• 3487 Citations
  • 32 h-Index
1994 …2023

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5-Cyano-6-oxo-1,6-dihydro-pyrimidines as potent antagonists targeting exchange proteins directly activated by cAMP

Chen, H., Tsalkova, T., Mei, F. C., Hu, Y., Cheng, X. & Zhou, J., Jun 15 2012, In : Bioorganic and Medicinal Chemistry Letters. 22, 12, p. 4038-4043 6 p.

Research output: Contribution to journalArticle

37 Scopus citations

A Combined Bioinformatics and Chemoinformatics Approach for Developing Asymmetric Bivalent AMPA Receptor Positive Allosteric Modulators as Neuroprotective Agents

Chen, H., Wang, C. Z., Ding, C., Wild, C., Copits, B., Swanson, G. T., Johnson, K. M. & Zhou, J., Feb 1 2013, In : ChemMedChem. 8, 2, p. 226-230 5 p.

Research output: Contribution to journalArticle

21 Scopus citations

A convenient and efficient synthesis of novel cyclic phospholipid analogues containing thio(seleno) phosphate-phosphonate linkages

Zhou, J. & Chen, R. Y., Jan 1 1998, In : Synthetic Communications. 28, 14, p. 2653-2657 5 p.

Research output: Contribution to journalArticle

6 Scopus citations

A facile synthesis of new 2-phosphonobenzyloxy-1, 3, 2-benzoxaza(dioxa or diaza)phospholes

Zhou, J. & Chen, R., Dec 1998, In : Organic Preparations and Procedures International. 30, 6, p. 716-719 4 p.

Research output: Contribution to journalArticle

1 Scopus citations

Allosteric Modulation of Class A GPCRs: Targets, Agents, and Emerging Concepts

Wold, E. A., Chen, J., Cunningham, K. & Zhou, J., Oct 1 2019, In : Journal of Medicinal Chemistry. 62, 1, p. 88-127 40 p.

Research output: Contribution to journalArticle

14 Scopus citations

Allosteric Modulation of G Protein-Coupled Receptors: An Emerging Approach of Drug Discovery

Wild, C., Cunningham, K. A. & Zhou, J., Feb 13 2014, In : Austin Journal of Pharmacology and Therapeutics. 2, p. 3

Research output: Contribution to journalArticle

AMPA receptor positive allosteric modulators attenuate morphine tolerance and dependence

Hu, X., Tian, X., Guo, X., He, Y., Chen, H., Zhou, J. & Wang, Z. J., Jul 15 2018, In : Neuropharmacology. 137, p. 50-58 9 p.

Research output: Contribution to journalArticle

3 Scopus citations

A new oridonin analog suppresses triple-negative breast cancer cells and tumor growth via the induction of death receptor 5

Wu, J., Ding, Y., Chen, C. H., Zhou, Z., Ding, C., Chen, H., Zhou, J. & Chen, C., Oct 1 2016, In : Cancer Letters. 380, 2, p. 393-402 10 p.

Research output: Contribution to journalArticle

34 Scopus citations

An NPY Y1 receptor antagonist unmasks latent sensitization and reveals the contribution of protein kinase A and Epac to chronic inflammatory pain

Fu, W., Nelson, T. S., Santos, D. F., Doolen, S., Gutierrez, J. J. P., Ye, N., Zhou, J. & K Taylor, B., Aug 1 2019, In : Pain. 160, 8, p. 1754-1765 12 p.

Research output: Contribution to journalArticle

4 Scopus citations

A novel EPAC-specific inhibitor suppresses pancreatic cancer cell migration and invasion

Almahariq, M., Tsalkova, T., Mei, F. C., Chen, H., Zhou, J., Sastry, S. K., Schwede, F. & Cheng, X., Jan 1 2013, In : Molecular pharmacology. 83, 1, p. 122-128 7 p.

Research output: Contribution to journalArticle

129 Scopus citations

Antifibrosis effect of novel oridonin analog CYD0618 via suppression of the NF-κB pathway

Cummins, C. B., Wang, X., Xu, J., Hughes, B. D., Ding, Y., Chen, H., Zhou, J. & Radhakrishnan, R., Dec 1 2018, In : Journal of Surgical Research. 232, p. 283-292 10 p.

Research output: Contribution to journalArticle

5 Scopus citations

Antinociceptive effects of N-acetylaspartylglutamate (NAAG) peptidase inhibitors ZJ-11, ZJ-17 and ZJ-43 in the rat formalin test and in the rat neuropathic pain model

Yamamoto, T., Hirasawa, S., Wroblewska, B., Grajkowska, E., Zhou, J., Kozikowski, A., Wroblewski, J. & Neale, J. H., Jul 1 2004, In : European Journal of Neuroscience. 20, 2, p. 483-494 12 p.

Research output: Contribution to journalArticle

77 Scopus citations

Apigenin inhibits pancreatic stellate cell activity in pancreatitis

Mrazek, A. A., Porro, L. J., Bhatia, V., Falzon, M., Spratt, H., Zhou, J., Chao, C. & Hellmich, M., Jun 1 2015, In : Journal of Surgical Research. 196, 1, p. 8-16 9 p.

Research output: Contribution to journalArticle

22 Scopus citations

Applications of bioorthogonal chemistry in tumor-targeted drug discovery

Liu, G., Wold, E. A. & Zhou, J., Jan 1 2019, In : Current topics in medicinal chemistry. 19, 11, p. 892-897 6 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

A simple, efficient procedure for the synthesis of some amino acid linked ureido phosphoramidate derivatives

Chen, R. Y. & Zhou, J., Dec 1 1996, In : Chinese Chemical Letters. 7, 6, p. 539-542 4 p.

Research output: Contribution to journalArticle

3 Scopus citations

BH4 domain of Bcl-2 as a novel target for cancer therapy

Liu, Z., Wild, C., Ding, Y., Ye, N., Chen, H., Wold, E. A. & Zhou, J., 2015, (Accepted/In press) In : Drug Discovery Today.

Research output: Contribution to journalArticle

20 Scopus citations

Biaryl analogues of conformationally constrained tricyclic tropanes as potent and selective norepinephrine reuptake inhibitors: Synthesis and evaluation of their uptake inhibition at monoamine transporter sites

Zhou, J., Zhang, A., Kläss, T., Johnson, K. M., Wang, C. Z., Ye, Y. P. & Kozikowski, A. P., May 8 2003, In : Journal of Medicinal Chemistry. 46, 10, p. 1997-2007 11 p.

Research output: Contribution to journalArticle

28 Scopus citations

Biochemical and Pharmacological Characterizations of ESI-09 Based EPAC Inhibitors: Defining the ESI-09 "Therapeutic Window"

Zhu, Y., Chen, H., Boulton, S., Mei, F., Ye, N., Melacini, G., Zhou, J. & Cheng, X., Mar 23 2015, In : Scientific reports. 5, 9344.

Research output: Contribution to journalArticle

59 Scopus citations

Crystal Structure of 2-[(P,P-Diphenoxy)phosphono(p-methyl)benzyl]-1, 2-benzisoselenazol-3(2H)-one

Zhou, J., Huang, J. M., Tang, Y. & Chen, R. Y., Dec 1 1999, In : Jiegou Huaxue. 18, 2, p. 103-106 4 p.

Research output: Contribution to journalArticle

2 Scopus citations

Crystal Structure of cis-2-[(P, P-Diethoxy) phosphono(m-nitro)benzyloxy]-4-phenyl-5,5-dimethyl-1,3,2-dioxaphosphorinane 2-sulfide

Zhou, J., Chen, R. Y. & Wang, H. G., Dec 1 1999, In : Jiegou Huaxue. 18, 2, p. 98-102 5 p.

Research output: Contribution to journalArticle

Cystathionine-β-synthase inhibition for colon cancer: Enhancement of the efficacy of aminooxyacetic acid via the prodrug approach

Chao, C., Zatarain, J. R., Ding, Y., Coletta, C., Mrazek, A. A., Druzhyna, N., Johnson, P., Chen, H., Hellmich, J. L., Asimakopoulou, A., Yanagi, K., Olah, G., Szoleczky, P., Törö, G., Bohanon, F. J., Cheema, M., Lewis, R., Eckelbarger, D., Ahmad, A., Modis, K. & 6 others, Untereiner, A., Szczesny, B., Papapetropoulos, A., Zhou, J., Hellmich, M. & Szabo, C., 2016, In : Molecular Medicine. 22, p. 361-379 19 p.

Research output: Contribution to journalArticle

21 Scopus citations
3 Scopus citations

Design, Synthesis, and Characterization of 4-Undecylpiperidine-2-carboxamides as Positive Allosteric Modulators of the Serotonin (5-HT) 5-HT2C Receptor

Wild, C. T., Miszkiel, J. M., Wold, E. A., Soto, C. A., Ding, C., Hartley, R. M., White, M., Anastasio, N., Cunningham, K. & Zhou, J., Oct 1 2019, In : Journal of Medicinal Chemistry. 62, 1, p. 288-305 18 p.

Research output: Contribution to journalArticle

9 Scopus citations

Design, synthesis, and characterization of novel apigenin analogues that suppress pancreatic stellate cell proliferation in vitro and associated pancreatic fibrosis in vivo

Chen, H., Mrazek, A. A., Wang, X., Ding, C., Ding, Y., Porro, L. J., Liu, H., Chao, C., Hellmich, M. R. & Zhou, J., Jul 1 2014, In : Bioorganic and Medicinal Chemistry. 22, 13, p. 3393-3404 12 p.

Research output: Contribution to journalArticle

24 Scopus citations

Design, synthesis and biological evaluation of spiropyrazolopyridone derivatives as potent dengue virus inhibitors

Xu, J., Xie, X., Chen, H., Zou, J., Xue, Y., Ye, N., Shi, P. Y. & Zhou, J., Jun 1 2020, In : Bioorganic and Medicinal Chemistry Letters. 30, 11, 127162.

Research output: Contribution to journalArticle

1 Scopus citations

Development of a concise synthetic approach to access oroxin A

Chen, H., He, G., Li, C., Dong, L., Xie, X., Wu, J., Gao, Y. & Zhou, J., 2014, In : RSC Advances. 4, 85, p. 45151-45154 4 p.

Research output: Contribution to journalArticle

4 Scopus citations

Development of new brain imaging agents based upon nocaine-modafinil hybrid monoamine transporter inhibitors

Musachio, J. L., Hong, J., Ichise, M., Seneca, N., Brown, A. K., Liow, J. S., Halldin, C., Innis, R. B., Pike, V. W., He, R., Zhou, J. & Kozikowski, A. P., Jun 15 2006, In : Bioorganic and Medicinal Chemistry Letters. 16, 12, p. 3101-3104 4 p.

Research output: Contribution to journalArticle

5 Scopus citations

Direct Activation of Bax Protein for Cancer Therapy

Liu, Z., Ding, Y., Ye, N., Wild, C., Chen, H. & Zhou, J., Mar 1 2016, In : Medicinal Research Reviews. 36, 2, p. 313-341 29 p.

Research output: Contribution to journalArticle

57 Scopus citations
2 Scopus citations

Discovery of novel conformationally constrained tropane-based biaryl and arylacetylene ligands as potent and selective norepinephrine transporter inhibitors and potential antidepressants

Zhou, J., Kläß, T., Johnson, K. M., Giberson, K. M. & Kozikowski, A. P., May 16 2005, In : Bioorganic and Medicinal Chemistry Letters. 15, 10, p. 2461-2465 5 p.

Research output: Contribution to journalArticle

4 Scopus citations

Discovery of novel mifepristone derivatives via suppressing KLF5 expression for the treatment of triple-negative breast cancer

Lin, Y., Liu, R., Zhao, P., Ye, J., Zheng, Z., Huang, J., Zhang, Y., Gao, Y., Chen, H., Liu, S., Zhou, J., Chen, C. & Chen, H., Feb 25 2018, In : European Journal of Medicinal Chemistry. 146, p. 354-367 14 p.

Research output: Contribution to journalArticle

6 Scopus citations

Discovery of O-alkylamino-tethered niclosamide derivatives as potent and orally bioavailable anticancer agents

Chen, H., Yang, Z., Ding, C., Chu, L., Zhang, Y., Terry, K., Liu, H., Shen, Q. & Zhou, J., Feb 14 2013, In : ACS Medicinal Chemistry Letters. 4, 2, p. 180-185 6 p.

Research output: Contribution to journalArticle

69 Scopus citations

Discovery of potent and selective BRD4 inhibitors capable of blocking TLR3-induced acute airway inflammation

Liu, Z., Tian, B., Chen, H., Wang, P., Brasier, A. R. & Zhou, J., May 10 2018, In : European Journal of Medicinal Chemistry. 151, p. 450-461 12 p.

Research output: Contribution to journalArticle

14 Scopus citations

Discovery of potent anticancer agent HJC0416, an orally bioavailable small molecule inhibitor of signal transducer and activator of transcription 3 (STAT3)

Chen, H., Yang, Z., Ding, C., Xiong, A., Wild, C., Wang, L., Ye, N., Cai, G., Flores, R. M., Ding, Y., Shen, Q. & Zhou, J., Jul 23 2014, In : European journal of medicinal chemistry. 82, p. 195-203 9 p.

Research output: Contribution to journalArticle

29 Scopus citations

Dual activity of niclosamide to suppress replication of integrated HIV-1 and Mycobacterium tuberculosis (Beijing)

Fan, X. Z., Xu, J., Files, M., Cirillo, J. D., Endsley, J. J., Zhou, J. & Endsley, M. A., May 2019, In : Tuberculosis. 116, p. S28-S33

Research output: Contribution to journalArticle

2 Scopus citations

Effect of N-(2-aminoethyl) ethanolamine on hypertrophic scarring changes in vitro: Finding novel anti-fibrotic therapies

Chen, Z., Gu, J., El Ayadi, A., Oberhauser, A., Zhou, J., Sousse, L., Finnerty, C., Herndon, D. & Boor, P. J., Jan 1 2019, In : Toxicology and Applied Pharmacology. 362, p. 9-19 11 p.

Research output: Contribution to journalArticle

1 Scopus citations

Efficacy of novel highly specific bromodomain-containing protein 4 inhibitors in innate inflammation–driven airway remodeling

Tian, B., Liu, Z., Litvinov, J., Maroto, R., Jamaluddin, M., Rytting, E., Patrikeev, I., Ochoa, L., Vargas, G., Motamedi, M., Ameredes, B., Zhou, J. & Brasier, A. R., Jan 1 2019, In : American Journal of Respiratory Cell and Molecular Biology. 60, 1, p. 68-83 16 p.

Research output: Contribution to journalArticle

7 Scopus citations

Efficient and Highly Regioselective Formation of the C=N Double Bond via Phosphoryl Thiourea Compounds

Zhou, J. & Chen, R. Y., Jan 1 1998, In : Journal of Chemical Research - Part S. 5, p. 254-255 2 p.

Research output: Contribution to journalArticle

4 Scopus citations

Efficient synthesis of ESI-09, a novel non-cyclic nucleotide EPAC antagonist

Chen, H., Ding, C., Wild, C., Liu, H., Wang, T., White, M. A., Cheng, X. & Zhou, J., Mar 20 2013, In : Tetrahedron Letters. 54, 12, p. 1546-1549 4 p.

Research output: Contribution to journalArticle

26 Scopus citations

Enhanced anti-fibrogenic effects of novel oridonin derivative CYD0692 in hepatic stellate cells

Bohanon, F. J., Wang, X., Graham, B. M., Prasai, A., Vasudevan, S. J., Ding, C., Ding, Y., Radhakrishnan, G., Rastellini, C., Zhou, J. & Radhakrishnan, R., Sep 7 2015, In : Molecular and Cellular Biochemistry. 410, 1-2, p. 293-300 8 p.

Research output: Contribution to journalArticle

16 Scopus citations

Enhanced effects of novel oridonin analog CYD0682 for hepatic fibrosis

Bohanon, F. J., Wang, X., Graham, B. M., Ding, C., Ding, Y., Radhakrishnan, G., Rastellini, C., Zhou, J. & Radhakrishnan, R., Dec 1 2015, In : Journal of Surgical Research. 199, 2, p. 441-449 9 p.

Research output: Contribution to journalArticle

19 Scopus citations

Ent-Kaurane-based regio- and stereoselective inverse electron demand hetero-Diels-Alder reactions: Synthesis of dihydropyran-fused diterpenoids

Ding, C., Wang, L., Chen, H., Wild, C., Ye, N., Ding, Y., Wang, T., White, M. A., Shen, Q. & Zhou, J., Nov 14 2014, In : Organic and Biomolecular Chemistry. 12, 42, p. 8442-8452 11 p.

Research output: Contribution to journalArticle

25 Scopus citations

Erythrosin B is a potent and broad-spectrum orthosteric inhibitor of the flavivirus NS2B-NS3 protease

Li, Z., Sakamuru, S., Huang, R., Brecher, M., Koetzner, C. A., Zhang, J., Chen, H., Qin, C. F., Zhang, Q. Y., Zhou, J., Kramer, L. D., Xia, M. & Li, H., Feb 1 2018, In : Antiviral Research. 150, p. 217-225 9 p.

Research output: Contribution to journalArticle

15 Scopus citations

Evolution in medicinal chemistry of ursolic acid derivatives as anticancer agents

Chen, H., Gao, Y., Wang, A., Zhou, X., Zheng, Y. & Zhou, J., Mar 6 2015, In : European Journal of Medicinal Chemistry. 92, p. 648-655 8 p.

Research output: Contribution to journalArticle

72 Scopus citations

Exchange protein directly activated by cAMP modulates ebola virus uptake into vascular endothelial cells

Drelich, A., Judy, B., He, X., Chang, Q., Yu, S., Li, X., Lu, F., Wakamiya, M., Popov, V., Zhou, J., Ksiazek, T. & Gong, B., Oct 16 2018, In : Viruses. 10, 10, 563.

Research output: Contribution to journalArticle

4 Scopus citations

Exchange protein directly activated by cAMP plays a critical role in regulation of vascular fibrinolysis

He, X., Drelich, A., Yu, S., Chang, Q., Gong, D., Zhou, Y., Qu, Y., Yuan, Y., Su, Z., Qiu, Y., Tang, S-J., Gaitas, A., Ksiazek, T., Xu, Z., Zhou, J., Feng, Z., Wakamiya, M., Lu, F. & Gong, B., Mar 15 2019, In : Life Sciences. 221, p. 1-12 12 p.

Research output: Contribution to journalArticle

1 Scopus citations

Exchange Proteins Directly Activated by cAMP and Their Roles in Respiratory Syncytial Virus Infection

Choi, E-J., Ren, Y., Chen, Y., Liu, S., Wu, W., Ren, J., Wang, P., Garofalo, R., Zhou, J. & Bao, X., Nov 15 2018, In : Journal of Virology. 92, 22

Research output: Contribution to journalArticle

Existing drugs as broad-spectrum and potent inhibitors for Zika virus by targeting NS2B-NS3 interaction

Li, Z., Brecher, M., Deng, Y. Q., Zhang, J., Sakamuru, S., Liu, B., Huang, R., Koetzner, C. A., Allen, C. A., Jones, S. A., Chen, H., Zhang, N. N., Tian, M., Gao, F., Lin, Q., Banavali, N., Zhou, J., Boles, N., Xia, M., Kramer, L. D. & 2 others, Qin, C. F. & Li, H., Aug 1 2017, In : Cell Research. 27, 8, p. 1046-1064 19 p.

Research output: Contribution to journalArticle

49 Scopus citations

Exploration of synthetic approaches and pharmacological evaluation of PNU-69176E and its stereoisomer as 5-HT2C receptor allosteric modulators

Ding, C., Bremer, N. M., Smith, T. D., Seitz, P. K., Anastasio, N. C., Cunningham, K. A. & Zhou, J., Jul 18 2012, In : ACS chemical neuroscience. 3, 7, p. 538-545 8 p.

Research output: Contribution to journalArticle

18 Scopus citations