David Beasley, PhD

Associate Director, World Health Organization Collaborating Center

  • 3805 Citations
  • 36 h-Index
19972019

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Article
2019

Defining a correlate of protection for chikungunya virus vaccines

Milligan, G. N., Schnierle, B. S., McAuley, A. J. & Beasley, D. W. C., Nov 28 2019, In : Vaccine. 37, 50, p. 7427-7436 10 p.

Research output: Contribution to journalArticle

4 Scopus citations
2018

Baseline mapping of Lassa fever virology, epidemiology and vaccine research and development review-article

Hallam, H. J., Hallam, S., Rodriguez, S., Barrett, A., Beasley, D., Chua, A., Ksiazek, T., Milligan, G., Sathiyamoorthy, V. & Reece, L. M., Dec 1 2018, In : npj Vaccines. 3, 1, 11.

Research output: Contribution to journalArticle

30 Scopus citations

Zika virus infection elicits auto-antibodies to C1q

Koma, T., Veljkovic, V., Anderson, D. E., Wang, L. F., Rossi, S. L., Shan, C., Shi, P. Y., Beasley, D. W., Bukreyeva, N., Smith, J. N., Hallam, S., Huang, C., Von Messling, V. & Paessler, S., Dec 1 2018, In : Scientific reports. 8, 1, 1882.

Research output: Contribution to journalArticle

9 Scopus citations
2017

Cross-neutralisation of viruses of the tick-borne encephalitis complex following tick-borne encephalitis vaccination and/or infection

McAuley, A. J., Sawatsky, B., Ksiazek, T., Torres, M., Korva, M., Lotrič-Furlan, S., Avšič-Županc, T., Von Messling, V., Holbrook, M. R., Freiberg, A., Beasley, D. & Bente, D., Dec 1 2017, In : npj Vaccines. 2, 1, 9.

Research output: Contribution to journalArticle

8 Scopus citations
2016

Challenges for the utilization of vaccines against arthritogenic alphaviruses

Beasley, D. & Aaskov, J. G., Apr 1 2016, In : Future Virology. 11, 4, p. 235-238 4 p.

Research output: Contribution to journalArticle

Plasticity of a critical antigenic determinant in the West Nile virus NY99 envelope protein domain III

Plante, J. A., Torres, M., Huang, C. Y. H. & Beasley, D. W. C., Sep 1 2016, In : Virology. 496, p. 97-105 9 p.

Research output: Contribution to journalArticle

Recovery of West Nile virus envelope protein domain III chimeras with altered antigenicity and mouse virulence

McAuley, A. J., Torres, M., Plante, J., Huang, C. Y. H., Bente, D. & Beasley, D., May 1 2016, In : Journal of Virology. 90, 9, p. 4757-4770 14 p.

Research output: Contribution to journalArticle

6 Scopus citations

Status of research and development of vaccines for chikungunya

Smalley, C., Erasmus, J. H., Chesson, C. B. & Beasley, D., Jun 3 2016, In : Vaccine. 34, 26, p. 2976-2981 6 p.

Research output: Contribution to journalArticle

37 Scopus citations

Supramolecular peptide hydrogel adjuvanted subunit vaccine elicits protective antibody responses against West Nile virus

Friedrich, B. M., Beasley, D. W. C. & Rudra, J. S., Nov 4 2016, In : Vaccine. 34, 46, p. 5479-5482 4 p.

Research output: Contribution to journalArticle

11 Scopus citations
2015

Immunogenicity and efficacy of flagellin-envelope fusion dengue vaccines in mice and monkeys

Liu, G., Song, L., Beasley, D., Putnak, R., Parent, J., Misczak, J., Li, H., Reiserova, L., Liu, X., Tian, H., Liu, W., Labonte, D., Duan, L., Kim, Y., Travalent, L., Wigington, D., Weaver, B. & Tussey, L., May 1 2015, In : Clinical and Vaccine Immunology. 22, 5, p. 516-525 10 p.

Research output: Contribution to journalArticle

14 Scopus citations

Utilization of an Eilat Virus-Based Chimera for Serological Detection of Chikungunya Infection

Erasmus, J. H., Needham, J., Raychaudhuri, S., Diamond, M. S., Beasley, D., Morkowski, S., Salje, H., Fernandez Salas, I., Kim, D. Y., Frolov, I., Nasar, F. & Weaver, S., Oct 22 2015, In : PLoS Neglected Tropical Diseases. 9, 10, e0004119.

Research output: Contribution to journalArticle

25 Scopus citations
2014

Co-circulation of west nile virus variants, Arizona, USA, 2010

Plante, J. A., Burkhalter, K. L., Mann, B. R., Godsey, M. S., Mutebi, J. P. & Beasley, D. W. C., Feb 1 2014, In : Emerging infectious diseases. 20, 2, p. 272-275 4 p.

Research output: Contribution to journalArticle

5 Scopus citations

Enhancement of protein expression by alphavirus replicons by designing self-replicating subgenomic RNAs

Kim, D. Y., Atasheva, S., McAuley, A. J., Plante, J. A., Frolova, E. I., Beasley, D. W. C. & Frolov, I., Jul 22 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 29, p. 10708-10713 6 p.

Research output: Contribution to journalArticle

14 Scopus citations

Multiplexed Digital mRNA Profiling of the Inflammatory Response in the West Nile Swiss Webster Mouse Model

Peña, J., Plante, J. A., Carillo, A. C., Roberts, K. K., Smith, J. K., Juelich, T. L., Beasley, D. W. C., Freiberg, A. N., Labute, M. X. & Naraghi-Arani, P., Jan 1 2014, In : PLoS neglected tropical diseases. 8, 10

Research output: Contribution to journalArticle

8 Scopus citations

Thermodynamic mechanism for the evasion of antibody neutralization in flaviviruses

Maillard, R. A., Liu, T., Beasley, D. W. C., Barrett, A. D. T., Hilser, V. J. & Lee, J. C., Jul 23 2014, In : Journal of the American Chemical Society. 136, 29, p. 10315-10324 10 p.

Research output: Contribution to journalArticle

6 Scopus citations
2013

Adaptation of yellow fever virus 17D to Vero cells is associated with mutations in structural and non-structural protein genes

Beasley, D. W. C., Morin, M., Lamb, A. R., Hayman, E., Watts, D. M., Lee, C. K., Trent, D. W. & Monath, T. P., Sep 1 2013, In : Virus Research. 176, 1-2, p. 280-284 5 p.

Research output: Contribution to journalArticle

7 Scopus citations

GeneSV - An approach to help characterize possible variations in genomic and protein sequences

Zemla, A., Kostova, T., Gorchakov, R., Volkova, E., Beasley, D. W., Cardosa, J., Weaver, S., Vasilakis, N. & Naraghi-Arani, P., Oct 31 2013, In : Bioinformatics and Biology Insights. 8, p. 1-16 16 p.

Research output: Contribution to journalArticle

2 Scopus citations

Molecular evolution of lineage 2 West Nile virus

McMullen, A. R., Albayrak, H., May, F. J., Davis, C. T., Beasley, D. W. C. & Barrett, A. D. T., Feb 1 2013, In : Journal of General Virology. 94, PART2, p. 318-325 8 p.

Research output: Contribution to journalArticle

37 Scopus citations
2012

Conservation of the DENV-2 type-specific and DEN complex-reactive antigenic sites among DENV-2 genotypes

Pitcher, T. J., Gromowski, G. D., Beasley, D. W. C. & Barrett, A. D. T., Jan 20 2012, In : Virology. 422, 2, p. 386-392 7 p.

Research output: Contribution to journalArticle

9 Scopus citations

Mutational analysis of the West Nile virus NS4B protein

Wicker, J. A., Whiteman, M. C., Beasley, D. W. C., Davis, C. T., McGee, C. E., Lee, J. C., Higgs, S., Kinney, R. M., Huang, C. Y. H. & Barrett, A. D. T., Apr 25 2012, In : Virology. 426, 1, p. 22-33 12 p.

Research output: Contribution to journalArticle

35 Scopus citations
2011

Envelope and pre-membrane protein structural amino acid mutations mediate diminished avian growth and virulence of a Mexican West Nile virus isolate

Langevin, S. A., Bowen, R. A., Ramey, W. N., Sanders, T. A., Maharaj, P. D., Fang, Y., Cornelius, J., Barker, C. M., Reisen, W. K., Beasley, D. W. C., Barrett, A. D. T., Kinney, R. M., Huang, C. Y. H. & Brault, A. C., Dec 1 2011, In : Journal of General Virology. 92, 12, p. 2810-2820 11 p.

Research output: Contribution to journalArticle

14 Scopus citations

Reduced avian virulence and viremia of West Nile virus isolates from Mexico and Texas

Brault, A. C., Langevin, S. A., Ramey, W. N., Fang, Y., Beasley, D. W. C., Barker, C. M., Sanders, T. A., Reisen, W. K., Barrett, A. D. T. & Bowen, R. A., Oct 1 2011, In : American Journal of Tropical Medicine and Hygiene. 85, 4, p. 758-767 10 p.

Research output: Contribution to journalArticle

20 Scopus citations
2010

Development and characterization of non-glycosylated E and NS1 mutant viruses as a potential candidate vaccine for West Nile virus

Whiteman, M. C., Li, L., Wicker, J. A., Kinney, R. M., Huang, C., Beasley, D. W. C., Chung, K. M., Diamond, M. S., Solomon, T. & Barrett, A. D. T., Jan 22 2010, In : Vaccine. 28, 4, p. 1075-1083 9 p.

Research output: Contribution to journalArticle

49 Scopus citations

Direct complement restriction of flavivirus infection requires glycan recognition by mannose-binding lectin

Fuchs, A., Lin, T. Y., Beasley, D. W., Stover, C. M., Schwaeble, W. J., Pierson, T. C. & Diamond, M. S., Aug 19 2010, In : Cell Host and Microbe. 8, 2, p. 186-195 10 p.

Research output: Contribution to journalArticle

55 Scopus citations

Inactivated yellow fever 17D vaccine: Development and nonclinical safety, immunogenicity and protective activity

Monath, T. P., Lee, C. K., Julander, J. G., Brown, A., Beasley, D. W., Watts, D. M., Hayman, E., Guertin, P., Makowiecki, J., Crowell, J., Levesque, P., Bowick, G. C., Morin, M., Fowler, E. & Trent, D. W., May 14 2010, In : Vaccine. 28, 22, p. 3827-3840 14 p.

Research output: Contribution to journalArticle

59 Scopus citations

Persistent infection with West Nile virus years after initial infection

Murray, K., Walker, C., Herrington, E., Lewis, J. A., McCormick, J., Beasley, D. W. C., Tesh, R. B. & Fisher-Hoch, S., Jan 1 2010, In : Journal of Infectious Diseases. 201, 1, p. 2-4 3 p.

Research output: Contribution to journalArticle

150 Scopus citations

Role of BC loop residues in structure, function and antigenicity of the West Nile virus envelope protein receptor-binding domain III

Zhang, S., Bovshik, E. I., Maillard, R., Gromowski, G. D., Volk, D. E., Schein, C. H., Huang, C. Y. H., Gorenstein, D. G., Lee, J. C., Barrett, A. D. T. & Beasley, D. W. C., Jul 1 2010, In : Virology. 403, 1, p. 85-91 7 p.

Research output: Contribution to journalArticle

20 Scopus citations
2009

Characterization of Culex Flavivirus (Flaviviridae) strains isolated from mosquitoes in the United States and Trinidad

Kim, D. Y., Guzman, H., Bueno, R., Dennett, J. A., Auguste, A. J., Carrington, C. V. F., Popov, V. L., Weaver, S. C., Beasley, D. W. C. & Tesh, R. B., Mar 30 2009, In : Virology. 386, 1, p. 154-159 6 p.

Research output: Contribution to journalArticle

77 Scopus citations

Development of resistance to passive therapy with a potently neutralizing humanized monoclonal antibody against West Nile virus

Zhang, S., Vogt, M. R., Oliphant, T., Engle, M., Bovshik, E. I., Diamond, M. S. & Beasley, D. W. C., Jul 15 2009, In : Journal of Infectious Diseases. 200, 2, p. 202-205 4 p.

Research output: Contribution to journalArticle

23 Scopus citations

Development pathway for biodefense vaccines

Barrett, A. D. T. & Beasley, D. W. C., Nov 5 2009, In : Vaccine. 27, SUPPL. 4, p. D2-D7

Research output: Contribution to journalArticle

8 Scopus citations

Structure of yellow fever virus envelope protein domain III

Volk, D. E., May, F. J., Gandham, S. H. A., Anderson, A., Von Lindern, J. J., Beasley, D. W. C., Barrett, A. D. T. & Gorenstein, D. G., Nov 10 2009, In : Virology. 394, 1, p. 12-18 7 p.

Research output: Contribution to journalArticle

25 Scopus citations
2008

Genetic variation of St. Louis encephalitis virus

May, F. J., Li, L., Zhang, S., Guzman, H., Beasley, D. W. C., Tesh, R. B., Higgs, S., Raj, P., Bueno, R., Randle, Y., Chandler, L. & Barrett, A. D. T., Aug 1 2008, In : Journal of General Virology. 89, 8, p. 1901-1910 10 p.

Research output: Contribution to journalArticle

24 Scopus citations
11 Scopus citations

NMR assignments of the sylvatic dengue 1 virus envelope protein domain III

Volk, D. E., Anderson, K. M., Gandham, S. H. A., May, F. J., Li, L., Beasley, D. W. C., Barrett, A. D. T. & Gorenstein, D. G., Dec 1 2008, In : Biomolecular NMR Assignments. 2, 2, p. 155-157 3 p.

Research output: Contribution to journalArticle

5 Scopus citations
2007

Solution structure of the envelope protein domain III of dengue-4 virus

Volk, D. E., Lee, Y. C., Li, X., Thiviyanathan, V., Gromowski, G. D., Li, L., Lamb, A. R., Beasley, D. W. C., Barrett, A. D. T. & Gorenstein, D. G., Jul 20 2007, In : Virology. 364, 1, p. 147-154 8 p.

Research output: Contribution to journalArticle

57 Scopus citations

Thioaptamer decoy targeting of AP-1 proteins influences cytokine expression and the outcome of arenavirus infections

Fennewald, S. M., Scott, E. P., Zhang, L., Yang, X., Aronson, J. F., Gorenstein, D. G., Luxon, B. A., Shope, R. E., Beasley, D. W. C., Barrett, A. D. T. & Herzog, N. K., Mar 1 2007, In : Journal of General Virology. 88, 3, p. 981-990 10 p.

Research output: Contribution to journalArticle

26 Scopus citations
2006

A mutation in the envelope protein fusion loop attenuates mouse neuroinvasiveness of the NY99 strain of West Nile virus

Zhang, S., Li, L., Woodson, S. E., Huang, C. Y. H., Kinney, R. M., Barrett, A. D. T. & Beasley, D. W. C., Sep 15 2006, In : Virology. 353, 1, p. 35-40 6 p.

Research output: Contribution to journalArticle

33 Scopus citations

A single amino acid substitution in the central portion of the West Nile virus NS4B protein confers a highly attenuated phenotype in mice

Wicker, J. A., Whiteman, M. C., Beasley, D. W. C., Davis, C. T., Zhang, S., Schneider, B. S., Higgs, S., Kinney, R. M. & Barrett, A. D. T., Jun 5 2006, In : Virology. 349, 2, p. 245-253 9 p.

Research output: Contribution to journalArticle

72 Scopus citations

Introductions of West Nile virus strains to Mexico

Deardorff, E., Estrada-Franco, J. G., Brault, A. C., Navarro-Lopez, R., Campomanes-Cortes, A., Paz-Ramirez, P., Solis-Hernandez, M., Ramey, W. N., Davis, C. T., Beasley, D. W. C., Tesh, R. B., Barrett, A. D. T. & Weaver, S. C., Feb 2006, In : Emerging infectious diseases. 12, 2, p. 314-318 5 p.

Research output: Contribution to journalArticle

Open Access
52 Scopus citations

Structure of the envelope protein domain III of Omsk hemorrhagic fever virus

Volk, D. E., Chavez, L., Beasley, D. W. C., Barrett, A. D. T., Holbrook, M. R. & Gorenstein, D. G., Jul 20 2006, In : Virology. 351, 1, p. 188-195 8 p.

Research output: Contribution to journalArticle

16 Scopus citations
2005

Differential expression of domain III neutralizing epitopes on the envelope proteins of West Nile virus strains

Li, L., Barrett, A. D. T. & Beasley, D. W. C., Apr 25 2005, In : Virology. 335, 1, p. 99-105 7 p.

Research output: Contribution to journalArticle

49 Scopus citations

Envelope protein glycosylation status influences mouse neuroinvasion phenotype of genetic lineage 1 West Nile virus strains

Beasley, D. W. C., Whiteman, M. C., Zhang, S., Huang, C. Y. H., Schneider, B. S., Smith, D. R., Gromowski, G. D., Higgs, S., Kinney, R. M. & Barrett, A. D. T., Jul 1 2005, In : Journal of virology. 79, 13, p. 8339-8347 9 p.

Research output: Contribution to journalArticle

224 Scopus citations

Phylogenetic analysis of North American West Nile virus isolates, 2001-2004: Evidence for the emergence of a dominant genotype

Davis, C. T., Ebel, G. D., Lanciotti, R. S., Brault, A. C., Guzman, H., Siirin, M., Lambert, A., Parsons, R. E., Beasley, D. W. C., Novak, R. J., Elizondo-Quiroga, D., Green, E. N., Young, D. S., Stark, L. M., Drebot, M. A., Artsob, H., Tesh, R. B., Kramer, L. D. & Barrett, A. D. T., Nov 25 2005, In : Virology. 342, 2, p. 252-265 14 p.

Research output: Contribution to journalArticle

186 Scopus citations

Short report: Serological evidence of West Nile virus activity in El Salvador

Cruz, L., Cardenas, V. M., Abarca, M., Rodriguez, T., Reyna, R. F., Serpas, M. V., Fontaine, R. E., Beasley, D. W. C., Travassos Da Rosa, A. P. A., Weaver, S. C., Tesh, R. B., Powers, A. M. & Suarez-Rangel, G., May 1 2005, In : American Journal of Tropical Medicine and Hygiene. 72, 5, p. 612-615 4 p.

Research output: Contribution to journalArticle

46 Scopus citations
2004

Characterization of a West Nile virus isolate from a human on the Gulf Coast of Texas

Granwehr, B. P., Li, L., Davis, C. T., Beasley, D. W. C. & Barrett, A. D. T., Nov 1 2004, In : Journal of Clinical Microbiology. 42, 11, p. 5375-5377 3 p.

Research output: Contribution to journalArticle

9 Scopus citations

Emergence of attenuated West Nile virus variants in Texas, 2003

Davis, C. T., Beasley, D. W. C., Guzman, H., Siirin, M., Parsons, R. E., Tesh, R. B. & Barrett, A. D. T., Dec 5 2004, In : Virology. 330, 1, p. 342-350 9 p.

Research output: Contribution to journalArticle

77 Scopus citations

Experimental Infection of Rhesus Macaques with West Nile Virus: Level and Duration of Viremia and Kinetics of the Antibody Response after Infection

Ratterree, M. S., Gutierrez, R. A., Travassos Da Rosa, A. P. A., Dille, B. J., Beasley, D. W. C., Bohm, R. P., Desai, S. M., Didier, P. J., Bikenmeyer, L. G., Dawson, G. J., Leary, T. P., Schochetman, G., Phillippi-Falkenstein, K., Arroyo, J., Barrett, A. D. T. & Tesh, R. B., Feb 15 2004, In : Journal of Infectious Diseases. 189, 4, p. 669-676 8 p.

Research output: Contribution to journalArticle

61 Scopus citations

Genome sequence and attenuating mutations in Nile virus isolate from Mexico

Beasley, D. W. C., Davis, C. T., Estrada-Franco, J., Navarro-Lopes, R., Campomanes-Cortes, A., Tesh, R. B., Weaver, S. C. & Barrett, A. D. T., Dec 2004, In : Emerging infectious diseases. 10, 12, p. 2221-2224 4 p.

Research output: Contribution to journalArticle

Open Access
65 Scopus citations

Protection against Japanese encephalitis virus strains representing four genotypes by passive transfer of sera raised against ChimeriVax™-JE experimental vaccine

Beasley, D. W. C., Li, L., Suderman, M. T., Guirakhoo, F., Trent, D. W., Monath, T. P., Shope, R. E. & Barrett, A. D. T., Sep 9 2004, In : Vaccine. 22, 27-28, p. 3722-3726 5 p.

Research output: Contribution to journalArticle

54 Scopus citations

Real-time reverse transcriptase-polymerase chain reaction quantification of West Nile virus transmitted by Culex pipiens quinquefasciatus

Vanlandingham, D. L., Schneider, B. S., Klingler, K., Fair, J., Beasley, D., Huang, J., Hamilton, P. & Higgs, S., Jul 1 2004, In : American Journal of Tropical Medicine and Hygiene. 71, 1, p. 120-123 4 p.

Research output: Contribution to journalArticle

70 Scopus citations