John Papaconstantinou, PhD

  • 5896 Citations
  • 44 h-Index
1961 …2019
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Research Output 1961 2019

  • 5896 Citations
  • 44 h-Index
  • 159 Article
  • 2 Chapter
  • 1 Review article
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Article
2019
2 Citations (Scopus)

Small molecule nicotinamide N-methyltransferase inhibitor activates senescent muscle stem cells and improves regenerative capacity of aged skeletal muscle

Neelakantan, H., Brightwell, C. R., Graber, T., Maroto, R., Wang, H. Y. L., McHardy, S. F., Papaconstantinou, J., Fry, C. & Watowich, S., Jan 1 2019, In : Biochemical Pharmacology.

Research output: Contribution to journalArticle

Nicotinamide N-Methyltransferase
Stem cells
Muscle Cells
Muscle
Skeletal Muscle
2017
7 Citations (Scopus)

Aged dominant negative p38α MAPK mice are resistant to age-dependent decline in adult-neurogenesis and context discrimination fear conditioning

Cortez, I. D., Bulavin, D. V., Wu, P., McGrath, E. L., Cunningham, K. A., Wakamiya, M., Papaconstantinou, J. & Dineley, K. T., Mar 30 2017, In : Behavioural Brain Research. 322, p. 212-222 11 p.

Research output: Contribution to journalArticle

Neurogenesis
Fear
Dentate Gyrus
Alzheimer Disease
Neurons
2016
9 Citations (Scopus)

8-Oxoguanine DNA glycosylase1-driven DNA repair-A paradoxical role in lung aging

German, P., Saenz, D., Szaniszlo, P., Aguilera-Aguirre, L., Pan, L., Hegde, M. L., Bacsi, A., Hajas, G., Radak, Z., Ba, X., Mitra, S., Papaconstantinou, J. & Boldogh, I., Apr 14 2016, (Accepted/In press) In : Mechanisms of Ageing and Development.

Research output: Contribution to journalArticle

DNA Repair
Lung
Cultured Cells
DNA
DNA Glycosylases
37 Citations (Scopus)

Amnion-epithelial-cell-derived exosomes demonstrate physiologic state of cell under oxidative stress

Sheller-Miller, S., Papaconstantinou, J., Urrabaz-Garza, R., Richardson, L., Saade, G., Salomon, C. & Menon, R., Jun 1 2016, In : PLoS One. 11, 6, e0157614.

Research output: Contribution to journalArticle

exosomes
amnion
Exosomes
Amnion
Oxidative stress
12 Citations (Scopus)

Mitochondrial-generated ROS down regulates insulin signaling via activation of the p38MAPK stress response pathway

Al Lahham, R., Deford, J. H. & Papaconstantinou, J., Jan 5 2016, In : Molecular and Cellular Endocrinology. 419, p. 1-11 11 p.

Research output: Contribution to journalArticle

Down-Regulation
Rotenone
Chemical activation
Insulin
Insulin Resistance
2015
12 Citations (Scopus)

Attenuation of p38α MAPK stress response signaling delays the in vivo aging of skeletal muscle myofibers and progenitor cells

Papaconstantinou, J., Wang, C. Z., Zhang, M., Yang, S., Deford, J., Bulavin, D. V. & Ansari, N., 2015, In : Aging. 7, 9, p. 718-733 16 p.

Research output: Contribution to journalArticle

p38 Mitogen-Activated Protein Kinases
Muscle Cells
Aldehyde Dehydrogenase
Skeletal Muscle
Stem Cells
4 Citations (Scopus)

IGF-1 mediated phosphorylation of specific IRS-1 serines in Ames dwarf fibroblasts is associated with longevity

Papaconstantinou, J. & Hsieh, C. C., 2015, In : Oncotarget. 6, 34, p. 35315-35323 9 p.

Research output: Contribution to journalArticle

Insulin Receptor Substrate Proteins
Insulin-Like Growth Factor I
Serine
Fibroblasts
Phosphorylation
27 Citations (Scopus)

Klotho protects dopaminergic neuron oxidant-induced degeneration by modulating ASK1 and p38 MAPK signaling pathways

Brobey, R. K., German, D., Sonsalla, P. K., Gurnani, P., Pastor, J., Hsieh, C. C., Papaconstantinou, J., Foster, P. P., Kuro-O, M. & Rosenblatt, K. P., Oct 9 2015, In : PLoS One. 10, 10, e0139914.

Research output: Contribution to journalArticle

MAP Kinase Kinase Kinase 5
Dopaminergic Neurons
p38 Mitogen-Activated Protein Kinases
mitogen-activated protein kinase
Oxidants
7 Citations (Scopus)

Topically applied metal chelator reduces thermal injury progression in a rat model of brass comb burn

Wang, C. Z., Ayadi, A. E., Goswamy, J., Finnerty, C. C., Mifflin, R., Sousse, L., Enkhbaatar, P., Papaconstantinou, J., Herndon, D. & Ansari, N. H., 2015, (Accepted/In press) In : Burns.

Research output: Contribution to journalArticle

Comb and Wattles
Aldehyde Dehydrogenase
Chelating Agents
Burns
Isoenzymes
2014
84 Citations (Scopus)

Histological evidence of oxidative stress and premature senescence in preterm premature rupture of the human fetal membranes recapitulated in vitro

Menon, R., Boldogh, I., Hawkins, H. K., Woodson, M., Polettini, J., Syed, T. A., Fortunato, S. J., Saade, G., Papaconstantinou, J. & Taylor, R. N., 2014, In : American Journal of Pathology. 184, 6, p. 1740-1751 12 p.

Research output: Contribution to journalArticle

Premature Rupture Fetal Membranes
Oxidative Stress
Membranes
Premature Birth
Rupture
53 Citations (Scopus)

HMGB1 promotes a p38MAPK associated non-infectious inflammatory response pathway in human fetal membranes

Bredeson, S., Papaconstantinou, J., Deford, J. H., Kechichian, T., Syed, T. A., Saade, G. & Menon, R., 2014, In : PLoS One. 9, 12, p. e113799

Research output: Contribution to journalArticle

Extraembryonic Membranes
extraembryonic membranes
Premature Birth
premature birth
inflammation
2013
46 Citations (Scopus)

Senescence of primary amniotic cells via oxidative DNA damage

Menon, R., Boldogh, I., Urrabaz-Garza, R., Polettini, J., Syed, T. A., Saade, G., Papaconstantinou, J. & Taylor, R. N., Dec 27 2013, In : PLoS One. 8, 12, e83416.

Research output: Contribution to journalArticle

cigarettes
DNA damage
amnion
DNA Damage
smoke
2012
23 Citations (Scopus)

Meta-analysis of gene expression in the mouse liver reveals biomarkers associated with inflammation increased early during aging

Lee, J. S., Ward, W. O., Ren, H., Vallanat, B., Darlington, G. J., Han, E. S., Laguna, J. C., DeFord, J. H., Papaconstantinou, J., Selman, C. & Corton, J. C., Jul 2012, In : Mechanisms of Ageing and Development. 133, 7, p. 467-478 12 p.

Research output: Contribution to journalArticle

Meta-Analysis
Biomarkers
Inflammation
Gene Expression
Liver
2011
13 Citations (Scopus)

Intestinal mitochondrial apoptotic signaling is activated during oxidative stress

Baregamian, N., Song, J., Papaconstantinou, J., Hawkins, H. K., Evers, B. M. & Chung, D. H., Aug 2011, In : Pediatric Surgery International. 27, 8, p. 871-877 7 p.

Research output: Contribution to journalArticle

Necrotizing Enterocolitis
Reactive Oxygen Species
Oxidative Stress
Epithelial Cells
Intercellular Signaling Peptides and Proteins
8 Citations (Scopus)

Ishemia-Reperfusion enhances GAPDH nitration in aging skeletal muscle

Bailey, C. E., Hammers, D. W., DeFord, J. H., Dimayuga, V. L., Amaning, J. K., Farrar, R. & Papaconstantinou, J., Oct 2011, In : Aging. 3, 10, p. 1003-1017 15 p.

Research output: Contribution to journalArticle

Glyceraldehyde-3-Phosphate Dehydrogenases
Reperfusion
Skeletal Muscle
Muscles
Tyrosine
20 Citations (Scopus)

Mitochondrial electron transport chain functions in long-lived Ames dwarf mice

Choksi, K. B., Nuss, J. E., DeFord, J. H. & Papaconstantinou, J., Aug 2011, In : Aging. 3, 8, p. 754-767 14 p.

Research output: Contribution to journalArticle

Electron Transport
Myocardium
Mitochondria
Skeletal Muscle
Oxidative Stress
2010
12 Citations (Scopus)

Activation of senescence and aging characteristics by mitochondrially generated ROS: How are they linked?

Papaconstantinou, J. & Hsieh, C. C., Oct 1 2010, In : Cell Cycle. 9, 19, p. 3831-3833 3 p.

Research output: Contribution to journalArticle

Thioredoxins
p38 Mitogen-Activated Protein Kinases
18 Citations (Scopus)

Immunostimulatory activity of potential probiotic yeast strains in the dorsal air pouch system and the gut mucosa

Kourelis, A., Kotzamanidis, C., Litopoulou-Tzanetaki, E., Papaconstantinou, J., Tzanetakis, N. & Yiangou, M., Jul 2010, In : Journal of Applied Microbiology. 109, 1, p. 260-271 12 p.

Research output: Contribution to journalArticle

Probiotics
Mucous Membrane
Yeasts
Air
Cytokines
74 Citations (Scopus)

The ASK1-Signalosome regulates p38 MAPK activity in response to levels of endogenous oxidative stress in the Klotho mouse models of aging

Hsieh, C. C., Kuro-o, M., Rosenblatt, K. P., Brobey, R. & Papaconstantinou, J., Sep 2010, In : Aging. 2, 9, p. 597-611 15 p.

Research output: Contribution to journalArticle

p38 Mitogen-Activated Protein Kinases
Reactive Oxygen Species
Oxidative Stress
Phosphotransferases
Apoptosis
3 Citations (Scopus)

α1-Acid glycoprotein production in rat dorsal air pouch in response to inflammatory stimuli, dexamethasone and honey bee venom

Vasileiadou, K., Pantazidis, G., Papadopoulou, K., Ligoudistianou, C., Kourelis, A., Petrakis, S., Masmanidou, E., Testa, T., Kourounakis, A. P., Hadjipetrou, L., Papaconstantinou, J. & Yiangou, M., Aug 2010, In : Experimental and Molecular Pathology. 89, 1, p. 63-71 9 p.

Research output: Contribution to journalArticle

Bee Venoms
Honey
Dexamethasone
Rats
Glycoproteins
2009

A proteomics analysis of the effects of chronic hemiparetic stroke on troponin T expression in human Vastus lateralis

Rabek, J. P., Hafer-Macko, C. E., Amaning, J. K., DeFord, J. H., Dimayuga, V. L., Madsen, M. A., Macko, R. F. & Papaconstantinou, J., Aug 2009, In : Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 64, 8, p. 839-849 11 p.

Research output: Contribution to journalArticle

Troponin T
Quadriceps Muscle
Proteomics
Stroke
Brain Injuries
20 Citations (Scopus)
p38 Mitogen-Activated Protein Kinases
Reactive Oxygen Species
Fibroblasts
Skin
Oxidative Stress
5 Citations (Scopus)

High-throughput liquid-liquid fractionation of multiple protein post-translational modifications

Deford, J. H., Nuss, J. E., Amaning, J., English, R. D., Tjernlund, D. & Papaconstantinou, J., Feb 2009, In : Journal of Proteome Research. 8, 2, p. 907-916 10 p.

Research output: Contribution to journalArticle

Proteome
Post Translational Protein Processing
Fractionation
Throughput
Liquids
58 Citations (Scopus)
Insulin-Like Growth Factor I
Reactive Oxygen Species
Aging of materials
Insulin
Physiological Phenomena
35 Citations (Scopus)

Oxidative modification and aggregation of creatine kinase from aged mouse skeletal muscle.

Nuss, J. E., Amaning, J. K., Bailey, C. E., DeFord, J. H., Dimayuga, V. L., Rabek, J. P. & Papaconstantinou, J., Jun 2009, In : Aging. 1, 6, p. 557-572 16 p.

Research output: Contribution to journalArticle

Creatine Kinase
Skeletal Muscle
Adenosine Triphosphate
MM Form Creatine Kinase
Enzyme Stability
69 Citations (Scopus)
MAP Kinase Kinase Kinase 5
Necrotizing Enterocolitis
Phosphorylation
JNK Mitogen-Activated Protein Kinases
Autophagy
2008
54 Citations (Scopus)
Electron Transport
Electron Transport Complex I
Heart Mitochondria
Proteins
Mitochondria
46 Citations (Scopus)

Age-related alterations in oxidatively damaged proteins of mouse skeletal muscle mitochondrial electron transport chain complexes

Choksi, K. B., Nuss, J. E., DeFord, J. H. & Papaconstantinou, J., Sep 15 2008, In : Free Radical Biology and Medicine. 45, 6, p. 826-838 13 p.

Research output: Contribution to journalArticle

Electron Transport
Muscle
Reactive Oxygen Species
Skeletal Muscle
Proteins
80 Citations (Scopus)

Decreased enzyme activities of chaperones PDI and BiP in aged mouse livers

Nuss, J. E., Choksi, K. B., DeFord, J. H. & Papaconstantinou, J., Jan 11 2008, In : Biochemical and Biophysical Research Communications. 365, 2, p. 355-361 7 p.

Research output: Contribution to journalArticle

Protein Disulfide-Isomerases
Enzyme activity
Liver
Carrier Proteins
Aging of materials
12 Citations (Scopus)

Implications of tyrosine phosphoproteomics in cervical carcinogenesis

Robinson-Bennett, B. L., DeFord, J., Diaz-Arrastia, C., Levine, L., Wang, H. Q., Hannigan, E. V. & Papaconstantinou, J., Jul 17 2008, In : Journal of Carcinogenesis. 7, 2.

Research output: Contribution to journalArticle

Annexin A1
Uterine Cervical Neoplasms
Tyrosine
Biopsy
Carcinogenesis
2007
61 Citations (Scopus)

Age-related increases in oxidatively damaged proteins of mouse kidney mitochondrial electron transport chain complexes

Choksi, K. B., Nuss, J. E., Boylston, W. H., Rabek, J. P. & Papaconstantinou, J., Nov 15 2007, In : Free Radical Biology and Medicine. 43, 10, p. 1423-1438 16 p.

Research output: Contribution to journalArticle

Electron Transport
Reactive Oxygen Species
Kidney
Mitochondria
Proteins
15 Citations (Scopus)

Lower levels of F2-isoprostanes in serum and livers of long-lived Ames dwarf mice

Choksi, K. B., Roberts, L. J., DeFord, J. H., Rabek, J. P. & Papaconstantinou, J., Dec 28 2007, In : Biochemical and Biophysical Research Communications. 364, 4, p. 761-764 4 p.

Research output: Contribution to journalArticle

F2-Isoprostanes
Oxidative stress
Liver
Oxidative Stress
Reactive Oxygen Species
2006
23 Citations (Scopus)

Identification of longevity-associated genes in long-lived Snell and Ames dwarf mice

Boylston, W. H., DeFord, J. H. & Papaconstantinou, J., Jun 2006, In : Age. 28, 2, p. 125-144 20 p.

Research output: Contribution to journalArticle

Genes
Gene Expression
Insulin
Insulin-Like Growth Factor I
Drosophila
35 Citations (Scopus)

Localization of superoxide anion production to mitochondrial electron transport chain in 3-NPA-treated cells

Bacsi, A., Woodberry, M., Widger, W., Papaconstantinou, J., Mitra, S., Peterson, J. & Boldogh, I., Oct 2006, In : Mitochondrion. 6, 5, p. 235-244 10 p.

Research output: Contribution to journalArticle

Electron Transport
Superoxides
Mitochondria
Antimycin A
Electron Transport Complex II
135 Citations (Scopus)
Thioredoxins
p38 Mitogen-Activated Protein Kinases
mitogen-activated protein kinase
Liver
reactive oxygen species
2005
12 Citations (Scopus)

Effects of endotoxin on serum chemokines in man

Schinkel, S., Schinkel, C., Pollard, V., Garofallo, R., Heberle, H., Reisner, P., Papaconstantinou, J. & Herndon, D., Feb 28 2005, In : European Journal of Medical Research. 10, 2, p. 76-80 5 p.

Research output: Contribution to journalArticle

Chemokines
Endotoxins
Chemokine CCL5
Interleukin-8
Serum
12 Citations (Scopus)

Hepatic gene and protein expression of primary components of the IGF-I axis in long lived Snell dwarf mice

Papaconstantinou, J., DeFord, J. H., Gerstner, A., Hsieh, C. C., Boylston, W. H., Guigneaux, M. M., Flurkey, K. & Harrison, D. E., Jun 2005, In : Mechanisms of Ageing and Development. 126, 6-7, p. 692-704 13 p.

Research output: Contribution to journalArticle

Insulin-Like Growth Factor I
Liver
Gene Expression
Proteins
Gene expression
2004
35 Citations (Scopus)

Akt/PKB and p38 MAPK signaling, translational initiation and longevity in Snell dwarf mouse livers

Hsieh, C. C. & Papaconstantinou, J., Oct 2004, In : Mechanisms of Ageing and Development. 125, 10-11 SPEC. ISS., p. 785-798 14 p.

Research output: Contribution to journalArticle

p38 Mitogen-Activated Protein Kinases
Liver
Proteins
Phosphorylation
Insulin-Like Growth Factor I
31 Citations (Scopus)

Altered cholesterologenic and lipogenic transcriptional profile in livers of aging Snell dwarf(Pit1dw/dwJ) mice

Boylston, W. H., Gerstner, A., DeFord, J. H., Madsen, M., Flurkey, K., Harrison, D. E. & Papaconstantinou, J., Oct 2004, In : Aging Cell. 3, 5, p. 283-296 14 p.

Research output: Contribution to journalArticle

Liver
isopentenyldiphosphate delta-isomerase
Squalene Monooxygenase
Hydroxymethylglutaryl-CoA Synthase
Geranyltranstransferase
28 Citations (Scopus)

Altered oxidative stress response of the long-lived Snell dwarf mouse

Madsen, M. A., Hsieh, C. C., Boylston, W. H., Flurkey, K., Harrison, D. & Papaconstantinou, J., Jun 11 2004, In : Biochemical and Biophysical Research Communications. 318, 4, p. 998-1005 8 p.

Research output: Contribution to journalArticle

Oxidative stress
Oxidative Stress
Phosphorylation
Mitogen-Activated Protein Kinase Kinases
Phosphotransferases
Mitochondria
Metabolic Networks and Pathways
Gene expression
Gene Expression
34 Citations (Scopus)

Gene expression analysis in mitochondria from chagasic mice: Alterations in specific metabolic pathways

Garg, N., Gerstner, A., Bhatia, V., DeFord, J. & Papaconstantinou, J., Aug 1 2004, In : Biochemical Journal. 381, 3, p. 743-752 10 p.

Research output: Contribution to journalArticle

Mitochondria
Metabolic Networks and Pathways
Gene expression
Genes
Gene Expression
49 Citations (Scopus)

Impaired mitochondrial respiratory chain and bioenergetics during chagasic cardiomyopathy development

Vyatkina, G., Bhatia, V., Gerstner, A., Papaconstantinou, J. & Garg, N., Jun 28 2004, In : Biochimica et Biophysica Acta - Molecular Basis of Disease. 1689, 2, p. 162-173 12 p.

Research output: Contribution to journalArticle

Electron Transport
Cardiomyopathies
Energy Metabolism
Mitochondria
Mitochondrial DNA
19th Century History
Crystalline Lens
embryology
Embryology
Amphibia
146 Citations (Scopus)

Oxidatively damaged proteins of heart mitochondrial electron transport complexes

Choksi, K. B., Boylston, W. H., Rabek, J. P., Widger, W. R. & Papaconstantinou, J., Mar 2 2004, In : Biochimica et Biophysica Acta - Molecular Basis of Disease. 1688, 2, p. 95-101 7 p.

Research output: Contribution to journalArticle

Mitochondrial Proteins
Electron Transport
Reactive Oxygen Species
Electron Transport Complex I
Proteins
2003
50 Citations (Scopus)

Age-associated changes in SAPK/JNK and p38 MAPK signaling in response to the generation of ROS by 3-nitropropionic acid

Hsieh, C. C., Rosenblatt, J. I. & Papaconstantinou, J., Jun 1 2003, In : Mechanisms of Ageing and Development. 124, 6, p. 733-746 14 p.

Research output: Contribution to journalArticle

p38 Mitogen-Activated Protein Kinases
Liver
Oxidative stress
Oxidative Stress
MAP Kinase Kinase 4
93 Citations (Scopus)
DNA Glycosylases
Mitochondrial DNA
Mitochondria
Uracil-DNA Glycosidase
Liver Extracts
112 Citations (Scopus)

Carbonylation of ER chaperone proteins in aged mouse liver

Rabek, J. P., Boylston, W. H. & Papaconstantinou, J., Jun 6 2003, In : Biochemical and Biophysical Research Communications. 305, 3, p. 566-572 7 p.

Research output: Contribution to journalArticle

Carbonylation
Protein Carbonylation
Liver
Disulfides
Macromolecules
2 Citations (Scopus)
DNA Sequence Analysis
Polymerase Chain Reaction
Alleles
Restriction Fragment Length Polymorphisms
Genotyping Techniques
72 Citations (Scopus)
Mitochondrial Diseases
Trypanosoma cruzi
Myocarditis
Oxidative Phosphorylation
Infection