Projects per year
Personal profile
Research Strategic Pillar
Dr. Randall Urban, VP and Chief Research Officer, has determined that UTMB research should be prioritized into six health communities. This researcher has received the following badge(s):
Research interests
We are working to develop improved drug delivery strategies, with special emphasis on drug and nanoparticle transport across the placenta in order to address the needs of pregnant women requiring medical therapy or diagnostics, and to answer questions regarding the safety of medication during pregnancy in relation to fetal development. Maintenance of the mother's health promotes successful pregnancy outcomes, and this may require pharmacologic therapy for pregnant women with asthma, diabetes, epilepsy, HIV, or other illnesses. For a small but significant percentage of women, cancer is discovered during pregnancy, which presents a special challenge to adequately treat the cancer and simultaneously protect the baby's growth within the womb. In some instances, fetal therapy is required to treat conditions such as fetal arrhythmias or congenital adrenal hyperplasia; these cases may require drug delivery to the fetus while trying to reduce unwanted side effects in the mother.
Education/Academic qualification
B.S. Chemical Engineering, Brigham Young University, Provo, Utah
Ph.D. Pharmaceutical Chemistry, University of Kansas, Lawrence, Kansas
Research Strategic Pillar Keywords
- Life Span Health
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Collaborations and top research areas from the last five years
Projects
- 1 Completed
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Folate-mediated Transport of Nanoparticles across the Placenta
Kalashnikova, I., Patrikeeva, S., Nanovskaya, T. N., Andreev, Y. A., Ahmed, M. S. & Rytting, E., 2024, In: Pharmaceutical Nanotechnology. 12, 2, p. 171-183 13 p.Research output: Contribution to journal › Article › peer-review
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Indomethacin Pharmacokinetics and Pharmacodynamics in Pregnancies With Preterm Labor: The Need for Dose-Ranging Trials
Balevic, S. J., Weiner, D., Hornik, C. P., Cohen-Wolkowiez, M., Gonzalez, D., Wang, X., Xu, M., Abdel-Rahman, S. Z. & Rytting, E., 2024, (Accepted/In press) In: Journal of clinical pharmacology.Research output: Contribution to journal › Article › peer-review
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B cell-specific mAb–siRNA conjugates improve experimental myasthenia
Ibtehaj, N., Bahauddin, A., Ivannikov, M., Rytting, E., Jamaluddin, M., Liang, Y., Sun, J., Haller, S., Wu, X. & Huda, R., Feb 2023, In: Journal of Autoimmunity. 135, 102983.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
Drug Transport Across the Placental Barrier
Bryant, V., Shah, M., Waltz, J. & Rytting, E., Jan 1 2023, Oral Bioavailability and Drug Delivery: From Basics to Advanced Concepts and Applications. wiley, p. 111-129 19 p.Research output: Chapter in Book/Report/Conference proceeding › Chapter
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PEGylated Polymeric Nanoparticles Loaded with 2-Methoxyestradiol for the Treatment of Uterine Leiomyoma in a Patient-Derived Xenograft Mouse Model
Enazy, S. A., Kirschen, G. W., Vincent, K., Yang, J., Saada, J., Shah, M., Oberhauser, A. F., Bujalowski, P., Motamedi, M., Salama, S. A., Kilic, G., Rytting, E. & Borahay, M., Sep 2023, In: Journal of Pharmaceutical Sciences. 112, 9, p. 2552-2560 9 p.Research output: Contribution to journal › Article › peer-review
5 Scopus citations