Gabrielle Rudenko, PhD

  • 1527 Citations
  • 19 h-Index
1992 …2023

Research output per year

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Research Output

  • 1527 Citations
  • 19 h-Index
  • 25 Article
  • 5 Review article
  • 1 Editorial
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Article
2018

Structural Plasticity of Neurexin 1α: Implications for its Role as Synaptic Organizer

Liu, J., Misra, A., Reddy, M. V. V. V. S., White, M. A., Ren, G. & Rudenko, G., Oct 19 2018, In : Journal of Molecular Biology. 430, 21, p. 4325-4343 19 p.

Research output: Contribution to journalArticle

3 Scopus citations
2017

Activator Protein-1: redox switch controlling structure and DNA-binding

Yin, Z., Machius, M., Nestler, E. J. & Rudenko, G., Nov 2 2017, In : Nucleic Acids Research. 45, 19, p. 11425-11436 12 p.

Research output: Contribution to journalArticle

10 Scopus citations

Molecular Mechanism of MDGA1: Regulation of Neuroligin 2:Neurexin Trans-synaptic Bridges

Gangwar, S. P., Zhong, X., Seshadrinathan, S., Chen, H., Machius, M. & Rudenko, G., Jun 21 2017, In : Neuron. 94, 6, p. 1132-1141.e4

Research output: Contribution to journalArticle

20 Scopus citations
2016

Data publication with the structural biology data grid supports live analysis

Meyer, P. A., Socias, S., Key, J., Ransey, E., Tjon, E. C., Buschiazzo, A., Lei, M., Botka, C., Withrow, J., Neau, D., Rajashankar, K., Anderson, K. S., Baxter, R. H., Blacklow, S. C., Boggon, T. J., Bonvin, A. M. J. J., Borek, D., Brett, T. J., Caflisch, A., Chang, C. I. & 50 others, Chazin, W. J., Corbett, K. D., Cosgrove, M. S., Crosson, S., Dhe-Paganon, S., Di Cera, E., Drennan, C. L., Eck, M. J., Eichman, B. F., Fan, Q. R., Ferré-D'Amaré, A. R., Fromme, J. C., Garcia, K. C., Gaudet, R., Gong, P., Harrison, S. C., Heldwein, E. E., Jia, Z., Keenan, R. J., Kruse, A. C., Kvansakul, M., McLellan, J. S., Modis, Y., Nam, Y., Otwinowski, Z., Pai, E. F., Pereira, P. J. B., Petosa, C., Raman, C. S., Rapoport, T. A., Roll-Mecak, A., Rosen, M. K., Rudenko, G., Schlessinger, J., Schwartz, T. U., Shamoo, Y., Sondermann, H., Tao, Y. J., Tolia, N. H., Tsodikov, O. V., Westover, K. D., Wu, H., Foster, I., Fraser, J. S., Maia, F. R. N. C., Gonen, T., Kirchhausen, T., Diederichs, K., Crosas, M. & Sliz, P., Mar 7 2016, In : Nature communications. 7, 10882.

Research output: Contribution to journalArticle

61 Scopus citations

Functional analysis of rare variants found in schizophrenia implicates a critical role for GIT1–PAK3 signaling in neuroplasticity

Kim, M. J., Biag, J., Fass, D. M., Lewis, M. C., Zhang, Q., Fleishman, M., Gangwar, S., Machius, M., Fromer, M., Purcell, S. M., McCarroll, S. A., Rudenko, G., Premont, R. T., Scolnick, E. M. & Haggarty, S. J., Jul 26 2016, (Accepted/In press) In : Molecular Psychiatry.

Research output: Contribution to journalArticle

12 Scopus citations

Molecular architecture of contactin-Associated protein-like 2 (CNTNAP2) and its interaction with contactin 2 (CNTN2)

Lu, Z., Reddy, M. V. V. V. S., Liu, J., Kalichava, A., Liu, J., Zhang, L., Chen, F., Wang, Y., Holthauzen, L. M. F., White, M. A., Seshadrinathan, S., Zhong, X., Ren, G. & Rudenko, G., Nov 11 2016, In : Journal of Biological Chemistry. 291, 46, p. 24133-24147 15 p.

Research output: Contribution to journalArticle

25 Scopus citations
2014

Calsyntenin-3 molecular architecture and interaction with neurexin 1α

Lu, Z., Wang, Y., Chen, F., Tong, H., Reddy, M. V. V. V. S., Luo, L., Seshadrinathan, S., Zhang, L., Holthauzen, L. M. F., Craig, A. M., Ren, G. & Rudenko, G., Dec 12 2014, In : Journal of Biological Chemistry. 289, 50, p. 34530-34542 13 p.

Research output: Contribution to journalArticle

28 Scopus citations

Threonine 149 phosphorylation enhances ΔFosB transcriptional activity to control psychomotor responses to cocaine

Cates, H. M., Thibault, M., Pfau, M., Heller, E., Eagle, A., Gajewski, P., Bagot, R., Colangelo, C., Abbott, T., Rudenko, G., Neve, R., Nestler, E. J. & Robison, A. J., Aug 20 2014, In : Journal of Neuroscience. 34, 34, p. 11461-11469 9 p.

Research output: Contribution to journalArticle

11 Scopus citations
2013

The Specific α-Neurexin Interactor Calsyntenin-3 Promotes Excitatory and Inhibitory Synapse Development

Pettem, K. L., Yokomaku, D., Luo, L., Linhoff, M. W., Prasad, T., Connor, S. A., Siddiqui, T. J., Kawabe, H., Chen, F., Zhang, L., Rudenko, G., Wang, Y. T., Brose, N. & Craig, A. M., Oct 2 2013, In : Neuron. 80, 1, p. 113-128 16 p.

Research output: Contribution to journalArticle

82 Scopus citations
2012

Small molecule screening identifies regulators of the transcription factor ΔfosB

Wang, Y., Cesena, T. I., Ohnishi, Y., Burger-Caplan, R., Lam, V., Kirchhoff, P. D., Larsen, S. D., Larsen, M. J., Nestler, E. J. & Rudenko, G., Jul 18 2012, In : ACS chemical neuroscience. 3, 7, p. 546-556 11 p.

Research output: Contribution to journalArticle

13 Scopus citations
2011

The structure of neurexin 1α reveals features promoting a role as synaptic organizer

Chen, F., Venugopal, V., Murray, B. & Rudenko, G., Jun 8 2011, In : Structure. 19, 6, p. 779-789 11 p.

Research output: Contribution to journalArticle

49 Scopus citations
2010

Mechanism of LDL binding and release probed by structure-based mutagenesis of the LDL receptor

Huang, S., Henry, L., Ho, Y. K., Pownall, H. J. & Rudenko, G., Feb 1 2010, In : Journal of Lipid Research. 51, 2, p. 297-308 12 p.

Research output: Contribution to journalArticle

32 Scopus citations

Model of human low-density lipoprotein and bound receptor based on CryoEM

Ren, G., Rudenko, G., Ludtke, S. J., Deisenhofer, J., Chiu, W. & Pownall, H. J., Jan 19 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 3, p. 1059-1064 6 p.

Research output: Contribution to journalArticle

56 Scopus citations
2008

Regulation of Neurexin 1β Tertiary Structure and Ligand Binding through Alternative Splicing

Shen, K. C., Kuczynska, D. A., Wu, I. J., Murray, B. H., Sheckler, L. R. & Rudenko, G., Mar 11 2008, In : Structure. 16, 3, p. 422-431 10 p.

Research output: Contribution to journalArticle

40 Scopus citations
2007

Dimerization and DNA-binding properties of the transcription factor ΔFosB

Jorissen, H. J. M. M., Ulery, P. G., Henry, L., Gourneni, S., Nestler, E. J. & Rudenko, G., Jul 17 2007, In : Biochemistry. 46, 28, p. 8360-8372 13 p.

Research output: Contribution to journalArticle

17 Scopus citations
2006

Crystal structure of the second LNS/LG domain from neurexin 1α: Ca2+ binding and the effects of alternative splicing

Sheckler, L. R., Henry, L., Sugita, S., Südhof, T. C. & Rudenko, G., Aug 11 2006, In : Journal of Biological Chemistry. 281, 32, p. 22896-22905 10 p.

Research output: Contribution to journalArticle

38 Scopus citations

Regulation of ΔFosB stability by phosphorylation

Ulery, P. G., Rudenko, G. & Nestler, E. J., Sep 7 2006, In : Journal of Neuroscience. 26, 19, p. 5131-5142 12 p.

Research output: Contribution to journalArticle

65 Scopus citations
2003

'MAD'ly phasing the extracellular domain of the LDL receptor: A medium-sized protein, large tungsten clusters and multiple non-isomorphous crystals

Rudenko, G., Henry, L., Vonrhein, C., Bricogne, G. & Deisenhofer, J., Nov 1 2003, In : Acta Crystallographica - Section D Biological Crystallography. 59, 11, p. 1978-1986 9 p.

Research output: Contribution to journalArticle

18 Scopus citations
2002

Structure of the LDL receptor extracellular domain at endosomal pH

Rudenko, G., Henry, L., Henderson, K., Ichtchenko, K., Brown, M. S., Goldstein, J. L. & Deisenhofer, J., Dec 20 2002, In : Science. 298, 5602, p. 2353-2358 6 p.

Research output: Contribution to journalArticle

336 Scopus citations
1999

The structure of the ligand-binding domain of neurexin Iβ: Regulation of LNS domain function by alternative splicing

Rudenko, G., Nguyen, T., Chelliah, Y., Südhof, T. C. & Deisenhofer, J., Oct 1 1999, In : Cell. 99, 1, p. 93-101 9 p.

Research output: Contribution to journalArticle

110 Scopus citations
1998

The atomic model of the human protective protein/cathepsin A suggests a structural basis for galactosialidosis

Rudenko, G., Bonten, E., Hol, W. G. J. & D'Azzo, A., Jan 20 1998, In : Proceedings of the National Academy of Sciences of the United States of America. 95, 2, p. 621-625 5 p.

Research output: Contribution to journalArticle

26 Scopus citations
1996
10 Scopus citations
1995

Three-dimensional structure of the human protective protein: structure of the precursor form suggests a complex activation mechanism

Rudenko, G., Bonten, E., d'Azzo, A. & GJ Hol, W., Nov 1995, In : Structure. 3, 11, p. 1249-1259 11 p.

Research output: Contribution to journalArticle

82 Scopus citations
1993

N-glycosylation and deletion mutants of the human MDR1 P-glycoprotein

Schinkel, A. H., Kemp, S., Dolle, M., Rudenko, G. & Wagenaar, E., Jan 1 1993, In : Journal of Biological Chemistry. 268, 10, p. 7474-7481 8 p.

Research output: Contribution to journalArticle

168 Scopus citations
1992

In search of new lead compounds for trypanosomiasis drug design: A protein structure-based linked-fragment approach

Verlinde, C. L. M. J., Rudenko, G. & Hol, W. G. J., Apr 1 1992, In : Journal of Computer-Aided Molecular Design. 6, 2, p. 131-147 17 p.

Research output: Contribution to journalArticle

70 Scopus citations