Kenichi Fujise, MD

Director, Cardiology Research

  • 1756 Citations
  • 22 h-Index
1993 …2021
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Research Output 1993 2019

  • 1756 Citations
  • 22 h-Index
  • 69 Article
  • 2 Chapter
  • 1 Letter
2019

Ticagrelor induces paraoxonase-1 (PON1) and better protects hypercholesterolemic mice against atherosclerosis compared to clopidogrel

Halim, H., Pinkaew, D., Chunhacha, P., Sinthujaroen, P., Thiagarajan, P. & Fujise, K., Jan 1 2019, In : PloS one. 14, 6, e0218934.

Research output: Contribution to journalArticle

Open Access
clopidogrel
Aryldialkylphosphatase
atherosclerosis
Atherosclerosis
mice
2017

Fortilin: A Potential Target for the Prevention and Treatment of Human Diseases

Pinkaew, D. & Fujise, K., 2017, (Accepted/In press) In : Advances in Clinical Chemistry.

Research output: Contribution to journalArticle

Liver
Diabetic Nephropathies
Apoptosis
Mitochondria
Atherosclerosis
9 Citations (Scopus)

Fortilin binds IRE1α and prevents ER stress from signaling apoptotic cell death

Pinkaew, D., Chattopadhyay, A., King, M. D., Chunhacha, P., Liu, Z., Stevenson-Lerner, H., Chen, Y., Sinthujaroen, P., McDougal, O. M. & Fujise, K., Dec 1 2017, In : Nature Communications. 8, 1, 41467.

Research output: Contribution to journalArticle

Unfolded Protein Response
Endoplasmic Reticulum Stress
endoplasmic reticulum
Cell death
death

Sex-dependent difference in the relationship between adipose-tissue cholesterol efflux and estradiol concentrations in young healthy humans

Iqbal, F., Durham, W. J., Melhem, A., Raslan, S., Tran, T., Wright, T. J., Asghar, R., Fujise, K., Volpi, E., Sidossis, L., Abate, N., Sheffield-Moore, M. & Tuvdendorj, D., 2017, (Accepted/In press) In : International Journal of Developmental Neuroscience.

Research output: Contribution to journalArticle

Sex Characteristics
Adipose Tissue
Estradiol
Cholesterol
HDL Cholesterol
2016
9 Citations (Scopus)

Fortilin potentiates the peroxidase activity of Peroxiredoxin-1 and protects against alcohol-induced liver damage in mice

Chattopadhyay, A., Pinkaew, D., Doan, H. Q., Jacob, R. B., Verma, S. K., Friedman, H., Peterson, A. C., Martinez, N., McDougal, O. M. & Fujise, K., Jan 4 2016, In : Scientific Reports. 6, 18701.

Research output: Contribution to journalArticle

Peroxiredoxins
Peroxidase
Alcohols
Liver
Cell Death

Inflammation and heart diseases

Adoni, N. A., Abusaid, G. H. & Fujise, K., Apr 19 2016, Inflammation, Lifestyle and Chronic Diseases: The Silent Link. CRC Press, p. 157-182 26 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Heart Diseases
Inflammation
3 Citations (Scopus)

Percutaneous Coronary Intervention After Transcatheter Aortic Valve Replacement: Approach and Challenges

Khan, A., Gilani, S., Dharmashankar, K., Jaffery, Z., Rangasetty, U. & Fujise, K., Jul 26 2016, In : Journal of the American College of Cardiology. 68, 4, p. 432-433 2 p.

Research output: Contribution to journalLetter

Percutaneous Coronary Intervention
Transcatheter Aortic Valve Replacement
2014
9 Citations (Scopus)

Elevation of serum fortilin levels is specific for apoptosis and signifies cell death in vivo

Sinthujaroen, P., Wanachottrakul, N., Pinkaew, D., Petersen, J. R., Phongdara, A., Sheffield-Moore, M. & Fujise, K., Dec 1 2014, In : BBA Clinical. 2, p. 103-111 9 p.

Research output: Contribution to journalArticle

Cell Death
Apoptosis
Serum
Biomarkers
Keratin-18
Coronary Restenosis
Drug-Eluting Stents
Coronary Balloon Angioplasty
Optical Coherence Tomography
Treatment Failure
1 Citation (Scopus)
Percutaneous Coronary Intervention
Anticoagulants
Hemorrhage
Length of Stay
Thigh
4 Citations (Scopus)

Safety of combination therapy with milrinone and esmolol for heart protection during percutaneous coronary intervention in acute myocardial infarction

Poh, K. K., Xu, X., Chan, M. Y., Lee, C. H., Tay, E. L., Low, A. F., Chan, K. H., Sia, W., Tang, L. Q., Tan, H. C., Lui, C. Y., Nguyen, V., Fujise, K. & Huang, M. H., 2014, In : European Journal of Clinical Pharmacology. 70, 5, p. 527-530 4 p.

Research output: Contribution to journalArticle

Milrinone
Percutaneous Coronary Intervention
Myocardial Infarction
Safety
Reperfusion Injury
2013
6 Citations (Scopus)

Fortilin reduces apoptosis in macrophages and promotes atherosclerosis

Pinkaew, D., Le, R. J., Chen, Y., Eltorky, M., Teng, B. B. & Fujise, K., Nov 15 2013, In : American Journal of Physiology - Heart and Circulatory Physiology. 305, 10

Research output: Contribution to journalArticle

Atherosclerosis
Macrophages
Apoptosis
LDL Receptors
Peritoneal Macrophages
10 Citations (Scopus)

Percutaneous hemodynamic support (Impella) in patients with advanced heart failure and/or cardiogenic shock not eligible to PROTECT II trial

Liu, W., Mukku, V. K., Gilani, S., Fujise, K. & Barbagelata, A., Dec 2013, In : International Journal of Angiology. 22, 4, p. 207-212 6 p.

Research output: Contribution to journalArticle

Cardiogenic Shock
Heart Failure
Hemodynamics
Percutaneous Coronary Intervention
Heart Arrest
2012
9 Citations (Scopus)

Delta-opioid augments cardiac contraction through β-adrenergic and CGRP-receptor co-signaling

Nguyen, V. T., Wu, Y., Guillory, A., McConnell, B. K., Fujise, K. & Huang, M. H., Jan 2012, In : Peptides. 33, 1, p. 77-82 6 p.

Research output: Contribution to journalArticle

D-Penicillamine (2,5)-Enkephalin
Calcitonin Gene-Related Peptide Receptors
Adrenergic Agents
Opioid Analgesics
Propranolol

Management of arrhythmias in heart failure. What a practicing physician should know in the current times

Ramineni, R., Bheemarasetti, M. K., Baranchuk, A., Mandalapu, T., Mukku, V. K., Fujise, K. & Barbagelata, A., 2012, In : Cardiology Journal. 19, 6, p. 567-577 11 p.

Research output: Contribution to journalArticle

Mineralocorticoid Receptor Antagonists
Cardiac Arrhythmias
Heart Failure
Physicians
Implantable Defibrillators
12 Citations (Scopus)

Morelloflavone, a biflavonoid inhibitor of migration-related kinases, ameliorates atherosclerosis in mice

Pinkaew, D., Hutadilok-Towatana, N., Teng, B. B., Mahabusarakam, W. & Fujise, K., Jan 2012, In : American Journal of Physiology - Heart and Circulatory Physiology. 302, 2

Research output: Contribution to journalArticle

Biflavonoids
Atherosclerosis
Phosphotransferases
Vascular Smooth Muscle
Smooth Muscle Myocytes
1 Citation (Scopus)

Reply

Kuo, H. K. & Fujise, K., Jul 3 2012, In : Journal of the American College of Cardiology. 60, 1, p. 82-83 2 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Use of impella ventricular assist device in patients with severe coronary artery disease presenting with cardiac arrest

Mukku, V., Cai, Q., Gilani, S., Fujise, K. & Barbagelata, A., Sep 2012, In : International Journal of Angiology. 21, 3, p. 163-166 4 p.

Research output: Contribution to journalArticle

Heart-Assist Devices
Heart Arrest
Coronary Artery Disease
Cardiogenic Shock
Heart Failure

Very late development of coronary artery aneurysm with total occlusion following sirolimus-eluting stent implantation

Mukku, V. K., Cai, Q., Barbagelata, A., Conti, V. & Fujise, K., Nov 2012, In : International Journal of Angiology. 21, 4, p. 229-231 3 p.

Research output: Contribution to journalArticle

Coronary Aneurysm
Sirolimus
Stents
Coronary Vessels
Aneurysm
2011
18 Citations (Scopus)

Cardiac allograft vasculopathy: Advances in diagnosis

Cai, Q., Rangasetty, U., Barbagelata, A., Fujise, K. & Koerner, M. M., Jan 2011, In : Cardiology in Review. 19, 1, p. 30-35 6 p.

Research output: Contribution to journalArticle

Allografts
Tunica Intima
Angiography
Stress Echocardiography
Coronary Angiography
5 Citations (Scopus)

Congenital coronary artery fistula presenting later in life

Abusaid, G. H., Hughes, D., Khalife, W., Parto, P., Gilani, S. & Fujise, K., Aug 2011, In : Journal of Cardiology Cases. 4, 1

Research output: Contribution to journalArticle

Fistula
Coronary Vessels
Coronary Sinus
Left Ventricular Dysfunction
Cardiac Catheterization
18 Citations (Scopus)

Heart protection by combination therapy with esmolol and milrinone at late-ischemia and early reperfusion

Huang, M. H., Wu, Y., Nguyen, V., Rastogi, S., McConnell, B. K., Wijaya, C., Uretsky, B. F., Poh, K. K., Tan, H. C. & Fujise, K., Jun 2011, In : Cardiovascular Drugs and Therapy. 25, 3, p. 223-232 10 p.

Research output: Contribution to journalArticle

Milrinone
Reperfusion
Ischemia
Therapeutics
Muscle Cells
22 Citations (Scopus)
Nutrition Surveys
Cardiovascular Diseases
Papillomavirus Infections
DNA
Odds Ratio
23 Citations (Scopus)

Morelloflavone from Garcinia dulcis as a novel biflavonoid inhibitor of HMG-CoA reductase

Tuansulong, K. A., Hutadilok-Towatana, N., Mahabusarakam, W., Pinkaew, D. & Fujise, K., Mar 2011, In : Phytotherapy Research. 25, 3, p. 424-428 5 p.

Research output: Contribution to journalArticle

Biflavonoids
Garcinia
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Hydroxymethylglutaryl CoA Reductases
NADP
23 Citations (Scopus)

Physical and functional antagonism between tumor suppressor protein p53 and fortilin, an anti-apoptotic protein

Chen, Y., Fujita, T., Zhang, D., Doan, H., Pinkaew, D., Liu, Z., Wu, J., Koide, Y., Chiu, A., Lin, C. C. J., Chang, J. Y., Ruan, K. H. & Fujise, K., Sep 16 2011, In : Journal of Biological Chemistry. 286, 37, p. 32575-32585 11 p.

Research output: Contribution to journalArticle

Tumor Suppressor Protein p53
Apoptosis Regulatory Proteins
Apoptosis
Tumors
Neoplasms
2010
2 Citations (Scopus)

Anti-apoptotic function of T-KTS+, T-KTS-, WT1+/+ and WT1+/- isoforms in breast cancer

Graidist, P., Nawakhanitworakul, R., Saekoo, J., Dechsukhum, C. & Fujise, K., Oct 2010, In : Asian Biomedicine. 4, 5, p. 711-720 10 p.

Research output: Contribution to journalArticle

Protein Isoforms
Breast Neoplasms
Caspase 7
Genes
Cells
1 Citation (Scopus)

Cardiac calcitonin gene-related peptide and left ventricular hypertrophy in the cardiac allograft

Huang, M. H., Lui, C. Y., Abusaid, G. H., Poh, K. K., Barbagelata, A. N., Uretsky, B. F. & Fujise, K., Apr 2010, In : Journal of Heart and Lung Transplantation. 29, 4, p. 487-488 2 p.

Research output: Contribution to journalArticle

Severity of Illness Index
Calcitonin Gene-Related Peptide
Homologous Transplantation
Graft Rejection
Left Ventricular Hypertrophy
2009
23 Citations (Scopus)

Embryonic lethality of fortilin-null mutant mice by BMP-pathway overactivation

Koide, Y., Kiyota, T., Tonganunt, M., Pinkaew, D., Liu, Z., Kato, Y., Hutadilok-Towatana, N., Phongdara, A. & Fujise, K., May 2009, In : Biochimica et Biophysica Acta - General Subjects. 1790, 5, p. 326-338 13 p.

Research output: Contribution to journalArticle

Fibroblasts
Embryonic Structures
Genes
DNA
Cell death
6 Citations (Scopus)

Management of hypertension in chronic heart failure

Manickavasagam, S., Merla, R., Koerner, M. M., Fujise, K., Kunapuli, S., Rosanio, S. & Barbagelata, A., Apr 2009, In : Expert Review of Cardiovascular Therapy. 7, 4, p. 423-433 11 p.

Research output: Contribution to journalArticle

Heart Failure
Hypertension
Antihypertensive Agents
Mortality
Left Ventricular Function
100 Citations (Scopus)

Morelloflavone, a biflavonoid, inhibits tumor angiogenesis by targeting Rho GTPases and extracellular signal-regulated kinase signaling pathways

Pang, X., Yi, T., Yi, Z., Cho, S. G., Qu, W., Pinkaew, D., Fujise, K. & Liu, M., Jan 15 2009, In : Cancer Research. 69, 2, p. 518-525 8 p.

Research output: Contribution to journalArticle

Biflavonoids
rho GTP-Binding Proteins
Extracellular Signal-Regulated MAP Kinases
Neoplasms
GTP Phosphohydrolases
22 Citations (Scopus)

Morelloflavone blocks injury-induced neointimal formation by inhibiting vascular smooth muscle cell migration

Pinkaew, D., Cho, S. G., Hui, D. Y., Wiktorowicz, J. E., Hutadilok-Towatana, N., Mahabusarakam, W., Tonganunt, M., Stafford, L. J., Phongdara, A., Liu, M. & Fujise, K., Jan 2009, In : Biochimica et Biophysica Acta - General Subjects. 1790, 1, p. 31-39 9 p.

Research output: Contribution to journalArticle

Vascular Smooth Muscle
Smooth Muscle Myocytes
Cell Movement
Muscle
Cells
28 Citations (Scopus)

Reducing ischaemia/reperfusion injury through δ-opioid-regulated intrinsic cardiac adrenergic cells: Adrenopeptidergic co-signalling

Huang, M. H., Nguyen, V., Wu, Y., Rastogi, S., Lui, C. Y., Birnbaum, Y., Wang, H. Q., Ware, D. L., Chauhan, M., Garg, N., Poh, K. K., Ye, L., Omar, A. R., Tan, H. C., Uretsky, B. F. & Fujise, K., 2009, In : Cardiovascular Research. 84, 3, p. 452-460 9 p.

Research output: Contribution to journalArticle

Calcitonin Gene-Related Peptide
D-Penicillamine (2,5)-Enkephalin
Reperfusion Injury
Adrenergic Agents
Opioid Analgesics
2008
34 Citations (Scopus)

Human fortilin is a molecular target of dihydroartemisinin

Fujita, T., Felix, K., Pinkaew, D., Hutadilok-Towatana, N., Liu, Z. & Fujise, K., Apr 2 2008, In : FEBS Letters. 582, 7, p. 1055-1060 6 p.

Research output: Contribution to journalArticle

dihydroartemisinin
Proteasome Endopeptidase Complex
Derivatives
Molecules
DNA
19 Citations (Scopus)

The critical role of the intrinsic VSMC proliferation and death programs in injury-induced neointimal hyperplasia

Mnjoyan, Z. H., Doan, D., Brandon, J. L., Felix, K., Sitter, C. L., Rege, A. A., Brock, T. A. & Fujise, K., May 2008, In : American Journal of Physiology - Heart and Circulatory Physiology. 294, 5

Research output: Contribution to journalArticle

Vascular Smooth Muscle
Smooth Muscle Myocytes
Hyperplasia
Cell Death
Carotid Arteries
2007
51 Citations (Scopus)

Fortilin binds Ca2+ and blocks Ca2+-dependent apoptosis in vivo

Graidist, P., Yazawa, M., Tonganunt, M., Nakatomi, A., Lin, C. C. J., Chang, J. Y., Phongdara, A. & Fujise, K., Dec 1 2007, In : Biochemical Journal. 408, 2, p. 181-191 11 p.

Research output: Contribution to journalArticle

Apoptosis
Thapsigargin
Assays
Amino Acids
Biochemistry
16 Citations (Scopus)

Pre-Hospital Reduced-Dose Fibrinolysis Coupled With Urgent Percutaneous Coronary Intervention Reduces Time to Reperfusion and Improves Angiographic Perfusion Score Compared With Prehospital Fibrinolysis Alone or Primary Percutaneous Coronary Intervention. Results of the PATCAR Pilot Trial

Smalling, R. W., Giesler, G. M., Julapalli, V. R., Denktas, A. E., Sdringola, S. M., Vooletich, M. T., McCarthy, J. J., Bradley, R. N., Persse, D. E., Richter, B. K., Yagi, M., Fujise, K. & Anderson, H. V., Oct 16 2007, In : Journal of the American College of Cardiology. 50, 16, p. 1612-1614 3 p.

Research output: Contribution to journalArticle

Drug Dose Response Relationship
Coronary Circulation
Myocardial Reperfusion
Coronary Balloon Angioplasty
Fibrinolytic Agents
2006
33 Citations (Scopus)

Establishing a role for shrimp fortilin in preventing cell death

Graidist, P., Fujise, K., Wanna, W., Sritunyalucksana, K. & Phongdara, A., May 31 2006, In : Aquaculture. 255, 1-4, p. 157-164 8 p.

Research output: Contribution to journalArticle

cell death
virus
shrimp
White spot syndrome virus
apoptosis
2005
32 Citations (Scopus)

Identification and characterization of syntenin binding protein in the black tiger shrimp Penaeus monodon

Tonganunt, M., Phongdara, A., Chotigeat, W. & Fujise, K., Nov 4 2005, In : Journal of Biotechnology. 120, 2, p. 135-145 11 p.

Research output: Contribution to journalArticle

Syntenins
Penaeidae
Tigers
Viruses
Macroglobulins
6 Citations (Scopus)

Restenosis: Emerging molecular targets: Going beyond drug-eluting stents

Chen, X. & Fujise, K., 2005, In : Drug Discovery Today: Disease Mechanisms. 2, 1, p. 1-9 9 p.

Research output: Contribution to journalArticle

Drug-Eluting Stents
Percutaneous Coronary Intervention
Vascular Smooth Muscle
Smooth Muscle Myocytes
Coronary Artery Disease
5 Citations (Scopus)

Resveratrol as cardioprotective agent: Evidence from bench and bedside

Burjonroppa, S. & Fujise, K., Jan 1 2005, Resveratrol in Health and Disease. CRC Press, p. 539-556 18 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Cardiotonic Agents
Atherosclerosis
Coronary Artery Disease
Morbidity
Mortality
2004
48 Citations (Scopus)

Antiapoptotic protein partners fortilin and MCL1 independently protect cells from 5-fluorouracil-induced cytotoxicity

Graidist, P., Phongdara, A. & Fujise, K., Sep 24 2004, In : Journal of Biological Chemistry. 279, 39, p. 40868-40875 8 p.

Research output: Contribution to journalArticle

Cytotoxicity
Fluorouracil
Small Interfering RNA
Proteins
Cells
18 Citations (Scopus)

Vascular access site complications with the use of closure devices in patients treated with platelet glycoprotein IIb/IIIa inhibitors during rescue angioplasty

Boccalandro, F., Assali, A., Fujise, K., Smalling, R. W. & Sdringola, S., Nov 2004, In : Catheterization and Cardiovascular Interventions. 63, 3, p. 284-289 6 p.

Research output: Contribution to journalArticle

Integrin beta3
Platelet Glycoprotein GPIIb-IIIa Complex
Percutaneous Coronary Intervention
Angioplasty
Blood Vessels
2003
20 Citations (Scopus)

Adenoviral gene transfer of fortilin attenuates neointima formation through suppression of vascular smooth muscle cell proliferation and migration

Tulis, D. A., Mnjoyan, Z. H., Schiesser, R. L., Shelat, H. S., Evans, A. J., Zoldhelyi, P. & Fujise, K., Jan 7 2003, In : Circulation. 107, 1, p. 98-105 8 p.

Research output: Contribution to journalArticle

Neointima
Vascular Smooth Muscle
Adenoviridae
Smooth Muscle Myocytes
Cell Movement
46 Citations (Scopus)

Outcome of access site in patients treated with platelet glycoprotein IIb/IIIa inhibitors in the era of closure devices

Assali, A. R., Sdringola, S., Moustapha, A., Ghani, M., Salloum, J., Schroth, G., Fujise, K., Anderson, H. V., Smalling, R. W. & Rosales, O. R., Jan 1 2003, In : Catheterization and Cardiovascular Interventions. 58, 1, p. 1-5 5 p.

Research output: Contribution to journalArticle

Integrin beta3
Platelet Glycoprotein GPIIb-IIIa Complex
Equipment and Supplies
Percutaneous Coronary Intervention
Blood Vessels
15 Citations (Scopus)

Paradoxical upregulation of tumor suppressor protein p53 in serum-stimulated vascular smooth muscle cells: A novel negative-feedback regulatory mechanism

Mnjoyan, Z. H., Dutta, R., Zhang, D., Teng, B. B. & Fujise, K., Jul 29 2003, In : Circulation. 108, 4, p. 464-471 8 p.

Research output: Contribution to journalArticle

Tumor Suppressor Protein p53
Vascular Smooth Muscle
Smooth Muscle Myocytes
Up-Regulation
Serum
54 Citations (Scopus)
Vascular Smooth Muscle
Smooth Muscle Myocytes
Muscle
Cells
Apoptosis
3 Citations (Scopus)

Rheolytic Thrombectomy Does Not Prevent Slow-, No-Reflow during Percutaneous Coronary Intervention in Acute Myocardial Infarction

Awadalla, H., Salloum, J., Moustapha, A., Assali, A., Sdringola, S., Fujise, K., Anderson, H. V., Rosales, O., Schroth, G. & Smalling, R. W., Jun 2003, In : International Journal of Angiology. 12, 3, p. 183-187 5 p.

Research output: Contribution to journalArticle

Thrombectomy
Percutaneous Coronary Intervention
Myocardial Infarction
No-Reflow Phenomenon
Catheters
2002
120 Citations (Scopus)

Physical and functional interaction between myeloid cell leukemia 1 protein (MCL1) and fortilin. The potential role of MCL1 as a fortilin chaperone

Zhang, D., Li, F., Weidner, D., Mnjoyan, Z. H. & Fujise, K., Oct 4 2002, In : Journal of Biological Chemistry. 277, 40, p. 37430-37438 9 p.

Research output: Contribution to journalArticle

Myeloid Leukemia
Myeloid Cells
Proteins
Apoptosis Regulatory Proteins
Small Interfering RNA
2001
1 Citation (Scopus)

CABG caveats

Sdringola, S., Assali, A. R., Ghani, M., Moustapha, A., Achour, H., Wamique Yusuf, S., Fujise, K., Rosales, O., Schroth, G. W., Vernon Anderson, H. & Smalling, R. W., 2001, In : Catheterization and Cardiovascular Interventions. 54, 3, p. 325-326 2 p.

Research output: Contribution to journalArticle

210 Citations (Scopus)

Characterization of Fortilin, a Novel Antiapoptotic Protein

Li, F., Zhang, D. & Fujise, K., Dec 14 2001, In : Journal of Biological Chemistry. 276, 50, p. 47542-47549 8 p.

Research output: Contribution to journalArticle

Cells
Apoptosis
Inhibitor of Apoptosis Proteins
Etoposide
Cell death