Helen Hellmich, PhD

  • 1358 Citations
  • 20 h-Index
19962019
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Research Output 1996 2019

  • 1358 Citations
  • 20 h-Index
  • 42 Article
  • 2 Chapter
  • 1 Comment/debate
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Article
2019

MicroRNA profiling identifies a novel compound with antidepressant properties

Sell, S., Boone, D. R., Weisz, H. A., Cardenas, C., Willey, H. E., Bolding, I. J., Micci, M., Falduto, M. T., Torres, K. E. O., Dewitt, D., Prough, D. & Hellmich, H., Jan 1 2019, In : PloS one. 14, 8, e0221163.

Research output: Contribution to journalArticle

Open Access
antidepressants
MicroRNAs
microRNA
Antidepressive Agents
Brain
1 Citation (Scopus)

Traumatic brain injury induces long-lasting changes in immune and regenerative signaling

Boone, D. R., Weisz, H. A., Willey, H. E., Torres, K. E. O., Falduto, M. T., Sinha, M., Spratt, H., Bolding, I. J., Johnson, K. M., Parsley, M. A., Dewitt, D., Prough, D. & Hellmich, H., Apr 1 2019, In : PloS one. 14, 4, e0214741.

Research output: Contribution to journalArticle

Open Access
Brain
brain
Genes
Cell signaling
Chronic Brain Injury
2018
8 Citations (Scopus)

Nano-Pulsed Laser Therapy Is Neuroprotective in a Rat Model of Blast-Induced Neurotrauma

Esenaliev, R., Petrov, I. Y., Petrov, Y., Guptarak, J., Boone, D. R., Mocciaro, E., Weisz, H., Parsley, M. A., Sell, S., Hellmich, H., Ford, J. M., Pogue, C., Dewitt, D., Prough, D. & Micci, M., Jul 1 2018, In : Journal of Neurotrauma. 35, 13, p. 1510-1522 13 p.

Research output: Contribution to journalArticle

Laser Therapy
Lasers
Caspase 3
Brain-Derived Neurotrophic Factor
Wounds and Injuries
2017
3 Citations (Scopus)

Effects of AAV-mediated knockdown of nNOS and GPx-1 gene expression in rat hippocampus after traumatic brain injury

Boone, D. R., Leek, J. M., Falduto, M. T., Torres, K. E. O., Sell, S., Parsley, M. A., Cowart, J. C., Uchida, T., Micci, M., Dewitt, D., Prough, D. & Hellmich, H., Oct 1 2017, In : PLoS One. 12, 10, e0185943.

Research output: Contribution to journalArticle

Dependovirus
Nitric Oxide Synthase Type I
hippocampus
Viruses
Gene expression
6 Citations (Scopus)

Evidence linking microRNA suppression of essential prosurvival genes with hippocampal cell death after traumatic brain injury

Boone, D. K., Weisz, H. A., Bi, M., Falduto, M. T., Torres, K. E. O., Willey, H. E., Volsko, C. M., Kumar, A. M., Micci, M., Dewitt, D., Prough, D. & Hellmich, H., Dec 1 2017, In : Scientific Reports. 7, 1, 6645.

Research output: Contribution to journalArticle

Essential Genes
MicroRNAs
Cell Death
Genes
Neurons
1 Citation (Scopus)

Stereotactic atlas-guided laser capture microdissection of brain regions affected by traumatic injury

Weisz, H. A., Boone, D. R., Sell, S. & Hellmich, H., Sep 11 2017, In : Journal of Visualized Experiments. 2017, 127, e56134.

Research output: Contribution to journalArticle

Microdissection
Laser Capture Microdissection
Atlases
Brain
Lasers
2016
1 Citation (Scopus)

Stochastic fluctuations in gene expression in aging hippocampal neurons could be exacerbated by traumatic brain injury

Shearer, J., Boone, D., Weisz, H., Jennings, K., Uchida, T., Parsley, M., Dewitt, D., Prough, D. & Hellmich, H., Apr 1 2016, In : Aging clinical and experimental research. 28, 2, p. 363-367 5 p.

Research output: Contribution to journalArticle

Gene Expression
Neurons
Cell Survival
Cell Death
Neurodegenerative Diseases
2015
8 Citations (Scopus)

Development of a novel imaging system for cell therapy in the brain

Micci, M., Boone, D. R., Parsley, M. A., Wei, J., Patrikeev, I., Motamedi, M. & Hellmich, H., Jul 21 2015, In : Stem Cell Research and Therapy. 6, 1, 129.

Research output: Contribution to journalArticle

Neural Stem Cells
Cell- and Tissue-Based Therapy
Stem cells
Imaging systems
Brain
20 Citations (Scopus)

Pathway-Focused PCR Array Profiling of Enriched Populations of Laser Capture Microdissected Hippocampal Cells after Traumatic Brain Injury

Boone, D. R., Micci, M., Taglialatela, I. G., Hellmich, J. L., Weisz, H. A., Bi, M., Prough, D., Dewitt, D. & Hellmich, H., May 1 2015, In : PLoS One. 10, 5, e0127287.

Research output: Contribution to journalArticle

Neurons
Brain
Lasers
neurons
brain
2014
16 Citations (Scopus)

Traumatic brain injury in vivo and in vitro contributes to cerebral vascular dysfunction through impaired gap junction communication between vascular smooth muscle cells

Yu, G. X., Mueller, M., Hawkins, B., Mathew, B. P., Parsley, M. A., Vergara, L. A., Hellmich, H., Prough, D. & Dewitt, D., Apr 15 2014, In : Journal of Neurotrauma. 31, 8, p. 739-748 10 p.

Research output: Contribution to journalArticle

Gap Junctions
Vascular Smooth Muscle
Smooth Muscle Myocytes
Blood Vessels
Fluorescence Recovery After Photobleaching
2013
14 Citations (Scopus)

Effects of trauma, hemorrhage and resuscitation in aged rats

Hawkins, B., Cowart, J. C., Parsley, M. A., Capra, B. A., Eidson, K. A., Hellmich, H., Dewitt, D. & Prough, D., Feb 16 2013, In : Brain Research. 1496, p. 28-35 8 p.

Research output: Contribution to journalArticle

Percussion
Resuscitation
Cerebrovascular Circulation
Hemorrhage
Wounds and Injuries
17 Citations (Scopus)
Microdissection
Laser Capture Microdissection
Gene expression
Neurons
Brain
15 Citations (Scopus)

Pathway Analysis Reveals Common Pro-Survival Mechanisms of Metyrapone and Carbenoxolone after Traumatic Brain Injury

Hellmich, H., Rojo, D. R., Micci, M., Sell, S., Boone, D. R., Crookshanks, J. M., Dewitt, D., Masel, B. E. & Prough, D., Jan 9 2013, In : PLoS One. 8, 1, e53230.

Research output: Contribution to journalArticle

metyrapone
Carbenoxolone
Metyrapone
Brain
Genes
2012
43 Citations (Scopus)

Traumatic Brain Injury-Induced Dysregulation of the Circadian Clock

Boone, D. R., Sell, S., Micci, M., Crookshanks, J. M., Parsley, M., Uchida, T., Prough, D., Dewitt, D. & Hellmich, H., Oct 3 2012, In : PLoS One. 7, 10, e46204.

Research output: Contribution to journalArticle

Circadian Clocks
circadian rhythm
Clocks
Brain
brain
2011
11 Citations (Scopus)

Cerebrovascular connexin expression: Effects of traumatic brain injury

Avila, M. A., Sell, S., Hawkins, B., Hellmich, H., Boone, D. R., Crookshanks, J. M., Prough, D. & Dewitt, D., Sep 1 2011, In : Journal of Neurotrauma. 28, 9, p. 1803-1811 9 p.

Research output: Contribution to journalArticle

Connexins
Messenger RNA
Gap Junctions
Connexin 43
Cerebral Arteries
24 Citations (Scopus)

Influence of stochastic gene expression on the cell survival rheostat after traumatic brain injury

Rojo, D. R., Prough, D., Falduto, M. T., Boone, D. R., Micci, M., Kahrig, K. M., Crookshanks, J. M., Jimenez, A., Uchida, T., Cowart, J. C., Hawkins, B., Avila, M., Dewitt, D. & Hellmich, H., 2011, In : PLoS One. 6, 8, e23111.

Research output: Contribution to journalArticle

Gene expression
Neurons
cell viability
Brain
Cell Survival
2009
27 Citations (Scopus)
Bombesin Receptors
Gastrin-Releasing Peptide
Interleukin-8
Breast Neoplasms
Epidermal Growth Factor
2008
15 Citations (Scopus)

Chelation of neurotoxic zinc levels does not improve neurobehavioral outcome after traumatic brain injury

Hellmich, H., Eidson, K., Cowart, J., Crookshanks, J., Boone, D. K., Shah, S., Uchida, T., Dewitt, D. & Prough, D., Aug 1 2008, In : Neuroscience Letters. 440, 2, p. 155-159 5 p.

Research output: Contribution to journalArticle

Zinc
Neurons
Hippocampus
Memory Disorders
Wounds and Injuries
13 Citations (Scopus)

L-arginine decreases fluid-percussion injury-induced neuronal nitrotyrosine immunoreactivity in rats

Avila, M. A., Sell, S., Kadoi, Y., Prough, D., Hellmich, H., Velasco, M. & Dewitt, D., Oct 2008, In : Journal of Cerebral Blood Flow and Metabolism. 28, 10, p. 1733-1741 9 p.

Research output: Contribution to journalArticle

Percussion
Arginine
Wounds and Injuries
Neurons
Tyrosine
2007
149 Citations (Scopus)

Clock Gene Expression in the Murine Gastrointestinal Tract: Endogenous Rhythmicity and Effects of a Feeding Regimen

Hoogerwerf, W. A., Hellmich, H., Cornélissen, G., Halberg, F., Shahinian, V. B., Bostwick, J., Savidge, T. C. & Cassone, V. M., Oct 2007, In : Gastroenterology. 133, 4, p. 1250-1260 11 p.

Research output: Contribution to journalArticle

Periodicity
Gastrointestinal Tract
Gene Expression
Genes
Myenteric Plexus
35 Citations (Scopus)

Injured Fluoro-Jade-positive hippocampal neurons contain high levels of zinc after traumatic brain injury

Hellmich, H., Eidson, K. A., Capra, B. A., Garcia, J. M., Boone, D. R., Hawkins, B., Uchida, T., Dewitt, D. & Prough, D., Jan 5 2007, In : Brain Research. 1127, 1, p. 119-126 8 p.

Research output: Contribution to journalArticle

Zinc
Neurons
Glutamic Acid
Wounds and Injuries
Laser Capture Microdissection
10 Citations (Scopus)

Repeated BCG treatment of mouse bladder selectively stimulates small GTPases and HLA antigens and inhibits single-spanning uroplakins

Saban, M. R., Hellmich, H., Simpson, C., Davis, C. A., Lang, M. L., Ihnat, M. A., O'Donnell, M. A., Wu, X. R. & Saban, R., Nov 2 2007, In : BMC Cancer. 7, 204.

Research output: Contribution to journalArticle

Uroplakins
Monomeric GTP-Binding Proteins
Mycobacterium bovis
HLA Antigens
Urinary Bladder
2006
13 Citations (Scopus)

Effects of hypertonic arginine on cerebral blood flow and intracranial pressure after traumatic brain injury combined with hemorrhagic hypotension

Prough, D., Kramer, G., Uchida, T., Stephenson, R. T., Hellmich, H. & Dewitt, D., Sep 2006, In : Shock. 26, 3, p. 290-295 6 p.

Research output: Contribution to journalArticle

Cerebrovascular Circulation
Intracranial Pressure
Hypotension
Arginine
Blood Pressure
26 Citations (Scopus)

Molecular correlates of age-specific responses to traumatic brain injury in mice

Shah, S. A., Prough, D., Garcia, J. M., Dewitt, D. & Hellmich, H., Nov 2006, In : Experimental Gerontology. 41, 11, p. 1201-1205 5 p.

Research output: Contribution to journalArticle

Brain
Neurons
Gene expression
Gene Expression
Wounds and Injuries
16 Citations (Scopus)

The inflammatory and normal transcriptome of mouse bladder detrusor and mucosa

Saban, M. R., Hellmich, H., Turner, M., Nguyen, N. B., Vadigepalli, R., Dyer, D. W., Hurst, R. E., Centola, M. & Saban, R., Jan 18 2006, In : BMC Physiology. 6

Research output: Contribution to journalArticle

Transcriptome
Mucous Membrane
Urinary Bladder
Inflammation
Transcriptional Regulatory Elements
2005
26 Citations (Scopus)

Analysis of long-term gene expression in neurons of the hippocampal subfields following traumatic brain injury in rats

Shimamura, M., Garcia, J. M., Prough, D., Dewitt, D., Uchida, T., Shah, S. A., Avila, M. A. A. & Hellmich, H., 2005, In : Neuroscience. 131, 1, p. 87-97 11 p.

Research output: Contribution to journalArticle

Gene Expression
Neurons
Caspase 9
Genes
Dentate Gyrus
35 Citations (Scopus)

Dose-dependent neuronal injury after traumatic brain injury

Hellmich, H., Capra, B., Eidson, K., Garcia, J., Kennedy, D., Uchida, T., Parsley, M., Cowart, J., Dewitt, D. & Prough, D., May 24 2005, In : Brain Research. 1044, 2, p. 144-154 11 p.

Research output: Contribution to journalArticle

Neurons
Wounds and Injuries
Coloring Agents
Laser Capture Microdissection
Percussion
30 Citations (Scopus)

Traumatic brain injury and hemorrhagic hypotension suppress neuroprotective gene expression in injured hippocampal neurons

Hellmich, H., Garcia, J. M., Shimamura, M., Shah, S. A., Avila, M. A., Uchida, T., Parsley, M. A., Capra, B. A., Eidson, K. A., Kennedy, D. R., Winston, J., Dewitt, D. & Prough, D., Apr 2005, In : Anesthesiology. 102, 4, p. 806-814 9 p.

Research output: Contribution to journalArticle

Hypotension
Gene Expression
Neurons
Laser Capture Microdissection
Genes
2004
36 Citations (Scopus)
Laser Capture Microdissection
Antisense RNA
Hippocampus
Ribonucleases
Gene Expression
44 Citations (Scopus)

Protective effects of zinc chelation in traumatic brain injury correlate with upregulation of neuroprotective genes in rat brain

Hellmich, H., Frederickson, C. J., Dewitt, D., Saban, R., Parsley, M. O., Stephenson, R., Velasco, M., Uchida, T., Shimamura, M. & Prough, D., Jan 30 2004, In : Neuroscience Letters. 355, 3, p. 221-225 5 p.

Research output: Contribution to journalArticle

Zinc
Up-Regulation
In Situ Nick-End Labeling
Brain
Edetic Acid
2003
10 Citations (Scopus)

Overexpression and purification of the vanilloid receptor in yeast (Saccharomyces cerevisiae)

Moiseenkova, V. Y., Hellmich, H. & Christensen, B. N., Oct 10 2003, In : Biochemical and Biophysical Research Communications. 310, 1, p. 196-201 6 p.

Research output: Contribution to journalArticle

TRPV Cation Channels
Yeast
Purification
Saccharomyces cerevisiae
Yeasts
2002
14 Citations (Scopus)

Characterization of the neurotrophic response to acute pancreatitis

Toma, H., Winston, J., Micci, M., Li, H., Hellmich, H. & Pasricha, P. J., 2002, In : Pancreas. 25, 1, p. 31-38 8 p.

Research output: Contribution to journalArticle

Pancreatitis
Nerve Growth Factors
Pancreas
Messenger RNA
Ciliary Neurotrophic Factor
33 Citations (Scopus)

Hypoxia induces mitochondrial DNA damage and stimulates expression of a DNA repair enzyme, the Escherichia coli muty DNA glycosylase homolog (MYH), in vivo, in the rat brain

Lee, H. M., Wang, C., Hu, Z., Greeley, G. H., Makalowski, W., Hellmich, H. & Englander, E., 2002, In : Journal of Neurochemistry. 80, 5, p. 928-937 10 p.

Research output: Contribution to journalArticle

DNA Glycosylases
DNA Repair Enzymes
Mitochondrial DNA
Escherichia coli
DNA Damage
20 Citations (Scopus)

Molecular cloning of the rat proteinase-activated receptor 4 (PAR4)

Hoogerwerf, W. A., Hellmich, H., Micci, M., Winston, J., Zhou, L. & Pasricha, P. J., Feb 18 2002, In : BMC Molecular Biology. 3, 2.

Research output: Contribution to journalArticle

Proteinase-Activated Receptors
Cloning
Molecular Cloning
Rats
Duodenum
2001
12 Citations (Scopus)

Expression and regulation of ClC-5 chloride channels: Effects of antisense and oxidants

Weng, T. X., Mo, L., Hellmich, H., Yu, A. S. L., Wood, T. & Wills, N. K., 2001, In : American Journal of Physiology - Cell Physiology. 280, 6 49-6

Research output: Contribution to journalArticle

Xenopus
Oxidants
Oocytes
Chlorides
COS Cells
146 Citations (Scopus)

The proteinase-activated receptor 2 is involved in nociception

Hoogerwerf, W. A., Zou, L., Shenoy, M., Sun, D., Micci, M., Hellmich, H., Xiao, S. Y., Winston, J. & Pasricha, P. J., Nov 15 2001, In : Journal of Neuroscience. 21, 22, p. 9036-9042 7 p.

Research output: Contribution to journalArticle

PAR-2 Receptor
Nociception
Afferent Neurons
Neurogenic Inflammation
Pain
86 Citations (Scopus)

Time course of LPS-induced gene expression in a mouse model of genitourinary inflammation

Saban, M. R., Hellmich, H., Nguyen, N. B., Winston, J., Hammond, T. G. & Saban, R., Jun 2001, In : Physiological Genomics. 2001, 5, p. 147-160 14 p.

Research output: Contribution to journalArticle

Lipopolysaccharides
Multigene Family
Inflammation
Gene Expression
Oligonucleotide Array Sequence Analysis

Time course of LPS-induced gene expression in a mouse model of genitourinary inflammation.

Saban, M. R., Hellmich, H., Nguyen, N. B., Winston, J., Hammond, T. G. & Saban, R., Apr 2 2001, In : Physiol Genomics. 5, 3, p. 147-160 14 p.

Research output: Contribution to journalArticle

Lipopolysaccharides
Multigene Family
Inflammation
Gene Expression
Oligonucleotide Array Sequence Analysis
2000
38 Citations (Scopus)

Chloride channel expression in cultured human fetal RPE cells: Response to oxidative stress

Wills, N. K., Weng, T., Mo, L., Hellmich, H., Yu, A., Wang, T., Buchheit, S. & Godley, B. F., 2000, In : Investigative Ophthalmology and Visual Science. 41, 13, p. 4247-4255 9 p.

Research output: Contribution to journalArticle

Chloride Channels
Oxidative Stress
Chlorides
Hydrogen Peroxide
Cyclamates
110 Citations (Scopus)

Human colorectal cancers express a constitutively active cholecystokinin-B/gastrin receptor that stimulates cell growth

Hellmich, M., Rui, X. L., Hellmich, H., Fleming, R. Y. D., Evers, B. M. & Townsend, C., Oct 13 2000, In : Journal of Biological Chemistry. 275, 41, p. 32122-32128 7 p.

Research output: Contribution to journalArticle

Cholecystokinin B Receptor
Cholecystokinin
Cell growth
Colorectal Neoplasms
Cells
1999
40 Citations (Scopus)

Comparison of amphibian and human ClC-5: Similarity of functional properties and inhibition by external pH

Mo, L., Hellmich, H., Fong, P., Wood, T., Embesi, J. & Wills, N. K., 1999, In : Journal of Membrane Biology. 168, 3, p. 253-264 12 p.

Research output: Contribution to journalArticle

Amphibians
5' Untranslated Regions
3' Untranslated Regions
Xenopus
Oocytes
1996
186 Citations (Scopus)
Glial Cell Line-Derived Neurotrophic Factor
Neural Plate
Neurogenesis
Embryonic Development
Organism Cloning