Jian Sha, MD, MS

  • 2596 Citations
  • 28 h-Index
20012020

Research output per year

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Research Output

  • 2596 Citations
  • 28 h-Index
  • 73 Article
  • 2 Review article
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Article
2020

New host-directed therapeutics for the treatment of Clostridioides difficile infection

Andersson, J. A., Peniche, A. G., Galindo, C. L., Boonma, P., Sha, J., Luna, R. A., Savidge, T. C., Chopra, A. K. & Dann, S. M., Mar 1 2020, In : mBio. 11, 2, e00053-20.

Research output: Contribution to journalArticle

Open Access
2019

A prokaryotic-eukaryotic hybrid viral vector for delivery of large cargos of genes and proteins into human cells

Zhu, J., Tao, P., Mahalingam, M., Sha, J., Kilgore, P., Chopra, A. K. & Rao, V., Aug 21 2019, In : Science Advances. 5, 8, eaax0064.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

T6SS and ExoA of flesh-eating Aeromonas hydrophila in peritonitis and necrotizing fasciitis during mono- And polymicrobial infections

Fernández-Bravo, A., Kilgore, P. B., Andersson, J. A., Blears, E., Figueras, M. J., Hasan, N. A., Colwell, R. R., Sha, J. & Chopra, A. K., Nov 26 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 48, p. 24084-24092 9 p.

Research output: Contribution to journalArticle

1 Scopus citations
2018

A bacteriophage T4 nanoparticle-based dual vaccine against anthrax and plague

Tao, P., Mahalingam, M., Zhu, J., Moayeri, M., Sha, J., Lawrence, W., Leppla, S. H., Chopra, A. & Rao, V. B., Sep 1 2018, In : mBio. 9, 5, e01926-18.

Research output: Contribution to journalArticle

10 Scopus citations

Combating multidrug-resistant pathogens with host-directed nonantibiotic therapeutics

Andersson, J. A., Sha, J., Kirtley, M. L., Reyes, E., Fitts, E. C., Dann-Grice, S. & Chopra, A., Jan 1 2018, In : Antimicrobial Agents and Chemotherapy. 62, 1, e01943.

Research output: Contribution to journalArticle

6 Scopus citations
2017

Identification of new virulence factors and vaccine candidates for Yersinia pestis

Andersson, J. A., Sha, J., Erova, T. E., Fitts, E. C., Ponnusamy, D., Kozlova, E. V., Kirtley, M. L. & Chopra, A., Oct 17 2017, In : Frontiers in cellular and infection microbiology. 7, OCT, 448.

Research output: Contribution to journalArticle

10 Scopus citations
2016

A Replication-Defective human type 5 adenovirus-based trivalent vaccine confers complete protection against plague in mice and nonhuman primates

Sha, J., Kirtley, M. L., Klages, C., Erova, T. E., Telepnev, M., Ponnusamy, D., Fitts, E. C., Baze, W. B., Sivasubramani, S. K., Lawrence, W., Patrikeev, I., Peel, J. E., Andersson, J. A., Kozlova, E. V., Tiner, B. L., Peterson, J., Mcwilliams, D., Patel, S., Rothe, E., Motin, V. & 1 others, Chopra, A., Jul 1 2016, In : Clinical and Vaccine Immunology. 23, 7, p. 586-600 15 p.

Research output: Contribution to journalArticle

10 Scopus citations

Cross-talk among flesh-eating Aeromonas hydrophila strains in mixed infection leading to necrotizing fasciitis

Ponnusamy, D., Kozlova, E. V., Sha, J., Erova, T. E., Azar, S. R., Fitts, E. C., Kirtley, M. L., Tiner, B. L., Andersson, J. A., Grim, C. J., Isom, R. P., Hasan, N. A., Colwell, R. R. & Chopra, A. K., Jan 19 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 3, p. 722-727 6 p.

Research output: Contribution to journalArticle

27 Scopus citations
4 Scopus citations

New insights into autoinducer-2 signaling as a virulence regulator in a mouse model of pneumonic plague

Fitts, E. C., Andersson, J. A., Kirtley, M. L., Sha, J., Erova, T. E., Chauhan, S., Motin, V. & Chopra, A., Nov 1 2016, In : mSphere. 1, 6, e00342-16.

Research output: Contribution to journalArticle

5 Scopus citations

New role for FDA-approved drugs in combating antibiotic-resistant bacteria

Andersson, J. A., Fitts, E. C., Kirtley, M. L., Ponnusamy, D., Peniche-Trujillo, A-G., Dann-Grice, S., Motin, V., Chauhan, S., Rosenzweig, J. A., Sha, J. & Chopra, A., Jun 1 2016, In : Antimicrobial Agents and Chemotherapy. 60, 6, p. 3717-3729 13 p.

Research output: Contribution to journalArticle

17 Scopus citations

Protective immunity elicited by oral immunization of mice with Salmonella enterica serovar typhimurium braun lipoprotein (Lpp) and acetyltransferase (MsbB) mutants

Erova, T. E., Kirtley, M. L., Fitts, E. C., Ponnusamy, D., Baze, W. B., Andersson, J. A., Cong, Y., Tiner, B. L., Sha, J. & Chopra, A., Nov 10 2016, In : Frontiers in cellular and infection microbiology. 6, NOV, 148.

Research output: Contribution to journalArticle

8 Scopus citations
2015

Combinational deletion of three membrane protein-encoding genes highly attenuates Yersinia pestis while retaining immunogenicity in a mouse model of pneumonic plague

Tiner, B. L., Sha, J., Kirtley, M. L., Erova, T. E., Popov, V. L., Baze, W. B., van Lier, C. J., Ponnusamy, D., Andersson, J. A., Motin, V. L., Chauhan, S. & Chopra, A. K., Jan 1 2015, In : Infection and immunity. 83, 4, p. 1318-1338 21 p.

Research output: Contribution to journalArticle

12 Scopus citations
5 Scopus citations

High-throughput, signature-tagged mutagenic approach to identify novel virulence factors of Yersinia pestis CO92 in a mouse model of infection

Ponnusamy, D., Fitts, E. C., Sha, J., Erova, T. E., Kozlova, E. V., Kirtley, M. L., Tiner, B. L., Andersson, J. A. & Chopra, A. K., Jan 1 2015, In : Infection and immunity. 83, 5, p. 2065-2081 17 p.

Research output: Contribution to journalArticle

10 Scopus citations

Intramuscular immunization of mice with a live-Attenuated triple mutant of yersinia pestis co92 induces robust humoral and cell-mediated immunity to completely protect animals against pneumonic plague

Tiner, B. L., Sha, J., Ponnusamy, D., Baze, W. B., Fitts, E. C., Popov, V., Van Lier, C. J., Erova, T. E. & Chopra, A., Dec 1 2015, In : Clinical and Vaccine Immunology. 22, 12, p. 1255-1268 14 p.

Research output: Contribution to journalArticle

7 Scopus citations
2014

Deletion of braun lipoprotein and plasminogen-activating protease-encoding genes attenuates Yersinia pestis in mouse models of bubonic and pneumonic plague

Van Lier, C. J., Sha, J., Kirtley, M. L., Cao, A., Tiner, B. L., Erova, T. E., Cong, Y., Kozlova, E. V., Popov, V. L., Baze, W. B. & Chopra, A. K., 2014, In : Infection and immunity. 82, 6, p. 2485-2503 19 p.

Research output: Contribution to journalArticle

19 Scopus citations

Functional genomic characterization of virulence factors from necrotizing fasciitis-causing strains of Aeromonas hydrophila

Grim, C. J., Kozlova, E. V., Ponnusamy, D., Fitts, E. C., Sha, J., Kirtley, M. L., van Lier, C. J., Tiner, B. L., Erova, T. E., Joseph, S. J., Read, T. D., Shak, J. R., Joseph, S. W., Singletary, E., Felland, T., Baze, W. B., Horneman, A. J. & Chopra, A. K., 2014, In : Applied and Environmental Microbiology. 80, 14, p. 4162-4183 22 p.

Research output: Contribution to journalArticle

29 Scopus citations
2013

A non-invasive in vivo imaging system to study dissemination of bioluminescent Yersinia pestis CO92 in a mouse model of pneumonic plague

Sha, J., Rosenzweig, J. A., Kirtley, M. L., van Lier, C. J., Fitts, E. C., Kozlova, E. V., Erova, T. E., Tiner, B. L. & Chopra, A. K., Feb 1 2013, In : Microbial Pathogenesis. 55, 1, p. 39-50 12 p.

Research output: Contribution to journalArticle

23 Scopus citations

Characterization of Aeromonas hydrophila wound pathotypes by comparative genomic and functional analyses of virulence genes

Grim, C. J., Kozlov, E. V., Sha, J., Fitts, E. C., van Lier, C. J., Kirtley, M. L., Joseph, S. J., Read, T. D., Burd, E. M., Tall, B. D., Joseph, S. W., Horneman, A. J., Chopra, A. K. & Shak, J. R., Mar 1 2013, In : mBio. 4, 2, e00064-13.

Research output: Contribution to journalArticle

38 Scopus citations

Deletion of the braun lipoprotein-encoding gene and altering the function of lipopolysaccharide attenuate the plague bacterium

Sha, J., Kirtley, M. L., van Lier, C. J., Wang, S., Erova, T. E., Kozlova, E. V., Cao, A., Cong, Y., Fitts, E. C., Rosenzweig, J. A. & Chopra, A. K., Mar 1 2013, In : Infection and immunity. 81, 3, p. 815-828 14 p.

Research output: Contribution to journalArticle

20 Scopus citations

Evaluation of protective potential of Yersinia pestis outer membrane protein antigens as possible candidates for a new-generation recombinant plague vaccine

Erova, T. E., Rosenzweig, J. A., Sha, J., Suarez, G., Sierra, J. C., Kirtley, M. L., Van Lier, C. J., Telepnev, M. V., Motin, V. L. & Chopra, A. K., Feb 1 2013, In : Clinical and Vaccine Immunology. 20, 2, p. 227-238 12 p.

Research output: Contribution to journalArticle

17 Scopus citations

Evaluation of the roles played by Hcp and VgrG type 6 secretion system effectors in aeromonas hydrophila SSU pathogenesis

Sha, J., Rosenzweig, J. A., Kozlova, E. V., Wang, S., Erova, T. E., Kirtley, M. L., van Lier, C. J. & Chopra, A. K., Jun 1 2013, In : Microbiology (United Kingdom). 159, PART 6, p. 1120-1135 16 p.

Research output: Contribution to journalArticle

24 Scopus citations

Mutated and Bacteriophage T4 Nanoparticle Arrayed F1-V Immunogens from Yersinia pestis as Next Generation Plague Vaccines

Tao, P., Mahalingam, M., Kirtley, M. L., van Lier, C. J., Sha, J., Yeager, L. A., Chopra, A. K. & Rao, V. B., Jul 1 2013, In : PLoS pathogens. 9, 7, e1003495.

Research output: Contribution to journalArticle

28 Scopus citations

The effects of modeled microgravity on growth kinetics, antibiotic susceptibility, cold growth, and the virulence potential of a yersinia pestis ymoa-deficient mutant and its isogenic parental strain

Lawal, A., Kirtley, M. L., Van Lier, C. J., Erova, T. E., Kozlova, E. V., Sha, J., Chopra, A. K. & Rosenzweig, J. A., Sep 1 2013, In : Astrobiology. 13, 9, p. 821-832 12 p.

Research output: Contribution to journalArticle

10 Scopus citations
2012

Actin cross-linking domain of Aeromonas hydrophila repeat in toxin A (RtxA) induces host cell rounding and apoptosis

Suarez, G., Khajanchi, B. K., Sierra, J. C., Erova, T. E., Sha, J. & Chopra, A. K., Sep 15 2012, In : Gene. 506, 2, p. 369-376 8 p.

Research output: Contribution to journalArticle

20 Scopus citations
10 Scopus citations

The two-component QseBC signalling system regulates in vitro and in vivo virulence of Aeromonas hydrophila

Khajanchi, B. K., Kozlova, E. V., Sha, J., Popov, V. L. & Chopra, A. K., Jan 1 2012, In : Microbiology. 158, 1, p. 259-271 13 p.

Research output: Contribution to journalArticle

40 Scopus citations
2011

Cethromycin-mediated protection against the plague pathogen Yersinia pestis in a rat model of infection and comparison with levofloxacin

Rosenzweig, J. A., Brackman, S. M., Kirtley, M. L., Sha, J., Erova, T. E., Yeager, L. A., Peterson, J. W., Xu, Z. Q. & Chopra, A. K., Nov 1 2011, In : Antimicrobial Agents and Chemotherapy. 55, 11, p. 5034-5042 9 p.

Research output: Contribution to journalArticle

14 Scopus citations
24 Scopus citations

Quorum sensing and c-di-GMP-dependent alterations in gene transcripts and virulence-associated phenotypes in a clinical isolate of Aeromonas hydrophila

Kozlova, E. V., Khajanchi, B. K., Sha, J. & Chopra, A. K., May 1 2011, In : Microbial Pathogenesis. 50, 5, p. 213-223 11 p.

Research output: Contribution to journalArticle

23 Scopus citations
2010

A type VI secretion system effector protein, VgrG1, from Aeromonas hydrophila that induces host cell toxicity by ADP ribosylation of actin

Suarez, G., Sierra, J. C., Erova, T. E., Sha, J., Horneman, A. J. & Chopra, A. K., Jan 1 2010, In : Journal of bacteriology. 192, 1, p. 155-168 14 p.

Research output: Contribution to journalArticle

129 Scopus citations

Comparative global gene expression profiles of wild-type yersinia pestis CO92 and its braun lipoprotein mutant at flea and human body temperatures

Galindo, C. L., Sha, J., Moen, S. T., Agar, S. L., Kirtley, M. L., Foltz, S. M., McIver, L. J., Kozlova, E. V., Garner, H. R. & Chopra, A. K., Jun 18 2010, In : Comparative and Functional Genomics. 2010, 342168.

Research output: Contribution to journalArticle

12 Scopus citations
11 Scopus citations

Distribution of virulence factors and molecular fingerprinting of Aeromonas species isolates from water and clinical samples: Suggestive evidence of water-to-human transmission

Khajanchi, B. K., Fadl, A. A., Borchardt, M. A., Berg, R. L., Horneman, A. J., Stemper, M. E., Joseph, S. W., Moyer, N. P., Sha, J. & Chopra, A. K., Apr 1 2010, In : Applied and Environmental Microbiology. 76, 7, p. 2313-2325 13 p.

Research output: Contribution to journalArticle

95 Scopus citations

Unraveling the mechanism of action of a new type III secretion system effector AexU from Aeromonas hydrophila

Sierra, J. C., Suarez, G., Sha, J., Baze, W. B., Foltz, S. M. & Chopra, A. K., Sep 2010, In : Microbial Pathogenesis. 49, 3, p. 122-134 13 p.

Research output: Contribution to journalArticle

23 Scopus citations
2009

Characterization of the rat pneumonic plague model: infection kinetics following aerosolization of Yersinia pestis CO92

Agar, S. L., Sha, J., Foltz, S. M., Erova, T. E., Walberg, K. G., Baze, W. B., Suarez, G., Peterson, J. W. & Chopra, A. K., Feb 1 2009, In : Microbes and Infection. 11, 2, p. 205-214 10 p.

Research output: Contribution to journalArticle

39 Scopus citations

Comparative analyses of transcriptional profiles in mouse organs using a pneumonic plague model after infection with wild-type Yersinia pestis CO92 and its Braun lipoprotein mutant

Chopra, A. K., Galindo, C. L., Moen, S. T., Kozlova, E. V., Sha, J., Garner, H. R. & Agar, S. L., Dec 1 2009, In : Comparative and Functional Genomics. 2009, 914762.

Research output: Contribution to journalArticle

11 Scopus citations

Deletion of Braun lipoprotein gene (lpp) and curing of plasmid pPCP1 dramatically alter the virulence of Yersinia pestis CO92 in a mouse model of pneumonic plague

Agar, S. L., Sha, J., Baze, W. B., Erova, T. E., Foltz, S. M., Suarez, G., Wang, S. & Chopra, A. K., Nov 16 2009, In : Microbiology. 155, 10, p. 3247-3259 13 p.

Research output: Contribution to journalArticle

23 Scopus citations

N-acylhomoserine lactones involved in quorum sensing control the type VI secretion system, biofilm formation, protease production, and in vivo virulence in a clinical isolate of Aeromonas hydrophila

Khajanchi, B. K., Sha, J., Kozlova, E. V., Erova, T. E., Suarez, G., Sierra, J. C., Popov, V. L., Horneman, A. J. & Chopra, A. K., Nov 30 2009, In : Microbiology. 155, 11, p. 3518-3531 14 p.

Research output: Contribution to journalArticle

87 Scopus citations

Phospholipase A2-activating protein (PLAA) enhances cisplatin-induced apoptosis in HeLa cells

Zhang, F., Suarez, G., Sha, J., Sierra, J. C., Peterson, J. W. & Chopra, A. K., Jul 1 2009, In : Cellular Signalling. 21, 7, p. 1085-1099 15 p.

Research output: Contribution to journalArticle

17 Scopus citations

Surface-expressed enolase contributes to the pathogenesis of clinical isolate ssu of Aeromonas hydrophilaa

Sha, J., Erova, T. E., Alyea, R. A., Wang, S., Olano, J. P., Pancholi, V. & Chopra, A. K., May 1 2009, In : Journal of bacteriology. 191, 9, p. 3095-3107 13 p.

Research output: Contribution to journalArticle

63 Scopus citations
2008

Alteration in the activation state of new inflammation-associated targets by phospholipase A2-activating protein (PLAA)

Zhang, F., Sha, J., Wood, T. G., Galindo, C. L., Garner, H. R., Burkart, M. F., Suarez, G., Sierra, J. C., Agar, S. L., Peterson, J. W. & Chopra, A. K., May 1 2008, In : Cellular Signalling. 20, 5, p. 844-861 18 p.

Research output: Contribution to journalArticle

13 Scopus citations

Braun lipoprotein (Lpp) contributes to virulence of yersiniae: Potential role of Lpp in inducing bubonic and pneumonic plague

Sha, J., Agar, S. L., Baze, W. B., Olano, J. P., Fadl, A. A., Erova, T. E., Wang, S., Foltz, S. M., Suarez, G., Motin, V. L., Chauhan, S., Kumpel, G. R., Peterson, J. W. & Chopra, A. K., Apr 1 2008, In : Infection and immunity. 76, 4, p. 1390-1409 20 p.

Research output: Contribution to journalArticle

60 Scopus citations

Characterization of a mouse model of plague after aerosolization of Yersinia pestis CO92

Agar, S. L., Sha, J., Foltz, S. M., Erova, T. E., Walberg, K. G., Parham, T. E., Baze, W. B., Suarez, G., Peterson, J. W. & Chopra, A. K., Sep 11 2008, In : Microbiology. 154, 7, p. 1939-1948 10 p.

Research output: Contribution to journalArticle

52 Scopus citations

Cold shock exoribonuclease R (VacB) is involved in Aeromonas hydrophila pathogenesis

Erova, T. E., Kosykh, V. G., Fadl, A. A., Sha, J., Horneman, A. J. & Chopra, A. K., May 1 2008, In : Journal of bacteriology. 190, 10, p. 3467-3474 8 p.

Research output: Contribution to journalArticle

42 Scopus citations
22 Scopus citations

Molecular characterization of a functional type VI secretion system from a clinical isolate of Aeromonas hydrophila

Suarez, G., Sierra, J. C., Sha, J., Wang, S., Erova, T. E., Fadl, A. A., Foltz, S. M., Horneman, A. J. & Chopra, A. K., Apr 1 2008, In : Microbial Pathogenesis. 44, 4, p. 344-361 18 p.

Research output: Contribution to journalArticle

134 Scopus citations

Mutation in the S-ribosylhomocysteinase (luxS) gene involved in quorum sensing affects biofilm formation and virulence in a clinical isolate of Aeromonas hydrophila

Kozlova, E. V., Popov, V. L., Sha, J., Foltz, S. M., Erova, T. E., Agar, S. L., Horneman, A. J. & Chopra, A. K., Nov 1 2008, In : Microbial Pathogenesis. 45, 5-6, p. 343-354 12 p.

Research output: Contribution to journalArticle

37 Scopus citations
2007

Biological characterization of a new type III secretion system effector from a clinical isolate of Aeromonas hydrophila-Part II

Sierra, J. C., Suarez, G., Sha, J., Foltz, S. M., Popov, V. L., Galindo, C. L., Garner, H. R. & Chopra, A. K., Oct 1 2007, In : Microbial Pathogenesis. 43, 4, p. 147-160 14 p.

Research output: Contribution to journalArticle

32 Scopus citations