Javier Navarro, PhD, MS

  • 3503 Citations
  • 29 h-Index
1976 …2019

Research output per year

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Research Output

  • 3503 Citations
  • 29 h-Index
  • 70 Article
  • 3 Review article
  • 2 Comment/debate
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Article
2019
2013

Chemokine CXCL1 dimer is a potent agonist for the CXCR2 receptor

Ravindran, A., Sawant, K. V., Sarmiento, J., Navarro, J. & Rajarathnam, K., Apr 26 2013, In : Journal of Biological Chemistry. 288, 17, p. 12244-12252 9 p.

Research output: Contribution to journalArticle

36 Scopus citations
2012

A chemokine receptor CXCR2 macromolecular complex regulates neutrophil functions in inflammatory diseases

Wu, Y., Wang, S., Farooq, S. M., Castelvetere, M. P., Hou, Y., Gao, J. L., Navarro, J. V., Oupicky, D., Sun, F. & Li, C., Feb 17 2012, In : Journal of Biological Chemistry. 287, 8, p. 5744-5755 12 p.

Research output: Contribution to journalArticle

42 Scopus citations
2011

Diverging mechanisms of activation of chemokine receptors revealed by novel chemokine agonists

Sarmiento, J., Shumate, C., Suetomi, K., Ravindran, A., Villegas, L., Rajarathnam, K. & Navarro, J., Dec 9 2011, In : PloS one. 6, 12, e27967.

Research output: Contribution to journalArticle

12 Scopus citations

The splice variant of the V2 vasopressin receptor adopts alternative topologies

Gonzalez, A., Borquez, M., Trigo, C. A., Brenet, M., Sarmiento, J. M., Figueroa, C. D., Navarro, J. & Gonzalez, C. B., Jun 7 2011, In : Biochemistry. 50, 22, p. 4981-4986 6 p.

Research output: Contribution to journalArticle

6 Scopus citations
2010

Probing the role of CXC motif in chemokine CXCL8 for high affinity binding and activation of CXCR1 and CXCR2 receptors

Joseph, P. R. B., Sarmiento, J. M., Mishra, A. K., Das, S. T., Garofalo, R. P., Navarro, J. & Rajarathnam, K., Sep 17 2010, In : Journal of Biological Chemistry. 285, 38, p. 29262-29269 8 p.

Research output: Contribution to journalArticle

35 Scopus citations
2009

Adenovirus mediated expression "in vivo" of the chemokine receptor CXCR1

Sarmiento, J., Kypreos, K. E., Prado, G. N., Suetomi, K., Stanzel, C., Maxwell, C., Shumate, D., Tandang-Silvas, M. R., Rajarathnam, K. & Navarro, J., Mar 1 2009, In : Journal of Structural and Functional Genomics. 10, 1, p. 17-23 7 p.

Research output: Contribution to journalArticle

4 Scopus citations

Postnatal expression of V2 vasopressin receptor splice variants in the rat cerebellum

Vargas, K. J., Sarmiento, J. M., Ehrenfeld, P., Añazco, C. C., Villanueva, C. I., Carmona, P. L., Brenet, M., Navarro, J., Müller-Esterl, W. & González, C. B., Apr 1 2009, In : Differentiation. 77, 4, p. 377-385 9 p.

Research output: Contribution to journalArticle

13 Scopus citations
2008

Vasopressin up-regulates the expression of growth-related immediate-early genes via two distinct EGF receptor transactivation pathways

Fuentes, L. Q., Reyes, C. E., Sarmiento, J. M., Villanueva, C. I., Figueroa, C. D., Navarro, J. & González, C. B., Sep 1 2008, In : Cellular Signalling. 20, 9, p. 1642-1650 9 p.

Research output: Contribution to journalArticle

14 Scopus citations
2007

Activation of ERK, JNK, Akt, and G-protein coupled signaling by hybrid angiotensin II AT1/bradykinin B2 receptors expressed in HEK-293 cells

Yu, J., Lubinsky, D., Tsomaia, N., Huang, Z., Taylor, L., Mierke, D., Navarro, J., Miraz, O. & Polgar, P., May 1 2007, In : Journal of Cellular Biochemistry. 101, 1, p. 192-204 13 p.

Research output: Contribution to journalArticle

9 Scopus citations

Chemokine signaling specificity: Essential role for the N-terminal domain of chemokine receptor

Prado, G. N., Suetomi, K., Shumate, D., Maxwell, C., Ravindran, A., Rajarathnam, K. & Navarro, J., Aug 7 2007, In : Biochemistry. 46, 31, p. 8961-8968 8 p.

Research output: Contribution to journalArticle

41 Scopus citations
2006

Probing receptor binding activity of interleukin-8 dimer using a disulfide trap

Rajarathnam, K., Prado, G. N., Fernando, H., Clark-Lewis, I. & Navarro, J., Jun 27 2006, In : Biochemistry. 45, 25, p. 7882-7888 7 p.

Research output: Contribution to journalArticle

45 Scopus citations
2005

Crystal structure of cone arrestin at 2.3 Å: Evolution of receptor specificity

Sutton, R. B., Vishnivetskiy, S. A., Robert, J., Hanson, S. M., Raman, D., Knox, B. E., Kono, M., Navarro, J. & Gurevich, V. V., Dec 16 2005, In : Journal of Molecular Biology. 354, 5, p. 1069-1080 12 p.

Research output: Contribution to journalArticle

132 Scopus citations
2004

Crystallization of transmembrane proteins in cubo: Mechanisms of crystal growth and defect formation

Qutub, Y., Reviakine, I., Maxwell, C., Navarro, J., Landau, E. M. & Vekilov, P. G., Nov 5 2004, In : Journal of Molecular Biology. 343, 5, p. 1243-1254 12 p.

Research output: Contribution to journalArticle

35 Scopus citations

Novel down-regulatory mechanism of the surface expression of the vasopressin V2 receptor by an alternative splice receptor variant

Sarmiento, J. M., Añazco, C. C., Campos, D. M., Prado, G. N., Navarro, J. & González, C. B., Nov 5 2004, In : Journal of Biological Chemistry. 279, 45, p. 47017-47023 7 p.

Research output: Contribution to journalArticle

28 Scopus citations
2002

Crystallization of membrane proteins in Cubo

Nollert, P., Navarro, J. & Landau, E. M., Jan 1 2002, In : Methods in enzymology. 343, p. 183-199 17 p.

Research output: Contribution to journalArticle

50 Scopus citations

Early structural rearrangements in the photocycle of an integral membrane sensory receptor

Edman, K., Royant, A., Nollert, P., Maxwell, C. A., Pebay-Peyroula, E., Navarro, J., Neutze, R. & Landau, E. M., Apr 23 2002, In : Structure. 10, 4, p. 473-482 10 p.

Research output: Contribution to journalArticle

49 Scopus citations

Functional role of internal water molecules in rhodopsin revealed by x-ray crystallography

Okada, T., Fujiyoshi, Y., Silow, M., Navarro, J., Landau, E. M. & Shichida, Y., Apr 30 2002, In : Proceedings of the National Academy of Sciences of the United States of America. 99, 9, p. 5982-5987 6 p.

Research output: Contribution to journalArticle

628 Scopus citations

Identification of a signal transduction switch in the chemokine receptor CXCR1

Suetomi, K., Rojo, D. & Navarro, J., Aug 30 2002, In : Journal of Biological Chemistry. 277, 35, p. 31563-31566 4 p.

Research output: Contribution to journalArticle

10 Scopus citations

Receptor-dependent G-protein activation in lipidic cubic phase

Navarro, J., Landau, E. M. & Fahmy, K., Jul 11 2002, In : Biopolymers - Biospectroscopy Section. 67, 3, p. 167-177 11 p.

Research output: Contribution to journalArticle

8 Scopus citations
2001

Polarized expression of the GFP-tagged rat V1a vasopressin receptor

Campos, D. M., Reyes, C. E., Sarmiento, J., Navarro, J. & González, C. B., Nov 30 2001, In : Biochemical and Biophysical Research Communications. 289, 2, p. 325-328 4 p.

Research output: Contribution to journalArticle

4 Scopus citations

Structural determinants of spectral tuning in retinal proteins - Bacteriorhodopsin vs sensory rhodopsin II

Hayashi, S., Tajkhorshid, E., Pebay-Peyroula, E., Royant, A., Landau, E. M., Navarro, J. & Schulten, K., Oct 18 2001, In : Journal of Physical Chemistry B. 105, 41, p. 10124-10131 8 p.

Research output: Contribution to journalArticle

90 Scopus citations

X-ray structure of sensory rhodopsin II at 2.1-Å resolution

Royant, A., Nollert, P., Edman, K., Neutze, R., Landau, E. M., Pebay-Peyroula, E. & Navarro, J., Aug 28 2001, In : Proceedings of the National Academy of Sciences of the United States of America. 98, 18, p. 10131-10136 6 p.

Research output: Contribution to journalArticle

246 Scopus citations
1999

Differential mechanisms of recognition and activation of interleukin-8 receptor subtypes

Suetomi, K., Lu, Z., Heck, T., Wood, T. G., Prusak, D. J., Dunn, K. J. & Navarro, J., Apr 23 1999, In : Journal of Biological Chemistry. 274, 17, p. 11768-11772 5 p.

Research output: Contribution to journalArticle

28 Scopus citations

PU.1 regulates the CXCR1 promoter

Wilkinson, N. C. & Navarro, J., Jan 1 1999, In : Journal of Biological Chemistry. 274, 1, p. 438-443 6 p.

Research output: Contribution to journalArticle

13 Scopus citations
1998

CXC chemokines suppress proliferation of myeloid progenitor cells by activation of the CXC chemokine receptor 2

Sanchez, X., Suetomi, K., Cousins-Hodges, B., Horton, J. K. & Navarro, J., Jan 15 1998, In : Journal of Immunology. 160, 2, p. 906-910 5 p.

Research output: Contribution to journalArticle

29 Scopus citations

Expression and regulation of leukotriene-synthesis enzymes in rat liver cells

Shimada, K., Navarro, J., Goeger, D. E., Mustafa, S. B., Weigel, P. H. & Weinman, S. A., Nov 10 1998, In : Hepatology. 28, 5, p. 1275-1281 7 p.

Research output: Contribution to journalArticle

32 Scopus citations
1997

Activation of HIV-1 coreceptor (CXCR4) mediates myelosuppression

Sanchez, X., Cousins-Hodges, B., Aguilar, T., Gosselink, P., Lu, Z. & Navarro, J., Oct 31 1997, In : Journal of Biological Chemistry. 272, 44, p. 27529-27531 3 p.

Research output: Contribution to journalArticle

37 Scopus citations

Chronic stimulation differentially modulates expression of mRNA for dihydropyridine receptor isoforms in rat fast twitch skeletal muscle

Péréon, Y., Navarro, J., Hamilton, M., Booth, F. W. & Palade, P., Jun 9 1997, In : Biochemical and Biophysical Research Communications. 235, 1, p. 217-222 6 p.

Research output: Contribution to journalArticle

22 Scopus citations

Dihydropyridine receptor gene expression in skeletal muscle from mdx and control mice

Péréon, Y., Dettbarn, C., Navarro, J., Noireaud, J. & Palade, P. T., Dec 31 1997, In : Biochimica et Biophysica Acta - Molecular Basis of Disease. 1362, 2-3, p. 201-207 7 p.

Research output: Contribution to journalArticle

11 Scopus citations

Regulatory elements controlling the cell-specific expression of the interleukin-8 receptor a and B genes

Wilklnson, N. C. & Navarro, J., Dec 1 1997, In : FASEB Journal. 11, 9, p. A1381

Research output: Contribution to journalArticle

1996

Regulation of dihydropyridine receptor and ryanodine receptor gene expression in regenerating skeletal muscle

Péréon, Y., Navarro, J., Sorrentino, V., Louboutin, J. P., Noireaud, J. & Palade, P., Dec 1996, In : Pflugers Archiv European Journal of Physiology. 433, 3, p. 221-229 9 p.

Research output: Contribution to journalArticle

13 Scopus citations

Role of the C terminus of the interleukin 8 receptor in signal transduction and internalization

Prado, G. N., Suzuki, H., Wilkinson, N., Cousins, B. & Navarro, J., Aug 27 1996, In : Journal of Biological Chemistry. 271, 32, p. 19186-19190 5 p.

Research output: Contribution to journalArticle

65 Scopus citations
1994

Functional and ligand binding specificity of the rabbit neutrophil IL-8 receptor

Thomas, K. M., Taylor, L., Prado, G., Romero, J., Moser, B., Car, B., Walz, A., Baggiolini, M. & Navarro, J., Mar 1 1994, In : Journal of Immunology. 152, 5, p. 2496-2500 5 p.

Research output: Contribution to journalArticle

11 Scopus citations

Molecular characterization of a novel rabbit interleukin-8 receptor isotype

Prado, G. N., Thomas, K. M., Suzuki, H., LaRosa, G. J., Wilkinson, N., Folco, E. & Navarro, J., Jan 1 1994, In : Journal of Biological Chemistry. 269, 17, p. 12391-12394 4 p.

Research output: Contribution to journalArticle

19 Scopus citations

Sarcoplasmic reticulum Ca2+ pump expression in denervated skeletal muscle

Schulte, L., Peters, D., Taylor, J., Navarro, J. & Kandarian, S., 1994, In : American Journal of Physiology - Cell Physiology. 267, 2 36-2

Research output: Contribution to journalArticle

Sarcoplasmic reticulum Ca2+ pump expression in denervated skeletal muscle

Schulte, L., Peters, D., Taylor, J., Navarro, J. & Kandarian, S., Jan 1 1994, In : American Journal of Physiology - Cell Physiology. 267, 2 36-2, p. C617-C622

Research output: Contribution to journalArticle

42 Scopus citations

The N terminus of interleukin-8 (IL-8) receptor confers high affinity binding to human IL-8

Suzuki, H., Prado, G. N., Wilkinson, N. & Navarro, J., Jul 15 1994, In : Journal of Biological Chemistry. 269, 28, p. 18263-18266 4 p.

Research output: Contribution to journalArticle

35 Scopus citations
1993

Regulation of sarcoplasmic reticulum calcium pump gene expression by hindlimb unweighting

Schulte, L. M., Navarro, J. & Kandarian, S. C., Jun 2 1993, In : American Journal of Physiology - Cell Physiology. 264, 5 33-5, p. C1308-C1315

Research output: Contribution to journalArticle

76 Scopus citations

The rabbit neutrophil N-formyl peptide receptor: cDNA cloning, expression, and structure/function implications

Ye, R. D., Quehenberger, O., Thomas, K. M., Navarro, J., Cavanagh, S. L., Prossnitz, E. R. & Cochrane, C. G., Jan 1 1993, In : Journal of Immunology. 150, 4, p. 1383-1394 12 p.

Research output: Contribution to journalArticle

39 Scopus citations
1992

Amino terminus of the interleukin-8 receptor is a major determinant of receptor subtype specificity

LaRosa, G. J., Thomas, K. M., Kaufmann, M. E., Mark, R., White, M., Taylor, L., Gray, G., Witt, D. & Navarro, J., Jan 1 1992, In : Journal of Biological Chemistry. 267, 35, p. 25402-25406 5 p.

Research output: Contribution to journalArticle

130 Scopus citations

Functional expression of the bradykinin-B2 receptor cDNA in Chinese hamster lung CCL39 fibroblasts

Taylor, L., Ricupero, D., Jean, J. C., Jackson, B. A., Navarro, J. & Polgar, P., Oct 30 1992, In : Biochemical and Biophysical Research Communications. 188, 2, p. 786-793 8 p.

Research output: Contribution to journalArticle

20 Scopus citations

Mechanisms in bradykinin stimulated arachidonate release and synthesis of prostaglandin and platelet activating factor

Ricupero, D., Taylor, L., Tlucko, A., Polgar, P. & Navarro, J., Jan 1 1992, In : Mediators of inflammation. 1, 2, p. 133-140 8 p.

Research output: Contribution to journalArticle

8 Scopus citations

Regulation of skeletal muscle dihydropyridine receptor gene expression by biomechanical unloading

Kandarian, S., O'Brien, S., Thomas, K., Schulte, L. & Navarro, J., Jan 1 1992, In : Journal of Applied Physiology. 72, 6, p. 2510-2514 5 p.

Research output: Contribution to journalArticle

47 Scopus citations
1991

The interleukin-8 receptor is encoded by a neutrophil-specific cDNA clone, F3R

Thomas, K. M., Taylor, L. & Navarro, J., Oct 2 1991, In : Journal of Biological Chemistry. 266, 23, p. 14839-14841 3 p.

Research output: Contribution to journalArticle

58 Scopus citations
1990

Functional reconstitution of fMet-Leu-Phe receptor in Xenopus laevis oocytes

Coats, W. D. & Navarro, J., May 16 1990, In : Journal of Biological Chemistry. 265, 11, p. 5964-5966 3 p.

Research output: Contribution to journalArticle

9 Scopus citations

Molecular cloning of the fMet-Leu-Phe receptor from neutrophils

Thomas, K. M., Pyun, H. Y. & Navarro, J., Dec 18 1990, In : Journal of Biological Chemistry. 265, 33, p. 20061-20064 4 p.

Research output: Contribution to journalArticle

70 Scopus citations
1989

Newly synthesized calsequestrin, destined for the sarcoplasmic reticulum, is contained in early/intermediate Golgi-derived clathrin-coated vesicles

Thomas, K., Navarro, J., Benson, R. J. J., Campbell, K. P., Rotundo, R. L. & Fine, R. E., Jan 1 1989, In : Journal of Biological Chemistry. 264, 6, p. 3140-3145 6 p.

Research output: Contribution to journalArticle

43 Scopus citations
1988

Insulin-regulatable tissues express a unique insulin-sensitive glucose transport protein

James, D. E., Brown, R., Navarro, J. & Pilch, P. F., Jan 1 1988, In : Nature. 333, 6169, p. 183-185 3 p.

Research output: Contribution to journalArticle

417 Scopus citations

Solubilization and Reconstitution of the Formylmethionylleucylphenylalanine Receptor Coupled to Guanine Nucleotide Regulatory Protein

Williamson, K., Dickey, B. F., Pyun, H. Y. & Navarro, J., Jul 1 1988, In : Biochemistry. 27, 14, p. 5371-5377 7 p.

Research output: Contribution to journalArticle

10 Scopus citations