Kota Ramana, PhD, MS

  • 3942 Citations
  • 36 h-Index
19962020
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Research Output 1996 2019

2019

Aldose reductase regulates hyperglycemia-induced huvec death via SIRT1/AMPK-α1/mTOR pathway

Pal, P. B., Sonowal, H., Shukla, K., Srivastava, S. K. & Ramana, K., Jan 1 2019, In : Journal of Molecular Endocrinology. 63, 1, p. 11-25 15 p.

Research output: Contribution to journalArticle

Aldehyde Reductase
AMP-Activated Protein Kinases
Human Umbilical Vein Endothelial Cells
Hyperglycemia
Glucose
2 Citations (Scopus)

Didymin by suppressing NF-κB activation prevents VEGF-induced angiogenesis in vitro and in vivo

Shukla, K., Sonowal, H., Saxena, A. & Ramana, K., Jan 1 2019, (Accepted/In press) In : Vascular Pharmacology.

Research output: Contribution to journalArticle

Vascular Endothelial Growth Factor A
Human Umbilical Vein Endothelial Cells
Neoplasms
E-Selectin
Vascular Cell Adhesion Molecule-1

Endotoxin-induced uveitis in rodents

Yadav, U. C. S. & Ramana, K., Jan 1 2019, Methods in Molecular Biology. Humana Press Inc., p. 161-168 8 p. (Methods in Molecular Biology; vol. 1960).

Research output: Chapter in Book/Report/Conference proceedingChapter

Uveitis
Endotoxins
Rodentia
Inflammation
Exudates and Transudates
Hypoxia-Inducible Factor 1
Aldehyde Reductase
Proteasome Endopeptidase Complex
Colonic Neoplasms
Vascular Endothelial Growth Factor A
Aldehyde Reductase
Macrophages
Lipopolysaccharides
2018
2 Citations (Scopus)

Aldose reductase inhibitor, fidarestat prevents doxorubicin-induced endothelial cell death and dysfunction

Sonowal, H., Pal, P., Shukla, K., Saxena, A., Srivastava, S. K. & Ramana, K., Apr 1 2018, In : Biochemical Pharmacology. 150, p. 181-190 10 p.

Research output: Contribution to journalArticle

Aldehyde Reductase
Endothelial cells
Cell death
Doxorubicin
Cell Death

Aldose reductase inhibitor, fidarestat prevents high-fat diet-induced intestinal polyps in APCmin/+ mice

Saxena, A., Tammali, R., Ramana, K. & Srivastava, S., Jan 1 2018, In : Current Cancer Drug Targets. 18, 9, p. 905-911 7 p.

Research output: Contribution to journalArticle

Intestinal Polyps
Aldehyde Reductase
High Fat Diet
Large Intestine
Polyps
9 Citations (Scopus)

Didymin prevents hyperglycemia-induced human umbilical endothelial cells dysfunction and death

Shukla, K., Sonowal, H., Saxena, A. & Ramana, K., Jun 1 2018, In : Biochemical Pharmacology. 152, p. 1-10 10 p.

Research output: Contribution to journalArticle

Umbilicus
Endothelial cells
Hyperglycemia
Cell Death
Endothelial Cells
3 Citations (Scopus)

Therapeutic Potential of Natural Antioxidants

Ramana, K., Reddy, A. B. M., Majeti, N. V. R. K. & Singhal, S. S., Jan 1 2018, In : Oxidative Medicine and Cellular Longevity. 2018, 1 p.

Research output: Contribution to journalEditorial

Oxidative stress
Plant Extracts
Medicinal Plants
Biological Products
Cardiomyopathies
1 Citation (Scopus)

Vialinin A, an Edible Mushroom-Derived p-Terphenyl Antioxidant, Prevents VEGF-Induced Neovascularization in Vitro and in Vivo

Sonowal, H., Shukla, K., Kota, S., Saxena, A. & Ramana, K., Jan 1 2018, In : Oxidative Medicine and Cellular Longevity. 2018, 1052102.

Research output: Contribution to journalArticle

Agaricales
Vascular Endothelial Growth Factor A
Antioxidants
Umbilicus
Endothelial cells
2017
10 Citations (Scopus)

Aldose reductase inhibitor, fidarestat regulates mitochondrial biogenesis via Nrf2/HO-1/AMPK pathway in colon cancer cells

Shukla, K., Sonowal, H., Saxena, A., Ramana, K. & Srivastava, S., Dec 28 2017, In : Cancer Letters. 411, p. 57-63 7 p.

Research output: Contribution to journalArticle

Aldehyde Reductase
AMP-Activated Protein Kinases
Organelle Biogenesis
Colonic Neoplasms
Epidermal Growth Factor
13 Citations (Scopus)

Aldose reductase inhibitor increases doxorubicin-sensitivity of colon cancer cells and decreases cardiotoxicity

Sonowal, H., Pal, P. B., Wen, J. J., Awasthi, S., Ramana, K. & Srivastava, S., Dec 1 2017, In : Scientific Reports. 7, 1, 3182.

Research output: Contribution to journalArticle

Aldehyde Reductase
Doxorubicin
Colonic Neoplasms
Colorectal Neoplasms
Anthracyclines
2 Citations (Scopus)

Aldose Reductase Inhibitor Protects against Hyperglycemic Stress by Activating Nrf2-Dependent Antioxidant Proteins

Shukla, K., Pal, P. B., Sonowal, H., Srivastava, S. & Ramana, K., 2017, In : Journal of Diabetes Research. 2017, 6785852.

Research output: Contribution to journalArticle

Aldehyde Reductase
Antioxidants
Monocytes
Proteins
Heme Oxygenase-1
5 Citations (Scopus)

Aldose reductase mediates NLRP3 inflammasome-initiated innate immune response in hyperglycemia-induced thp1 monocytes and male mice

Pal, P. B., Sonowal, H., Shukla, K., Srivastava, S. & Ramana, K., Oct 1 2017, In : Endocrinology. 158, 10, p. 3661-3675 15 p.

Research output: Contribution to journalArticle

Inflammasomes
Aldehyde Reductase
Innate Immunity
Hyperglycemia
Monocytes
2 Citations (Scopus)

Applications of Antioxidants in Ameliorating Drugs and Xenobiotics Toxicity: Mechanistic Approach

Abdel-Daim, M. M., Moustafa, Y. M., Umezawa, M., Ramana, K. & Azzini, E., 2017, In : Oxidative Medicine and Cellular Longevity. 2017, 4565127.

Research output: Contribution to journalEditorial

6 Citations (Scopus)
Endothelial cells
Vascular Endothelial Growth Factor A
Lipid Peroxidation
Endothelial Cells
Lipids
4 Citations (Scopus)

Lipid Peroxidation Products in Human Health and Disease 2016

Ramana, K., Srivastava, S. & Singhal, S. S., 2017, In : Oxidative Medicine and Cellular Longevity. 2017, 2163285.

Research output: Contribution to journalEditorial

Lipid Peroxidation
Oxidative Stress
Health
2016

Corrigendum to "Aldose reductase inhibition suppresses oxidative stress-induced inflammatory disorders" [Chem. Biol. Interact. (2011) 330-338]

Srivastava, S., Yadav, U. C. S., Reddy, A. B. M., Mishra, R., Saxena, A., Tammali, R., Shoeb, M., Ansari, N., Bhatnagar, A., Petrash, M. J., Srivastava, S. & Ramana, K., 2016, (Accepted/In press) In : Chemico-Biological Interactions.

Research output: Contribution to journalArticle

Endotoxins
Inflammation
Research
3,3',4,5'-tetrahydroxystilbene

Immune, Inflammatory, and Oxidative Responses in Cardiovascular Complications

Ramana, K., Srivastava, S. & Reddy, A. B. M., 2016, In : Oxidative Medicine and Cellular Longevity. 2016, 6858402.

Research output: Contribution to journalEditorial

Cardiotonic Agents
Cardiac Myocytes
Oxidative Stress
Cardiovascular Diseases
Biomarkers
15 Citations (Scopus)

Regulatory roles of glutathione-S-transferases and 4-hydroxynonenal in stress-mediated signaling and toxicity

Awasthi, Y. C., Ramana, K., Chaudhary, P., Srivastava, S. & Awasthi, S., Sep 15 2016, (Accepted/In press) In : Free Radical Biology and Medicine.

Research output: Contribution to journalArticle

Glutathione Transferase
Toxicity
Oxidative stress
Oxidative Stress
Modulation
2014
53 Citations (Scopus)

4-hydroxynonenal in the pathogenesis and progression of human diseases

Shoeb, M., Ansari, N., Srivastava, S. & Ramana, K., Jan 2014, In : Current Medicinal Chemistry. 21, 2, p. 230-237 8 p.

Research output: Contribution to journalArticle

Disease Progression
Oxidative stress
Poisons
Lipid Peroxidation
Oxidative Stress
8 Citations (Scopus)

Aldose reductase inhibition suppresses azoxymethane-induced colonic premalignant lesions in C57BL/KsJ-db/db mice

Saxena, A., Shoeb, M., Tammali, R., Ramana, K. & Srivastava, S., Dec 1 2014, In : Cancer Letters. 355, 1, p. 141-147 7 p.

Research output: Contribution to journalArticle

Azoxymethane
Aldehyde Reductase
Obese Mice
Colonic Neoplasms
Obesity
6 Citations (Scopus)

Lipid peroxidation products in human health and disease 2014

Ramana, K. V., Srivastava, S. & Singhal, S. S., 2014, In : Oxidative Medicine and Cellular Longevity. 2014, p. 162414 1 p.

Research output: Contribution to journalArticle

Animals
Health
Lipids
6 Citations (Scopus)

Lipid peroxidation products in human health and disease 2014.

Ramana, K. V., Sanjay, S. & Sharad, S. S., Sep 14 2014, In : Oxidative Medicine and Cellular Longivity.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Therapeutic potential of natural pharmacological agents in the treatment of human diseases

Ramana, K., Singhal, S. S. & Reddy, A. B., Dec 28 2014, In : BioMed Research International. 2014, 573452.

Research output: Contribution to journalArticle

Pharmacognosy
Traditional Medicine
Pharmacology
Therapeutics
2013

Aldose Reductase: A Potential Drug Target for the Treatment of Sepsis Complications.

Mohammad, S. & Ramana, K. V., 2013, In : J Biochem Pharm Res. 1, p. 168-175

Research output: Contribution to journalArticle

18 Citations (Scopus)
TNF-Related Apoptosis-Inducing Ligand
Aldehyde Reductase
Death Domain Receptors
Colonic Neoplasms
Up-Regulation
27 Citations (Scopus)

Aldose Reductase Inhibition Prevents Allergic Airway Remodeling through PI3K/AKT/GSK3β Pathway in Mice

Yadav, U. C. S., Naura, A. S., Aguilera-Aguirre, L., Boldogh, I., Boulares, H. A., Calhoun, W., Ramana, K. & Srivastava, S., Feb 27 2013, In : PLoS One. 8, 2, e57442.

Research output: Contribution to journalArticle

aldehyde reductase
Airway Remodeling
Aldehyde Reductase
phosphatidylinositol 3-kinase
Phosphatidylinositol 3-Kinases
20 Citations (Scopus)

Aldose reductase inhibition prevents colon cancer growth by restoring phosphatase and tensin homolog through modulation of miR-21 and FOXO3a

Saxena, A., Tammali, R., Ramana, K. & Srivastava, S., Apr 10 2013, In : Antioxidants and Redox Signaling. 18, 11, p. 1249-1262 14 p.

Research output: Contribution to journalArticle

Aldehyde Reductase
Phosphoric Monoester Hydrolases
Colonic Neoplasms
Modulation
Acids
20 Citations (Scopus)

Aldose reductase inhibition suppresses colon cancer cell viability by modulating microRNA-21 mediated programmed cell death 4 (PDCD4) expression

Saxena, A., Shoeb, M., Ramana, K. & Srivastava, S., Oct 2013, In : European Journal of Cancer. 49, 15, p. 3311-3319 9 p.

Research output: Contribution to journalArticle

Aldehyde Reductase
MicroRNAs
Colonic Neoplasms
Cell Survival
Cell Death
12 Citations (Scopus)

Aldose reductase regulates acrolein-induced cytotoxicity in human small airway epithelial cells

Yadav, U. C. S., Ramana, K. & Srivastava, S., 2013, In : Free Radical Biology and Medicine. 65, p. 15-25 11 p.

Research output: Contribution to journalArticle

Acrolein
Aldehyde Reductase
Cytotoxicity
Epithelial Cells
Mitochondria
7 Citations (Scopus)

Endotoxin-induced uveitis in rodents

Yadav, U. C. S. & Ramana, K., 2013, Methods in Molecular Biology. Vol. 1031. p. 155-162 8 p. (Methods in Molecular Biology; vol. 1031).

Research output: Chapter in Book/Report/Conference proceedingChapter

Uveitis
Endotoxins
Rodentia
Inflammation
Anterior Chamber
22 Citations (Scopus)

Lipid peroxidation products in human health and disease

Ramana, K., Srivastava, S. & Singhal, S. S., 2013, In : Oxidative Medicine and Cellular Longevity. 583438.

Research output: Contribution to journalArticle

Oxidative stress
Malondialdehyde
Aldehydes
Rats
Animals
10 Citations (Scopus)

Piceatannol suppresses endotoxin-induced ocular inflammation in rats

Kalariya, N. M., Shoeb, M., Reddy, A. B. M., Sawhney, R. & Ramana, K., 2013, In : International Immunopharmacology. 17, 2, p. 439-446 8 p.

Research output: Contribution to journalArticle

Endotoxins
Inflammation
Uveitis
Anti-Inflammatory Agents
Nitric Oxide Synthase Type II
6 Citations (Scopus)

Prevention of allergic rhinitis by aldose reductase inhibition in a murine model.

Yadav, U. C. S., Mishra, R., Aguilera-Aguirre, L., Sur, S., Bolodgh, I., Ramana, K. & Srivatsava, S. K., Jun 2013, In : Inflammation & allergy drug targets. 12, 3, p. 178-186 9 p.

Research output: Contribution to journalArticle

Aldehyde Reductase
Nose
Cell Degranulation
Tryptases
Cytokines
71 Citations (Scopus)
Aldehydes
Lipid Peroxidation
Lipids
Oxidation-Reduction
Poisons
2012
27 Citations (Scopus)

Antidiabetic drug metformin suppresses endotoxin-induced uveitis in rats

Kalariya, N. M., Shoeb, M., Ansari, N., Srivastava, S. & Ramana, K., Jun 2012, In : Investigative Ophthalmology and Visual Science. 53, 7, p. 3431-3440 10 p.

Research output: Contribution to journalArticle

Metformin
Uveitis
Hypoglycemic Agents
Endotoxins
AMP-Activated Protein Kinases
25 Citations (Scopus)
Macrophages
Arachidonic Acid
Anti-Inflammatory Agents
Lipopolysaccharides
Epoprostenol
23 Citations (Scopus)

A potential therapeutic role for aldose reductase inhibitors in the treatment of endotoxin-related inflammatory diseases

Pandey, S., Srivastava, S. & Ramana, K., Mar 2012, In : Expert Opinion on Investigational Drugs. 21, 3, p. 329-339 11 p.

Research output: Contribution to journalArticle

Aldehyde Reductase
Endotoxins
Diabetes Complications
Therapeutics
Endotoxemia
4 Citations (Scopus)

Focus on Molecules: Lutein

Kalariya, N. M., Ramana, K. & vanKuijk, F. J. G. M., Sep 2012, In : Experimental Eye Research. 102, p. 107-108 2 p.

Research output: Contribution to journalArticle

Lutein
Macular Degeneration
Retina

How Does Oxidative Stress Affect Inflammasome Activation?

Mohammad, S. & Ramana, K. V., 2012, In : J Clin Cell Immunol. 3, p. 107

Research output: Contribution to journalArticle

20 Citations (Scopus)

Prevention of VEGF-induced growth and tube formation in human retinal endothelial cells by aldose reductase inhibition

Yadav, U. C. S., Srivastava, S. & Ramana, K., Sep 2012, In : Journal of Diabetes and its Complications. 26, 5, p. 369-377 9 p.

Research output: Contribution to journalArticle

Aldehyde Reductase
Vascular Endothelial Growth Factor A
Endothelial Cells
Growth
p38 Mitogen-Activated Protein Kinases

What is the role of 4-hydroxynonenal in inflammation?

Ramana, K. V., 2012, In : Biochem AnaBiochem. 1

Research output: Contribution to journalArticle

2011
81 Citations (Scopus)

Aldose reductase: New insights for an old enzyme

Ramana, K. V., Apr 1 2011, In : Biomolecular Concepts. 2, 1-2, p. 103-114 12 p.

Research output: Contribution to journalArticle

Aldehyde Reductase
Oxidative stress
Diabetes Complications
Aldehydes
Chemical activation
81 Citations (Scopus)

Aldose reductase: New insights for an old enzyme

Ramana, K. V., 2011, In : Biomol Concepts. 2, p. 103-114

Research output: Contribution to journalArticle

7 Citations (Scopus)

Aldose reductase deficiency in mice protects from ragweed pollen extract (RWE)-induced allergic asthma

Yadav, U. C. S., Aguilera-Aguirre, L., Boldogh, I., Ramana, K. & Srivastava, S., Nov 3 2011, In : Respiratory Research. 12, 145.

Research output: Contribution to journalArticle

Aldehyde Reductase
Asthma
Respiratory Hypersensitivity
Eosinophils
Therapeutic Irrigation
18 Citations (Scopus)

Aldose reductase deficiency protects from autoimmune- and endotoxin-induced uveitis in mice

Yadav, U. C. S., Shoeb, M., Srivastava, S. & Ramana, K., Oct 2011, In : Investigative Ophthalmology and Visual Science. 52, 11, p. 8076-8085 10 p.

Research output: Contribution to journalArticle

Aldehyde Reductase
Uveitis
Endotoxins
T-Lymphocytes
Chemokines