Eric Wagner, PhD

Program Director, Biochemistry & Molecular Biology

  • 3551 Citations
  • 25 h-Index
19992023
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Research Output 1999 2020

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Article
2020

Downregulation of CFIm25 amplifies dermal fibrosis through alternative polyadenylation

Weng, T., Huang, J., Wagner, E. J., Ko, J., Wu, M., Wareing, N. E., Xiang, Y., Chen, N. Y., Ji, P., Molina, J. G., Volcik, K. A., Han, L., Mayes, M. D., Blackburn, M. R. & Assassi, S., Feb 3 2020, In : The Journal of experimental medicine. 217, 2

Research output: Contribution to journalArticle

Open Access
Polyadenylation
Fibrosis
Down-Regulation
Skin
3' Untranslated Regions
2019
3 Citations (Scopus)

Cleavage factor 25 deregulation contributes to pulmonary fibrosis through alternative polyadenylation

Weng, T., Ko, J., Masamha, C. P., Xia, Z., Xiang, Y., Chen, N. Y., Molina, J. G., Collum, S., Mertens, T. C., Luo, F., Philip, K., Davies, J., Huang, J., Wilson, C., Thandavarayan, R. A., Bruckner, B. A., Jyothula, S. S. K., Volcik, K. A., Li, L., Han, L. & 5 others, Li, W., Assassi, S., Karmouty-Quintana, H., Wagner, E. & Blackburn, M. R., May 1 2019, In : Journal of Clinical Investigation. 129, 5, p. 1984-1999 16 p.

Research output: Contribution to journalArticle

Open Access
Idiopathic Pulmonary Fibrosis
Polyadenylation
Pulmonary Fibrosis
Fibroblasts
Down-Regulation
1 Citation (Scopus)

Composition of the survival motor neuron (SMN) complex in drosophila melanogaster

Gregory Matera, A., Raimer, A. C., Schmidt, C. A., Kelly, J. A., Droby, G. N., Baillat, D., Ten Have, S., Lamond, A. I., Wagner, E. & Gray, K. M., Feb 1 2019, In : G3: Genes, Genomes, Genetics. 9, 2, p. 491-503 13 p.

Research output: Contribution to journalArticle

Open Access
SMN Complex Proteins
Motor Neurons
Drosophila melanogaster
Survival
Small Nuclear Ribonucleoproteins
1 Citation (Scopus)

Development of Poly(A)-ClickSeq as a tool enabling simultaneous genome-wide poly(A)-site identification and differential expression analysis

Elrod, N. D., Jaworski, E. A., Ji, P., Wagner, E. & Routh, A., Jan 1 2019, (Accepted/In press) In : Methods.

Research output: Contribution to journalArticle

Poly A
Genes
Genome
RNA
Gene Expression
3 Citations (Scopus)

Nudt21 regulates the alternative polyadenylation of Pak1 and is predictive in the prognosis of glioblastoma patients

Chu, Y., Elrod, N., Wang, C., Li, L., Chen, T., Routh, A., Xia, Z., Li, W., Wagner, E. & Ji, P., Jan 1 2019, In : Oncogene.

Research output: Contribution to journalArticle

Polyadenylation
Glioblastoma
3' Untranslated Regions
Glioma
Genes

The Integrator Complex Attenuates Promoter-Proximal Transcription at Protein-Coding Genes

Elrod, N. D., Henriques, T., Huang, K. L., Tatomer, D. C., Wilusz, J. E., Wagner, E. J. & Adelman, K., Dec 5 2019, In : Molecular cell. 76, 5, p. 738-752.e7

Research output: Contribution to journalArticle

RNA
RNA Polymerase II
Genes
Proteins
Peptide Elongation Factors
2018
27 Citations (Scopus)

3′ UTR shortening represses tumor-suppressor genes in trans by disrupting ceRNA crosstalk

Park, H. J., Ji, P., Kim, S., Xia, Z., Rodriguez, B., Li, L., Su, J., Chen, K., Masamha, C. P., Baillat, D., Fontes-Garfias, C. R., Shyu, A. B., Neilson, J. R., Wagner, E. & Li, W., May 21 2018, (Accepted/In press) In : Nature Genetics. p. 1-7 7 p.

Research output: Contribution to journalArticle

3' Untranslated Regions
Tumor Suppressor Genes
Proto-Oncogenes
MicroRNAs
Neoplasms
5 Citations (Scopus)

Integrator subunit 4 is a ‘Symplekin-like’ scaffold that associates with INTS9/11 to form the Integrator cleavage module

Albrecht, T. R., Shevtsov, S. P., Wu, Y., Mascibroda, L. G., Peart, N. J., Huang, K-L., Sawyer, I. A., Tong, L., Dundr, M. & Wagner, E., Jan 1 2018, In : Nucleic Acids Research. 46, 8, p. 4241-4255 15 p.

Research output: Contribution to journalArticle

Cleavage And Polyadenylation Specificity Factor
Terminal Repeat Sequences
RNA Polymerase II
Histones
Catalytic Domain
8 Citations (Scopus)

Self-oligomerization regulates stability of survival motor neuron protein isoforms by sequestering an SCFSlmb degron

Gray, K. M., Kaifer, K. A., Baillat, D., Wen, Y., Bonacci, T. R., Ebert, A. D., Raimer, A. C., Spring, A. M., Have, S. T., Glascock, J. J., Gupta, K., Van Duyne, G. D., Emanuele, M. J., Lamond, A. I., Wagner, E., Lorson, C. L. & Gregory Matera, A., Jan 15 2018, In : Molecular Biology of the Cell. 29, 2, p. 96-110 15 p.

Research output: Contribution to journalArticle

Motor Neurons
Protein Isoforms
Spinal Muscular Atrophy
Exons
Duplicate Genes
3 Citations (Scopus)

TC3A: The Cancer 3′ UTR Atlas

Feng, X., Li, L., Wagner, E. & Li, W., Jan 1 2018, In : Nucleic Acids Research. 46, D1, p. D1027-D1030

Research output: Contribution to journalArticle

Atlases
3' Untranslated Regions
Polyadenylation
Neoplasms
Neoplasm Genes
2017
5 Citations (Scopus)

A distal auxiliary element facilitates cleavage and polyadenylation of Dux4 mRNA in the pathogenic haplotype of FSHD

Peart, N. & Wagner, E., May 24 2017, (Accepted/In press) In : Human Genetics. p. 1-11 11 p.

Research output: Contribution to journalArticle

Polyadenylation
Homeobox Genes
Haplotypes
Messenger RNA
Single Nucleotide Polymorphism
19 Citations (Scopus)

Human mutations in integrator complex subunits link transcriptome integrity to brain development

Oegema, R., Baillat, D., Schot, R., van Unen, L. M., Brooks, A., Kia, S. K., Hoogeboom, A. J. M., Xia, Z., Li, W., Cesaroni, M., Lequin, M. H., van Slegtenhorst, M., Dobyns, W. B., de Coo, I. F. M., Verheijen, F. W., Kremer, A., van der Spek, P. J., Heijsman, D., Wagner, E., Fornerod, M. & 1 others, Mancini, G. M. S., May 1 2017, In : PLoS Genetics. 13, 5, e1006809.

Research output: Contribution to journalArticle

Transcriptome
transcriptome
brain
mutation
Mutation
7 Citations (Scopus)

Molecular basis for the interaction between Integrator subunits IntS9 and IntS11 and its functional importance

Wu, Y., Albrecht, T. R., Baillat, D., Wagner, E. & Tong, L., Apr 25 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 17, p. 4394-4399 6 p.

Research output: Contribution to journalArticle

Small Nuclear RNA
Endonucleases
Untranslated RNA
Two-Hybrid System Techniques
RNA Polymerase II
13 Citations (Scopus)

Poly(A)-ClickSeq: Click-chemistry for next-generation 3'-end sequencing without RNA enrichment or fragmentation

Routh, A., Ji, P., Jaworski, E., Xia, Z., Li, W. & Wagner, E., Jul 1 2017, In : Nucleic Acids Research. 45, 12, e112.

Research output: Contribution to journalArticle

Click Chemistry
RNA Sequence Analysis
Poly A
Polyadenylation
RNA
2016
11 Citations (Scopus)

CFIm25 regulates glutaminase alternative terminal exon definition to modulate MIR-23 function

Masamha, C. P., Xia, Z., Peart, N., Collum, S., Li, W., Wagner, E. & Shyu, A. B., Jun 1 2016, In : RNA. 22, 6, p. 830-838 9 p.

Research output: Contribution to journalArticle

Glutaminase
MicroRNAs
Exons
Polyadenylation
Protein Isoforms
4 Citations (Scopus)
Clustered Regularly Interspaced Short Palindromic Repeats
Genetic Engineering
Epitopes
Silver Staining
HEK293 Cells
5 Citations (Scopus)

Discovery and characterization of a novel CCND1/MRCK gene fusion in mantle cell lymphoma

Masamha, C. P., Albrecht, T. R. & Wagner, E., 2016, In : Journal of Hematology and Oncology. 9, 1, 30.

Research output: Contribution to journalArticle

Mantle-Cell Lymphoma
Myotonic Dystrophy
Gene Fusion
Cyclin D1
Phosphotransferases
3 Citations (Scopus)

Gain-of-function reporters for analysis of mrna 3´-end formation: Design and optimization

Peart, N. & Wagner, E., Mar 1 2016, In : BioTechniques. 60, 3, p. 137-140 4 p.

Research output: Contribution to journalArticle

Messenger RNA
RNA 3' End Processing
Housekeeping
Radioactivity
Processing
2015
32 Citations (Scopus)

Integrator: Surprisingly diverse functions in gene expression

Baillat, D. & Wagner, E., May 1 2015, In : Trends in Biochemical Sciences. 40, 5, p. 257-264 8 p.

Research output: Contribution to journalArticle

Small Nuclear RNA
Gene expression
RNA Polymerase II
Genes
Gene Expression
2014
133 Citations (Scopus)

CFIm25 links alternative polyadenylation to glioblastoma tumour suppression

Masamha, C. P., Xia, Z., Yang, J., Albrecht, T. R., Li, M., Shyu, A. B., Li, W. & Wagner, E., 2014, In : Nature. 510, 7505, p. 412-416 5 p.

Research output: Contribution to journalArticle

Polyadenylation
Glioblastoma
3' Untranslated Regions
Neoplasms
RNA 3' End Processing
118 Citations (Scopus)

Dynamic analyses of alternative polyadenylation from RNA-seq reveal a 3'2-UTR landscape across seven tumour types

Xia, Z., Donehower, L. A., Cooper, T. A., Neilson, J. R., Wheeler, D. A., Wagner, E. & Li, W., 2014, In : Nature Communications. 5, 5274.

Research output: Contribution to journalArticle

Untranslated Regions
Polyadenylation
3' Untranslated Regions
Tumors
tumors
59 Citations (Scopus)

Integrator regulates transcriptional initiation and pause release following activation

Gardini, A., Baillat, D., Cesaroni, M., Hu, D., Marinis, J. M., Wagner, E., Lazar, M. A., Shilatifard, A. & Shiekhattar, R., 2014, In : Molecular Cell. 56, 1, p. 128-139 12 p.

Research output: Contribution to journalArticle

Immediate-Early Genes
RNA Polymerase II
Epidermal Growth Factor
Transcriptional Activation
Multiprotein Complexes
23 Citations (Scopus)

MicroRNA-566 activates EGFR signaling and its inhibition sensitizes glioblastoma cells to nimotuzumab

Zhang, K. L., Zhou, X., Han, L., Chen, L. Y., Chen, L. C., Shi, Z. D., Yang, M., Ren, Y., Yang, J. X., Frank, T. S., Zhang, C. B., Zhang, J. X., Pu, P. Y., Zhang, J. N., Jiang, T., Wagner, E., Li, M. & Kang, C. S., Mar 20 2014, In : Molecular Cancer. 13, 1, 63.

Research output: Contribution to journalArticle

Glioblastoma
MicroRNAs
Epidermal Growth Factor Receptor
Cell Proliferation
Glioma
2013
12 Citations (Scopus)

Functional analysis of the integrator subunit 12 identifies a microdomain that mediates activation of the drosophila integrator complex

Chen, J., Waltenspiel, B., Warren, W. D. & Wagner, E., Feb 15 2013, In : Journal of Biological Chemistry. 288, 7, p. 4867-4877 11 p.

Research output: Contribution to journalArticle

Small Nuclear RNA
Functional analysis
Drosophila
Chemical activation
RNA 3' End Processing
5 Citations (Scopus)

Half Pint/Puf68 is required for negative regulation of splicing by the SR factor Transformer2

Wang, S., Wagner, E. & Mattox, W., Aug 2013, In : RNA Biology. 10, 8, p. 1396-1406 11 p.

Research output: Contribution to journalArticle

Introns
Proteins
Co-Repressor Proteins
Alternative Splicing
Drosophila
13 Citations (Scopus)

Non-mRNA 3′ end formation: How the other half lives

Peart, N., Sataluri, A., Baillat, D. & Wagner, E., Sep 2013, In : Wiley Interdisciplinary Reviews: RNA. 4, 5, p. 491-506 16 p.

Research output: Contribution to journalArticle

RNA
Small Nuclear RNA
Processing
Machinery
Untranslated RNA
5 Citations (Scopus)

Nuclear-localized Asunder regulates cytoplasmic dynein localization via its role in the Integrator complex

Jodoin, J. N., Sitaram, P., Albrecht, T. R., May, S. B., Shboul, M., Lee, E., Reversade, B., Wagner, E. & Lee, L. A., Sep 15 2013, In : Molecular Biology of the Cell. 24, 18, p. 2954-2965 12 p.

Research output: Contribution to journalArticle

Cytoplasmic Dyneins
Dyneins
Nuclear Envelope
Spermatocytes
Drosophila
5 Citations (Scopus)

The snRNA-processing complex, Integrator, is required for ciliogenesis and dynein recruitment to the nuclear envelope via distinct mechanisms

Jodoin, J. N., Shboul, M., Albrecht, T. R., Lee, E., Wagner, E., Reversade, B. & Lee, L. A., Dec 15 2013, In : Biology Open. 2, 12, p. 1390-1396 7 p.

Research output: Contribution to journalArticle

small nuclear RNA
Small Nuclear RNA
Dyneins
Nuclear Envelope
nuclear membrane
2012
28 Citations (Scopus)

An RNAi screen identifies additional members of the Drosophila Integrator complex and a requirement for cyclin C/Cdk8 in snRNA 3′-end formation

Chen, J., Ezzeddine, N., Waltenspiel, B., Albrecht, T. R., Warren, W. D., Marzluff, W. F. & Wagner, E., Dec 2012, In : RNA. 18, 12, p. 2148-2156 9 p.

Research output: Contribution to journalArticle

Cyclin C
Small Nuclear RNA
RNA Interference
Drosophila
RNA Polymerase II
23 Citations (Scopus)

snRNA 3′ end formation requires heterodimeric association of integrator subunits

Albrecht, T. R. & Wagner, E., Mar 2012, In : Molecular and Cellular Biology. 32, 6, p. 1112-1123 12 p.

Research output: Contribution to journalArticle

Small Nuclear RNA
RNA 3' End Processing
Poly A
Endonucleases
RNA Precursors
412 Citations (Scopus)

Understanding the language of Lys36 methylation at histone H3

Wagner, E. & Carpenter, P. B., Feb 2012, In : Nature Reviews Molecular Cell Biology. 13, 2, p. 115-126 12 p.

Research output: Contribution to journalArticle

Histones
Methylation
Chromatin
Language
Euchromatin
2011
25 Citations (Scopus)

A brief survey of mRNA surveillance

Van Hoof, A. & Wagner, E., Nov 2011, In : Trends in Biochemical Sciences. 36, 11, p. 585-592 8 p.

Research output: Contribution to journalArticle

Messenger RNA
Eukaryotic Cells
Aberrations
Surveys and Questionnaires
RNA
43 Citations (Scopus)

A subset of Drosophila integrator proteins is essential for efficient U7 snRNA and spliceosomal snRNA 3′-end formation

Ezzeddine, N., Chen, J., Waltenspiel, B., Burch, B., Albrecht, T., Zhuo, M., Warren, W. D., Marzluff, W. F. & Wagner, E., Jan 2011, In : Molecular and Cellular Biology. 31, 2, p. 328-341 14 p.

Research output: Contribution to journalArticle

Small Nuclear RNA
Drosophila Proteins
Drosophila
Vertebrates
mRNA Cleavage and Polyadenylation Factors
2010
34 Citations (Scopus)

snRNA 3′ end formation: The dawn of the Integrator complex

Chen, J. & Wagner, E., Aug 2010, In : Biochemical Society Transactions. 38, 4, p. 1082-1087 6 p.

Research output: Contribution to journalArticle

Small Nuclear RNA
Biosynthesis
Processing
Small Nuclear Ribonucleoproteins
Untranslated RNA
2009
57 Citations (Scopus)

Knockdown of SLBP results in nuclear retention of histone mRNA

Sullivan, K. D., Mullen, T. E., Marzluff, W. F. & Wagner, E., Mar 2009, In : RNA. 15, 3, p. 459-472 14 p.

Research output: Contribution to journalArticle

Histones
Carrier Proteins
Messenger RNA
RNA Stability
Protein Biosynthesis
2008
403 Citations (Scopus)

Metabolism and regulation of canonical histone mRNAs: Life without a poly(A) tail

Marzluff, W. F., Wagner, E. & Duronio, R. J., Nov 2008, In : Nature Reviews Genetics. 9, 11, p. 843-854 12 p.

Research output: Contribution to journalArticle

Histones
Messenger RNA
S Phase
Epigenomics
Chromatin
49 Citations (Scopus)

SLIP1, a factor required for activation of histone mRNA translation by the stem-loop binding protein

Cakmakci, N. G., Lerner, R. S., Wagner, E., Zheng, L. & Marzluff, W. F., Feb 2008, In : Molecular and Cellular Biology. 28, 3, p. 1182-1194 13 p.

Research output: Contribution to journalArticle

Protein Biosynthesis
Histones
Carrier Proteins
Messenger RNA
Proteins
2007
58 Citations (Scopus)

A Genome-wide RNA Interference Screen Reveals that Variant Histones Are Necessary for Replication-Dependent Histone Pre-mRNA Processing

Wagner, E., Burch, B. D., Godfrey, A. C., Salzler, H. R., Duronio, R. J. & Marzluff, W. F., Nov 30 2007, In : Molecular Cell. 28, 4, p. 692-699 8 p.

Research output: Contribution to journalArticle

RNA Precursors
RNA Interference
Histones
Genome
U7 Small Nuclear Ribonucleoproteins
2006
15 Citations (Scopus)

Conserved zinc fingers mediate multiple functions of ZFP100, a U7snRNP associated protein

Wagner, E., Ospina, J. K., Hu, Y., Dundr, M., Matera, A. G. & Marzluff, W. F., 2006, In : RNA. 12, 7, p. 1206-1218 13 p.

Research output: Contribution to journalArticle

U7 Small Nuclear Ribonucleoproteins
Zinc Fingers
Histones
RNA Precursors
Messenger RNA
78 Citations (Scopus)

Nuclear autoantigenic sperm protein (NASP), a linker histone chaperone that is required for cell proliferation

Richardson, R. T., Alekseev, O. M., Grossman, G., Widgren, E. E., Thresher, R., Wagner, E., Sullivan, K. D., Marzluff, W. F. & O'Rand, M. G., Jul 28 2006, In : Journal of Biological Chemistry. 281, 30, p. 21526-21534 9 p.

Research output: Contribution to journalArticle

Histone Chaperones
Cell proliferation
Spermatozoa
Cell Proliferation
Histones
22 Citations (Scopus)

ZFP100, a component of the active U7 snRNP limiting for histone pre-mRNA processing, is required for entry into S phase

Wagner, E. & Marzluff, W. F., Sep 2006, In : Molecular and Cellular Biology. 26, 17, p. 6702-6712 11 p.

Research output: Contribution to journalArticle

U7 Small Nuclear Ribonucleoproteins
RNA Precursors
S Phase
Histones
Small Nuclear Ribonucleoproteins
2005
65 Citations (Scopus)

A CPSF-73 homologue is required for cell cycle progression but not cell growth and interacts with a protein having features of CPSF-100

Dominski, Z., Yang, X. C., Purdy, M., Wagner, E. & Marzluff, W. F., Feb 2005, In : Molecular and Cellular Biology. 25, 4, p. 1489-1500 12 p.

Research output: Contribution to journalArticle

Cleavage And Polyadenylation Specificity Factor
Cell Cycle
Growth
Proteins
RNA Precursors
29 Citations (Scopus)

Characterization of the intronic splicing silencers flanking FGFR2 exon IIIb

Wagner, E., Baraniak, A. P., Sessions, O. M., Mauger, D., Moskowitz, E. & Garcia-Blanco, M., Apr 8 2005, In : Journal of Biological Chemistry. 280, 14, p. 14017-14027 11 p.

Research output: Contribution to journalArticle

Exons
Polypyrimidine Tract-Binding Protein
Protein Binding
Binding Sites
RNA Splice Sites
21 Citations (Scopus)

Expression of an RNAi-resistant SLBP restores proper S-phase progression

Wagner, E., Berkow, A. & Marzluff, W. F., Jun 2005, In : Biochemical Society Transactions. 33, 3, p. 471-473 3 p.

Research output: Contribution to journalArticle

RNA Interference
S Phase
Carrier Proteins
Histones
DNA Replication
29 Citations (Scopus)

Nuclear import of the stem-loop binding protein and localization during the cell cycle

Erkmann, J. A., Wagner, E., Dong, J., Zhang, Y., Kutay, U. & Marzluff, W. F., 2005, In : Molecular Biology of the Cell. 16, 6, p. 2960-2971 12 p.

Research output: Contribution to journalArticle

Cell Nucleus Active Transport
Cell Cycle
Carrier Proteins
Histones
Messenger RNA
34 Citations (Scopus)

The polypyrimidine tract binding protein is required for efficient picornavirus gene expression and propagation

Florez, P. M., Sessions, O. M., Wagner, E., Gromeier, M. & Garcia-Blanco, M., May 2005, In : Journal of Virology. 79, 10, p. 6172-6179 8 p.

Research output: Contribution to journalArticle

Polypyrimidine Tract-Binding Protein
Picornaviridae
binding proteins
Gene Expression
gene expression
2004
275 Citations (Scopus)

Autoregulation of Polypyrimidine Tract Binding Protein by Alternative Splicing Leading to Nonsense-Mediated Decay

Wollerton, M. C., Gooding, C., Wagner, E., Garcia-Blanco, M. & Smith, C. W. J., Jan 16 2004, In : Molecular Cell. 13, 1, p. 91-100 10 p.

Research output: Contribution to journalArticle

Polypyrimidine Tract-Binding Protein
Protein Splicing
Alternative Splicing
Carrier Proteins
Homeostasis
12 Citations (Scopus)

Imaging alternative splicing in living cells.

Wagner, E., Baines, A., Albrecht, T., Brazas, R. M. & Garcia-Blanco, M., 2004, In : Methods in molecular biology (Clifton, N.J.). 257, p. 29-46 18 p.

Research output: Contribution to journalArticle

Alternative Splicing
Recombinant DNA
Tumor Biomarkers
Fluorescence
Neoplasm Metastasis
2003
69 Citations (Scopus)
Receptor, Fibroblast Growth Factor, Type 2
Exons
Alternative Splicing
Epithelial Cells
RNA Precursors
25 Citations (Scopus)

Of urchins and men: Evolution of an alternative splicing unit in fibroblast growth factor receptor genes

Mistry, N., Harrington, W., Lasda, E., Wagner, E. & Garcia-Blanco, M., Feb 1 2003, In : RNA. 9, 2, p. 209-217 9 p.

Research output: Contribution to journalArticle

Fibroblast Growth Factor Receptors
Alternative Splicing
Genes
Sea Urchins
Proteome