403-408 6 p.

Research output: Contribution to journalArticle

14 Scopus citations
1990

2,3,7,8-Tetrachlorodibenzo-p-dioxin-inducible, Ah receptor-mediated bending of enhancer DNA

Elferink, C. J. & Whitlock, J. P., Apr 25 1990, In : Journal of Biological Chemistry. 265, 10, p. 5718-5721 4 p.

Research output: Contribution to journalArticle

49 Scopus citations

Protein-DNA interactions at a dioxin-responsive enhancer. Evidence that the transformed Ah receptor is heteromeric

Elferink, C. J., Gasiewicz, T. A. & Whitlock, J. P., Dec 18 1990, In : Journal of Biological Chemistry. 265, 33, p. 20708-20712 5 p.

Research output: Contribution to journalArticle

92 Scopus citations
1988

Regulation of 5-aminolevulinate synthase in mouse erythroleukemia cells is different from that in liver

Elferink, C. J., Sassa, S. & May, B. K., Jan 1 1988, In : Journal of Biological Chemistry. 263, 26, p. 13012-13016 5 p.

Research output: Contribution to journalArticle

20 Scopus citations

Regulation of 5-aminolevulinate synthase mRNA in different rat tissues

Srivastava, G., Borthwick, I. A., Maguire, D. J., Elferink, C. J., Bawden, M. J., Mercer, J. F. B. & May, B. K., Jan 1 1988, In : Journal of Biological Chemistry. 263, 11, p. 5202-5209 8 p.

Research output: Contribution to journalArticle

82 Scopus citations
1987

A unique gene for 5-aminolevulinate synthase in chickens. Evidence for expression of an identical messenger RNA in hepatic and erythroid tissues.

Elferink, C. J., Srivastava, G., Maguire, D. J., Borthwick, I. A., May, B. K. & Elliott, W. H., Mar 25 1987, In : Journal of Biological Chemistry. 262, 9, p. 3988-3992 5 p.

Research output: Contribution to journalArticle

13 Scopus citations