Courtney Townsend, MD

  • 12132 Citations
  • 57 h-Index
1961 …2019

Research output per year

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Research Output

2019

Kinase suppressor of Ras 1 and Exo70 promote fatty acid-stimulated neurotensin secretion through ERK1/2 signaling

Rock, S., Li, X., Song, J., Townsend, C. M., Weiss, H. L., Rychahou, P., Gao, T., Li, J. & Mark Evers, B., Mar 2019, In : PloS one. 14, 3, e0211134.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations
2018

FFAR4 is involved in regulation of neurotensin release from neuroendocrine cells and male C57BL/6 mice

Li, J., Song, J., Li, X., Rock, S. B., Sinner, H. F., Weiss, H. L., Weiss, T., Townsend, C., Gao, T. & Evers, B. M., Aug 1 2018, In : Endocrinology. 159, 8, p. 2939-2952 14 p.

Research output: Contribution to journalArticle

4 Scopus citations

Neurotensin Receptor 3/Sortilin Contributes to Tumorigenesis of Neuroendocrine Tumors Through Augmentation of Cell Adhesion and Migration

Kim, J. T., Napier, D. L., Weiss, H. L., Lee, E. Y., Townsend, C. M. & Evers, B. M., Feb 2018, In : Neoplasia (United States). 20, 2, p. 175-181 7 p.

Research output: Contribution to journalArticle

4 Scopus citations
2017

Hormonal effects on gastrointestinal cancer growth

Townsend, C., Singh, P. & Thompson, J. C., Jan 1 2017, Growth of the Gastrointestinal Tract: Gastrointestinal Hormones and Growth Factors. CRC Press, p. 207-221 15 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

SAGES rebuttal

Jones, D. B., Hunter, J. G., Townsend, C., Minter, R. M., Roberts, P. L., Brethauer, S. & Soper, N. J., Oct 1 2017, In : Gastrointestinal Endoscopy. 86, 4, p. 751-754 4 p.

Research output: Contribution to journalLetter

4 Scopus citations
2016

Activation of AMPK stimulates neurotensin secretion in neuroendocrine cells

Li, J., Song, J., Weiss, H. L., Weiss, T., Townsend, C. & Mark Evers, B., Jan 1 2016, In : Molecular Endocrinology. 30, 1, p. 26-36 11 p.

Research output: Contribution to journalArticle

3 Scopus citations

Characterization of mentorship programs in departments of surgery in the United States

Kibbe, M. R., Pellegrini, C. A., Townsend, C., Helenowski, I. B. & Patti, M. G., Oct 1 2016, In : JAMA Surgery. 151, 10, p. 900-906 7 p.

Research output: Contribution to journalArticle

25 Scopus citations
2015

Differential expression and tumorigenic function of neurotensin receptor 1 in neuroendocrine tumor cells

Kim, J. T., Li, J., Song, J., Lee, E. Y., Weiss, H. L., Townsend, C. M. & Evers, B. M., 2015, In : Oncotarget. 6, 29, p. 26960-26970 11 p.

Research output: Contribution to journalArticle

14 Scopus citations

Neurotensin, a novel target of Wnt/β-catenin pathway, promotes growth of neuroendocrine tumor cells

Kim, J. T., Liu, C., Zaytseva, Y. Y., Weiss, H. L., Townsend, C. M. & Evers, B. M., Mar 15 2015, In : International Journal of Cancer. 136, 6, p. 1475-1481 7 p.

Research output: Contribution to journalArticle

14 Scopus citations

The risk paradox: Use of elective cholecystectomy in older patients is independent of their risk of developing complications

Riall, T. S., Adhikari, D., Parmar, A. D., Linder, S. K., Dimou, F. M., Crowell, W., Tamirisa, N. P., Townsend, C. M. & Goodwin, J. S., Apr 1 2015, In : Journal of the American College of Surgeons. 220, 4, p. 682-690 9 p.

Research output: Contribution to journalArticle

8 Scopus citations
2014

Cotargeting the PI3K and RAS pathways for the treatment of neuroendocrine tumors

Valentino, J. D., Li, J., Zaytseva, Y. Y., Mustain, W. C., Elliott, V. A., Kim, J. T., Harris, J. W., Campbell, K., Weiss, H., Wang, C., Song, J., Anthony, L., Townsend, C. M. & Evers, B. M., 2014, In : Clinical Cancer Research. 20, 5, p. 1212-1222 11 p.

Research output: Contribution to journalArticle

38 Scopus citations

Dual inhibition of PI3K and mTOR signaling pathways decreases human pancreatic neuroendocrine tumor metastatic progression

Djukom, C., Porro, L. J., Mrazek, A., Townsend, C. M., Hellmich, M. R. & Chao, C., Jan 1 2014, In : Pancreas. 43, 1, p. 88-92 5 p.

Research output: Contribution to journalArticle

13 Scopus citations
2013

Association between cholecystectomy with vs without intraoperative cholangiography and risk of common duct injury

Sheffield, K. M., Riall, T. S., Han, Y., Kuo, Y. F., Townsend, C. M. & Goodwin, J. S., Sep 2 2013, In : JAMA - Journal of the American Medical Association. 310, 8, p. 812-820 9 p.

Research output: Contribution to journalArticle

50 Scopus citations

Deregulation of Wnt/β-catenin signaling through genetic or epigenetic alterations in human neuroendocrine tumors

Kim, J. T., Li, J., Jang, E. R., Gulhati, P., Rychahou, P. G., Napier, D. L., Wang, C., Weiss, H. L., Lee, E. Y., Anthony, L., Townsend, C. M., Liu, C. & Evers, B. M., May 1 2013, In : Carcinogenesis. 34, 5, p. 953-961 9 p.

Research output: Contribution to journalArticle

48 Scopus citations

Overexpression of Evi-1 oncoprotein represses TGF-β signaling in colorectal cancer

Deng, X., Cao, Y., Liu, Y., Li, F., Sambandam, K., Rajaraman, S., Perkins, A. S., Fields, A. P., Hellmich, M. R., Townsend, C. M., Thompson, E. A. & Ko, T. C., Apr 1 2013, In : Molecular Carcinogenesis. 52, 4, p. 255-264 10 p.

Research output: Contribution to journalArticle

20 Scopus citations

PTHrP is a novel mediator for TGF-β-induced apoptosis

Cao, Y., Zhang, W., Gao, X., Zhang, G., Falzon, M., Townsend, C. M., Hellmich, M. R. & Ko, T. C., Jun 1 2013, In : Regulatory Peptides. 184, p. 40-46 7 p.

Research output: Contribution to journalArticle

6 Scopus citations

Time trends and geographic variation in use of minimally invasive breast biopsy

Zimmermann, C. J., Sheffield, K. M., Duncan, C. B., Han, Y., Cooksley, C. D., Townsend, C. M. & Riall, T. S., Apr 2013, In : Journal of the American College of Surgeons. 216, 4, p. 814-824 11 p.

Research output: Contribution to journalArticle

9 Scopus citations
2012

A proposal for enhancing the general surgical workforce and access to surgical care

Polk, H. C., Bland, K. I., Ellison, E. C., Grosfeld, J., Trunkey, D. D., Stain, S. C. & Townsend, C. M., Apr 1 2012, In : Annals of surgery. 255, 4, p. 611-617 7 p.

Research output: Contribution to journalArticle

33 Scopus citations

Pi3K p110α/Akt signaling negatively regulates secretion of the intestinal peptide neurotensin through interference of granule transport

Li, J., Song, J., Cassidy, M. G., Rychahou, P., Starr, M. E., Liu, J., Li, X., Epperly, G., Weiss, H. L., Townsend, C. M., Gao, T. & Mark Evers, B., Aug 1 2012, In : Molecular Endocrinology. 26, 8, p. 1380-1393 14 p.

Research output: Contribution to journalArticle

19 Scopus citations

Preoperative laboratory testing in patients undergoing elective, low-risk ambulatory surgery

Benarroch-Gampel, J., Sheffield, K. M., Duncan, C. B., Brown, K. M., Han, Y., Townsend, C. M. & Riall, T. S., Sep 1 2012, In : Annals of surgery. 256, 3, p. 518-528 11 p.

Research output: Contribution to journalArticle

83 Scopus citations

Variation in the use of intraoperative cholangiography during cholecystectomy

Sheffield, K. M., Han, Y., Kuo, Y. F., Townsend, C. M., Goodwin, J. S. & Riall, T. S., Apr 1 2012, In : Journal of the American College of Surgeons. 214, 4, p. 668-679 12 p.

Research output: Contribution to journalArticle

31 Scopus citations
2011

Characterization of promoter elements regulating the expression of the human neurotensin/neuromedin N gene

Wang, X., Gulhati, P., Li, J., Dobner, P. R., Weiss, H., Townsend, C. M. & Evers, B. M., Jan 7 2011, In : Journal of Biological Chemistry. 286, 1, p. 542-554 13 p.

Research output: Contribution to journalArticle

6 Scopus citations

Dietary fiber enhances TGF-β signaling and growth inhibition in the gut

Cao, Y., Gao, X., Zhang, W., Zhang, G., Nguyen, A. K., Liu, X., Jimenez, F., Cox, C. S., Townsend, C. M. & Ko, T. C., Jul 1 2011, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 301, 1, p. G156-G164

Research output: Contribution to journalArticle

21 Scopus citations

Gallstone pancreatitis in older patients: Are we operating enough?

Trust, M. D., Sheffield, K. M., Boyd, C. A., Benarroch-Gampel, J., Zhang, D., Townsend, C. M. & Riall, T. S., Sep 1 2011, In : Surgery. 150, 3, p. 515-525 11 p.

Research output: Contribution to journalArticle

39 Scopus citations

Implementation of a critical pathway for complicated gallstone disease: Translation of population-based data into clinical practice

Sheffield, K. M., Ramos, K. E., Djukom, C. D., Jimenez, C. J., Mileski, W. J., Kimbrough, T. D., Townsend, C. M. & Riall, T. S., May 1 2011, In : Journal of the American College of Surgeons. 212, 5, p. 835-843 9 p.

Research output: Contribution to journalArticle

25 Scopus citations

MTORC1 inhibition increases neurotensin secretion and gene expression through activation of the MEK/ERK/c-jun pathway in the human endocrine cell line BON

Li, J., Liu, J., Song, J., Wang, X., Weiss, H. L., Townsend, C. M., Gao, T. & Evers, B. M., Jul 1 2011, In : American Journal of Physiology - Cell Physiology. 301, 1, p. C213-C226

Research output: Contribution to journalArticle

18 Scopus citations

Overuse of ct in patients with complicated gallstone disease

Benarroch-Gampel, J., Boyd, C. A., Sheffield, K. M., Townsend, C. M. & Riall, T. S., Oct 2011, In : Journal of the American College of Surgeons. 213, 4, p. 524-530 7 p.

Research output: Contribution to journalArticle

32 Scopus citations
37 Scopus citations

The effect of PTEN on serotonin synthesis and secretion from the carcinoid cell line BON

Silva, S. R., Zaytseva, Y. Y., Jackson, L. N., Lee, E. Y., Weiss, H. L., Bowen, K. A., Townsend, C. M. & Evers, B. M., Apr 1 2011, In : Anticancer Research. 31, 4, p. 1153-1160 8 p.

Research output: Contribution to journalArticle

13 Scopus citations

VEGFR-2 expression in carcinoid cancer cells and its role in tumor growth and metastasis

Silva, S. R., Bowen, K. A., Rychahou, P. G., Jackson, L. N., Weiss, H. L., Lee, E. Y., Townsend, C. M. & Evers, B. M., Mar 1 2011, In : International Journal of Cancer. 128, 5, p. 1045-1056 12 p.

Research output: Contribution to journalArticle

48 Scopus citations
2010

Crew resource management improved perception of patient safety in the operating room

Gore, D. C., Powell, J. M., Baer, J. G., Sexton, K. H., Richardson, C. J., Marshall, D. R., Chinkes, D. L. & Townsend, C. M., Jan 1 2010, In : American Journal of Medical Quality. 25, 1, p. 60-63 4 p.

Research output: Contribution to journalArticle

38 Scopus citations

Dissecting racial disparities in the treatment of patients with locoregional pancreatic cancer: A 2-step process

Riall, T. S., Townsend, C. M., Kuo, Y. F., Freeman, J. L. & Goodwin, J. S., Feb 15 2010, In : Cancer. 116, 4, p. 930-939 10 p.

Research output: Contribution to journalArticle

43 Scopus citations
102 Scopus citations
2009

Bombesin enhances TGF-β growth inhibitory effect through apoptosis induction in intestinal epithelial cells

Liu, X., Zhao, J., Li, F., Guo, Y. S., Hellmich, M. R., Townsend, C. M., Cao, Y. & Ko, T. C., Nov 27 2009, In : Regulatory Peptides. 158, 1-3, p. 26-31 6 p.

Research output: Contribution to journalArticle

3 Scopus citations

Development and characterization of a novel in vivo model of carcinoid syndrome

Jackson, L. N., Chen, L. A., Larson, S. D., Silva, S. R., Rychahou, P. G., Boor, P., Li, J., Defreitas, G., Stafford, W. L., Townsend, C. M. & Evers, B. M., Apr 15 2009, In : Clinical Cancer Research. 15, 8, p. 2747-2755 9 p.

Research output: Contribution to journalArticle

23 Scopus citations
28 Scopus citations

Readmission after pancreatectomy for pancreatic cancer in medicare patients

Reddy, D. M., Townsend, C. M., Kuo, Y. F., Freeman, J. L., Goodwin, J. S. & Riall, T. S., Sep 17 2009, In : Journal of Gastrointestinal Surgery. 13, 11, p. 1963-1975 13 p.

Research output: Contribution to journalArticle

101 Scopus citations

Surgical Privileging and Credentialing: A Report of a Discussion and Study Group of the American Surgical Association

Bass, B. L., Polk, H. C., Jones, R. S., Townsend, C. M., Whittemore, A. D., Pellegrini, C. A., Busuttil, R. W., Lillemoe, K. D., Trunkey, D. D., Mulholland, M. W. & Grosfeld, J. L., Sep 1 2009, In : Journal of the American College of Surgeons. 209, 3, p. 396-404 9 p.

Research output: Contribution to journalArticle

28 Scopus citations

TGF-β repression of Id2 induces apoptosis in gut epithelial cells

Cao, Y., Liu, X., Zhang, W., Deng, X., Zhang, H., Liu, Y., Chen, L., Thompson, E. A., Townsend, C. M. & Ko, T. C., Feb 26 2009, In : Oncogene. 28, 8, p. 1089-1098 10 p.

Research output: Contribution to journalArticle

24 Scopus citations
2008

672 patients with acinar cell carcinoma of the pancreas: a population-based comparison to pancreatic adenocarcinoma

Wisnoski, N. C., Townsend, C. M., Nealon, W. H., Freeman, J. L. & Riall, T. S., Aug 1 2008, In : Surgery. 144, 2, p. 141-148 8 p.

Research output: Contribution to journalArticle

115 Scopus citations

Outcomes following pancreatic resection: Variability among high-volume providers

Riall, T. S., Nealon, W. H., Goodwin, J. S., Townsend, C. M. & Freeman, J. L., Aug 1 2008, In : Surgery. 144, 2, p. 133-140 8 p.

Research output: Contribution to journalArticle

54 Scopus citations

PKD1, PKD2, and their substrate Kidins220 regulate neurotensin secretion in the BON human endocrine cell line

Li, J., Andy Chen, L., Townsend, C. M. & Evers, B. M., Feb 1 2008, In : Journal of Biological Chemistry. 283, 5, p. 2614-2621 8 p.

Research output: Contribution to journalArticle

25 Scopus citations

Samuel D. Gross and the American surgical association

Townsend, C. M., Sep 1 2008, In : Annals of surgery. 248, 3, p. 351-359 9 p.

Research output: Contribution to journalArticle

4 Scopus citations

Synergistic regulation of COX-2 expression by bombesin and transforming growth factor-β

Guo, Y. S., Chen, Z., Wen, X. D., Ko, T. C., Townsend, C. M. & Hellmich, M. R., Aug 1 2008, In : Digestive Diseases and Sciences. 53, 8, p. 2045-2052 8 p.

Research output: Contribution to journalArticle

4 Scopus citations
2007

Constitutively active CCK2 receptor splice variant increases Src-dependent HIF-1α expression and tumor growth

Chao, C., Goluszko, E., Lee, Y. T., Kolokoltsov, A. A., Davey, R. A., Uchida, T., Townsend, C. M. & Hellmich, M. R., Feb 15 2007, In : Oncogene. 26, 7, p. 1013-1019 7 p.

Research output: Contribution to journalArticle

28 Scopus citations

Cyclic adenosine 5′-monophosphate-stimulated neurotensin secretion is mediated through Rap1 downstream of both Epac and protein kinase A signaling pathways

Li, J., O'Connor, K. L., Cheng, X., Mei, F. C., Uchida, T., Townsend, C. M. & Evers, B. M., Jan 1 2007, In : Molecular Endocrinology. 21, 1, p. 159-171 13 p.

Research output: Contribution to journalArticle

33 Scopus citations

Identification of apoptotic genes mediating TGF-β/Smad3-induced cell death in intestinal epithelial cells using a genomic approach

Cao, Y., Chen, L., Zhang, W., Liu, Y., Papaconstantinou, H. T., Bush, C. R., Townsend, C. M., Thompson, E. A. & Ko, T. C., Jan 1 2007, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 292, 1, p. G28-G38

Research output: Contribution to journalArticle

20 Scopus citations

Incidence of Additional Primary Cancers in Patients with Invasive Intraductal Papillary Mucinous Neoplasms and Sporadic Pancreatic Adenocarcinomas

Riall, T. S., Stager, V. M., Nealon, W. H., Townsend, C. M., Kuo, Y. F., Goodwin, J. S. & Freeman, J. L., May 1 2007, In : Journal of the American College of Surgeons. 204, 5, p. 803-813 11 p.

Research output: Contribution to journalArticle

52 Scopus citations

The health workforce: A position statement

Grosfeld, J. L., Polk, H. C., Pelligrini, C. A., Mulholland, M. W., Lillemoe, K. D., Bass, B. L., Busuttil, R. W., Kron, I. L., Jones, R. S., Townsend, C. M. & Sheldon, G. F., Oct 1 2007, In : Annals of surgery. 246, 4, p. 525-526 2 p.

Research output: Contribution to journalArticle

14 Scopus citations