John Winston, PhD

Vice Chair, IACUC

  • 2017 Citations
  • 27 h-Index
1984 …2020

Research output per year

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Research Output

  • 2017 Citations
  • 27 h-Index
  • 54 Article
  • 1 Editorial
2020

Neonatal injury increases gut permeability by epigenetically suppressing e-cadherin in adulthood

Kline, K. T., Lian, H., Zhong, X. S., Luo, X., Winston, J. H., Cong, Y., Savidge, T. C., Dashwood, R. H., Powell, D. & Li, Q., Feb 15 2020, In : Journal of Immunology. 204, 4, p. 980-989 10 p.

Research output: Contribution to journalArticle

1 Scopus citations
2018

Neonatal Colonic Inflammation Epigenetically Aggravates Epithelial Inflammatory Responses to Injury in Adult Life

Zhong, X. S., Winston, J. H., Luo, X., Kline, K. T., Nayeem, S. Z., Cong, Y., Savidge, T. C., Dashwood, R. H., Powell, D. W. & Li, Q., Jan 1 2018, In : CMGH. 6, 1, p. 65-78 14 p.

Research output: Contribution to journalArticle

6 Scopus citations
5 Scopus citations
2017

Impaired Interoception in a Preclinical Model of Functional Dyspepsia

Winston, J. H., Aguirre, J. E., Shi, X. Z. & Sarna, S. K., Mar 29 2017, (Accepted/In press) In : Digestive Diseases and Sciences. p. 1-11 11 p.

Research output: Contribution to journalArticle

3 Scopus citations
10 Scopus citations

Obituary: Sushil K. Sarna, Ph.D.

Shi, X-Z., Winston, J., Powell, D. & Shaker, R., Apr 29 2017, In : Neurogastroenterology and Motility.

Research output: Contribution to journalArticle

Open Access

Pathogenesis of abdominal pain in bowel obstruction: Role of mechanical stress-induced upregulation of nerve growth factor in gut smooth muscle cells

Lin, Y. M., Fu, Y., Winston, J., Radhakrishnan, R., Sarna, S. K., Huang, L-Y. & Shi, X-Z., Apr 1 2017, In : Pain. 158, 4, p. 583-592 10 p.

Research output: Contribution to journalArticle

18 Scopus citations

Sushil K. Sarna, PhD—In Memoriam

Winston, J., Shi, X-Z. & Powell, D. W., Jun 1 2017, In : Gastroenterology. 152, 8, p. 1803-1804 2 p.

Research output: Contribution to journalEditorial

2016

Auricular vagal nerve stimulation ameliorates burn-induced gastric dysmotility via sympathetic-COX-2 pathways in rats

Li, H., Yin, J., Zhang, Z., Winston, J., Shi, X-Z. & Chen, J. D. Z., Jan 1 2016, In : Neurogastroenterology and Motility. 28, 1, p. 36-42 7 p.

Research output: Contribution to journalArticle

6 Scopus citations
11 Scopus citations
8 Scopus citations
2015

Genesis of anxiety, depression, and ongoing abdominal discomfort in ulcerative colitis-like colon inflammation

Chen, J., Winston, J. H., Fu, Y., Guptarak, J., Jensen, K. L., Shi, X. Z., Green, T. A. & Sarna, S. K., Jan 1 2015, In : American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 308, 1, p. R18-R27

Research output: Contribution to journalArticle

32 Scopus citations

Genesis of anxiety, depression, and ongoing abdominal discomfort in ulcerative colitis-like colon inflammation

Chen, J., Winston, J. H., Fu, Y., Guptarak, J., Jensen, K. L., Shi, X. Z., Green, T. A. & Sarna, S. K., Jan 1 2015, In : American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 308, 1, p. R18-R27

Research output: Contribution to journalArticle

Genesis of anxiety, depression, and ongoing abdominal discomfort in ulcerative colitis-like colon inflammation

Chen, J., Winston, J. H., Fu, Y., Guptarak, J., Jensen, K. L., Shi, X. Z., Green, T. A. & Sarna, S. K., Jan 1 2015, In : American Journal of Physiology - Endocrinology and Metabolism. 308, 1, p. R18-R27

Research output: Contribution to journalArticle

Symptom generation by mucosal inflammation in irritable bowel syndrome

Sarna, S. K. & Winston, J., Aug 1 2015, In : Gastroenterology. 149, 2, p. 287-289 3 p.

Research output: Contribution to journalArticle

2014
31 Scopus citations
8 Scopus citations
2013

Are Interstitial Cells of Cajal Involved in Mechanical Stress-Induced Gene Expression and Impairment of Smooth Muscle Contractility in Bowel Obstruction?

Wu, C. C., Lin, Y. M., Gao, J., Winston, J. H., Cheng, L. K. & Shi, X. Z., Sep 30 2013, In : PloS one. 8, 9, e76222.

Research output: Contribution to journalArticle

8 Scopus citations
7 Scopus citations

Developmental origins of functional dyspepsia-like gastric hypersensitivity in rats

Winston, J. H. & Sarna, S. K., Mar 2013, In : Gastroenterology. 144, 3, p. 570-579.e3

Research output: Contribution to journalArticle

30 Scopus citations

Neurological and cellular regulation of visceral hypersensitivity induced by chronic stress and colonic inflammation in rats

Chen, J., Winston, J. H. & Sarna, S. K., Sep 17 2013, In : Neuroscience. 248, p. 469-478 10 p.

Research output: Contribution to journalArticle

38 Scopus citations
26 Scopus citations
2011
50 Scopus citations

PhyloChip microarray analysis reveals altered gastrointestinal microbial communities in a rat model of colonic hypersensitivity

Nelson, T. A., Holmes, S., Alekseyenko, A. V., Shenoy, M., Desantis, T., Wu, C. H., Andersen, G. L., Winston, J., Sonnenburg, J., Pasricha, P. J. & Spormann, A., Feb 1 2011, In : Neurogastroenterology and Motility. 23, 2, p. 169-e42

Research output: Contribution to journalArticle

23 Scopus citations
2010

Adrenergic Stimulation Mediates Visceral Hypersensitivity to Colorectal Distension Following Heterotypic Chronic Stress

Winston, J. H., Xu, G. Y. & Sarna, S. K., Jan 2010, In : Gastroenterology. 138, 1, p. 294-304.e3

Research output: Contribution to journalArticle

69 Scopus citations

Ameliorating effects of mirtazapine on visceral hypersensitivity in rats with neonatal colon sensitivity

Yin, J., Wang, W., Winston, J. H., Zhang, R. & Chen, J. D. Z., Sep 1 2010, In : Neurogastroenterology and Motility. 22, 9, p. 1022-1028+e267

Research output: Contribution to journalArticle

14 Scopus citations
2009
45 Scopus citations

The endogenous hydrogen sulfide producing enzyme cystathionine-β synthase contributes to visceral hypersensitivity in a rat model of irritable bowel syndrome

Xu, G. Y., Winston, J. H., Shenoy, M., Zhou, S., Chen, J. D. Z. & Pasricha, P. J., Aug 6 2009, In : Molecular pain. 5, 44.

Research output: Contribution to journalArticle

62 Scopus citations
2008

A Rat Model of Chronic Gastric Sensorimotor Dysfunction Resulting From Transient Neonatal Gastric Irritation

Liu, L. S., Winston, J. H., Shenoy, M. M., Song, G. Q., Chen, J. D. Z. & Pasricha, P. J., Jun 2008, In : Gastroenterology. 134, 7, p. 2070-2079 10 p.

Research output: Contribution to journalArticle

51 Scopus citations

P2X receptor-mediated visceral hyperalgesia in a rat model of chronic visceral hypersensitivity

Xu, G. Y., Shenoy, M., Winston, J. H., Mittal, S. & Pasricha, P. J., Sep 1 2008, In : Gut. 57, 9, p. 1230-1237 8 p.

Research output: Contribution to journalArticle

98 Scopus citations
2007

Monocyte chemoattractant protein-1 production by intestinal myofibroblasts in response to staphylococcal enterotoxin A: Relevance to staphylococcal enterotoxigenic disease

Pinchuk, I. V., Beswick, E. J., Saada, J. I., Suarez, G., Winston, J., Mifflin, R. C., Di Mari, J. F., Powell, D. W. & Reyes, V. E., Jun 15 2007, In : Journal of Immunology. 178, 12, p. 8097-8106 10 p.

Research output: Contribution to journalArticle

Open Access
31 Scopus citations

The ClC-3 chloride transport protein traffics through the plasma membrane via interaction of an N-terminal dileucine cluster with clathrin

Zhao, Z., Li, X., Hao, J., Winston, J. H. & Weinman, S. A., Sep 28 2007, In : Journal of Biological Chemistry. 282, 39, p. 29022-29031 10 p.

Research output: Contribution to journalArticle

35 Scopus citations

The Vanilloid Receptor Initiates and Maintains Colonic Hypersensitivity Induced by Neonatal Colon Irritation in Rats

Winston, J., Shenoy, M., Medley, D., Naniwadekar, A. & Pasricha, P. J., Feb 2007, In : Gastroenterology. 132, 2, p. 615-627 13 p.

Research output: Contribution to journalArticle

168 Scopus citations

Transient Receptor Potential Vanilloid 1 Mediates Hyperalgesia and Is Up-Regulated in Rats With Chronic Pancreatitis

Xu, G. Y., Winston, J. H., Shenoy, M., Yin, H., Pendyala, S. & Pasricha, P. J., Oct 2007, In : Gastroenterology. 133, 4, p. 1282-1292 11 p.

Research output: Contribution to journalArticle

101 Scopus citations
2006
69 Scopus citations
2005

Molecular and behavioral changes in nociception in a novel rat model of chronic pancreatitis for the study of pain

Winston, J. H., He, Z. J., Shenoy, M., Xiao, S. Y. & Pasricha, P. J., Sep 1 2005, In : Pain. 117, 1-2, p. 214-222 9 p.

Research output: Contribution to journalArticle

69 Scopus citations

The role of mast cells in the pathogenesis of pain in chronic pancreatitis

Hoogerwerf, W. A., Gondesen, K., Xiao, S. Y., Winston, J. H., Willis, W. D. & Pasricha, P. J., Mar 3 2005, In : BMC Gastroenterology. 5, 8.

Research output: Contribution to journalArticle

44 Scopus citations

Traumatic brain injury and hemorrhagic hypotension suppress neuroprotective gene expression in injured hippocampal neurons

Hellmich, H. L., Garcia, J. M., Shimamura, M., Shah, S. A., Avila, M. A., Uchida, T., Parsley, M. A., Capra, B. A., Eidson, K. A., Kennedy, D. R., Winston, J. H., DeWitt, D. S. & Prough, D. S., Apr 1 2005, In : Anesthesiology. 102, 4, p. 806-814 9 p.

Research output: Contribution to journalArticle

30 Scopus citations
2004

Modulation of TRPV1 by nonreceptor tyrosine kinase, c-Src kinase

Jin, X., Morsy, N., Winston, J., Pasricha, P. J., Garrett, K. & Akbarali, H. I., Aug 1 2004, In : American Journal of Physiology - Cell Physiology. 287, 2 56-2, p. C558-C563

Research output: Contribution to journalArticle

76 Scopus citations

Trypsin mediates nociception via the proteinase-activated receptor 2: A potentially novel role in pancreatic pain

Hoogerwerf, W. A., Shenoy, M., Winston, J. H., Xiao, S. Y., He, Z. & Pasricha, P. J., Sep 2004, In : Gastroenterology. 127, 3, p. 883-891 9 p.

Research output: Contribution to journalArticle

60 Scopus citations
2003

Acute pancreatitis results in referred mechanical hypersensitivity and neuropeptide up-regulation that can be suppressed by the protein kinase inhibitor K252a

Winston, J. H., Toma, H., Shenoy, M., He, Z. J., Zou, L., Xiao, S. Y., Micci, M. A. & Pasricha, P. J., Aug 2003, In : Journal of Pain. 4, 6, p. 329-337 9 p.

Research output: Contribution to journalArticle

48 Scopus citations
19 Scopus citations
2002

Characterization of the neurotrophic response to acute pancreatitis

Toma, H., Winston, J. H., Micci, M. A., Li, H., Hellmich, H. L. & Pasricha, P. J., Jan 1 2002, In : Pancreas. 25, 1, p. 31-38 8 p.

Research output: Contribution to journalArticle

15 Scopus citations

Molecular cloning of the rat proteinase-activated receptor 4 (PAR4)

Hoogerwerf, W. A., Lee Hellmich, H., Micci, M. A., Winston, J. H., Zhou, L. & Pasricha, P. J., Feb 18 2002, In : BMC Molecular Biology. 3, 2.

Research output: Contribution to journalArticle

20 Scopus citations
2001

Nerve growth factor regulates VR-1 mRNA levels in cultures of adult dorsal root ganglion neurons

Winston, J., Toma, H., Shenoy, M. & Pasricha, P. J., Feb 22 2001, In : Pain. 89, 2-3, p. 181-186 6 p.

Research output: Contribution to journalArticle

162 Scopus citations

The proteinase-activated receptor 2 is involved in nociception

Hoogerwerf, W. A., Zou, L., Shenoy, M., Sun, D., Micci, M. A., Lee-Hellmich, H., Xiao, S. Y., Winston, J. H. & Pasricha, P. J., Nov 15 2001, In : Journal of Neuroscience. 21, 22, p. 9036-9042 7 p.

Research output: Contribution to journalArticle

Open Access
147 Scopus citations

Time course of LPS-induced gene expression in a mouse model of genitourinary inflammation

Saban, M. R., Hellmich, H., Nguyen, N. B., Winston, J., Hammond, T. G. & Saban, R., Jun 1 2001, In : Physiological Genomics. 2001, 5, p. 147-160 14 p.

Research output: Contribution to journalArticle

86 Scopus citations
2000

Nerve growth factor expression is up-regulated in the rat model of l-arginine-lnduced acute pancreatitis

Toma, H., Winston, J., Micci, M. A., Shenoy, M. & Pasricha, P. J., Jan 1 2000, In : Gastroenterology. 119, 5, p. 1373-1381 9 p.

Research output: Contribution to journalArticle

53 Scopus citations
1999

Regulation of forestomach-specific expression of the murine adenosine deaminase gene

Xu, P. A., Winston, J. H., Datta, S. K. & Kellems, R. E., Apr 9 1999, In : Journal of Biological Chemistry. 274, 15, p. 10316-10323 8 p.

Research output: Contribution to journalArticle

11 Scopus citations
1998

Rat trehalase: cDNA cloning and mRNA expression in adult rat tissues and during intestinal ontogeny

Oesterreicher, T. J., Nanthakumar, N. N., Winston, J. H. & Henning, S. J., May 1998, In : American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 274, 5 43-5, p. R1220-R1227

Research output: Contribution to journalArticle

24 Scopus citations