Gangduo Wang, MD, PhD

  • 1542 Citations
  • 21 h-Index
20042019
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Research Output 2004 2019

  • 1542 Citations
  • 21 h-Index
  • 42 Article
  • 1 Review article
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Article
2019
3 Citations (Scopus)

Contribution of poly(ADP-ribose)polymerase-1 activation and apoptosis in trichloroethene-mediated autoimmunity

Wang, G., Ma, H., Wang, J. & Khan, M., Jan 1 2019, In : Toxicology and Applied Pharmacology. 362, p. 28-34 7 p.

Research output: Contribution to journalArticle

Trichloroethylene
Poly(ADP-ribose) Polymerases
Autoimmunity
Chemical activation
Apoptosis
Trichloroethylene
Cytochrome P-450 CYP2E1
Oxidative stress
Autoimmunity
Oxidative Stress

Redox regulation of hepatic NLRP3 inflammasome activation and immune dysregulation in trichloroethene-mediated autoimmunity

Wang, H., Wang, G., Liang, Y., Du, X., Boor, P. J., Sun, J. & Khan, M., Nov 1 2019, In : Free Radical Biology and Medicine. 143, p. 223-231 9 p.

Research output: Contribution to journalArticle

Inflammasomes
Trichloroethylene
Autoimmunity
Oxidation-Reduction
Chemical activation
2018
2 Citations (Scopus)
Inflammasomes
Kupffer cells
Trichloroethylene
autoimmune hepatitis
Kupffer Cells
2017

Altered miRNA expression in aniline-mediated cell cycle progression in rat spleen

Wang, G., Wang, J. & Khan, M., May 30 2017, (Accepted/In press) In : Toxicology Mechanisms and Methods. p. 1-7 7 p.

Research output: Contribution to journalArticle

MicroRNAs
Rats
Cell Cycle
Spleen
Cells
1 Citation (Scopus)

Autoimmune potential of perchloroethylene: Role of lipid-derived aldehydes

Wang, G., Wang, J., Ansari, G. & Khan, M., Oct 15 2017, In : Toxicology and Applied Pharmacology. 333, p. 76-83 8 p.

Research output: Contribution to journalArticle

Tetrachloroethylene
Aldehydes
Autoimmunity
Lipids
Malondialdehyde
2016
7 Citations (Scopus)

Significance of lipid-derived reactive aldehyde-specificimmune complexes in systemic lupus erythematosus

Wang, G., Pierangeli, S. S., Willis, R., Gonzalez, E., Petri, M. & Khan, M., Oct 1 2016, In : PLoS One. 11, 10, e0164739.

Research output: Contribution to journalArticle

lupus erythematosus
Aldehydes
Systemic Lupus Erythematosus
aldehydes
Oxidative stress
2015
6 Citations (Scopus)

Disorder of G2-M checkpoint control in aniline-induced cell proliferation in rat spleen

Wang, J., Wang, G. & Khan, M., Jul 20 2015, In : PLoS One. 10, 7, e0131457.

Research output: Contribution to journalArticle

aniline
Cell proliferation
Rats
cell proliferation
spleen
17 Citations (Scopus)

Disruption of cytochrome P4501A2 in mice leads to increased susceptibility to hyperoxic lung injury

Wang, L., Lingappan, K., Jiang, W., Couroucli, X. I., Welty, S. E., Shivanna, B., Barrios, R., Wang, G., Khan, M., Gonzalez, F. J., Jackson Roberts, L. & Moorthy, B., 2015, In : Free Radical Biology and Medicine. 82, p. 147-159 13 p.

Research output: Contribution to journalArticle

Cytochrome P-450 CYP1A2
Lung Injury
Cytochromes
Hyperoxia
F2-Isoprostanes
7 Citations (Scopus)
Reactive Nitrogen Species
Trichloroethylene
Autoimmunity
Aldehydes
Lipids
2014
26 Citations (Scopus)

Mice deficient in the gene for cytochrome P450 (CYP)1A1 are more susceptible than wild-type to hyperoxic lung injury: Evidence for protective role of CYP1A1 against oxidative stress

Lingappan, K., Jiang, W., Wang, L., Wang, G., Couroucli, X. I., Shivanna, B., Welty, S. E., Barrios, R., Khan, M., Nebert, D. W., Roberts, L. J. & Moorthy, B., Sep 12 2014, In : Toxicological Sciences. 141, 1, p. 68-77 10 p., kfu106.

Research output: Contribution to journalArticle

Cytochrome P-450 CYP1A1
Oxidative stress
Lung Injury
Cytochrome P-450 Enzyme System
Oxidative Stress
4 Citations (Scopus)

Nitrosative stress and nitrated proteins in trichloroethene-mediated autoimmunity

Wang, G., Wang, J., Luo, X., Ansari, G. & Khan, M., Jun 3 2014, In : PLoS One. 9, 6, e98660.

Research output: Contribution to journalArticle

Trichloroethylene
acetylcysteine
autoimmunity
Heat-Shock Proteins
Autoimmunity
1 Citation (Scopus)

Proteomic identification of carbonylated proteins in the kidney of trichloroethene-exposed MRL+/+ mice

Fan, X., Wang, G., English, R. D. & Khan, M., Jan 2014, In : Toxicology Mechanisms and Methods. 24, 1, p. 21-30 10 p.

Research output: Contribution to journalArticle

Trichloroethylene
Proteomics
Kidney
Proteins
Oxidation
2013
18 Citations (Scopus)

N-Acetylcysteine protects against trichloroethene-mediated autoimmunity by attenuating oxidative stress

Wang, G., Wang, J., Ma, H., Ansari, G. & Khan, M., Nov 15 2013, In : Toxicology and Applied Pharmacology. 273, 1, p. 189-195 7 p.

Research output: Contribution to journalArticle

Trichloroethylene
Oxidative stress
Acetylcysteine
Autoimmunity
Oxidative Stress
21 Citations (Scopus)

Sensitization of lung cancer cells to cisplatin by β-elemene is mediated through blockade of cell cycle progression: Antitumor efficacies of β-elemene and its synthetic analogs

Li, Q. Q., Wang, G., Huang, F., Li, J. M., Cuff, C. F. & Reed, E., Mar 2013, In : Medical Oncology. 30, 1, 488.

Research output: Contribution to journalArticle

Cisplatin
Lung Neoplasms
Cell Cycle
Non-Small Cell Lung Carcinoma
Cell Proliferation
37 Citations (Scopus)

β-Elemene enhances susceptibility to cisplatin in resistant ovarian carcinoma cells via downregulation of ERCC-1 and XIAP and inactivation of JNK

Li, Q. Q., Lee, R. X., Liang, H., Wang, G., Li, J. M., Zhong, Y. & Reed, E., Sep 2013, In : International Journal of Oncology. 43, 3, p. 721-728 8 p.

Research output: Contribution to journalArticle

X-Linked Inhibitor of Apoptosis Protein
JNK Mitogen-Activated Protein Kinases
DNA Repair
Cisplatin
Down-Regulation
31 Citations (Scopus)

β-Elemene promotes cisplatin-induced cell death in human bladder cancer and other carcinomas

Quentin Li, Q., Wang, G., Liang, H., Li, J. M., Huang, F., Agarwal, P. K., Zhong, Y. & Reed, E., Apr 2013, In : Anticancer Research. 33, 4, p. 1421-1428 8 p.

Research output: Contribution to journalArticle

Urinary Bladder Neoplasms
Cisplatin
Cell Death
Carcinoma
Small Cell Lung Carcinoma
2012
18 Citations (Scopus)

Blocking p55PIK signaling inhibits proliferation and induces differentiation of leukemia cells

Wang, G., Deng, Y., Cao, X., Lai, S., Tong, Y., Luo, X., Feng, Y., Xia, X., Gong, J. & Hu, J., Nov 2012, In : Cell Death and Differentiation. 19, 11, p. 1870-1879 10 p.

Research output: Contribution to journalArticle

Cell Differentiation
Trans-Activators
Leukemia
Cell Cycle
Proteins
20 Citations (Scopus)
Inbred MRL lpr Mouse
Autoimmunity
Aldehydes
Lipid Peroxidation
Malondialdehyde
28 Citations (Scopus)
Th17 Cells
Trichloroethylene
Malondialdehyde
Autoimmunity
Proteins
2011
12 Citations (Scopus)

Enhanced expression of cyclins and cyclin-dependent kinases in aniline-induced cell proliferation in rat spleen

Wang, J., Wang, G., Ma, H. & Khan, M., Jan 15 2011, In : Toxicology and Applied Pharmacology. 250, 2, p. 213-220 8 p.

Research output: Contribution to journalArticle

Cell proliferation
Protein Kinases
Phosphorylation
Rats
Phosphotransferases
2010
84 Citations (Scopus)

Antineoplastic effect of β-elemene on prostate cancer cells and other types of solid tumour cells

Li, Q. Q., Wang, G., Huang, F., Banda, M. & Reed, E., Aug 2010, In : Journal of Pharmacy and Pharmacology. 62, 8, p. 1018-1027 10 p.

Research output: Contribution to journalArticle

Antineoplastic Agents
Prostatic Neoplasms
Neoplasms
Poly(ADP-ribose) Polymerases
In Situ Nick-End Labeling
44 Citations (Scopus)

Evaluation of cisplatin in combination with β-elemene as a regimen for prostate cancer chemotherapy

Li, Q. Q., Wang, G., Reed, E., Huang, L. & Cuff, C. F., Nov 2010, In : Basic and Clinical Pharmacology and Toxicology. 107, 5, p. 868-876 9 p.

Research output: Contribution to journalArticle

Chemotherapy
Cisplatin
Prostatic Neoplasms
Drug Therapy
Cells
121 Citations (Scopus)

Markers of oxidative and nitrosative stress in systemic lupus erythematosus: Correlation with disease activity

Wang, G., Pierangeli, S. S., Papalardo, E., Ansari, G. & Khan, M., Jul 2010, In : Arthritis and Rheumatism. 62, 7, p. 2064-2072 9 p.

Research output: Contribution to journalArticle

Systemic Lupus Erythematosus
Oxidative Stress
Antibodies
Malondialdehyde
Serum
2009
18 Citations (Scopus)
Protein Carbonylation
Nitration
Carbonylation
Trichloroethylene
Autoimmunity
70 Citations (Scopus)

β-Elemene, a novel plant-derived antineoplastic agent, increases cisplatin chemosensitivity of lung tumor cells by triggering apoptosis

Li, Q. Q., Wang, G., Zhang, M., Cuff, C. F., Huang, L. & Reed, E., 2009, In : Oncology Reports. 22, 1, p. 161-170 10 p.

Research output: Contribution to journalArticle

Antineoplastic Agents
Cisplatin
Apoptosis
Lung
Non-Small Cell Lung Carcinoma
2008
30 Citations (Scopus)

Activation of oxidative stress-responsive signaling pathways in early splenotoxic response of aniline

Wang, J., Wang, G., Ansari, G. & Khan, M., Jul 15 2008, In : Toxicology and Applied Pharmacology. 230, 2, p. 227-234 8 p.

Research output: Contribution to journalArticle

Oxidative stress
Oxidative Stress
Chemical activation
Phosphorylation
Transcription Factor AP-1
44 Citations (Scopus)
Trichloroethylene
T-cells
Autoimmunity
Aldehydes
Lipid Peroxidation
2007
70 Citations (Scopus)

In vitro combination characterization of the new anticancer plant drug β-elemene with taxanes against human lung carcinoma

Zhao, J., Li, Q. Q., Zou, B., Wang, G., Li, X., Kim, J. E., Cuff, C. F., Huang, L., Reed, E. & Gardner, K., Aug 2007, In : International Journal of Oncology. 31, 2, p. 241-252 12 p.

Research output: Contribution to journalArticle

Taxoids
docetaxel
Carcinoma
Lung
Pharmaceutical Preparations
22 Citations (Scopus)
Trichloroethylene
Autoimmunity
Aldehydes
Lipid Peroxidation
Lipids
37 Citations (Scopus)

Oxidative and nitrosative stress in trichloroethene-mediated autoimmune response

Wang, G., Cai, P., Ansari, G. & Khan, M., Jan 18 2007, In : Toxicology. 229, 3, p. 186-193 8 p.

Research output: Contribution to journalArticle

Trichloroethylene
Autoimmunity
Oxidative Stress
Reactive Nitrogen Species
Lipid Peroxidation
26 Citations (Scopus)
Phosphatidylinositol 3-Kinase
Myometrium
Leiomyoma
Sirolimus
Estrogens
2005
140 Citations (Scopus)

Antiproliferative effect of β-elemene in chemoresistant ovarian carcinoma cells is mediated through arrest of the cell cycle at the G2-M phase

Li, X., Wang, G., Zhao, J., Ding, H., Cunningham, C., Chen, F., Flynn, D. C., Reed, E. & Li, Q. Q., Apr 2005, In : Cellular and Molecular Life Sciences. 62, 7-8, p. 894-904 11 p.

Research output: Contribution to journalArticle

G2 Phase
Cell Cycle Checkpoints
Cell Division
Cells
Carcinoma
191 Citations (Scopus)

Antitumor effect of β-elemene in non-small-cell lung cancer cells is mediated via induction of cell cycle arrest and apoptotic cell death

Wang, G., Li, X., Huang, F., Zhao, J., Ding, H., Cunningham, C., Coad, J. E., Flynn, D. C., Reed, E. & Li, Q. Q., Apr 2005, In : Cellular and Molecular Life Sciences. 62, 7-8, p. 881-893 13 p.

Research output: Contribution to journalArticle

Cell death
Cell Cycle Checkpoints
Non-Small Cell Lung Carcinoma
Cell Death
Cells
5 Citations (Scopus)

Demonstration of differential gene expression between sensitive and resistant ovarian tumor cells by fluorescence differential display-PCR analysis

Li, L., Luan, Y., Li, X., Tang, B., Zhang, W., Li, D., Zhao, J., Wang, G., Ding, H., Reed, E. & Li, Q. Q., May 2005, In : Oncology Reports. 13, 5, p. 793-799 7 p.

Research output: Contribution to journalArticle

Fluorescence
Gene Expression
Cell Line
Polymerase Chain Reaction
Carboplatin
5 Citations (Scopus)

Differential expression of cyclins A, B1, D3 and E in G1 phase of the cell cycle between the synchronized and asynchronously growing MOLT-4 cells.

Yu, C., Hu, J., Feng, Y., Tao, D., Wu, J., Qin, J., Liu, S., Zhang, M., Wang, G., Li, X., Zhao, J., Ding, H., Reed, E., Li, Q. Q. & Gong, J., Oct 2005, In : International journal of molecular medicine.. 16, 4, p. 645-651 7 p.

Research output: Contribution to journalArticle

Cyclin B1
Cyclin A
Cyclin E
G1 Phase
Cell Cycle
11 Citations (Scopus)

Overexpression of the N-terminal end of the p55gamma regulatory subunit of phosphatidylinositol 3-kinase blocks cell cycle progression in gastric carcinoma cells.

Hu, J., Liu, S., Wang, J., Luo, X., Gao, X., Xia, X., Feng, Y., Tao, D., Wang, G., Li, X., Zhao, J., Ding, H., Reed, E., Li, Q. Q. & Gong, J., May 2005, In : International Journal of Oncology. 26, 5, p. 1321-1327 7 p.

Research output: Contribution to journalArticle

Phosphatidylinositol 3-Kinase
Stomach
Cell Cycle
Carcinoma
Cell Proliferation
2004
38 Citations (Scopus)

Apoptosis in prostate cancer: progressive and therapeutic implications (Review).

Wang, G., Reed, E. & Li, Q. Q., Jul 2004, In : International Journal of Molecular Medicine. 14, 1, p. 23-34 12 p.

Research output: Contribution to journalArticle

Prostatic Neoplasms
Apoptosis
Androgens
Neoplasms
NF-kappa B
119 Citations (Scopus)

Correlation of serum VEGF levels with clinical stage, therapy efficacy, tumor metastasis and patient survival in ovarian cancer

Li, L., Wang, L., Zhang, W., Tang, B., Zhang, J., Song, H., Yao, D., Tang, Y., Chen, X., Yang, Z., Wang, G., Li, X., Zhao, J., Ding, H., Reed, E. & Li, Q. Q., May 2004, In : Anticancer Research. 24, 3 B, p. 1973-1979 7 p.

Research output: Contribution to journalArticle

Ovarian Neoplasms
Vascular Endothelial Growth Factor A
Neoplasm Metastasis
Survival
Serum
31 Citations (Scopus)

Development and characterization of five cell models for chemoresistance studies of human ovarian carcinoma.

Li, L., Luan, Y., Wang, G., Tang, B., Li, D., Zhang, W., Li, X., Zhao, J., Ding, H., Reed, E. & Li, Q. Q., Aug 2004, In : International Journal of Molecular Medicine. 14, 2, p. 257-264 8 p.

Research output: Contribution to journalArticle

Carcinoma
Drug Resistance
Paclitaxel
Ovarian Neoplasms
Carboplatin
22 Citations (Scopus)

Mechanisms underlying the synergistic effect of SU5416 and cisplatin on cytotoxicity in human ovarian tumor cells.

Zhong, X., Li, X., Wang, G., Zhu, Y., Hu, G., Zhao, J., Neace, C., Ding, H., Reed, E. & Li, Q. Q., Aug 2004, In : International Journal of Oncology. 25, 2, p. 445-451 7 p.

Research output: Contribution to journalArticle

Cisplatin
NF-kappa B
Apoptosis
Neoplasms
Inhibitor of Apoptosis Proteins
147 Citations (Scopus)

Molecular basis of cellular response to cisplatin chemotherapy in non-small cell lung cancer (Review)

Wang, G., Reed, E. & Li, Q. Q., Nov 2004, In : Oncology Reports. 12, 5, p. 955-965 11 p.

Research output: Contribution to journalArticle

Non-Small Cell Lung Carcinoma
Cisplatin
Drug Therapy
Apoptosis
DNA Damage