• 1546 Citations
  • 22 h-Index
1985 …2019
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Research Output 1985 2019

2019

Development of disease and immunity at the genital epithelium following intrarectal inoculation of male guinea pigs with herpes simplex virus type 2

Bourne, N., Banasik, B. N., Perry, C. L., Miller, A. L., White, M., Pyles, R. & Milligan, G., Jan 2 2019, In : Virology. 526, p. 180-188 9 p.

Research output: Contribution to journalArticle

Human Herpesvirus 2
Virus Shedding
Foreskin
Perineum
Immunity

Increased frequency of virus shedding by herpes simplex virus 2-infected Guinea pigs in the absence of CD4 T lymphocytes

Bourne, N., Perry, C. L., Banasik, B. N., Miller, A. L., White, M., Pyles, R., Schäfer, H. & Milligan, G., Feb 1 2019, In : Journal of Virology. 93, 4, e0172118.

Research output: Contribution to journalArticle

Human herpesvirus 2
Virus Shedding
viral shedding
Human Herpesvirus 2
guinea pigs
2018
9 Citations (Scopus)

Baseline mapping of Lassa fever virology, epidemiology and vaccine research and development review-article

Hallam, H. J., Hallam, S., Rodriguez, S. E., Barrett, A., Beasley, D., Chua, A., Ksiazek, T., Milligan, G., Sathiyamoorthy, V. & Reece, L. M., Dec 1 2018, In : npj Vaccines. 3, 1, 11.

Research output: Contribution to journalArticle

Lassa Fever
Lassa virus
Virology
Epidemiology
Vaccines
4 Citations (Scopus)

Characterization of a murine model of non-lethal, symptomatic dengue virus infection

Sarathy, V., White, M., Li, L., Kaiser, J. A., Campbell, G., Milligan, G., Bourne, N. & Barrett, A., Dec 1 2018, In : Scientific Reports. 8, 1, 4900.

Research output: Contribution to journalArticle

Dengue Virus
Virus Diseases
Infection
Dengue
Severe Dengue
2 Citations (Scopus)

Current status of Severe Fever with Thrombocytopenia Syndrome vaccine development

Reece, L. M., Beasley, D., Milligan, G., Sarathy, V. & Barrett, A., Apr 1 2018, In : Current Opinion in Virology. 29, p. 72-78 7 p.

Research output: Contribution to journalReview article

Thrombocytopenia
Fever
Vaccines
Viruses
Phlebovirus

Defining a correlate of protection for chikungunya virus vaccines

Milligan, G., Schnierle, B. S., McAuley, A. J. & Beasley, D., Jan 1 2018, (Accepted/In press) In : Vaccine.

Research output: Contribution to journalArticle

Chikungunya virus
Vaccines
Clinical Trials
vaccines
complications (disease)
Dengue Virus
Nucleosides
Adenosine
Dengue Vaccines
Interferon Receptors
1 Citation (Scopus)

Transcriptional Analysis of the Guinea Pig Mucosal Immune Response to Intravaginal Infection with Herpes Simplex Virus Type 2

Veselenak, R. L., Milligan, G., Miller, A. L., Pyles, R. & Bourne, N., May 1 2018, In : Virology. 518, p. 349-357 9 p.

Research output: Contribution to journalArticle

Mucosal Immunity
Human Herpesvirus 2
Guinea Pigs
Infection
Immunity
2017
4 Citations (Scopus)

A combined carrier-adjuvant system of peptide nanofibers and toll-like receptor agonists potentiates robust CD8+ T cell responses

Rudra, J. S., Banasik, B. N. & Milligan, G., Jan 1 2017, (Accepted/In press) In : Vaccine.

Research output: Contribution to journalArticle

nanofibers
Nanofibers
Toll-Like Receptors
agonists
adjuvants
3 Citations (Scopus)

A lethal model of disseminated dengue virus type 1 infection in AG129 mice

Milligan, G., Sarathy, V., White, M. M., Greenberg, M. B., Campbell, G., Pyles, R., Barrett, A. & Bourne, N., Oct 1 2017, In : Journal of General Virology. 98, 10, p. 2507-2519 13 p., 000923.

Research output: Contribution to journalArticle

Dengue Virus
Virus Diseases
Dengue
Antibody-Dependent Enhancement
Vaccines
Sheep
Anti-Infective Agents
HIV
Therapeutic Irrigation
Nonoxynol
2016

Detection of herpes simplex virus type 2 (HSV-2) -specific cell-mediated immune responses in guinea pigs during latent HSV-2 genital infection

Perry, C. L., Banasik, B. N., Gorder, S. R., Xia, J., Auclair, S., Bourne, N. & Milligan, G., Dec 1 2016, In : Journal of Immunological Methods. 439, p. 1-7 7 p.

Research output: Contribution to journalArticle

Herpes Genitalis
Human Herpesvirus 2
Guinea Pigs
Virus Latency
Infection
11 Citations (Scopus)

Dysregulation of toll-like receptor 7 compromises innate and adaptive T cell responses and host resistance to an attenuated West Nile virus infection in old mice

Xie, G., Luo, H., Pang, L., Peng, B., Winkelmann, E., McGruder, B., Hesse, J., Whiteman, M., Campbell, G., Milligan, G., Cong, Y., Barrett, A. & Wang, T., 2016, In : Journal of Virology. 90, 3, p. 1333-1344 12 p.

Research output: Contribution to journalArticle

Toll-Like Receptor 7
West Nile virus
Virus Diseases
T-lymphocytes
T-Lymphocytes
1 Citation (Scopus)

In vivo rectal mucosal barrier function imaging in a large-animal model by using confocal endomicroscopy: Implications for injury assessment and use in HIV prevention studies

Vargas, G., Vincent, K., Zhu, Y., Szafron, D., Brown, T. C., Villarreal, P. P., Bourne, N., Milligan, G. & Motamedib, M., Aug 1 2016, In : Antimicrobial Agents and Chemotherapy. 60, 8, p. 4600-4609 10 p.

Research output: Contribution to journalArticle

Animal Models
HIV
Wounds and Injuries
Mucous Membrane
Benzalkonium Compounds
13 Citations (Scopus)

Research and development of Zika virus vaccines

Dawes, B. E., Smalley, C. A., Tiner, B. L., Beasley, D., Milligan, G., Reece, L. M., Hombach, J. & Barrett, A., Jul 28 2016, In : npj Vaccines. 1, 16007.

Research output: Contribution to journalReview article

Vaccines
Flavivirus
Research
Flaviviridae
Microcephaly
19 Citations (Scopus)

Status of vaccine research and development of vaccines for Nipah virus

Satterfield, B. A., Dawes, B. E. & Milligan, G., Jun 3 2016, In : Vaccine. 34, 26, p. 2971-2975 5 p.

Research output: Contribution to journalArticle

Nipah Virus
Nipah virus
research and development
Vaccines
vaccines
2015
25 Citations (Scopus)

A dengue virus type 4 model of disseminated lethal infection in AG129 mice

Milligan, G., Sarathy, V., Infante, E., Li, L., Campbell, G., Beatty, P. R., Harris, E., Barrett, A. & Bourne, N., May 4 2015, In : PLoS One. 10, 5, e0125476.

Research output: Contribution to journalArticle

Dengue virus
Dengue Virus
Viruses
dengue
Dengue
32 Citations (Scopus)
Interferon alpha-beta Receptor
Dengue virus
Dengue Virus
interferons
Dengue
10 Citations (Scopus)
Dengue Virus
Dengue
Infection
Antiviral Agents
Vaccines
20 Citations (Scopus)

Mouse models of dengue virus infection for vaccine testing

Sarathy, V., Milligan, G., Bourne, N. & Barrett, A., Dec 10 2015, In : Vaccine. 33, 50, p. 7051-7060 10 p.

Research output: Contribution to journalArticle

Dengue virus
Dengue Virus
Virus Diseases
dengue
Vaccines
2014
2 Citations (Scopus)

Adjuvants: Making Vaccines Immunogenic

Milligan, G., Dec 9 2014, Vaccinology: An Essential Guide. Wiley Blackwell, p. 93-108 16 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Vaccines
Antigens
European Union
Recombinant Proteins
Safety

Control and Eradication of Human and Animal Diseases by Vaccination

Bourne, N. & Milligan, G., Dec 9 2014, Vaccinology: An Essential Guide. Wiley Blackwell, p. 43-58 16 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Immunization Programs
Animal Diseases
Vaccination
Rinderpest virus
Variola virus
6 Citations (Scopus)
Mycoplasma genitalium
Workflow
Gene expression
Guinea Pigs
Gene Expression
17 Citations (Scopus)

Investigating the efficacy of monovalent and tetravalent dengue vaccine formulations against DENV-4 challenge in AG129 mice

Fuchs, J., Chu, H., O'Day, P., Pyles, R., Bourne, N., Das, S. C., Milligan, G., Barrett, A., Partidos, C. D. & Osorio, J. E., Nov 12 2014, In : Vaccine. 32, 48, p. 6537-6543 7 p.

Research output: Contribution to journalArticle

Dengue Vaccines
Dengue virus
dengue
Vaccines
vaccines

Microbial-Based and Material-Based Vaccine Delivery Systems

Torres, A., Rudra, J. S. & Milligan, G., Dec 9 2014, Vaccinology: An Essential Guide. Wiley Blackwell, p. 127-151 25 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Vaccines
Biocompatible Materials
Viruses
Bacteria
Antigens

Preface

Milligan, G. & Barrett, A., Dec 9 2014, Vaccinology: An Essential Guide. Wiley Blackwell, p. ix

Research output: Chapter in Book/Report/Conference proceedingForeword/postscript

11 Citations (Scopus)

Subcapsular sinus macrophages limit dissemination of West Nile virus particles after inoculation but are not essential for the development of West Nile virus-specific T cell responses

Winkelmann, E. R., Widman, D. G., Xia, J., Johnson, A. J., van Rooijen, N., Mason, P. W., Bourne, N. & Milligan, G., Feb 2014, In : Virology. 450-451, p. 278-289 12 p.

Research output: Contribution to journalArticle

West Nile virus
Virion
Macrophages
T-Lymphocytes
Flavivirus

The Host Immune Response, Protective Immunity, and Correlates of Protection

Milligan, G., Dec 9 2014, Vaccinology: An Essential Guide. Wiley Blackwell, p. 73-92 20 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Immunity
Vaccines
Adaptive Immunity
T-Lymphocytes
Pattern Recognition Receptors
3 Citations (Scopus)

Vaccinology: An Essential Guide

Milligan, G. & Barrett, A., Dec 9 2014, Wiley Blackwell. 390 p.

Research output: Book/ReportBook

Vaccines
Reference Books
Licensure
Communicable Diseases
History
8 Citations (Scopus)

Virus-specific immune memory at peripheral sites of Herpes Simplex Virus type 2 (HSV-2) infection in Guinea pigs

Xia, J., Veselenak, R. L., Gorder, S. R., Bourne, N. & Milligan, G., Dec 8 2014, In : PLoS One. 9, 12, e114652.

Research output: Contribution to journalArticle

Human herpesvirus 2
Computer peripheral equipment
Human Herpesvirus 2
Virus Diseases
Viruses
2013
13 Citations (Scopus)
Flavivirus
West Nile virus
B-lymphocytes
Immunization
immunization
2012
9 Citations (Scopus)

Influence of methamphetamine on genital herpes simplex virus type 2 infection in a mouse model

Valencia, F., Bubar, M. J., Milligan, G., Cunningham, K. & Bourne, N., Sep 2012, In : Sexually Transmitted Diseases. 39, 9, p. 720-725 6 p.

Research output: Contribution to journalArticle

Herpes Genitalis
Human Herpesvirus 2
Methamphetamine
Virus Diseases
Cytokines
8 Citations (Scopus)

Intrinsic adjuvanting of a novel single-cycle flavivirus vaccine in the absence of type I interferon receptor signaling

Winkelmann, E. R., Widman, D. G., Xia, J., Ishikawa, T., Miller-Kittrell, M., Nelson, M. H., Bourne, N., Scholle, F., Mason, P. W. & Milligan, G., Feb 14 2012, In : Vaccine. 30, 8, p. 1465-1475 11 p.

Research output: Contribution to journalArticle

Interferon alpha-beta Receptor
Flavivirus
interferons
Vaccines
vaccines
2011
10 Citations (Scopus)

Rapid clearance of herpes simplex virus type 2 by CD8+ T cells requires high level expression of effector T cell functions

Nelson, M. H., Bird, M. D., Chu, C. F., Johnson, A. J., Friedrich, B. M., Allman, W. R. & Milligan, G., Apr 2011, In : Journal of Reproductive Immunology. 89, 1, p. 10-17 8 p.

Research output: Contribution to journalArticle

Human Herpesvirus 2
T-Lymphocytes
Epithelium
Viruses
Interleukin-4
2010
5 Citations (Scopus)

Benzalkonium chloride causes colposcopic changes and increased susceptibility to genital herpes infection in mice

Vincent, K., Bell, B. A., Johnston, R. K., Stegall, R., Vargas, G., Tan, A., Stanberry, L. R., Rosenthal, S. L., Milligan, G., Motamedi, M. & Bourne, N., Sep 2010, In : Sexually Transmitted Diseases. 37, 9, p. 579-584 6 p.

Research output: Contribution to journalArticle

Benzalkonium Compounds
Herpes Genitalis
Colposcopy
Anti-Infective Agents
Infection
9 Citations (Scopus)
Herpes Genitalis
Human Herpesvirus 2
Virus Diseases
Simplexvirus
Interferon-gamma
14 Citations (Scopus)

Immunogenicity of RepliVAX WN, a novel single-cycle West Nile virus vaccine

Nelson, M. H., Winkelmann, E., Ma, Y., Xia, J., Mason, P. W., Bourne, N. & Milligan, G., Dec 16 2010, In : Vaccine. 29, 2, p. 174-182 9 p.

Research output: Contribution to journalArticle

West Nile Virus Vaccines
West Nile virus
Immunization
immune response
vaccines
2009
9 Citations (Scopus)

3,4-methylenedioxymethamphetamine increases susceptiblity to genital herpes simplex virus infection in mice

Pennock, J. W., Stegall, R., Bubar, M. J., Milligan, G., Cunningham, K. & Bourne, N., Oct 15 2009, In : Journal of Infectious Diseases. 200, 8, p. 1247-1250 4 p.

Research output: Contribution to journalArticle

N-Methyl-3,4-methylenedioxyamphetamine
Herpes Genitalis
Human Herpesvirus 2
Virus Diseases
Sexually Transmitted Diseases
8 Citations (Scopus)

Differential virological and immunological outcome of severe acute respiratory syndrome coronavirus infection in susceptible and resistant transgenic mice expressing human angiotensin-converting enzyme 2

Yoshikawa, N., Yoshikawa, T., Hill, T., Huang, C., Watts, D. M., Makino, S., Milligan, G., Chan, T., Peters, C. J. & Tseng, C-T., Jun 2009, In : Journal of Virology. 83, 11, p. 5451-5465 15 p.

Research output: Contribution to journalArticle

Coronavirus Infections
Severe Acute Respiratory Syndrome
peptidyl-dipeptidase A
Transgenic Mice
genetically modified organisms
22 Citations (Scopus)

Estradiol improves genital herpes vaccine efficacy in mice

Pennock, J. W., Stegall, R., Bell, B., Vargas, G., Motamedi, M., Milligan, G. & Bourne, N., Sep 25 2009, In : Vaccine. 27, 42, p. 5830-5836 7 p.

Research output: Contribution to journalArticle

Herpes Genitalis
genitalia
estradiol
Estradiol
Vaccines
2008
24 Citations (Scopus)

Antibody-mediated protection against genital herpes simplex virus type 2 disease in mice by Fc gamma receptor-dependent and -independent mechanisms

Chu, C. F., Meador, M. G., Young, C. G., Strasser, J. E., Bourne, N. & Milligan, G., Jun 2008, In : Journal of Reproductive Immunology. 78, 1, p. 58-67 10 p.

Research output: Contribution to journalArticle

IgG Receptors
Herpes Genitalis
Human Herpesvirus 2
Virus Diseases
Fc Receptors
45 Citations (Scopus)

Effector CD4+ T-cell involvement in clearance of infectious herpes simplex virus type 1 from sensory ganglia and spinal cords

Johnson, A. J., Chu, C. F. & Milligan, G., Oct 2008, In : Journal of Virology. 82, 19, p. 9678-9688 11 p.

Research output: Contribution to journalArticle

Sensory Ganglia
Human herpesvirus 1
Human Herpesvirus 1
spinal cord
Spinal Cord
48 Citations (Scopus)

T lymphocytes contribute to antiviral immunity and pathogenesis in experimental human metapneumovirus infection

Kolli, D., Bataki, E. L., Spetch, L., Guerrero-Plata, A., Jewell, A. M., Piedra, P. A., Milligan, G., Garofalo, R. & Casola, A., Sep 2008, In : Journal of Virology. 82, 17, p. 8560-8569 10 p.

Research output: Contribution to journalArticle

Human metapneumovirus
Metapneumovirus
Antiviral Agents
Immunity
pathogenesis
2007
7 Citations (Scopus)

Early resolution of herpes simplex virus type 2 infection of the murine genital tract involves stimulation of genital parenchymal cells by gamma interferon

Bird, M. D., Chu, C. F., Johnson, A. J. & Milligan, G., Jan 2007, In : Journal of Virology. 81, 1, p. 423-426 4 p.

Research output: Contribution to journalArticle

Human herpesvirus 2
Human Herpesvirus 2
Virus Diseases
interferon-gamma
genitalia
2005
6 Citations (Scopus)

A soluble divalent class I MHC/IgG1 fusion protein activates CD8+ T cells in vivo

Carey, B., DeLay, M., Strasser, J. E., Chalk, C., Dudley-McClain, K., Milligan, G., Brunner, H. I., Thornton, S. & Hirsch, R., Jul 2005, In : Clinical Immunology. 116, 1, p. 65-76 12 p.

Research output: Contribution to journalArticle

Major Histocompatibility Complex
Immunoglobulin G
T-Lymphocytes
Antigen Presentation
Human Herpesvirus 1
55 Citations (Scopus)

Clearance of herpes simplex virus type 2 by CD8+ T cells requires gamma interferon and either perform- or Fas-mediated cytolytic mechanisms

Dobbs, M. E., Strasser, J. E., Chu, C. F., Chalk, C. & Milligan, G., Dec 2005, In : Journal of Virology. 79, 23, p. 14546-14554 9 p.

Research output: Contribution to journalArticle

Human herpesvirus 2
Human Herpesvirus 2
interferon-gamma
Interferon-gamma
ovalbumin
4 Citations (Scopus)

Effects of candidate vaginally-applied microbicide compounds on innate immune cells

Milligan, G., Young, C. G., Meador, M. G., Chu, C. F. & Stanberry, L. R., Aug 2005, In : Journal of Reproductive Immunology. 66, 2, p. 103-116 14 p.

Research output: Contribution to journalArticle

Anti-Infective Agents
Macrophages
Detergents
Polymers
Carrageenan
23 Citations (Scopus)

Efficacy and toxicity of zinc salts as candidate topical microbicides against vaginal herpes simplex virus type 2 infection

Bourne, N., Stegall, R., Montano, R., Meador, M., Stanberry, L. R. & Milligan, G., Mar 2005, In : Antimicrobial Agents and Chemotherapy. 49, 3, p. 1181-1183 3 p.

Research output: Contribution to journalArticle

Local Anti-Infective Agents
Human Herpesvirus 2
Virus Diseases
Zinc
Salts
83 Citations (Scopus)
T Independent Antigens
Antigen Presentation
Interleukin-4
Estrogen Receptors
Estradiol
44 Citations (Scopus)
Virus Shedding
Human Herpesvirus 2
Immunization
Glycoproteins
Guinea Pigs