• 3364 Citations
  • 32 h-Index
1994 …2023

Research output per year

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Research Output

2019

Allosteric Modulation of Class A GPCRs: Targets, Agents, and Emerging Concepts

Wold, E. A., Chen, J., Cunningham, K. & Zhou, J., Oct 1 2019, In : Journal of Medicinal Chemistry. 62, 1, p. 88-127 40 p.

Research output: Contribution to journalArticle

11 Scopus citations

An NPY Y1 receptor antagonist unmasks latent sensitization and reveals the contribution of protein kinase A and Epac to chronic inflammatory pain

Fu, W., Nelson, T. S., Santos, D. F., Doolen, S., Gutierrez, J. J. P., Ye, N., Zhou, J. & K Taylor, B., Aug 1 2019, In : Pain. 160, 8, p. 1754-1765 12 p.

Research output: Contribution to journalArticle

3 Scopus citations

Applications of bioorthogonal chemistry in tumor-targeted drug discovery

Liu, G., Wold, E. A. & Zhou, J., Jan 1 2019, In : Current topics in medicinal chemistry. 19, 11, p. 892-897 6 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations
1 Scopus citations

Design, Synthesis, and Characterization of 4-Undecylpiperidine-2-carboxamides as Positive Allosteric Modulators of the Serotonin (5-HT) 5-HT2C Receptor

Wild, C. T., Miszkiel, J. M., Wold, E. A., Soto, C. A., Ding, C., Hartley, R. M., White, M., Anastasio, N., Cunningham, K. & Zhou, J., Oct 1 2019, In : Journal of Medicinal Chemistry. 62, 1, p. 288-305 18 p.

Research output: Contribution to journalArticle

8 Scopus citations
1 Scopus citations

Dual activity of niclosamide to suppress replication of integrated HIV-1 and Mycobacterium tuberculosis (Beijing)

Fan, X. Z., Xu, J., Files, M., Cirillo, J. D., Endsley, J., Zhou, J. & Endsley, M., Jan 1 2019, In : Tuberculosis.

Research output: Contribution to journalArticle

Effect of N-(2-aminoethyl) ethanolamine on hypertrophic scarring changes in vitro: Finding novel anti-fibrotic therapies

Chen, Z., Gu, J., El Ayadi, A., Oberhauser, A., Zhou, J., Sousse, L., Finnerty, C., Herndon, D. & Boor, P. J., Jan 1 2019, In : Toxicology and Applied Pharmacology. 362, p. 9-19 11 p.

Research output: Contribution to journalArticle

1 Scopus citations

Efficacy of novel highly specific bromodomain-containing protein 4 inhibitors in innate inflammation–driven airway remodeling

Tian, B., Liu, Z., Litvinov, J., Maroto, R., Jamaluddin, M., Rytting, E., Patrikeev, I., Ochoa, L., Vargas, G., Motamedi, M., Ameredes, B., Zhou, J. & Brasier, A. R., Jan 1 2019, In : American Journal of Respiratory Cell and Molecular Biology. 60, 1, p. 68-83 16 p.

Research output: Contribution to journalArticle

7 Scopus citations

Exchange protein directly activated by cAMP plays a critical role in regulation of vascular fibrinolysis

He, X., Drelich, A., Yu, S., Chang, Q., Gong, D., Zhou, Y., Qu, Y., Yuan, Y., Su, Z., Qiu, Y., Tang, S-J., Gaitas, A., Ksiazek, T., Xu, Z., Zhou, J., Feng, Z., Wakamiya, M., Lu, F. & Gong, B., Mar 15 2019, In : Life Sciences. 221, p. 1-12 12 p.

Research output: Contribution to journalArticle

HFIP-promoted Michael reactions: direct para-selective C-H activation of anilines with maleimides

Li, B., Mao, Q., Zhou, J., Liu, F. & Ye, N., Jan 1 2019, In : Organic and Biomolecular Chemistry. 17, 8, p. 2242-2246 5 p.

Research output: Contribution to journalArticle

6 Scopus citations

Methylglyoxal and a spinal TRPA1-AC1-Epac cascade facilitate pain in the db/db mouse model of type 2 diabetes

Griggs, R. B., Santos, D. F., Laird, D. E., Doolen, S., Donahue, R. R., Wessel, C. R., Fu, W., Sinha, G. P., Wang, P., Zhou, J., Brings, S., Fleming, T., Nawroth, P. P., Susuki, K. & Taylor, B. K., Jul 1 2019, In : Neurobiology of Disease. 127, p. 76-86 11 p.

Research output: Contribution to journalArticle

Orphan Receptor GPR88 as an Emerging Neurotherapeutic Target

Ye, N., Li, B., Mao, Q., Wold, E. A., Tian, S., Allen, J. & Zhou, J., Jan 16 2019, In : ACS Chemical Neuroscience. 10, 1, p. 190-200 11 p., 10.1021/acschemneuro.8b00572.

Research output: Contribution to journalReview article

Pharmacoproteomics reveal novel protective activity of bromodomain containing 4 inhibitors on vascular homeostasis in TLR3-mediated airway remodeling

Zhao, Y., Tian, B., Sun, H., Zhang, J., Zhang, Y., Ivannikov, M., Motamedi, M., Liu, Z., Zhou, J., Kaphalia, L., Calhoun, W., Maroto, R. & Brasier, A. R., Aug 15 2019, In : Journal of Proteomics. 205, 103415.

Research output: Contribution to journalArticle

3 Scopus citations

Recent Advances in Developing K-Ras Plasma Membrane Localization Inhibitors

Ye, N., Xu, Q., Li, W., Wang, P. & Zhou, J., Jan 1 2019, In : Current topics in medicinal chemistry. 19, 23, p. 2114-2127 14 p.

Research output: Contribution to journalReview article

2 Scopus citations

Structure-activity relationship studies on Bax activator SMBA1 for the treatment of ER-positive and triple-negative breast cancer

Liu, G., Yin, T., Kim, H., Ding, C., Yu, Z., Wang, H., Chen, H., Yan, R., Wold, E. A., Zou, H., Liu, X., Ding, Y., Shen, Q. & Zhou, J., Sep 15 2019, In : European journal of medicinal chemistry. 178, p. 589-605 17 p.

Research output: Contribution to journalArticle

Structure-guided drug design identifies a BRD4-selective small molecule that suppresses HIV

Niu, Q., Liu, Z., Alamer, E., Fan, X., Chen, H., Endsley, J., Gelman, B. B., Tian, B., Kim, J. H., Michael, N. L., Robb, M. L., Ananworanich, J., Zhou, J. & Hu, H., Aug 1 2019, In : Journal of Clinical Investigation. 129, 8, p. 3361-3373 13 p.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Synthesis and pharmacological evaluation of non-catechol G protein biased and unbiased dopamine D1 receptor agonists

Wang, P., Felsing, D., Chen, H., Raval, S., Allen, J. & Zhou, J., May 9 2019, In : ACS Medicinal Chemistry Letters. 10.1021/acsmedchemlett.9b00050, p. 792-799 8 p., 10.1021/acsmedchemlett.9b00050.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Targeting the 5-HT2C Receptor in Biological Context and the Current State of 5-HT2C Receptor Ligand Development

Wold, E. A., Wild, C. T., Cunningham, K. A. & Zhou, J., Jan 1 2019, In : Current topics in medicinal chemistry. 19, 16, p. 1381-1398 18 p.

Research output: Contribution to journalReview article

5 Scopus citations

Validation of the epigenetic reader bromodomain-containing protein 4 (BRD4) as a therapeutic target for treatment of airway remodeling

Brasier, A. R. & Zhou, J., Jan 1 2019, (Accepted/In press) In : Drug Discovery Today.

Research output: Contribution to journalReview article

2018

AMPA receptor positive allosteric modulators attenuate morphine tolerance and dependence

Hu, X., Tian, X., Guo, X., He, Y., Chen, H., Zhou, J. & Wang, Z. J., Jul 15 2018, In : Neuropharmacology. 137, p. 50-58 9 p.

Research output: Contribution to journalArticle

3 Scopus citations

Antifibrosis effect of novel oridonin analog CYD0618 via suppression of the NF-κB pathway

Cummins, C. B., Wang, X., Xu, J., Hughes, B. D., Ding, Y., Chen, H., Zhou, J. & Radhakrishnan, R., Dec 1 2018, In : Journal of Surgical Research. 232, p. 283-292 10 p.

Research output: Contribution to journalArticle

4 Scopus citations

Discovery of novel mifepristone derivatives via suppressing KLF5 expression for the treatment of triple-negative breast cancer

Lin, Y., Liu, R., Zhao, P., Ye, J., Zheng, Z., Huang, J., Zhang, Y., Gao, Y., Chen, H., Liu, S., Zhou, J., Chen, C. & Chen, H., Feb 25 2018, In : European Journal of Medicinal Chemistry. 146, p. 354-367 14 p.

Research output: Contribution to journalArticle

6 Scopus citations

Discovery of potent and selective BRD4 inhibitors capable of blocking TLR3-induced acute airway inflammation

Liu, Z., Tian, B., Chen, H., Wang, P., Brasier, A. R. & Zhou, J., May 10 2018, In : European Journal of Medicinal Chemistry. 151, p. 450-461 12 p.

Research output: Contribution to journalArticle

12 Scopus citations

Erythrosin B is a potent and broad-spectrum orthosteric inhibitor of the flavivirus NS2B-NS3 protease

Li, Z., Sakamuru, S., Huang, R., Brecher, M., Koetzner, C. A., Zhang, J., Chen, H., Qin, C. F., Zhang, Q. Y., Zhou, J., Kramer, L. D., Xia, M. & Li, H., Feb 1 2018, In : Antiviral Research. 150, p. 217-225 9 p.

Research output: Contribution to journalArticle

15 Scopus citations

Exchange protein directly activated by cAMP modulates ebola virus uptake into vascular endothelial cells

Drelich, A., Judy, B., He, X., Chang, Q., Yu, S., Li, X., Lu, F., Wakamiya, M., Popov, V., Zhou, J., Ksiazek, T. & Gong, B., Oct 16 2018, In : Viruses. 10, 10, 563.

Research output: Contribution to journalArticle

3 Scopus citations

Exchange Proteins Directly Activated by cAMP and Their Roles in Respiratory Syncytial Virus Infection

Choi, E-J., Ren, Y., Chen, Y., Liu, S., Wu, W., Ren, J., Wang, P., Garofalo, R., Zhou, J. & Bao, X., Nov 15 2018, In : Journal of Virology. 92, 22

Research output: Contribution to journalArticle

Functional Modulation of Voltage-Gated Sodium Channels by a FGF14-Based Peptidomimetic

Ali, S. R., Liu, Z., Nenov, M. N., Folorunso, O., Singh, A., Scala, F., Chen, H., James, T. F., Alshammari, M., Panova-Elektronova, N. I., White, M., Zhou, J. & Laezza, F., May 16 2018, In : ACS Chemical Neuroscience. 9, 5, p. 976-987 12 p.

Research output: Contribution to journalArticle

6 Scopus citations

GPCR Allosteric Modulators: Mechanistic Advantages and Therapeutic Applications

Wold, E. A. & Zhou, J., Jan 1 2018, In : Current Topics in Medicinal Chemistry. 18, 23, p. 2002-2006 5 p.

Research output: Contribution to journalArticle

2 Scopus citations

Identification of peptidomimetics as novel chemical probes modulating fibroblast growth factor 14 (FGF14) and voltage-gated sodium channel 1.6 (Nav1.6) protein-protein interactions

Liu, Z., Wadsworth, P., Singh, A. K., Chen, H., Wang, P., Folorunso, O., Scaduto, P., Ali, S. R., Laezza, F. & Zhou, J., Jan 1 2018, (Accepted/In press) In : Bioorganic and Medicinal Chemistry Letters.

Research output: Contribution to journalArticle

2 Scopus citations

Luteolin-mediated inhibition of hepatic stellate cell activation via suppression of the STAT3 pathway

Cummins, C. B., Wang, X., Nunez Lopez, O., Graham, G., Tie, H. Y., Zhou, J. & Radhakrishnan, R., Jun 1 2018, In : International Journal of Molecular Sciences. 19, 6, 1567.

Research output: Contribution to journalArticle

6 Scopus citations

Mucosal bromodomain-containing protein 4 mediates aeroallergen-induced inflammation and remodeling

Tian, B., Hosoki, K., Liu, Z., Yang, J., Zhao, Y., Sun, H., Zhou, J., Rytting, E., Kaphalia, L., Calhoun, W., Sur, S. & Brasier, A. R., Jan 1 2018, (Accepted/In press) In : Journal of Allergy and Clinical Immunology.

Research output: Contribution to journalArticle

7 Scopus citations

Natural Compound Oridonin Inhibits Endotoxin-Induced Inflammatory Response of Activated Hepatic Stellate Cells

Cummins, C. B., Wang, X., Sommerhalder, C., Bohanon, F. J., Nunez Lopez, O., Tie, H. Y., Rontoyanni, V. G., Zhou, J. & Radhakrishnan, R., Jan 1 2018, In : BioMed Research International. 2018, 6137420.

Research output: Contribution to journalArticle

4 Scopus citations

Proteolysis Targeting Chimera (PROTAC): A Paradigm-Shifting Approach in Small Molecule Drug Discovery

Wang, P. & Zhou, J., Jan 1 2018, In : Current Topics in Medicinal Chemistry. 18, 16, p. 1354-1356 3 p.

Research output: Contribution to journalReview article

15 Scopus citations

Regio- and Stereospecific Synthesis of Oridonin D-Ring Aziridinated Analogues for the Treatment of Triple-Negative Breast Cancer via Mediated Irreversible Covalent Warheads

Ding, Y., Li, D., Ding, C., Wang, P., Liu, Z., Wold, E. A., Ye, N., Chen, H., White, M., Shen, Q. & Zhou, J., Apr 12 2018, In : Journal of Medicinal Chemistry. 61, 7, p. 2737-2752 16 p.

Research output: Contribution to journalArticle

12 Scopus citations

Selective Antagonists of the Bronchiolar Epithelial NF-κB-Bromodomain-Containing Protein 4 Pathway in Viral-Induced Airway Inflammation

Tian, B., Liu, Z., Yang, J., Sun, H., Zhao, Y., Wakamiya, M., Chen, H., Rytting, E., Zhou, J. & Brasier, A. R., Jan 1 2018, (Accepted/In press) In : Cell Reports.

Research output: Contribution to journalArticle

11 Scopus citations

Selective BCL-X L inhibition promotes apoptosis in combination with MLN8237 in medulloblastoma and pediatric glioblastoma cells

Levesley, J., Steele, L., Brüning-Richardson, A., Davison, A., Zhou, J., Ding, C., Lawler, S. & Short, S. C., Jan 22 2018, In : Neuro-Oncology. 20, 2, p. 203-214 12 p.

Research output: Contribution to journalArticle

1 Scopus citations

Small Molecule Neuromedin U Receptor 2 Agonists Suppress Food Intake and Decrease Visceral Fat in Animal Models.

Sampson, C. M., Kasper, J., Felsing, D., Raval, S., Ye, N., P, W., Rytting, E., Zhou, J., Allen, J. & Hommel, J., Aug 23 2018, In : Pharmacology Research and Perspectives. 6, (5):e00425. , doi: 10.1002/prp2.425.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Synthesis and structure–activity relationship studies of MI-2 analogues as MALT1 inhibitors

Wu, G., Wang, H., Zhou, W., Zeng, B., Mo, W., Zhu, K., Liu, R., Zhou, J., Chen, C. & Chen, H., Jan 1 2018, (Accepted/In press) In : Bioorganic and Medicinal Chemistry.

Research output: Contribution to journalArticle

5 Scopus citations

Targeting the NRF-2/RHOA/ROCK signaling pathway with a novel aziridonin, YD0514, to suppress breast cancer progression and lung metastasis

Li, D., Wang, H., Ding, Y., Zhang, Z., Zheng, Z., Dong, J., Kim, H., Meng, X., Zhou, Q., Zhou, J., Fang, L. & Shen, Q., Jun 28 2018, In : Cancer Letters. 424, p. 97-108 12 p.

Research output: Contribution to journalArticle

9 Scopus citations

Therapeutic potential of oridonin and its analogs: From anticancer and antiinflammation to neuroprotection

Xu, J., Wold, E. A., Ding, Y., Shen, Q. & Zhou, J., Jan 1 2018, In : Molecules. 23, 2, 474.

Research output: Contribution to journalReview article

18 Scopus citations
2017

Chemistry and Bioactivity of ent-Kaurene Diterpenoids

Ding, C., Ding, Y., Chen, H. & Zhou, J., 2017, Studies in Natural Products Chemistry. Elsevier B.V., Vol. 54. p. 141-197 57 p. (Studies in Natural Products Chemistry; vol. 54).

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Scopus citations

Drug Discovery Targeting Bromodomain-Containing Protein 4

Liu, Z., Wang, P., Chen, H., Wold, E. A., Tian, B., Brasier, A. R. & Zhou, J., Jun 8 2017, In : Journal of Medicinal Chemistry. 60, 11, p. 4533-4558 26 p.

Research output: Contribution to journalReview article

71 Scopus citations

Exchange proteins directly activated by cAMP (EPACs): Emerging therapeutic targets

Wang, P., Liu, Z., Chen, H., Ye, N., Cheng, X. & Zhou, J., Apr 15 2017, In : Bioorganic and Medicinal Chemistry Letters. 27, 8, p. 1633-1639 7 p.

Research output: Contribution to journalReview article

19 Scopus citations

Existing drugs as broad-spectrum and potent inhibitors for Zika virus by targeting NS2B-NS3 interaction

Li, Z., Brecher, M., Deng, Y. Q., Zhang, J., Sakamuru, S., Liu, B., Huang, R., Koetzner, C. A., Allen, C. A., Jones, S. A., Chen, H., Zhang, N. N., Tian, M., Gao, F., Lin, Q., Banavali, N., Zhou, J., Boles, N., Xia, M., Kramer, L. D. & 2 others, Qin, C. F. & Li, H., Aug 1 2017, In : Cell Research. 27, 8, p. 1046-1064 19 p.

Research output: Contribution to journalArticle

43 Scopus citations

Fragment-based drug design: Strategic advances and lessons learned

Chen, H., Zhou, X., Gao, Y., Chen, H. & Zhou, J., Jun 3 2017, Drug Discovery Technologies. Elsevier Inc., Vol. 2-8. p. 212-232 21 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Identification of novel 2-(benzo[d]isoxazol-3-yl)-2-oxo-N-phenylacetohydrazonoyl cyanide analoguesas potent EPAC antagonists

Ye, N., Zhu, Y., Liu, Z., Mei, F. C., Chen, H., Wang, P., Cheng, X. & Zhou, J., Jul 7 2017, In : European Journal of Medicinal Chemistry. 134, p. 62-71 10 p.

Research output: Contribution to journalArticle

2 Scopus citations

Modulation of Bax and mTOR for cancer therapeutics

Li, R., Ding, C., Zhang, J., Xie, M., Park, D., Ding, Y., Chen, G., Zhang, G., Gilbert-Ross, M., Zhou, W., Marcus, A. I., Sun, S. Y., Chen, Z. G., Sica, G. L., Ramalingam, S. S., Magis, A. T., Fu, H., Khuri, F. R., Curran, W. J., Owonikoko, T. K. & 3 others, Shin, D. M., Zhou, J. & Deng, X., Jun 1 2017, In : Cancer Research. 77, 11, p. 3001-3012 12 p.

Research output: Contribution to journalArticle

7 Scopus citations

Small-molecule inhibitors of protein-protein interactions

Liu, Z., Chen, H., Wold, E. A. & Zhou, J., Jun 3 2017, Drug Discovery Technologies. Elsevier Inc., Vol. 2-8. p. 329-353 25 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations