• 3487 Citations
  • 32 h-Index
1994 …2023

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Article
2016

Scaffold repurposing of old drugs towards new cancer drug discovery

Chen, H., Wu, J., Gao, Y., Chen, H. & Zhou, J., Aug 1 2016, In : Current Topics in Medicinal Chemistry. 16, 19, p. 2107-2114 8 p.

Research output: Contribution to journalArticle

12 Scopus citations

STAT3 inhibition suppresses hepatic stellate cell fibrogenesis: HJC0123, a potential therapeutic agent for liver fibrosis

Lopez, O. N., Bohanon, F. J., Wang, X., Ye, N., Gorgun, T., Rojas-Khalil, Y., Chen, H., Chen, H., Zhou, J. & Radhakrishnan, R., 2016, In : RSC Advances. 6, 102, p. 100652-100663 12 p.

Research output: Contribution to journalArticle

9 Scopus citations

Suppression of Cocaine-Evoked Hyperactivity by Self-Adjuvanting and Multivalent Peptide Nanofiber Vaccines

Rudra, J. S., Ding, Y., Neelakantan, H., Ding, C., Appavu, R., Stutz, S., Snook, J. D., Chen, H., Cunningham, K. A. & Zhou, J., May 18 2016, In : ACS Chemical Neuroscience. 7, 5, p. 546-552 7 p.

Research output: Contribution to journalArticle

20 Scopus citations

Targeting XBP1-mediated β-catenin expression associated with bladder cancer with newly synthetic Oridonin analogues

Chen, W., Zhou, J., Wu, K., Huang, J., Ding, Y., Yun, E. J., Wang, B., Ding, C., Hernandez, E., Santoyo, J., Chen, H., Lin, H., Sagalowsky, A., He, D., Zhou, J. & Hsieh, J. T., Jan 1 2016, In : Oncotarget. 7, 35, p. 56842-56854 13 p.

Research output: Contribution to journalArticle

15 Scopus citations
2015

Apigenin inhibits pancreatic stellate cell activity in pancreatitis

Mrazek, A. A., Porro, L. J., Bhatia, V., Falzon, M., Spratt, H., Zhou, J., Chao, C. & Hellmich, M., Jun 1 2015, In : Journal of Surgical Research. 196, 1, p. 8-16 9 p.

Research output: Contribution to journalArticle

22 Scopus citations

BH4 domain of Bcl-2 as a novel target for cancer therapy

Liu, Z., Wild, C., Ding, Y., Ye, N., Chen, H., Wold, E. A. & Zhou, J., 2015, (Accepted/In press) In : Drug Discovery Today.

Research output: Contribution to journalArticle

20 Scopus citations

Biochemical and Pharmacological Characterizations of ESI-09 Based EPAC Inhibitors: Defining the ESI-09 "Therapeutic Window"

Zhu, Y., Chen, H., Boulton, S., Mei, F., Ye, N., Melacini, G., Zhou, J. & Cheng, X., Mar 23 2015, In : Scientific reports. 5, 9344.

Research output: Contribution to journalArticle

59 Scopus citations

Enhanced anti-fibrogenic effects of novel oridonin derivative CYD0692 in hepatic stellate cells

Bohanon, F. J., Wang, X., Graham, B. M., Prasai, A., Vasudevan, S. J., Ding, C., Ding, Y., Radhakrishnan, G., Rastellini, C., Zhou, J. & Radhakrishnan, R., Sep 7 2015, In : Molecular and Cellular Biochemistry. 410, 1-2, p. 293-300 8 p.

Research output: Contribution to journalArticle

16 Scopus citations

Enhanced effects of novel oridonin analog CYD0682 for hepatic fibrosis

Bohanon, F. J., Wang, X., Graham, B. M., Ding, C., Ding, Y., Radhakrishnan, G., Rastellini, C., Zhou, J. & Radhakrishnan, R., Dec 1 2015, In : Journal of Surgical Research. 199, 2, p. 441-449 9 p.

Research output: Contribution to journalArticle

19 Scopus citations

Evolution in medicinal chemistry of ursolic acid derivatives as anticancer agents

Chen, H., Gao, Y., Wang, A., Zhou, X., Zheng, Y. & Zhou, J., Mar 6 2015, In : European Journal of Medicinal Chemistry. 92, p. 648-655 8 p.

Research output: Contribution to journalArticle

72 Scopus citations

Medicinal chemistry in oncology: New approaches and future trends

Zhou, J., 2015, In : Current Topics in Medicinal Chemistry. 15, 8, p. 698 1 p.

Research output: Contribution to journalArticle

P-selectin-mediated platelet adhesion promotes tumor growth

Qi, C., Wei, B., Zhou, W., Yang, Y., Li, B., Guo, S., Li, J., Ye, J., Li, J., Zhang, Q., Lan, T., He, X., Cao, L., Zhou, J., Geng, J. & Wang, L., Jan 1 2015, In : Oncotarget. 6, 9, p. 6584-6596 13 p.

Research output: Contribution to journalArticle

Open Access
25 Scopus citations

Small-Molecule Bcl2 BH4 Antagonist for Lung Cancer Therapy

Han, B., Park, D., Li, R., Xie, M., Owonikoko, T. K., Zhang, G., Sica, G. L., Ding, C., Zhou, J., Magis, A. T., Chen, Z. G., Shin, D. M., Ramalingam, S. S., Khuri, F. R., Curran, W. J. & Deng, X., Jun 8 2015, In : Cancer Cell. 27, 6, p. 852-863 12 p.

Research output: Contribution to journalArticle

69 Scopus citations

Structure-Activity Relationship Studies of Substituted 2-(Isoxazol-3-yl)-2-oxo-N′-phenyl-acetohydrazonoyl Cyanide Analogues: Identification of Potent Exchange Proteins Directly Activated by cAMP (EPAC) Antagonists

Ye, N., Zhu, Y., Chen, H., Liu, Z., Mei, F. C., Wild, C., Chen, H., Cheng, X. & Zhou, J., Jul 17 2015, In : Journal of Medicinal Chemistry. 58, 15, p. 6033-6047 15 p.

Research output: Contribution to journalArticle

21 Scopus citations

Targeting Krüppel-like factor 5 (KLF5) for cancer therapy

Gao, Y., Ding, Y., Chen, H., Chen, H. & Zhou, J., 2015, In : Current Topics in Medicinal Chemistry. 15, 8, p. 699-713 15 p.

Research output: Contribution to journalArticle

26 Scopus citations
2014

Allosteric Modulation of G Protein-Coupled Receptors: An Emerging Approach of Drug Discovery

Wild, C., Cunningham, K. A. & Zhou, J., Feb 13 2014, In : Austin Journal of Pharmacology and Therapeutics. 2, p. 3

Research output: Contribution to journalArticle

Design, synthesis, and characterization of novel apigenin analogues that suppress pancreatic stellate cell proliferation in vitro and associated pancreatic fibrosis in vivo

Chen, H., Mrazek, A. A., Wang, X., Ding, C., Ding, Y., Porro, L. J., Liu, H., Chao, C., Hellmich, M. R. & Zhou, J., Jul 1 2014, In : Bioorganic and Medicinal Chemistry. 22, 13, p. 3393-3404 12 p.

Research output: Contribution to journalArticle

24 Scopus citations

Development of a concise synthetic approach to access oroxin A

Chen, H., He, G., Li, C., Dong, L., Xie, X., Wu, J., Gao, Y. & Zhou, J., 2014, In : RSC Advances. 4, 85, p. 45151-45154 4 p.

Research output: Contribution to journalArticle

4 Scopus citations

Discovery of potent anticancer agent HJC0416, an orally bioavailable small molecule inhibitor of signal transducer and activator of transcription 3 (STAT3)

Chen, H., Yang, Z., Ding, C., Xiong, A., Wild, C., Wang, L., Ye, N., Cai, G., Flores, R. M., Ding, Y., Shen, Q. & Zhou, J., Jul 23 2014, In : European journal of medicinal chemistry. 82, p. 195-203 9 p.

Research output: Contribution to journalArticle

29 Scopus citations

Ent-Kaurane-based regio- and stereoselective inverse electron demand hetero-Diels-Alder reactions: Synthesis of dihydropyran-fused diterpenoids

Ding, C., Wang, L., Chen, H., Wild, C., Ye, N., Ding, Y., Wang, T., White, M. A., Shen, Q. & Zhou, J., Nov 14 2014, In : Organic and Biomolecular Chemistry. 12, 42, p. 8442-8452 11 p.

Research output: Contribution to journalArticle

25 Scopus citations

Glipizide, an antidiabetic drug, suppresses tumor growth and metastasis by inhibiting angiogenesis

Qi, C., Zhou, Q., Li, B., Yang, Y., Cao, L., Ye, Y., Li, J., Ding, Y., Wang, H., Wang, J., He, X., Zhang, Q., Lan, T., Lee, K. K. H., Li, W., Song, X., Zhou, J., Yang, X. & Wang, L., Jan 1 2014, In : Oncotarget. 5, 20, p. 9966-9979 14 p.

Research output: Contribution to journalArticle

Open Access
25 Scopus citations

KRAS – An Evolving Cancer Target

Ye, N. & Zhou, J., Jan 12 2014, In : Austin Journal of Cancer and Clinical Research. 1, p. 3

Research output: Contribution to journalArticle

Oridonin inhibits hepatic stellate cell proliferation and fibrogenesis

Bohanon, F. J., Wang, X., Ding, C., Ding, Y., Radhakrishnan, G. L., Rastellini, C., Zhou, J. & Radhakrishnan, R. S., Jul 2014, In : Journal of Surgical Research. 190, 1, p. 55-63 9 p.

Research output: Contribution to journalArticle

42 Scopus citations

Small-molecule Bax agonists for cancer therapy

Xin, M., Li, R., Xie, M., Park, D., Owonikoko, T. K., Sica, G. L., Corsino, P. E., Zhou, J., Ding, C., White, M. A., Magis, A. T., Ramalingam, S. S., Curran, W. J., Khuri, F. R. & Deng, X., Jan 1 2014, In : Nature communications. 5, 4935.

Research output: Contribution to journalArticle

Open Access
72 Scopus citations

STAT3 modulation to enhance motor neuron differentiation in human neural stem cells

Natarajan, R., Singal, V., Benes, R., Gao, J., Chan, H., Chen, H., Yu, Y., Zhou, J. & Wu, P., Jun 19 2014, In : PloS one. 9, 6, e100405.

Research output: Contribution to journalArticle

11 Scopus citations
2013

A Combined Bioinformatics and Chemoinformatics Approach for Developing Asymmetric Bivalent AMPA Receptor Positive Allosteric Modulators as Neuroprotective Agents

Chen, H., Wang, C. Z., Ding, C., Wild, C., Copits, B., Swanson, G. T., Johnson, K. M. & Zhou, J., Feb 1 2013, In : ChemMedChem. 8, 2, p. 226-230 5 p.

Research output: Contribution to journalArticle

21 Scopus citations

A novel EPAC-specific inhibitor suppresses pancreatic cancer cell migration and invasion

Almahariq, M., Tsalkova, T., Mei, F. C., Chen, H., Zhou, J., Sastry, S. K., Schwede, F. & Cheng, X., Jan 1 2013, In : Molecular pharmacology. 83, 1, p. 122-128 7 p.

Research output: Contribution to journalArticle

129 Scopus citations

Discovery of O-alkylamino-tethered niclosamide derivatives as potent and orally bioavailable anticancer agents

Chen, H., Yang, Z., Ding, C., Chu, L., Zhang, Y., Terry, K., Liu, H., Shen, Q. & Zhou, J., Feb 14 2013, In : ACS Medicinal Chemistry Letters. 4, 2, p. 180-185 6 p.

Research output: Contribution to journalArticle

69 Scopus citations

Efficient synthesis of ESI-09, a novel non-cyclic nucleotide EPAC antagonist

Chen, H., Ding, C., Wild, C., Liu, H., Wang, T., White, M. A., Cheng, X. & Zhou, J., Mar 20 2013, In : Tetrahedron Letters. 54, 12, p. 1546-1549 4 p.

Research output: Contribution to journalArticle

26 Scopus citations

Fragment-based drug design and identification of HJC0123, a novel orally bioavailable STAT3 inhibitor for cancer therapy

Chen, H., Yang, Z., Ding, C., Chu, L., Zhang, Y., Terry, K., Liu, H., Shen, Q. & Zhou, J., Apr 1 2013, In : European journal of medicinal chemistry. 62, p. 498-507 10 p.

Research output: Contribution to journalArticle

55 Scopus citations

Identification and characterization of small molecules as potent and specific EPAC2 antagonists

Chen, H., Tsalkova, T., Chepurny, O. G., Mei, F. C., Holz, G. G., Cheng, X. & Zhou, J., Feb 14 2013, In : Journal of Medicinal Chemistry. 56, 3, p. 952-962 11 p.

Research output: Contribution to journalArticle

40 Scopus citations

NAAG peptidase inhibitor improves motor function and reduces cognitive dysfunction in a model of TBI with secondary hypoxia

Gurkoff, G. G., Feng, J. F., Van, K. C., Izadi, A., Ghiasvand, R., Shahlaie, K., Song, M., Lowe, D. A., Zhou, J. & Lyeth, B. G., Jun 17 2013, In : Brain Research. 1515, p. 98-107 10 p.

Research output: Contribution to journalArticle

16 Scopus citations

Novel nitrogen-enriched oridonin analogues with thiazole-fused a-ring: Protecting group-free synthesis, enhanced anticancer profile, and improved aqueous solubility

Ding, C., Zhang, Y., Chen, H., Yang, Z., Wild, C., Chu, L., Liu, H., Shen, Q. & Zhou, J., Jun 27 2013, In : Journal of Medicinal Chemistry. 56, 12, p. 5048-5058 11 p.

Research output: Contribution to journalArticle

69 Scopus citations

Oridonin ring A-based diverse constructions of enone functionality: Identification of novel dienone analogues effective for highly aggressive breast cancer by inducing apoptosis

Ding, C., Zhang, Y., Chen, H., Yang, Z., Wild, C., Ye, N., Ester, C. D., Xiong, A., White, M. A., Shen, Q. & Zhou, J., Nov 14 2013, In : Journal of Medicinal Chemistry. 56, 21, p. 8814-8825 12 p.

Research output: Contribution to journalArticle

49 Scopus citations

Overcoming synthetic challenges of oridonin a-ring structural diversification: Regio- and stereoselective installation of azides and 1,2,3-triazoles at the c-1, c-2, or c-3 position

Ding, C., Zhang, Y., Chen, H., Wild, C., Wang, T., White, M. A., Shen, Q. & Zhou, J., Jul 19 2013, In : Organic Letters. 15, 14, p. 3718-3721 4 p.

Research output: Contribution to journalArticle

37 Scopus citations
2012

5-Cyano-6-oxo-1,6-dihydro-pyrimidines as potent antagonists targeting exchange proteins directly activated by cAMP

Chen, H., Tsalkova, T., Mei, F. C., Hu, Y., Cheng, X. & Zhou, J., Jun 15 2012, In : Bioorganic and Medicinal Chemistry Letters. 22, 12, p. 4038-4043 6 p.

Research output: Contribution to journalArticle

37 Scopus citations

Exploration of synthetic approaches and pharmacological evaluation of PNU-69176E and its stereoisomer as 5-HT2C receptor allosteric modulators

Ding, C., Bremer, N. M., Smith, T. D., Seitz, P. K., Anastasio, N. C., Cunningham, K. A. & Zhou, J., Jul 18 2012, In : ACS chemical neuroscience. 3, 7, p. 538-545 8 p.

Research output: Contribution to journalArticle

18 Scopus citations

NAAG peptidase inhibitor reduces cellular damage in a model of TBI with secondary hypoxia

Feng, J. F., Gurkoff, G. G., Van, K. C., Song, M., Lowe, D. A., Zhou, J. & Lyeth, B. G., Aug 21 2012, In : Brain Research. 1469, p. 144-152 9 p.

Research output: Contribution to journalArticle

22 Scopus citations
2011

Post-injury administration of NAAG peptidase inhibitor prodrug, PGI-02776, in experimental TBI

Feng, J. F., Van, K. C., Gurkoff, G. G., Kopriva, C., Olszewski, R. T., Song, M., Sun, S., Xu, M., Neale, J. H., Yuen, P. W., Lowe, D. A., Zhou, J. & Lyeth, B. G., Jun 13 2011, In : Brain Research. 1395, p. 62-73 12 p.

Research output: Contribution to journalArticle

21 Scopus citations
2010

The novel triple reuptake inhibitor JZAD-IV-22 exhibits an antidepressant pharmacological profile without locomotor stimulant or sensitization properties

Caldarone, B. J., Paterson, N. E., Zhou, J., Brunner, D., Kozikowski, A. P., Westphal, K. G. C., Korte-Bouws, G. A. H., Prins, J., Korte, S. M., Olivier, B. & Ghavami, A., Dec 1 2010, In : Journal of Pharmacology and Experimental Therapeutics. 335, 3, p. 762-770 9 p.

Research output: Contribution to journalArticle

19 Scopus citations
2008

HDAC inhibitor increases histone H3 acetylation and reduces microglia inflammatory response following traumatic brain injury in rats

Zhang, B., West, E. J., Van, K. C., Gurkoff, G. G., Zhou, J., Zhang, X. M., Kozikowski, A. P. & Lyeth, B. G., Aug 21 2008, In : Brain Research. 1226, p. 181-191 11 p.

Research output: Contribution to journalArticle

93 Scopus citations

Inhibition of protein deacetylation by trichostatin A impairs microtubule-kinetochore attachment

Ma, Y., Cai, S., Lu, Q., Lu, X., Jiang, Q., Zhou, J. & Zhang, C., Oct 1 2008, In : Cellular and Molecular Life Sciences. 65, 19, p. 3100-3109 10 p.

Research output: Contribution to journalArticle

16 Scopus citations

Intracerebroventricular administration of N-acetylaspartylglutamate (NAAG) peptidase inhibitors is analgesic in inflammatory pain

Yamamoto, T., Kozikowski, A., Zhou, J. & Neale, J. H., Aug 1 2008, In : Molecular pain. 4, 31.

Research output: Contribution to journalArticle

24 Scopus citations

Phencyclidine and Dizocilpine Induced Behaviors Reduced by N-acetylaspartylglutamate Peptidase Inhibition via Metabotropic Glutamate Receptors

Olszewski, R. T., Wegorzewska, M. M., Monteiro, A. C., Krolikowski, K. A., Zhou, J., Kozikowski, A. P., Long, K., Mastropaolo, J., Deutsch, S. I. & Neale, J. H., Jan 1 2008, In : Biological Psychiatry. 63, 1, p. 86-91 6 p.

Research output: Contribution to journalArticle

51 Scopus citations
2007

Local administration of N-acetylaspartylglutamate (NAAG) peptidase inhibitors is analgesic in peripheral pain in rats

Yamamoto, T., Saito, O., Aoe, T., Bartolozzi, A., Sarva, J., Zhou, J., Kozikowski, A., Wroblewska, B., Bzdega, T. & Neale, J. H., Jan 1 2007, In : European Journal of Neuroscience. 25, 1, p. 147-158 12 p.

Research output: Contribution to journalArticle

41 Scopus citations

Positional assignment of differentially substituted bisaminoacylated pdCpAs

Maloney, D. J., Ghanem, N., Zhou, J. & Hecht, S. M., Sep 25 2007, In : Organic and Biomolecular Chemistry. 5, 19, p. 3135-3138 4 p.

Research output: Contribution to journalArticle

4 Scopus citations
2006

Development of new brain imaging agents based upon nocaine-modafinil hybrid monoamine transporter inhibitors

Musachio, J. L., Hong, J., Ichise, M., Seneca, N., Brown, A. K., Liow, J. S., Halldin, C., Innis, R. B., Pike, V. W., He, R., Zhou, J. & Kozikowski, A. P., Jun 15 2006, In : Bioorganic and Medicinal Chemistry Letters. 16, 12, p. 3101-3104 4 p.

Research output: Contribution to journalArticle

5 Scopus citations

NAAG peptidase inhibitor increases dialysate NAAG and reduces glutamate, aspartate and GABA levels in the dorsal hippocampus following fluid percussion injury in the rat

Zhong, C., Zhao, X., Van, K. C., Bzdega, T., Smyth, A., Zhou, J., Kozikowski, A. P., Jiang, J., O'Connor, W. T., Berman, R. F., Neale, J. H. & Lyeth, B. G., May 1 2006, In : Journal of neurochemistry. 97, 4, p. 1015-1025 11 p.

Research output: Contribution to journalArticle

70 Scopus citations

Role of the increased noradrenergic neurotransmission in drug self-administration

Wee, S., Wang, Z., He, R., Zhou, J., Kozikowski, A. P. & Woolverton, W. L., Apr 28 2006, In : Drug and Alcohol Dependence. 82, 2, p. 151-157 7 p.

Research output: Contribution to journalArticle

19 Scopus citations

Tandemly activated tRNAs as participants in protein synthesis

Wang, B., Zhou, J., Lodder, M., Anderson, R. D. & Hecht, S. M., May 19 2006, In : Journal of Biological Chemistry. 281, 20, p. 13865-13868 4 p.

Research output: Contribution to journalArticle

13 Scopus citations