Courtney Townsend, MD

  • 12061 Citations
  • 57 h-Index
1961 …2019

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2006

Overexpression of wild-type PKD2 leads to increased proliferation and invasion of BON endocrine cells

Jackson, L. N., Li, J., Chen, L. A., Townsend, C. M. & Evers, B. M., Sep 29 2006, In : Biochemical and Biophysical Research Communications. 348, 3, p. 945-949 5 p.

Research output: Contribution to journalArticle

21 Scopus citations

Pancreatic Cancer in the General Population: Improvements in Survival Over the Last Decade

Riall, T. S., Nealon, W. H., Goodwin, J. S., Zhang, D., Kuo, Y. F., Townsend, C. M. & Freeman, J. L., Nov 1 2006, In : Journal of Gastrointestinal Surgery. 10, 9, p. 1212-1224 13 p.

Research output: Contribution to journalArticle

97 Scopus citations

TGF-β inhibits Akt-induced transformation in intestinal epithelial cells

Cao, Y., Deng, C., Townsend, C. M. & Ko, T. C., Aug 1 2006, In : Surgery. 140, 2, p. 322-329 8 p.

Research output: Contribution to journalArticle

14 Scopus citations
2005

Gastrointestinal hormone receptors in primary human colorectal carcinomas

Chao, C., Tallman, M. L., Ives, K. L., Townsend, C. M. & Hellmich, M. R., Dec 2005, In : Journal of Surgical Research. 129, 2, p. 313-321 9 p.

Research output: Contribution to journalArticle

17 Scopus citations

Inhibition of mitochondrial gene transcription suppresses neurotensin secretion in the human carcinoid cell line BON

Li, N., Wang, Q., Li, J., Wang, X., Hellmich, M. R., Rajaraman, S., Greeley, G. H., Townsend, C. M. & Evers, B. M., Feb 1 2005, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 288, 2 51-2, p. G213-G220

Research output: Contribution to journalArticle

3 Scopus citations

Insulinlike growth factor-I-mediated migration and invasion of human colon carcinoma cells requires activation of c-Met and urokinase plasminogen activator receptor

Bauer, T. W., Fan, F., Liu, W., Johnson, M., Parikh, N. U., Parry, G. C., Callahan, J., Mazar, A. P., Gallick, G. E., Ellis, L. M., Cance, W. G., Slingluff, C. L., Smythe, W. R. & Townsend, C. M., May 1 2005, In : Annals of surgery. 241, 5, p. 748-758 11 p.

Research output: Contribution to journalArticle

51 Scopus citations

Long-term oncologic outcome following preoperative combined modality therapy and total mesorectal excision of locally advanced rectal cancer

Guillem, J. G., Chessin, D. B., Cohen, A. M., Shia, J., Mazumdar, M., Enker, W., Paty, P. B., Weiser, M. R., Klimstra, D., Saltz, L., Minsky, B. D., Wong, W. D., Bland, K. I., Cance, W. G., Copeland, E. M., Greene, F. L., Townsend, C. M., Merchant, N. & Cohen, A. M., May 1 2005, In : Annals of surgery. 241, 5, p. 829-838 10 p.

Research output: Contribution to journalArticle

310 Scopus citations

Myristoylated alanine-rich C kinase substrate-mediated neurotensin release via protein kinase C-δ downstream of the Rho/ROK pathway

Li, J., O'Connort, K. L., Greeley, G. H., Blackshear, P. J., Townsend, C. M. & Evers, B. M., Mar 4 2005, In : Journal of Biological Chemistry. 280, 9, p. 8351-8357 7 p.

Research output: Contribution to journalArticle

30 Scopus citations

Presidential address - Southern surgical association: Surgical science in the southern

Townsend, C. M., May 1 2005, In : Annals of surgery. 241, 5, p. 673-683 11 p.

Research output: Contribution to journalArticle

4 Scopus citations

Src regulates constitutive internalization and rapid resensitization of a cholecystokinin 2 receptor splice variant

Chao, C., Ives, K. L., Goluszko, E., Kolokoltsov, A. A., Davey, R. A., Townsend, C. M. & Hellmich, M. R., Sep 30 2005, In : Journal of Biological Chemistry. 280, 39, p. 33368-33373 6 p.

Research output: Contribution to journalArticle

15 Scopus citations

Surgical treatment of advanced-stage carcinoid tumors: Lessons learned

Boudreaux, J. P., Putty, B., Frey, D. J., Woltering, E., Anthony, L., Daly, I., Ramcharan, T., Lopera, J., Castaneda, W., Townsend, C. M., Blumgart, L. H., Martin, R. C. G. & Choti, M. A., Jun 1 2005, In : Annals of surgery. 241, 6, p. 839-846 8 p.

Research output: Contribution to journalArticle

97 Scopus citations

TGF-β signaling in colon cancer cells

Li, F., Cao, Y., Townsend, C. M. & Ko, T. C., Mar 1 2005, In : World Journal of Surgery. 29, 3, p. 306-311 6 p.

Research output: Contribution to journalArticle

42 Scopus citations

Tumor-associated down-regulation of 15-lipoxygenase-1 is reversed by celecoxib in colorectal cancer

Heslin, M. J., Hawkins, A., Boedefeld, W., Arnoletti, J. P., Frolov, A., Soong, R., Urist, M. M., Bland, K. I., Merchant, N., Chung, D. H. & Townsend, C. M., Jun 1 2005, In : Annals of surgery. 241, 6, p. 941-947 7 p.

Research output: Contribution to journalArticle

34 Scopus citations
2004

Agonist-independent activation of Src tyrosine kinase by a cholecystokinin-2 (CCK2) receptor splice variant

Olszewska-Pazdrak, B., Townsend, C. M. & Hellmich, M. R., Sep 24 2004, In : Journal of Biological Chemistry. 279, 39, p. 40400-40404 5 p.

Research output: Contribution to journalArticle

25 Scopus citations

Akt interacts directly with Smad3 to regulate the sensitivity to TGF-β-induced apoptosis

Conery, A. R., Cao, Y., Thompson, E. A., Townsend, C. M., Ko, T. C. & Luo, K., Apr 1 2004, In : Nature Cell Biology. 6, 4, p. 366-372 7 p.

Research output: Contribution to journalArticle

288 Scopus citations

Epidermal Growth Factor Potentiates Cholecystokinin/Gastrin Receptor-mediated Ca2+ Release by Activation of Mitogen-activated Protein Kinases

Olszewska-Pazdrak, B., Ives, K. L., Park, J., Townsend, C. M. & Hellmich, M. R., Jan 16 2004, In : Journal of Biological Chemistry. 279, 3, p. 1853-1860 8 p.

Research output: Contribution to journalArticle

10 Scopus citations

The role of protein kinase D in neurotensin secretion mediated by protein kinase C-α/-δ and Rho/Rho kinase

Li, J., O'Connor, K. L., Hellmich, M. R., Greeley, G. H., Townsend, C. M. & Evers, B. M., Jul 2 2004, In : Journal of Biological Chemistry. 279, 27, p. 28466-28474 9 p.

Research output: Contribution to journalArticle

39 Scopus citations
2003

Bombesin stimulates nuclear factor κB activation and expression of proangiogenic factors in prostate cancer cells

Levine, L., Lucci, J. A., Pazdrak, B., Cheng, J. Z., Guo, Y. S., Townsend, C. M. & Hellmich, M. R., Jul 1 2003, In : Cancer Research. 63, 13, p. 3495-3502 8 p.

Research output: Contribution to journalArticle

111 Scopus citations

Phosphatidylinositol 3-kinase mediates proliferative signals in intestinal epithelial cells

Sheng, H., Shao, J., Townsend, C. M. & Evers, B. M., Oct 1 2003, In : Gut. 52, 10, p. 1472-1478 7 p.

Research output: Contribution to journalArticle

99 Scopus citations
2002
85 Scopus citations

Glucocorticoids and polyamine inhibitors synergize to kill human leukemic CEM cells

Miller, A. L., Johnson, B. H., Medh, R. D., Townsend, C. M. & Brad Thompson, E., Jan 29 2002, In : Neoplasia. 4, 1, p. 68-81 14 p.

Research output: Contribution to journalArticle

16 Scopus citations

Laparoscopic hysterectomy using a computer-enhanced surgical robot

Diaz-Arrastia, C., Jurnalov, C., Gomez, G. & Townsend, C., Sep 1 2002, In : Surgical Endoscopy and Other Interventional Techniques. 16, 9, p. 1271-1273 3 p.

Research output: Contribution to journalArticle

156 Scopus citations

Phorbol ester-mediated neurotensin secretion is dependent on the PKC-α and -δ isoforms

Li, J., Hellmich, M. R., Greeley, G. H., Townsend, C. M. & Evers, B. M., Nov 1 2002, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 283, 5 46-5, p. G1197-G1206

Research output: Contribution to journalArticle

25 Scopus citations
2001

Activator Protein-1 Transcription Factor Mediates Bombesin-stimulated Cyclooxygenase-2 Expression in Intestinal Epithelial Cells

Guo, Y. S., Hellmich, M. R., Wen, X. D. & Townsend, C. M., Jun 22 2001, In : Journal of Biological Chemistry. 276, 25, p. 22941-22947 7 p.

Research output: Contribution to journalArticle

115 Scopus citations

Amino acid, glucose, and lipid kinetics after palliative resection in a patient with glucagonoma syndrome

Bernstein, M., Jahoor, F., Townsend, C. M. & Klein, S., Jan 1 2001, In : Metabolism: Clinical and Experimental. 50, 6, p. 720-722 3 p.

Research output: Contribution to journalArticle

6 Scopus citations

The role of caspases in methotrexate-induced gastrointestinal toxicity

Papaconstantinou, H. T., Xie, C., Zhang, W., Ansari, N. H., Hellmich, M. R., Townsend, C. M. & Ko, T. C., Jan 1 2001, In : Surgery. 130, 5, p. 859-865 7 p., 65075.

Research output: Contribution to journalArticle

41 Scopus citations
2000

Gut peptide receptor expression in human pancreatic cancers

Ehlers, R. A., Kim, S. H., Zhang, Y., Ethridge, R. T., Murrilo, C., Hellmich, M. R., Evans, D. B., Townsend, C. M. & Evers, B. M., Jun 1 2000, In : Annals of surgery. 231, 6, p. 838-848 11 p.

Research output: Contribution to journalArticle

61 Scopus citations

Human colorectal cancers express a constitutively active cholecystokinin-B/gastrin receptor that stimulates cell growth

Hellmich, M. R., Rui, X. L., Hellmich, H. L., Fleming, R. Y. D., Evers, B. M. & Townsend, C. M., Oct 13 2000, In : Journal of Biological Chemistry. 275, 41, p. 32122-32128 7 p.

Research output: Contribution to journalArticle

Open Access
113 Scopus citations

Induction of apoptosis in human gastric cancer by sodium butyrate

Litvak, D. A., Hwang, K. O., Evers, B. M. & Townsend, C. M., May 16 2000, In : Anticancer Research. 20, 2 A, p. 779-784 6 p.

Research output: Contribution to journalArticle

35 Scopus citations

Prevention of Mucosal Atrophy: Role of Glutamine and Caspases in Apoptosis in Intestinal Epithelial Cells

Papaconstantinou, H. T., Chung, D. H., Zhang, W., Ansari, N. H., Hellmich, M. R., Townsend, C. M. & Ko, T. C., Jan 1 2000, In : Journal of Gastrointestinal Surgery. 4, 4, p. 416-423 8 p.

Research output: Contribution to journalArticle

52 Scopus citations

Roles of gastrointestinal hormones in pancreatic cancer

Guo, Y. S. & Townsend, C. M., Jan 1 2000, In : Journal of Hepato-Biliary-Pancreatic Surgery. 7, 3, p. 276-285 10 p.

Research output: Contribution to journalArticle

21 Scopus citations

Signaling mechanisms regulating bombesin-mediated AP-1 gene induction in the human gastric cancer SIIA

Kim, H. J., Evers, B. M., Litvak, D. A., Hellmich, M. R. & Townsend, C. M., Sep 19 2000, In : American Journal of Physiology - Cell Physiology. 279, 2 48-2, p. C326-C334

Research output: Contribution to journalArticle

17 Scopus citations
1999

Characterization of two novel proabsorptive peptide YY analogs, BIM- 43073D and BIM-43004C

Litvak, D. A., Iseki, H., Evers, B. M., Greeley, G. H., Hellmich, M. R., Iwase, K., Balasubramaniam, A. & Townsend, C. M., Jan 1 1999, In : Digestive Diseases and Sciences. 44, 3, p. 643-648 6 p.

Research output: Contribution to journalArticle

11 Scopus citations

Enterotrophic Effects of Glucagon-Like Peptide 2 Are Enhanced by Neurotensin

Litvak, D. A., Evers, B. M., Hellmich, M. R. & Townsend, C. M., Jan 1 1999, In : Journal of Gastrointestinal Surgery. 3, 4, p. 432-440 9 p.

Research output: Contribution to journalArticle

8 Scopus citations

Inhibition of gastric cancer by camptothecin involves apoptosis and multiple cellular pathways

Litvak, D. A., Papaconstantinou, H. T., Hwang, K. O., Mimi, K., Evers, B. M. & Townsend, C. M., Jan 1 1999, In : Surgery. 126, 2, p. 223-230 8 p.

Research output: Contribution to journalArticle

15 Scopus citations

JMV1155: A novel inhibitor of glycine-extended progastrin-mediated growth of a human colon cancer in vivo

Litvak, D. A., Hellmich, M. R., Iwase, K., Evers, B. M., Martinez, J., Amblard, M. & Townsend, C. M., Apr 20 1999, In : Anticancer Research. 19, 1 A, p. 45-49 5 p.

Research output: Contribution to journalArticle

23 Scopus citations

Multiple protein kinase pathways are involved in gastrin-releasing peptide receptor-regulated secretion

Hellmich, M. R., Ives, K. L., Udupi, V., Soloff, M. S., Greeley, G. H., Christensen, B. N. & Townsend, C. M., Aug 20 1999, In : Journal of Biological Chemistry. 274, 34, p. 23901-23909 9 p.

Research output: Contribution to journalArticle

59 Scopus citations

Targeting Molecular Pathways with Camptothecin as Novel Therapy for Gastric Cancer

Litvak, D. A., Papaconstantinou, H. T., Evers, B. M. & Townsend, C. M., Jan 1 1999, In : Journal of Gastrointestinal Surgery. 3, 6, p. 618-624 7 p.

Research output: Contribution to journalArticle

5 Scopus citations
1998

A human gastric cancer cell line possesses a functional receptor for gastrin-releasing peptide

Bold, R. J., Kim, H. J., Ishizuka, J., Townsend, C. M. & Thompson, J. C., Jan 1 1998, In : Cancer Investigation. 16, 1, p. 12-17 6 p.

Research output: Contribution to journalArticle

14 Scopus citations

A novel cytotoxic agent for human carcinoid tumors

Litvak, D. A., Papaconstantinou, H. T., Ko, T. C., Townsend, J., Fabri, P. J. & Moley, J. F., Jan 1 1998, In : Surgery. 124, 6, p. 1071-1076 6 p.

Research output: Contribution to journalArticle

8 Scopus citations

A Novel Strategy for Inhibiting Growth of Human Pancreatic Cancer Cells by Blocking Cyclin-Dependent Kinase Activity

Iseki, H., Ko, T. C., Xue, X. Y., Seapan, A. & Townsend, C. M., Jan 1 1998, In : Journal of Gastrointestinal Surgery. 2, 1, p. 36-43 8 p.

Research output: Contribution to journalArticle

19 Scopus citations

Aspirin prevents tumors in a murine model of familial adenomatous polyposis

Mahmoud, N. N., Dannenberg, A. J., Mestre, J., Bilinski, R. T., Churchill, M. R., Martucci, C., Newmark, H., Bertagnolli, M. M., Townsend, J. & Beauchamp, R. D., Jan 1 1998, In : Surgery. 124, 2, p. 225-231 7 p.

Research output: Contribution to journalArticle

106 Scopus citations

Bombesin stimulates in vitro growth of human breast cancer independent of estrogen receptors status

Bold, R. J., Ishizuka, J., Yao, C. Z., Townsend, C. M. & Thompson, J. C., Dec 1 1998, In : Anticancer Research. 18, 6 A, p. 4051-4056 6 p.

Research output: Contribution to journalArticle

17 Scopus citations

Butyrate-induced differentiation of Caco-2 cells is associated with apoptosis and early induction of p21(Waf1/Cip1) and p27(Kip1)

Litvak, D. A., Evers, B. M., Hwang, K. O., Hellmich, M. R., Ko, T. C., Townsend, J., Mercer, D. W., Hodin, R. A., Postier, R. G. & Soybel, D. I., Jan 1 1998, In : Surgery. 124, 2, p. 161-170 10 p.

Research output: Contribution to journalArticle

102 Scopus citations

DNA methylation contributes to expression of the human neurotensin/neuromedin N gene

Dong, Z., Wang, X., Zhao, Q., Townsend, C. M. & Evers, B. M., Mar 1 1998, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 274, 3 37-3, p. G535-G543

Research output: Contribution to journalArticle

24 Scopus citations

Gene therapy for primary and metastatic pancreatic cancer with intraperitoneal retroviral vector bearing the wild-type p53 gene

Hwang, R. F., Maria Gordon, E., French Anderson, W., Parekh, D., Lillemoe, K. D., Thompson, J. C., Townsend, J., Vickers, S. M., Daniel Beauchamp, R. & Norman, J. G., Jan 1 1998, In : Surgery. 124, 2, p. 143-151 9 p.

Research output: Contribution to journalArticle

56 Scopus citations

Glucagon-Like Peptide 2 Is a Potent Growth Factor for Small Intestine and Colon

Litvak, D. A., Hellmich, M. R., Evers, B. M., Banker, N. A. & Townsend, C. M., Jan 1 1998, In : Journal of Gastrointestinal Surgery. 2, 2, p. 146-150 5 p.

Research output: Contribution to journalArticle

70 Scopus citations

Glutamine deprivation induces apoptosis in intestinal epithelial cells

Papaconstantinou, H. T., Hwang, K. O., Rajaraman, S., Hellmich, M. R., Townsend, J., Ko, T. C., Hodin, R. A., Parekh, D., Buchman, T. G. & Warner, B. W., Jan 1 1998, In : Surgery. 124, 2, p. 152-160 9 p.

Research output: Contribution to journalArticle

92 Scopus citations

Insulin-like growth factor-I promotes multidrug resistance in MCLM colon cancer cells

Guo, Y. S., Jin, G. F., Houston, C. W., Thompson, J. C. & Townsend, C. M., May 1 1998, In : Journal of Cellular Physiology. 175, 2, p. 141-148 8 p.

Research output: Contribution to journalArticle

52 Scopus citations

Interferon-mediated activation of the STAT signaling pathway in a human carcinoid tumor

Wang, S., Tyring, S. K., Townsend, C. M. & Evers, B. M., Jan 1 1998, In : Annals of surgical oncology. 5, 7, p. 642-649 8 p.

Research output: Contribution to journalArticle

4 Scopus citations