David Beasley, PhD

Associate Director, World Health Organization Collaborating Center

  • 3739 Citations
  • 35 h-Index
1997 …2024

Research output per year

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Research Output

  • 3739 Citations
  • 35 h-Index
  • 75 Article
  • 5 Chapter
  • 3 Review article
  • 1 Conference contribution
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Article
2018

Baseline mapping of Lassa fever virology, epidemiology and vaccine research and development review-article

Hallam, H. J., Hallam, S., Rodriguez, S., Barrett, A., Beasley, D., Chua, A., Ksiazek, T., Milligan, G., Sathiyamoorthy, V. & Reece, L. M., Dec 1 2018, In : npj Vaccines. 3, 1, 11.

Research output: Contribution to journalArticle

26 Scopus citations

Defining a correlate of protection for chikungunya virus vaccines

Milligan, G., Schnierle, B. S., McAuley, A. J. & Beasley, D., Jan 1 2018, (Accepted/In press) In : Vaccine.

Research output: Contribution to journalArticle

1 Scopus citations

Zika virus infection elicits auto-antibodies to C1q

Koma, T., Veljkovic, V., Anderson, D. E., Wang, L. F., Rossi, S., Shan, C., Shi, P-Y., Beasley, D., Bukreyeva, N., Smith, J. N., Hallam, S., Huang, C., Von Messling, V. & Paessler, S., Dec 1 2018, In : Scientific Reports. 8, 1, 1882.

Research output: Contribution to journalArticle

7 Scopus citations
2017

Cross-neutralisation of viruses of the tick-borne encephalitis complex following tick-borne encephalitis vaccination and/or infection

McAuley, A. J., Sawatsky, B., Ksiazek, T., Torres, M., Korva, M., Lotrič-Furlan, S., Avšič-Županc, T., Von Messling, V., Holbrook, M. R., Freiberg, A., Beasley, D. & Bente, D., Dec 1 2017, In : npj Vaccines. 2, 1, 9.

Research output: Contribution to journalArticle

8 Scopus citations
2016

Challenges for the utilization of vaccines against arthritogenic alphaviruses

Beasley, D. & Aaskov, J. G., Apr 1 2016, In : Future Virology. 11, 4, p. 235-238 4 p.

Research output: Contribution to journalArticle

Plasticity of a critical antigenic determinant in the West Nile virus NY99 envelope protein domain III

Plante, J. A., Torres, M., Huang, C. Y. H. & Beasley, D. W. C., Sep 1 2016, In : Virology. 496, p. 97-105 9 p.

Research output: Contribution to journalArticle

Recovery of West Nile virus envelope protein domain III chimeras with altered antigenicity and mouse virulence

McAuley, A. J., Torres, M., Plante, J., Huang, C. Y. H., Bente, D. & Beasley, D., May 1 2016, In : Journal of Virology. 90, 9, p. 4757-4770 14 p.

Research output: Contribution to journalArticle

6 Scopus citations

Status of research and development of vaccines for chikungunya

Smalley, C., Erasmus, J. H., Chesson, C. B. & Beasley, D., Jun 3 2016, In : Vaccine. 34, 26, p. 2976-2981 6 p.

Research output: Contribution to journalArticle

34 Scopus citations

Supramolecular peptide hydrogel adjuvanted subunit vaccine elicits protective antibody responses against West Nile virus

Friedrich, B. M., Beasley, D. W. C. & Rudra, J. S., Nov 4 2016, In : Vaccine. 34, 46, p. 5479-5482 4 p.

Research output: Contribution to journalArticle

11 Scopus citations
2015

Immunogenicity and efficacy of flagellin-envelope fusion dengue vaccines in mice and monkeys

Liu, G., Song, L., Beasley, D., Putnak, R., Parent, J., Misczak, J., Li, H., Reiserova, L., Liu, X., Tian, H., Liu, W., Labonte, D., Duan, L., Kim, Y., Travalent, L., Wigington, D., Weaver, B. & Tussey, L., May 1 2015, In : Clinical and Vaccine Immunology. 22, 5, p. 516-525 10 p.

Research output: Contribution to journalArticle

11 Scopus citations

Utilization of an Eilat Virus-Based Chimera for Serological Detection of Chikungunya Infection

Erasmus, J. H., Needham, J., Raychaudhuri, S., Diamond, M. S., Beasley, D., Morkowski, S., Salje, H., Fernandez Salas, I., Kim, D. Y., Frolov, I., Nasar, F. & Weaver, S., Oct 22 2015, In : PLoS Neglected Tropical Diseases. 9, 10, e0004119.

Research output: Contribution to journalArticle

23 Scopus citations

Yellow fever virus: Genetic and phenotypic diversity and implications for detection, prevention and therapy

Beasley, D. W. C., McAuley, A. J. & Bente, D. A., 2015, In : Antiviral Research. 115, p. 48-70 23 p.

Research output: Contribution to journalArticle

33 Scopus citations
2014

Co-circulation of west nile virus variants, Arizona, USA, 2010

Plante, J., Burkhalter, K. L., Mann, B. R., Godsey, M. S., Mutebi, J. P. & Beasley, D., Feb 2014, In : Emerging Infectious Diseases. 20, 2, p. 272-275 4 p.

Research output: Contribution to journalArticle

5 Scopus citations

Enhancement of protein expression by alphavirus replicons by designing self-replicating subgenomic RNAs

Kim, D. Y., Atasheva, S., McAuley, A. J., Plante, J., Frolova, E. I., Beasley, D. & Frolov, I., Jul 22 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 29, p. 10708-10713 6 p.

Research output: Contribution to journalArticle

13 Scopus citations

Multiplexed Digital mRNA Profiling of the Inflammatory Response in the West Nile Swiss Webster Mouse Model

Peña, J., Plante, J., Carillo, A. C., Roberts, K. K., Smith, J. K., Juelich, T. L., Beasley, D., Freiberg, A., Labute, M. X. & Naraghi-Arani, P., 2014, In : PLoS Neglected Tropical Diseases. 8, 10

Research output: Contribution to journalArticle

8 Scopus citations

Thermodynamic mechanism for the evasion of antibody neutralization in flaviviruses

Maillard, R. A., Liu, T., Beasley, D., Barrett, A., Hilser, V. J. & Lee, J., Jul 23 2014, In : Journal of the American Chemical Society. 136, 29, p. 10315-10324 10 p.

Research output: Contribution to journalArticle

6 Scopus citations
2013

Adaptation of yellow fever virus 17D to Vero cells is associated with mutations in structural and non-structural protein genes

Beasley, D., Morin, M., Lamb, A. R., Hayman, E., Watts, D. M., Lee, C. K., Trent, D. W. & Monath, T. P., Sep 2013, In : Virus Research. 176, 1-2, p. 280-284 5 p.

Research output: Contribution to journalArticle

7 Scopus citations

GeneSV - An approach to help characterize possible variations in genomic and protein sequences

Zemla, A., Kostova, T., Gorchakov, R., Volkova, E., Beasley, D., Cardosa, J., Weaver, S., Vasilakis, N. & Naraghi-Arani, P., Oct 31 2013, In : Bioinformatics and Biology Insights. 8, p. 1-16 16 p.

Research output: Contribution to journalArticle

2 Scopus citations

Molecular evolution of lineage 2 West Nile virus

McMullen, A. R., Albayrak, H., May, F. J., Davis, C. T., Beasley, D. & Barrett, A., Feb 1 2013, In : Journal of General Virology. 94, PART2, p. 318-325 8 p.

Research output: Contribution to journalArticle

37 Scopus citations
33 Scopus citations
2012

Conservation of the DENV-2 type-specific and DEN complex-reactive antigenic sites among DENV-2 genotypes

Pitcher, T. J., Gromowski, G. D., Beasley, D. & Barrett, A., Jan 20 2012, In : Virology. 422, 2, p. 386-392 7 p.

Research output: Contribution to journalArticle

9 Scopus citations

Mutational analysis of the West Nile virus NS4B protein

Wicker, J. A., Whiteman, M. C., Beasley, D., Davis, C. T., McGee, C. E., Lee, J., Higgs, S., Kinney, R. M., Huang, C. Y. H. & Barrett, A., Apr 25 2012, In : Virology. 426, 1, p. 22-33 12 p.

Research output: Contribution to journalArticle

33 Scopus citations
2011

Envelope and pre-membrane protein structural amino acid mutations mediate diminished avian growth and virulence of a Mexican West Nile virus isolate

Langevin, S. A., Bowen, R. A., Ramey, W. N., Sanders, T. A., Maharaj, P. D., Fang, Y., Cornelius, J., Barker, C. M., Reisen, W. K., Beasley, D., Barrett, A., Kinney, R. M., Huang, C. Y. H. & Brault, A. C., Dec 2011, In : Journal of General Virology. 92, 12, p. 2810-2820 11 p.

Research output: Contribution to journalArticle

14 Scopus citations

Reduced avian virulence and viremia of West Nile virus isolates from Mexico and Texas

Brault, A. C., Langevin, S. A., Ramey, W. N., Fang, Y., Beasley, D., Barker, C. M., Sanders, T. A., Reisen, W. K., Barrett, A. & Bowen, R. A., Oct 2011, In : American Journal of Tropical Medicine and Hygiene. 85, 4, p. 758-767 10 p.

Research output: Contribution to journalArticle

19 Scopus citations

Safety and immunogenicity of a chimeric vaccine for West Nile virus in aged subjects

Beasley, D., May 2011, In : Expert Review of Vaccines. 10, 5, p. 601-604 4 p.

Research output: Contribution to journalArticle

3 Scopus citations

Vaccines and immunotherapeutics for the prevention and treatment of infections with West Nile virus

Beasley, D., Feb 2011, In : Immunotherapy. 3, 2, p. 269-285 17 p.

Research output: Contribution to journalArticle

51 Scopus citations
2010

Development and characterization of non-glycosylated E and NS1 mutant viruses as a potential candidate vaccine for West Nile virus

Whiteman, M. C., Li, L., Wicker, J. A., Kinney, R. M., Huang, C., Beasley, D., Chung, K. M., Diamond, M. S., Solomon, T. & Barrett, A., Jan 22 2010, In : Vaccine. 28, 4, p. 1075-1083 9 p.

Research output: Contribution to journalArticle

49 Scopus citations

Direct complement restriction of flavivirus infection requires glycan recognition by mannose-binding lectin

Fuchs, A., Lin, T. Y., Beasley, D., Stover, C. M., Schwaeble, W. J., Pierson, T. C. & Diamond, M. S., Aug 19 2010, In : Cell Host and Microbe. 8, 2, p. 186-195 10 p.

Research output: Contribution to journalArticle

53 Scopus citations

Inactivated yellow fever 17D vaccine: Development and nonclinical safety, immunogenicity and protective activity

Monath, T. P., Lee, C. K., Julander, J. G., Brown, A., Beasley, D., Watts, D. M., Hayman, E., Guertin, P., Makowiecki, J., Crowell, J., Levesque, P., Bowick, G. C., Morin, M., Fowler, E. & Trent, D. W., May 14 2010, In : Vaccine. 28, 22, p. 3827-3840 14 p.

Research output: Contribution to journalArticle

59 Scopus citations

Persistent infection with West Nile virus years after initial infection

Murray, K., Walker, C., Herrington, E., Lewis, J. A., McCormick, J., Beasley, D., Tesh, R. B. & Fisher-Hoch, S., Jan 2010, In : Journal of Infectious Diseases. 201, 1, p. 2-4 3 p.

Research output: Contribution to journalArticle

144 Scopus citations

Role of BC loop residues in structure, function and antigenicity of the West Nile virus envelope protein receptor-binding domain III

Zhang, S., Bovshik, E. I., Maillard, R., Gromowski, G. D., Volk, D. E., Schein, C. H., Huang, C. Y. H., Gorenstein, D. G., Lee, J., Barrett, A. & Beasley, D., Jul 2010, In : Virology. 403, 1, p. 85-91 7 p.

Research output: Contribution to journalArticle

20 Scopus citations
2009

Characterization of Culex Flavivirus (Flaviviridae) strains isolated from mosquitoes in the United States and Trinidad

Kim, D. Y., Guzman, H., Bueno, R., Dennett, J. A., Auguste, A. J., Carrington, C. V. F., Popov, V. L., Weaver, S. C., Beasley, D. W. C. & Tesh, R. B., Mar 30 2009, In : Virology. 386, 1, p. 154-159 6 p.

Research output: Contribution to journalArticle

75 Scopus citations

Development of resistance to passive therapy with a potently neutralizing humanized monoclonal antibody against West Nile virus

Zhang, S., Vogt, M. R., Oliphant, T., Engle, M., Bovshik, E. I., Diamond, M. S. & Beasley, D., Jul 15 2009, In : Journal of Infectious Diseases. 200, 2, p. 202-205 4 p.

Research output: Contribution to journalArticle

23 Scopus citations

Development pathway for biodefense vaccines

Barrett, A. & Beasley, D., Nov 5 2009, In : Vaccine. 27, SUPPL. 4

Research output: Contribution to journalArticle

8 Scopus citations

Structure of yellow fever virus envelope protein domain III

Volk, D. E., May, F. J., Gandham, S. H. A., Anderson, A., Von Lindern, J. J., Beasley, D., Barrett, A. & Gorenstein, D. G., Nov 10 2009, In : Virology. 394, 1, p. 12-18 7 p.

Research output: Contribution to journalArticle

25 Scopus citations
2008

Current use and development of vaccines for Japanese encephalitis

Beasley, D., Lewthwaite, P. & Solomon, T., Jan 2008, In : Expert Opinion on Biological Therapy. 8, 1, p. 95-106 12 p.

Research output: Contribution to journalArticle

69 Scopus citations

Genetic variation of St. Louis encephalitis virus

May, F. J., Li, L., Zhang, S., Guzman, H., Beasley, D., Tesh, R. B., Higgs, S., Raj, P., Bueno, R., Randle, Y., Chandler, L. & Barrett, A., Aug 2008, In : Journal of General Virology. 89, 8, p. 1901-1910 10 p.

Research output: Contribution to journalArticle

24 Scopus citations

Long range communication in the envelope protein domain III and its effect on the resistance of West Nile virus to antibody-mediated neutralization

Maillard, R. A., Jordan, M., Beasley, D., Barrett, A. & Lee, J., Jan 4 2008, In : Journal of Biological Chemistry. 283, 1, p. 613-622 10 p.

Research output: Contribution to journalArticle

11 Scopus citations

NMR assignments of the sylvatic dengue 1 virus envelope protein domain III

Volk, D. E., Anderson, K. M., Gandham, S. H. A., May, F. J., Li, L., Beasley, D., Barrett, A. & Gorenstein, D. G., Dec 2008, In : Biomolecular NMR Assignments. 2, 2, p. 155-157 3 p.

Research output: Contribution to journalArticle

5 Scopus citations
2007

Solution structure of the envelope protein domain III of dengue-4 virus

Volk, D. E., Lee, Y. C., Li, X., Thiviyanathan, V., Gromowski, G. D., Li, L., Lamb, A. R., Beasley, D., Barrett, A. & Gorenstein, D. G., Jul 20 2007, In : Virology. 364, 1, p. 147-154 8 p.

Research output: Contribution to journalArticle

57 Scopus citations

Thioaptamer decoy targeting of AP-1 proteins influences cytokine expression and the outcome of arenavirus infections

Fennewald, S. M., Scott, E. P., Zhang, L., Yang, X., Aronson, J. F., Gorenstein, D. G., Luxon, B. A., Shope, R. E., Beasley, D. W. C., Barrett, A. D. T. & Herzog, N. K., Mar 2007, In : Journal of General Virology. 88, 3, p. 981-990 10 p.

Research output: Contribution to journalArticle

26 Scopus citations
2006

A mutation in the envelope protein fusion loop attenuates mouse neuroinvasiveness of the NY99 strain of West Nile virus

Zhang, S., Li, L., Woodson, S. E., Huang, C. Y. H., Kinney, R. M., Barrett, A. & Beasley, D., Sep 15 2006, In : Virology. 353, 1, p. 35-40 6 p.

Research output: Contribution to journalArticle

32 Scopus citations

A single amino acid substitution in the central portion of the West Nile virus NS4B protein confers a highly attenuated phenotype in mice

Wicker, J. A., Whiteman, M. C., Beasley, D., Davis, C. T., Zhang, S., Schneider, B. S., Higgs, S., Kinney, R. M. & Barrett, A., Jun 5 2006, In : Virology. 349, 2, p. 245-253 9 p.

Research output: Contribution to journalArticle

69 Scopus citations

Introductions of West Nile virus strains to Mexico

Deardorff, E., Estrada-Franco, J. G., Brault, A. C., Navarro-Lopez, R., Campomanes-Cortes, A., Paz-Ramirez, P., Solis-Hernandez, M., Ramey, W. N., Davis, C. T., Beasley, D., Tesh, R. B., Barrett, A. & Weaver, S., Feb 2006, In : Emerging Infectious Diseases. 12, 2, p. 314-318 5 p.

Research output: Contribution to journalArticle

52 Scopus citations

Structure of the envelope protein domain III of Omsk hemorrhagic fever virus

Volk, D. E., Chavez, L., Beasley, D., Barrett, A., Holbrook, M. R. & Gorenstein, D. G., Jul 20 2006, In : Virology. 351, 1, p. 188-195 8 p.

Research output: Contribution to journalArticle

16 Scopus citations
2005

Differential expression of domain III neutralizing epitopes on the envelope proteins of West Nile virus strains

Li, L., Barrett, A. & Beasley, D., Apr 25 2005, In : Virology. 335, 1, p. 99-105 7 p.

Research output: Contribution to journalArticle

49 Scopus citations

Envelope protein glycosylation status influences mouse neuroinvasion phenotype of genetic lineage 1 West Nile virus strains

Beasley, D., Whiteman, M. C., Zhang, S., Huang, C. Y. H., Schneider, B. S., Smith, D. R., Gromowski, G. D., Higgs, S., Kinney, R. M. & Barrett, A., Jul 2005, In : Journal of Virology. 79, 13, p. 8339-8347 9 p.

Research output: Contribution to journalArticle

222 Scopus citations

Phylogenetic analysis of North American West Nile virus isolates, 2001-2004: Evidence for the emergence of a dominant genotype

Davis, C. T., Ebel, G. D., Lanciotti, R. S., Brault, A. C., Guzman, H., Siirin, M., Lambert, A., Parsons, R. E., Beasley, D., Novak, R. J., Elizondo-Quiroga, D., Green, E. N., Young, D. S., Stark, L. M., Drebot, M. A., Artsob, H., Tesh, R. B., Kramer, L. D. & Barrett, A., Nov 25 2005, In : Virology. 342, 2, p. 252-265 14 p.

Research output: Contribution to journalArticle

185 Scopus citations

Recent advances in the molecular biology of West Nile virus

Beasley, D., Dec 2005, In : Current Molecular Medicine. 5, 8, p. 835-850 16 p.

Research output: Contribution to journalArticle

45 Scopus citations

Short report: Serological evidence of West Nile virus activity in El Salvador

Cruz, L., Cardenas, V. M., Abarca, M., Rodriguez, T., Reyna, R. F., Serpas, M. V., Fontaine, R. E., Beasley, D. W. C., Travassos Da Rosa, A. P. A., Weaver, S. C., Tesh, R. B., Powers, A. M. & Suarez-Rangel, G., May 2005, In : American Journal of Tropical Medicine and Hygiene. 72, 5, p. 612-615 4 p.

Research output: Contribution to journalArticle

46 Scopus citations