Douglas Dewitt, PhD

  • 4322 Citations
  • 36 h-Index
1980 …2020

Research output per year

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Article
2020

MicroRNA sequencing of rat hippocampus and human biofluids identifies acute, chronic, focal and diffuse traumatic brain injuries

Weisz, H. A., Kennedy, D., Widen, S., Spratt, H., Sell, S. L., Bailey, C., Moore, M., DeWitt, D. S., Prough, D. S., Levin, H., Robertson, C. & Hellmich, H. L., Dec 1 2020, In : Scientific reports. 10, 1, 3341.

Research output: Contribution to journalArticle

Open Access
2019

Cerebral Blood Flow and Blood Pressure: Dependent or Codependent?

Dewitt, D. & Prough, D., Jul 1 2019, In : Critical care medicine. 47, 7, p. 1007-1009 3 p.

Research output: Contribution to journalArticle

Effects of blast-induced neurotrauma on pressurized rodent middle cerebral arteries

Rodriguez, U. A., Zeng, Y., Parsley, M. A., Hawkins, B. E., Prough, D. S. & Dewitt, D. S., Apr 2019, In : Journal of Visualized Experiments. 2019, 146, e58792.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

MicroRNA profiling identifies a novel compound with antidepressant properties

Sell, S., Boone, D. R., Weisz, H. A., Cardenas, C., Willey, H. E., Bolding, I. J., Micci, M., Falduto, M. T., Torres, K. E. O., Dewitt, D., Prough, D. & Hellmich, H., Jan 1 2019, In : PloS one. 14, 8, e0221163.

Research output: Contribution to journalArticle

Open Access

Modulation of Peroxynitrite Reduces Norepinephrine Requirements in Ovine MRSA Septic Shock

Fukuda, S., Ihara, K., Andersen, C. R., Randolph, A. C., Nelson, C. L., Zeng, Y., Kim, J., Dewitt, D. S., Rojas, J. D., Koutrouvelis, A., Herndon, D., Prough, D. S. & Enkhbaatar, P., Nov 1 2019, In : Shock. 52, 5, p. E92-E99

Research output: Contribution to journalArticle

2 Scopus citations

Traumatic brain injury induces long-lasting changes in immune and regenerative signaling

Boone, D. R., Weisz, H. A., Willey, H. E., Torres, K. E. O., Falduto, M. T., Sinha, M., Spratt, H., Bolding, I. J., Johnson, K. M., Parsley, M. A., Dewitt, D., Prough, D. & Hellmich, H., Apr 1 2019, In : PloS one. 14, 4, e0214741.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations
2018

Effects of Mild Blast Traumatic Brain Injury on Cerebral Vascular, Histopathological, and Behavioral Outcomes in Rats

Rodriguez, U., Zeng, Y., Deyo, D., Parsley, M. A., Hawkins, B., Prough, D. S. & DeWitt, D. S., Jan 15 2018, In : Journal of Neurotrauma. 35, 2, p. 375-392 18 p.

Research output: Contribution to journalArticle

12 Scopus citations

Nano-Pulsed Laser Therapy Is Neuroprotective in a Rat Model of Blast-Induced Neurotrauma

Esenaliev, R., Petrov, I. Y., Petrov, Y., Guptarak, J., Boone, D. R., Mocciaro, E., Weisz, H., Parsley, M. A., Sell, S., Hellmich, H., Ford, J. M., Pogue, C., Dewitt, D., Prough, D. & Micci, M., Jul 1 2018, In : Journal of Neurotrauma. 35, 13, p. 1510-1522 13 p.

Research output: Contribution to journalArticle

11 Scopus citations

Pre-clinical testing of therapies for traumatic brain injury

Dewitt, D., Hawkins, B., Dixon, C. E., Kochanek, P. M., Armstead, W., Bass, C. R., Bramlett, H. M., Buki, A., Dietrich, W. D., Ferguson, A. R., Hall, E. D., Hayes, R. L., Hinds, S. R., Laplaca, M. C., Long, J. B., Meaney, D. F., Mondello, S., Noble-Haeusslein, L. J., Poloyac, S. M., Prough, D. & 8 others, Robertson, C. S., Saatman, K. E., Shultz, S. R., Shear, D. A., Smith, D. H., Valadka, A. B., Vandevord, P. & Zhang, L., Dec 1 2018, In : Journal of Neurotrauma. 35, 23, p. 2737-2754 18 p.

Research output: Contribution to journalArticle

17 Scopus citations

Proteomic changes in traumatic brain injury: experimental approaches

Sowers, J. L., Wu, P., Zhang, K., Dewitt, D. & Prough, D., Dec 1 2018, In : Current Opinion in Neurology. 31, 6, p. 709-717 9 p.

Research output: Contribution to journalArticle

3 Scopus citations
2017

Effects of AAV-mediated knockdown of nNOS and GPx-1 gene expression in rat hippocampus after traumatic brain injury

Boone, D. R., Leek, J. M., Falduto, M. T., Torres, K. E. O., Sell, S. L., Parsley, M. A., Cowart, J. C., Uchida, T., Micci, M. A., DeWitt, D. S., Prough, D. S. & Hellmich, H. L., Oct 2017, In : PloS one. 12, 10, e0185943.

Research output: Contribution to journalArticle

3 Scopus citations

Evidence linking microRNA suppression of essential prosurvival genes with hippocampal cell death after traumatic brain injury

Boone, D. K., Weisz, H. A., Bi, M., Falduto, M. T., Torres, K. E. O., Willey, H. E., Volsko, C. M., Kumar, A. M., Micci, M., Dewitt, D., Prough, D. & Hellmich, H., Dec 1 2017, In : Scientific Reports. 7, 1, 6645.

Research output: Contribution to journalArticle

8 Scopus citations

Military Blast Exposure and Chronic Neurodegeneration: Summary of Working Groups and Expert Panel Findings and Recommendations

Brix, K. A., Brody, D. L., Grimes, J. B., Yitzhak, A., Agoston, D., Aldag, M., Armstrong, R., Arun, P., Audette, M., Babcock, D., Balaban, C., Banton, R., Bellgowan, P., Borkholder, D., Broglio, S., Brokaw, E., Cantu, R., Carr, W., Chapman, S., Cmarik, J. & 96 others, Colder, B., Colombe, J., Cook, D., Cozzarelli, T., Da Silva, U. O., Daphalapurkar, N., Dardzinski, B., DeGraba, T., DeMar, J., DeWitt, D., Dickstein, D., Duckworth, J., Elder, G., Fazel-Rezai, R., Fine, M., Fiskum, G., Fournier, A., Ganpule, S., Gill, J., Glenn, J. F., Greene, C., Greig, N., Haering, C., Harrington, J., Hein, A., Helmick, K., Hicks, R., Hinds, S., Hoffman, S., Horkayne-Szakaly, I., Iacono, D., Ishii, E., Jones, R. V., Karami, G., Krawczyk, D., Labutta, R., Latta, R., Lattimore, T., Leggieri, M., Leonessa, F., Lin, A., Ling, G., Long, M., Lu, K. P., Panker, S. M., McCabe, J., Merkle, A., Montenigro, P., Mueller, G. P., Ng, L., Nigam, S., O'Donnell, J., Okonkwo, D., Pauli, I., Perl, D., Peskind, E., Pfister, B., Philippens, M., Piehler, T., Proctor, J., Przekwas, A., Qashu, F., Raskind, M., Razumovsky, A., Reifman, J., Reyes, P., Rigby, P., Risling, M., Robinson, M., Rooks, T., Rosen, C., Rosseau, G., Sammons-Jackson, W., Santago, A., Shoge, R., Sours, C., Stone, J., Templin, M., Tepe, V., Thielen, P., Thomas, M., Timmes, T., Tortella, F., Tucker, L., Tweedie, D., Hamm, D. V., Christie Vu, B., Wang, Y., West, T., Wilde, E., Willis, A., Wu, J., Zai, L., Zander, N., Zheng, J. & Ziejewski, M., Sep 2017, In : Journal of neurotrauma. 34, S1, p. S18-S25

Research output: Contribution to journalArticle

3 Scopus citations

Persistent Behavioral Deficits in Rats after Parasagittal Fluid Percussion Injury

Sell, S., Johnson, K., Dewitt, D. & Prough, D., Mar 1 2017, In : Journal of Neurotrauma. 34, 5, p. 1086-1096 11 p.

Research output: Contribution to journalArticle

15 Scopus citations
2016

Development of a stretch-induced neurotrauma model for medium-throughput screening in vitro: Identification of rifampicin as a neuroprotectant

López-García, I., Gero, D., Szczesny, B., Szoleczky, P., Olah, G., Modis, K., Zhang, K., Gao, J., Wu, P., Sowers, L., Dewitt, D., Prough, D. & Szabo, C., 2016, (Accepted/In press) In : British Journal of Pharmacology.

Research output: Contribution to journalArticle

8 Scopus citations

Human neural stem cell transplantation-mediated alteration of microglial/macrophage phenotypes after traumatic brain injury

Gao, J., Grill, R. J., Dunn, T. J., Bedi, S., Labastida, J. A., Hetz, R. A., Xue, H., Thonhoff, J. R., Dewitt, D., Prough, D., Cox, C. S. & Wu, P., 2016, In : Cell Transplantation. 25, 10, p. 1863-1877 15 p.

Research output: Contribution to journalArticle

20 Scopus citations

Inflammatory cytokine receptor blockade in a rodent model of mild traumatic brain injury

Perez-Polo, J. R., Rea, H. C., Johnson, K. M., Parsley, M. A., Unabia, G. C., Xu, G. Y., Prough, D., Dewitt, D., Paulucci-Holthauzen, A. A., Werrbach-Perez, K. & Hulsebosch, C. E., Jan 1 2016, In : Journal of Neuroscience Research. 94, 1, p. 27-38 12 p.

Research output: Contribution to journalArticle

9 Scopus citations

Stochastic fluctuations in gene expression in aging hippocampal neurons could be exacerbated by traumatic brain injury

Shearer, J., Boone, D., Weisz, H., Jennings, K., Uchida, T., Parsley, M., Dewitt, D., Prough, D. & Hellmich, H., Apr 1 2016, In : Aging clinical and experimental research. 28, 2, p. 363-367 5 p.

Research output: Contribution to journalArticle

1 Scopus citations

Tau Oligomers Derived from Traumatic Brain Injury Cause Cognitive Impairment and Accelerate Onset of Pathology in Htau Mice

Gerson, J., Castillo-Carranza, D. L., Sengupta, U., Bodani, R., Prough, D., Dewitt, D., Hawkins, B. & Kayed, R., Nov 15 2016, In : Journal of Neurotrauma. 33, 22, p. 2034-2043 10 p.

Research output: Contribution to journalArticle

35 Scopus citations
2015

A rodent model of mild traumatic brain blast injury

Perez-Polo, J. R., Rea, H. C., Johnson, K. M., Parsley, M. A., Unabia, G. C., Xu, G. Y., Prough, D., Dewitt, D. S., Spratt, H. & Hulsebosch, C. E., Apr 1 2015, In : Journal of Neuroscience Research. 93, 4, p. 549-561 13 p.

Research output: Contribution to journalArticle

29 Scopus citations

Measurement of Postreplicative DNA Metabolism and Damage in the Rodent Brain

Patel, J. P., Sowers, M. L., Herring, J. L., Theruvathu, J. A., Emmett, M., Hawkins, B., Zhang, K., Dewitt, D., Prough, D. & Sowers, L., Dec 21 2015, In : Chemical Research in Toxicology. 28, 12, p. 2352-2363 12 p.

Research output: Contribution to journalArticle

4 Scopus citations

Pathway-Focused PCR Array Profiling of Enriched Populations of Laser Capture Microdissected Hippocampal Cells after Traumatic Brain Injury

Boone, D. R., Micci, M., Taglialatela, I. G., Hellmich, J. L., Weisz, H. A., Bi, M., Prough, D., Dewitt, D. & Hellmich, H., May 1 2015, In : PLoS One. 10, 5, e0127287.

Research output: Contribution to journalArticle

20 Scopus citations
2014

Optoacoustic detection of intra- and extracranial hematomas in rats after blast injury

Petrov, A., Wynne, K. E., Parsley, M. A., Petrov, I. Y., Petrov, Y., Ruppert, K. A., Prough, D. S., DeWitt, D. S. & Esenaliev, R. O., Jun 2014, In : Photoacoustics. 2, 2, p. 75-80 6 p.

Research output: Contribution to journalArticle

16 Scopus citations

Traumatic brain injury in vivo and in vitro contributes to cerebral vascular dysfunction through impaired gap junction communication between vascular smooth muscle cells

Yu, G. X., Mueller, M., Hawkins, B. E., Mathew, B. P., Parsley, M. A., Vergara, L. A., Hellmich, H. L., Prough, D. S. & Dewitt, D. S., Apr 15 2014, In : Journal of neurotrauma. 31, 8, p. 739-748 10 p.

Research output: Contribution to journalArticle

16 Scopus citations
2013

Challenges in the development of Rodent models of mild traumatic brain injury

DeWitt, D. S., Perez-Polo, R., Hulsebosch, C. E., Dash, P. K. & Robertson, C. S., May 1 2013, In : Journal of neurotrauma. 30, 9, p. 688-701 14 p.

Research output: Contribution to journalArticle

65 Scopus citations

Detection of structural and metabolic changes in traumatically injured hippocampus by quantitative differential proteomics

Wu, P., Zhao, Y., Haidacher, S. J., Wang, E., Parsley, M. O., Gao, J., Sadygov, R. G., Starkey, J. M., Luxon, B. A., Spratt, H., Dewitt, D. S., Prough, D. S. & Denner, L., May 1 2013, In : Journal of neurotrauma. 30, 9, p. 775-788 14 p.

Research output: Contribution to journalArticle

16 Scopus citations

Effects of trauma, hemorrhage and resuscitation in aged rats

Hawkins, B. E., Cowart, J. C., Parsley, M. A., Capra, B. A., Eidson, K. A., Hellmich, H. L., Dewitt, D. S. & Prough, D. S., Feb 16 2013, In : Brain Research. 1496, p. 28-35 8 p.

Research output: Contribution to journalArticle

14 Scopus citations

Inflammatory consequences in a rodent model of mild traumatic brain injury

Perez-Polo, J. R., Rea, H. C., Johnson, K. M., Parsley, M. A., Unabia, G. C., Xu, G. J., Infante, S. K., Dewitt, D. S. & Hulsebosch, C. E., May 1 2013, In : Journal of neurotrauma. 30, 9, p. 727-740 14 p.

Research output: Contribution to journalArticle

57 Scopus citations
53 Scopus citations

Pathway Analysis Reveals Common Pro-Survival Mechanisms of Metyrapone and Carbenoxolone after Traumatic Brain Injury

Hellmich, H. L., Rojo, D. R., Micci, M. A., Sell, S. L., Boone, D. R., Crookshanks, J. M., DeWitt, D. S., Masel, B. E. & Prough, D. S., Jan 9 2013, In : PloS one. 8, 1, e53230.

Research output: Contribution to journalArticle

16 Scopus citations

Rapid accumulation of endogenous Tau oligomers in a rat model of traumatic brain injury: Possible link between traumatic brain injury and sporadic tauopathies

Hawkins, B. E., Krishnamurthy, S., Castillo-Carranza, D. L., Sengupta, U., Prough, D. S., Jackson, G. R., DeWitt, D. S. & Kayed, R., Jun 7 2013, In : Journal of Biological Chemistry. 288, 23, p. 17042-17050 9 p.

Research output: Contribution to journalArticle

85 Scopus citations
2012

Cellular bioenergetics is regulated by PARP1 under resting conditions and during oxidative stress

Módis, K., Gerö, D., Erdélyi, K., Szoleczky, P., Dewitt, D. & Szabo, C., Mar 1 2012, In : Biochemical Pharmacology. 83, 5, p. 633-643 11 p.

Research output: Contribution to journalArticle

54 Scopus citations

Fluorophilia: Fluorophore-containing compounds adhere non-specifically to injured neurons

Hawkins, B. E., Frederickson, C. J., Dewitt, D. S. & Prough, D. S., Jan 13 2012, In : Brain Research. 1432, p. 28-35 8 p.

Research output: Contribution to journalArticle

6 Scopus citations

Galveston brain injury conference 2010: Clinical and experimental aspects of blast injury

Masel, B. E., Bell, R. S., Brossart, S., Grill, R. J., Hayes, R. L., Levin, H. S., Rasband, M. N., Ritzel, D. V., Wade, C. E. & Dewitt, D. S., Aug 10 2012, In : Journal of neurotrauma. 29, 12, p. 2143-2171 29 p.

Research output: Contribution to journalArticle

24 Scopus citations

Identification of agents that reduce renal hypoxia-reoxygenation injury using cell-based screening: Purine nucleosides are alternative energy sources in LLC-PK1 cells during hypoxia

Szoleczky, P., Módis, K., Nagy, N., Dóri Tóth, Z., Dewitt, D., Szabó, C. & Gero, D., Jan 1 2012, In : Archives of Biochemistry and Biophysics. 517, 1, p. 53-70 18 p.

Research output: Contribution to journalArticle

17 Scopus citations

Molecular mechanisms underlying effects of neural stem cells against traumatic axonal injury

Wang, E., Gao, J., Yang, Q., Parsley, M. O., Dunn, T. J., Zhang, L., Dewitt, D. S., Denner, L., Prough, D. S. & Wu, P., Jan 20 2012, In : Journal of neurotrauma. 29, 2, p. 295-312 18 p.

Research output: Contribution to journalArticle

22 Scopus citations

Traumatic Brain Injury-Induced Dysregulation of the Circadian Clock

Boone, D. R., Sell, S. L., Micci, M. A., Crookshanks, J. M., Parsley, M., Uchida, T., Prough, D. S., DeWitt, D. S. & Hellmich, H. L., Oct 3 2012, In : PloS one. 7, 10, e46204.

Research output: Contribution to journalArticle

43 Scopus citations
2011

Cerebrovascular connexin expression: Effects of traumatic brain injury

Avila, M. A., Sell, S. L., Hawkins, B. E., Hellmich, H. L., Boone, D. R., Crookshanks, J. M., Prough, D. S. & Dewitt, D. S., Sep 1 2011, In : Journal of neurotrauma. 28, 9, p. 1803-1811 9 p.

Research output: Contribution to journalArticle

12 Scopus citations

Cytoprotective effect of γ-tocopherol against tumor necrosis factor α induced cell dysfunction in L929 cells

Oláh, G., Módis, K., Gero, D., Suzuki, K., Dewit, D., Traber, D. L. & Szabó, C., Nov 1 2011, In : International journal of molecular medicine. 28, 5, p. 711-720 10 p.

Research output: Contribution to journalArticle

5 Scopus citations

Influence of stochastic gene expression on the cell survival rheostat after traumatic brain injury

Rojo, D. R., Prough, D. S., Falduto, M. T., Boone, D. R., Micci, M. A., Kahrig, K. M., Crookshanks, J. M., Jimenez, A., Uchida, T., Cowart, J. C., Hawkins, B. E., Avila, M., DeWitt, D. S. & Hellmich, H. L., Aug 18 2011, In : PloS one. 6, 8, e23111.

Research output: Contribution to journalArticle

24 Scopus citations
2010
22 Scopus citations
2009

Blast-related brain injury: imaging for clinical and research applications: report of the 2008 st. louis workshop

Benzinger, T. L. S., Brody, D., Cardin, S., Curley, K. C., Mintun, M. A., Mun, S. K., Wong, K. H., Wrathall, J. R., Armstrong, R. C., Bayly, P. V., Bentley, T. B., Chavko, M., Corbetta, M., Culver, J. P., DeWitt, D. S., Faden, A. I., Fiskum, G., Fitzpatrick, S. M., Gennarelli, T., Ghajar, J. & 36 others, Gullapalli, R. P., Hovda, D., Jost, R. G., Kharasch, E. D., Kharasch, K., Kochanek, P., Lammle, M., Leggieri, M. J., Latour, L. L., Little, D. M., Mac Donald, C. L., Macedonia, C., Marcus, D., McCabe, J. T., McCarron, R. M., Moore, D., Mukherjee, P., Povlishock, J., Pancrazio, J., Petersen, S., Peskind, E. R., Pierce, K. J., Pineda, J. A., Raskind, M., Riedel, C., Ritzel, D., Shimony, J. S., Smith, A. B., Smith, D. H., Smirniotopoulos, J., Song, V. S. K., Sterkel, B. B., Svetlov, S., VandeVord, P. J., Young, A. W. & Zipfel, G., Dec 1 2009, In : Journal of neurotrauma. 26, 12, p. 2127-2144 18 p.

Research output: Contribution to journalArticle

58 Scopus citations
2008

Chelation of neurotoxic zinc levels does not improve neurobehavioral outcome after traumatic brain injury

Hellmich, H. L., Eidson, K., Cowart, J., Crookshanks, J., Boone, D. K., Shah, S., Uchida, T., DeWitt, D. S. & Prough, D. S., Aug 1 2008, In : Neuroscience Letters. 440, 2, p. 155-159 5 p.

Research output: Contribution to journalArticle

16 Scopus citations

Hypertonic resuscitation improves neuronal and behavioral outcomes after traumatic brain injury plus hemorrhage

Sell, S. L., Avila, M. A., Yu, G., Vergara, L., Prough, D. S., Grady, J. J. & DeWitt, D. S., May 2008, In : Anesthesiology. 108, 5, p. 873-881 9 p.

Research output: Contribution to journalArticle

25 Scopus citations

L-arginine decreases fluid-percussion injury-induced neuronal nitrotyrosine immunoreactivity in rats

Avila, M. A., Sell, S. L., Kadoi, Y., Prough, D. S., Hellmich, H. L., Velasco, M. & Dewitt, D. S., Oct 1 2008, In : Journal of Cerebral Blood Flow and Metabolism. 28, 10, p. 1733-1741 9 p.

Research output: Contribution to journalArticle

13 Scopus citations
2007

Injured Fluoro-Jade-positive hippocampal neurons contain high levels of zinc after traumatic brain injury

Hellmich, H. L., Eidson, K. A., Capra, B. A., Garcia, J. M., Boone, D. R., Hawkins, B. E., Uchida, T., DeWitt, D. S. & Prough, D. S., Jan 5 2007, In : Brain Research. 1127, 1, p. 119-126 8 p.

Research output: Contribution to journalArticle

37 Scopus citations
2006
13 Scopus citations

Molecular correlates of age-specific responses to traumatic brain injury in mice

Shah, S. A., Prough, D. S., Garcia, J. M., DeWitt, D. S. & Hellmich, H. L., Nov 1 2006, In : Experimental Gerontology. 41, 11, p. 1201-1205 5 p.

Research output: Contribution to journalArticle

26 Scopus citations
2005

Analysis of long-term gene expression in neurons of the hippocampal subfields following traumatic brain injury in rats

Shimamura, M., Garcia, J. M., Prough, D. S., Dewitt, D. S., Uchida, T., Shah, S. A., Avila, M. A. A. & Hellmich, H. L., Feb 9 2005, In : Neuroscience. 131, 1, p. 87-97 11 p.

Research output: Contribution to journalArticle

26 Scopus citations

Dose-dependent neuronal injury after traumatic brain injury

Hellmich, H. L., Capra, B., Eidson, K., Garcia, J., Kennedy, D., Uchida, T., Parsley, M., Cowart, J., DeWitt, D. S. & Prough, D. S., May 24 2005, In : Brain Research. 1044, 2, p. 144-154 11 p.

Research output: Contribution to journalArticle

36 Scopus citations