Junji Iwahara

2013

Speed-stability paradox in DNA-scanning by zinc-finger proteins

Iwahara, J. & Levy, Y., 2013, In: Transcription. 4, 2

Research output: Contribution to journal › Article › peer-review

Open Access

2012

Asymmetrical roles of zinc fingers in dynamic DNA-scanning process by the inducible transcription factor Egr-1

Zandarashvili, L., Vuzman, D., Esadze, A., Takayama, Y., Sahu, D., Levy, Y. & Iwahara, J., Jun 26 2012, In: Proceedings of the National Academy of Sciences of the United States of America. 109, 26, p. E1724-E1732

Research output: Contribution to journal › Article › peer-review

Open Access

90 Scopus citations

2011

Dynamics of lysine side-chain amino groups in a protein studied by heteronuclear ¹H-¹⁵N NMR spectroscopy

Esadze, A., Li, D. W., Wang, T., Brüschweiler, R. & Iwahara, J., Feb 2 2011, In: Journal of the American Chemical Society. 133, 4, p. 909-919 11 p.

Research output: Contribution to journal › Article › peer-review

67 Scopus citations

Signature of mobile hydrogen bonding of lysine side chains from long-range ¹⁵N-¹³C scalar J-couplings and computation

Zandarashvili, L., Li, D. W., Wang, T., Brüschweiler, R. & Iwahara, J., Jun 22 2011, In: Journal of the American Chemical Society. 133, 24, p. 9192-9195 4 p.

Research output: Contribution to journal › Article › peer-review

34 Scopus citations

2010

NMR studies of translocation of the Zif268 protein between its target DNA Sites

Takayama, Y., Sahu, D. & Iwahara, J., Sep 21 2010, In: Biochemistry. 49, 37, p. 7998-8005 8 p.

Research output: Contribution to journal › Article › peer-review

30 Scopus citations

Structure-independent analysis of the breadth of the positional distribution of disordered groups in macromolecules from order parameters for long, variable-length vectors using nmr paramagnetic relaxation enhancement

Iwahara, J. & Clore, G. M., Sep 29 2010, In: Journal of the American Chemical Society. 132, 38, p. 13346-13356 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

38 Scopus citations

2009

Theory, practice, and applications of paramagnetic relaxation enhancement for the characterization of transient low-population states of biological macromolecules and their complexes

Marius Clore, G. & Iwahara, J., Sep 9 2009, In: Chemical Reviews. 109, 9, p. 4108-4139 32 p.

Research output: Contribution to journal › Article › peer-review

Open Access

636 Scopus citations

2008

Direct evidence for deprotonation of a lysine side chain buried in the hydrophobic core of a protein

Takayama, Y., Castañeda, C. A., Chimenti, M., García-Moreno, B. & Iwahara, J., May 28 2008, In: Journal of the American Chemical Society. 130, 21, p. 6714-6715 2 p.

Research output: Contribution to journal › Article › peer-review

50 Scopus citations

Observing in-phase single-quantum ¹⁵N multiplets for NH₂ / NH₃⁺ groups with two-dimensional heteronuclear correlation spectroscopy

Takayama, Y., Sahu, D. & Iwahara, J., Oct 2008, In: Journal of Magnetic Resonance. 194, 2, p. 313-316 4 p.

Research output: Contribution to journal › Article › peer-review

Open Access

10 Scopus citations

Redox properties of the A-domain of the HMGB1 protein

Sahu, D., Debnath, P., Takayama, Y. & Iwahara, J., Dec 10 2008, In: FEBS Letters. 582, 29, p. 3973-3978 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

38 Scopus citations

2007

Heteronuclear NMR spectroscopy for lysine NH₃ groups in proteins: Unique effect of water exchange on ¹⁵N transverse relaxation

Iwahara, J., Jung, Y. S. & Clore, G. M., Mar 14 2007, In: Journal of the American Chemical Society. 129, 10, p. 2971-2980 10 p.

Research output: Contribution to journal › Article › peer-review

87 Scopus citations

Intramolecular domain-domain association/dissociation and phosphoryl transfer in the mannitol transporter of Escherichia coli are not coupled

Suh, J. Y., Iwahara, J. & Clore, G. M., Feb 27 2007, In: Proceedings of the National Academy of Sciences of the United States of America. 104, 9, p. 3153-3158 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

19 Scopus citations

KUJIRA, a package of integrated modules for systematic and interactive analysis of NMR data directed to high-throughput NMR structure studies

Kobayashi, N., Iwahara, J., Koshiba, S., Tomizawa, T., Tochio, N., Güntert, P., Kigawa, T. & Yokoyama, S., Sep 2007, In: Journal of Biomolecular NMR. 39, 1, p. 31-52 22 p.

Research output: Contribution to journal › Article › peer-review

142 Scopus citations

Practical aspects of ¹H transverse paramagnetic relaxation enhancement measurements on macromolecules

Iwahara, J., Tang, C. & Marius Clore, G., Feb 2007, In: Journal of Magnetic Resonance. 184, 2, p. 185-195 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

223 Scopus citations

TROSY-based z-exchange spectroscopy: Application to the determination of the activation energy for intermolecular protein translocation between specific sites on different DNA molecules

Sahu, D., Clore, G. M. & Iwahara, J., Oct 31 2007, In: Journal of the American Chemical Society. 129, 43, p. 13232-13237 6 p.

Research output: Contribution to journal › Article › peer-review

42 Scopus citations

2006

Detecting transient intermediates in macromolecular binding by paramagnetic NMR

Iwahara, J. & Clore, G. M., Apr 27 2006, In: Nature. 440, 7088, p. 1227-1230 4 p.

Research output: Contribution to journal › Article › peer-review

334 Scopus citations

Direct observation of enhanced translocation of a homeodomain between DNA cognate sites by NMR exchange spectroscopy

Iwahara, J. & Clore, G. M., Jan 18 2006, In: Journal of the American Chemical Society. 128, 2, p. 404-405 2 p.

Research output: Contribution to journal › Article › peer-review

Open Access

83 Scopus citations

NMR structural and kinetic characterization of a homeodomain diffusing and hopping on nonspecific DNA

Iwahara, J., Zweckstetter, M. & Clore, G. M., Oct 10 2006, In: Proceedings of the National Academy of Sciences of the United States of America. 103, 41, p. 15062-15067 6 p.

Research output: Contribution to journal › Article › peer-review

162 Scopus citations

Sensitivity improvement for correlations involving arginine side-chain Nε/Hε resonances in multi-dimensional NMR experiments using broadband ¹⁵N 180° pulses

Iwahara, J. & Clore, G. M., Dec 2006, In: Journal of Biomolecular NMR. 36, 4, p. 251-257 7 p.

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Visualization of transient encounter complexes in protein-protein association

Tang, C., Iwahara, J. & Clore, G. M., Nov 16 2006, In: Nature. 444, 7117, p. 383-386 4 p.

Research output: Contribution to journal › Article › peer-review

362 Scopus citations

2005

Accurate determination of leucine and valine side-chain conformations using U-[¹⁵N/¹³C/²H]/ [¹H-(methine/methyl)-Leu/Val] isotope labeling, NOE pattern recognition, and methine Cγ-Hγ/Cβ-Hβ residual dipolar couplings: Application to the 34-kDa enzyme IIA^Chitobiose

Tang, C., Iwahara, J. & Clore, G. M., Oct 2005, In: Journal of Biomolecular NMR. 33, 2, p. 105-121 17 p.

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Compensating increases in protein backbone flexibility occur when the Dead ringer AT-rich interaction domain (ARID) binds DNA: A nitrogen-15 relaxation study

Iwahara, J., Peterson, R. D. & Clubb, R. T., May 2005, In: Protein Science. 14, 5, p. 1140-1150 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

7 Scopus citations

2004

Characterization of nonspecific protein-DNA interactions by ¹H paramagnetic relaxation enhancement

Iwahara, J., Schwieters, C. D. & Clore, G. M., Oct 13 2004, In: Journal of the American Chemical Society. 126, 40, p. 12800-12808 9 p.

Research output: Contribution to journal › Article › peer-review

72 Scopus citations

Ensemble Approach for NMR Structure Refinement against ¹H Paramagnetic Relaxation Enhancement Data Arising from a Flexible Paramagnetic Group Attached to a Macromolecule

Iwahara, J., Schwieters, C. D. & Clore, G. M., May 12 2004, In: Journal of the American Chemical Society. 126, 18, p. 5879-5896 18 p.

Research output: Contribution to journal › Article › peer-review

300 Scopus citations

2003

EDTA-derivatized deoxythymidine as a tool for rapid determination of protein binding polarity to DNA by intermolecular paramagnetic relaxation enhancement

Iwahara, J., Anderson, D. E., Murphy, E. C. & Clore, G. M., Jun 4 2003, In: Journal of the American Chemical Society. 125, 22, p. 6634-6635 2 p.

Research output: Contribution to journal › Article › peer-review

73 Scopus citations

2002

Regulation of directionality in bacteriophage λ site-specific recombination: Structure of the Xis protein

Sam, M. D., Papagiannis, C. V., Connolly, K. M., Corselli, L., Iwahara, J., Lee, J., Phillips, M., Wojciak, J. M., Johnson, R. C. & Clubb, R. T., 2002, In: Journal of Molecular Biology. 324, 4, p. 791-805 15 p.

Research output: Contribution to journal › Article › peer-review

42 Scopus citations

Solution structure determination of the two DNA-binding domains in the Shizosaccharomyces pombe Abp1 protein by a combination of dipolar coupling and diffusion anisotropy restraints

Kikuchi, J., Iwahara, J., Kigawa, T., Murakami, Y., Okazaki, T. & Yokoyama, S., 2002, In: Journal of Biomolecular NMR. 22, 4, p. 333-347 15 p.

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

The structure of the Dead ringer-DNA complex reveals how AT-rich interaction domains (ARIDs) recognize DNA

Iwahara, J., Iwahara, M., Daughdrill, G. W. & Ford, J., Mar 1 2002, In: EMBO Journal. 21, 5, p. 1197-1209 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

58 Scopus citations

2001

Crystal structure of the CENP-B protein-DNA complex: The DNA-binding domains of CENP-B induce kinks in the CENP-B box DNA

Tanaka, Y., Nureki, O., Kurumizaka, H., Fukai, S., Kawaguchi, S., Ikuta, M., Iwahara, J., Okazaki, T. & Yokoyama, S., Dec 3 2001, In: EMBO Journal. 20, 23, p. 6612-6618 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

84 Scopus citations

Improved NMR spectra of a protein-DNA complex through rational mutagenesis and the application of a sensitivity optimized isotope-filtered NOESY experiment

Iwahara, J., Wojciak, J. M. & Clubb, R. T., 2001, In: Journal of Biomolecular NMR. 19, 3, p. 231-241 11 p.

Research output: Contribution to journal › Article › peer-review

61 Scopus citations

Structure of sortase, the transpeptidase that anchors proteins to the cell wall of Staphylococcus aureus

Ilangovan, U., Ton-That, H., Iwahara, J., Schneewind, O. & Clubb, R. T., May 22 2001, In: Proceedings of the National Academy of Sciences of the United States of America. 98, 11, p. 6056-6061 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

275 Scopus citations

The Mu repressor-DNA complex contains an immobilized 'wing' within the minor groove

Wojciak, J. M., Iwahara, J. & Clubb, R. T., 2001, In: Nature Structural Biology. 8, 1, p. 84-90 7 p.

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

1999

Solution structure of the DNA binding domain from Dead ringer, a sequence-specific AT-rich interaction domain (ARID)

Iwahara, J. & Clubb, R. T., Nov 1 1999, In: EMBO Journal. 18, 21, p. 6084-6094 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

57 Scopus citations

Solution structure of the Eps15 homology domain of a human POB1 (partner of RalBP1)

Koshiba, S., Kigawa, T., Iwahara, J., Kikuchi, A. & Yokoyama, S., Jan 15 1999, In: FEBS Letters. 442, 2-3, p. 138-142 5 p.

Research output: Contribution to journal › Article › peer-review

Open Access

24 Scopus citations

1998

A helix-turn-helix structure unit in human centromere protein B (CENP-B)

Iwahara, J., Kigawa, T., Kitagawa, K., Masumoto, H., Okazaki, T. & Yokoyama, S., Feb 2 1998, In: EMBO Journal. 17, 3, p. 827-837 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

35 Scopus citations

1997

Regional polysterism in the GTP-bound form of the human c-Ha-Ras protein

Ito, Y., Yamasaki, K., Iwahara, J., Terada, T., Kamiya, A., Shirouzu, M., Muto, Y., Kawai, G., Yokoyama, S., Laue, E. D., Wälchli, M., Shibata, T., Nishimura, S. & Miyazawa, T., Jul 29 1997, In: Biochemistry. 36, 30, p. 9109-9119 11 p.

Research output: Contribution to journal › Article › peer-review

152 Scopus citations

1996

Gaussian spectral-density function for protein internal motions

Ishima, R., Iwahara, J. J., Yokoyama, S. & Nagayama, K., 1996, In: Journal of Magnetic Resonance - Series B. 111, 3, p. 281-284 4 p.

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Junji Iwahara, PhD

Research output

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