Kota Ramana, PhD, MS

  • 4106 Citations
  • 36 h-Index
19962021

Research output per year

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Research Output

Methods for Treating COPD

Ramana, K. V., 1800, Patent No. US 8785483B2

Research output: Patent

Methods involving aldose reductase inhibitors

Ramana, K. V., 1800, Patent No. US 8273746

Research output: Patent

1996

Induction of hepatic cytochrome P450 by phenobarbitone in rhesus monkey (Macaca mulatta)

Ramana, K. V. & Kohli, K. K., Jan 1 1996, In : Drug and Chemical Toxicology. 19, 1-2, p. 97-107 11 p.

Research output: Contribution to journalArticle

5 Scopus citations
1998

Differential effects of phenobarbitone on the hepatic and renal glutathione-S-transferases in the rhesus monkey

Ramana, K. V. & Kohli, K. K., Feb 1 1998, In : Indian Journal of Pharmacology. 30, 1, p. 34-37 4 p.

Research output: Contribution to journalArticle

3 Scopus citations

Gene regulation of cytochrome P450 - An overview

Ramana, K. V. & Kohli, K. K., May 1 1998, In : Indian Journal of Experimental Biology. 36, 5, p. 437-446 10 p.

Research output: Contribution to journalReview article

14 Scopus citations
1999
2 Scopus citations

Purification and characterization of the hepatic CYP2C and 3A isozymes from phenobarbitone pretreated rhesus monkey

Ramana, K. V. & Kohli, K. K., Sep 11 1999, In : Molecular and Cellular Biochemistry. 198, 1-2, p. 79-88 10 p.

Research output: Contribution to journalArticle

6 Scopus citations
2000

Kinetic and structural characterization of the glutathione-binding site of aldose reductase

Dixit, B. L., Balendiran, G. K., Watowich, S. J., Srivastava, S., Ramana, K. V., Petrash, J. M., Bhatnagar, A. & Srivastava, S. K., Jul 14 2000, In : Journal of Biological Chemistry. 275, 28, p. 21587-21595 9 p.

Research output: Contribution to journalArticle

76 Scopus citations

Selective recognition of glutathiolated aldehydes by aldose reductase

Ramana, K. V., Dixit, B. L., Srivastava, S., Balendiran, G. K., Srivastava, S. K. & Bhatnagar, A., Oct 10 2000, In : Biochemistry. 39, 40, p. 12172-12180 9 p.

Research output: Contribution to journalArticle

86 Scopus citations
2001

Characterization of the glutathione binding site of aldose reductase

Ramana, K. V., Dixit, B. L., Srivastava, S., Bhatnagar, A., Balendiran, G. K., Watowich, S. J., Petrash, J. M. & Srivastava, S. K., Jan 30 2001, In : Chemico-Biological Interactions. 130-132, p. 537-548 12 p.

Research output: Contribution to journalArticle

18 Scopus citations

Metabolic regulation of aldose reductase activity by nitric oxide donors

Dixit, B. L., Ramana, K. V., Chandra, D., Jackson, E. B., Srivastava, S., Bhatnagar, A. & Srivastava, S. K., Jan 30 2001, In : Chemico-Biological Interactions. 130-132, p. 573-581 9 p.

Research output: Contribution to journalArticle

8 Scopus citations

Structural and kinetic modifications of aldose reductase by S-nitrosothiols

Srivastava, S., Dixit, B. L., Ramana, K. V., Chandra, A., Chandra, D., Zacarias, A., Petrash, J. M., Bhatnagar, A. & Srivastava, S. K., Aug 15 2001, In : Biochemical Journal. 358, 1, p. 111-118 8 p.

Research output: Contribution to journalArticle

32 Scopus citations
2002

Aldose reductase mediates mitogenic signaling in vascular smooth muscle cells

Ramana, K. V., Chandra, D., Srivastava, S., Bhatnagar, A., Aggarwal, B. B. & Srivastava, S. K., Aug 30 2002, In : Journal of Biological Chemistry. 277, 35, p. 32063-32070 8 p.

Research output: Contribution to journalArticle

99 Scopus citations

Estimation of oxygen free radicals and nonenzymatic antioxidants in living-related donor kidney transplantation

Minz, M., Ramana, K. V., Sakhuja, V. K. & Ganguly, N. K., Sep 1 2002, In : Transplantation proceedings. 34, 6, 1 p.

Research output: Contribution to journalArticle

1 Scopus citations

Inhibition of fiber cell globulization and hyperglycemia-induced lens opacification by aminopeptidase inhibitor bestatin

Chandra, D., Ramana, K. V., Wang, L., Christensen, B. N., Bhatnagar, A. & Srivastava, S. K., Jul 9 2002, In : Investigative Ophthalmology and Visual Science. 43, 7, p. 2285-2292 8 p.

Research output: Contribution to journalArticle

39 Scopus citations

Nitric oxide prevents aldose reductase activation and sorbitol accumulation during diabetes

Chandra, D., Jackson, E. B., Ramana, K. V., Kelley, R., Srivastava, S. K. & Bhatnagar, A., Oct 1 2002, In : Diabetes. 51, 10, p. 3095-3101 7 p.

Research output: Contribution to journalArticle

Open Access
60 Scopus citations
2003

Aldose reductase and the stress response

Bhatnagar, A., Liu, S. Q., Srivastava, S., Ramana, K. V. & Srivastava, S. K., Dec 1 2003, In : ACS Symposium Series. 865, p. 199-210 12 p.

Research output: Contribution to journalArticle

1 Scopus citations

Aldose reductase detoxifies lipid aldehydes and their glutathione conjugates

Srivastava, S. K., Ramana, K. V., Srivastava, S. & Bhatnagar, A., Dec 1 2003, In : ACS Symposium Series. 865, p. 37-48 12 p.

Research output: Contribution to journalArticle

2 Scopus citations
80 Scopus citations

Aldose reductase mediates the mitogenic signals of cytokines

Ramana, K. V., Chandra, D., Srivastava, S., Bhatnagar, A. & Srivastava, S. K., Feb 1 2003, In : Chemico-Biological Interactions. 143-144, p. 587-596 10 p.

Research output: Contribution to journalArticle

21 Scopus citations

Aldose reductase regulates reactive oxygen species mediated-inflammatory signals

Ramana, K. V., Chandra, D., Srivastava, S., Bhatnagar, A., Aggarwal, B. B. & Srivastava, S. K., Dec 1 2003, In : ACS Symposium Series. 865, p. 213-223 11 p.

Research output: Contribution to journalArticle

Nitric oxide regulates the polyol pathway of glucose metabolism in vascular smooth muscle cells

Ramana, K. V., Chandra, D., Srivastava, S., Bhatnagar, A. & Srivastava, S. K., Mar 1 2003, In : FASEB Journal. 17, 3, p. 417-425 9 p.

Research output: Contribution to journalArticle

43 Scopus citations

Regulation of aldose reductase and the polyol pathway activity by nitric oxide

Srivastava, S. K., Ramana, K. V., Chandra, D., Srivastava, S. & Bhatnagar, A., Feb 1 2003, In : Chemico-Biological Interactions. 143-144, p. 333-340 8 p.

Research output: Contribution to journalArticle

27 Scopus citations

Role of aldose reductase in the detoxification of oxidized phospholipids

Srivastava, S., Ramana, K. V., Srivastava, S. K., D'Souza, S. E. & Bhatnagar, A., Dec 1 2003, In : ACS Symposium Series. 865, p. 49-64 16 p.

Research output: Contribution to journalArticle

2 Scopus citations

Role of aldose reductase in TNF-α-induced apoptosis of vascular endothelial cells

Chandra, D., Ramana, K. V., Friedrich, B., Srivastava, S., Bhatnagar, A. & Srivastava, S. K., Feb 1 2003, In : Chemico-Biological Interactions. 143-144, p. 605-612 8 p.

Research output: Contribution to journalArticle

15 Scopus citations
2004

Activation of nulcear factor-κB by hyperglycemia in vascular smooth muscle cells is regulated by aldose reductase

Ramana, K. V., Friedrich, B., Srivastava, S., Bhatnagar, A. & Srivastava, S. K., Nov 1 2004, In : Diabetes. 53, 11, p. 2910-2920 11 p.

Research output: Contribution to journalArticle

131 Scopus citations

Aldose reductase regulates TNF-α-induced cell signaling and apoptosis in vascular endothelial cells

Ramana, K. V., Bhatnagar, A. & Srivastava, S. K., Jul 16 2004, In : FEBS Letters. 570, 1-3, p. 189-194 6 p.

Research output: Contribution to journalArticle

40 Scopus citations

Inhibition of aldose reductase attenuates TNF-α-induced expression of adhesion molecules in endothelial cells

Ramana, K. V., Bhatnagar, A. & Srivastava, S. K., Aug 1 2004, In : FASEB Journal. 18, 11, p. 1209-1218 10 p.

Research output: Contribution to journalArticle

68 Scopus citations

Oxidative stress-induced up-regulation of the chloride channel and Na +/Ca2+ exchanger during cataractogenesis in diabetic rats

Ramana, K. V., Chandra, D., Wills, N. K., Bhatnagar, A. & Srivastava, S. K., May 1 2004, In : Journal of Diabetes and Its Complications. 18, 3, p. 177-182 6 p.

Research output: Contribution to journalArticle

15 Scopus citations
2005

Regulation of lens aldose reductase activity by nitric oxide

Srivastava, S., Tammali, R., Chandra, D., Greer, D. A., Ramana, K. V., Bhatnagar, A. & Srivastava, S. K., Dec 1 2005, In : Experimental Eye Research. 81, 6, p. 664-672 9 p.

Research output: Contribution to journalArticle

6 Scopus citations

Requirement of aldose reductase for the hyperglycemic activation of protein kinase C and formation of diacylglycerol in vascular smooth muscle cells

Ramana, K. V., Friedrich, B., Tammali, R., West, M. B., Bhatnagar, A. & Srivastava, S. K., Mar 1 2005, In : Diabetes. 54, 3, p. 818-829 12 p.

Research output: Contribution to journalArticle

97 Scopus citations

Role of aldose reductase and oxidative damage in diabetes and the consequent potential for therapeutic options

Srivastava, S. K., Ramana, K. V. & Bhatnagar, A., May 1 2005, In : Endocrine Reviews. 26, 3, p. 380-392 13 p.

Research output: Contribution to journalReview article

356 Scopus citations
2006

Aldose reductase mediates the lipopolysaccharide-induced release of inflammatory mediators in RAW264.7 murine macrophages

Ramana, K. V., Fadl, A. A., Tammali, R., Reddy, A. B. M., Chopra, A. K. & Srivastava, S. K., Nov 3 2006, In : Journal of Biological Chemistry. 281, 44, p. 33019-33029 11 p.

Research output: Contribution to journalArticle

114 Scopus citations

Aldose reductase prevents aldehyde toxicity in cultured human lens epithelial cells

Pladzyk, A., Ramana, K. V., Ansari, N. H. & Srivastava, S. K., Aug 1 2006, In : Experimental Eye Research. 83, 2, p. 408-416 9 p.

Research output: Contribution to journalArticle

17 Scopus citations

Aldose reductase regulates growth factor-induced cyclooxygenase-2 expression and prostaglandin E2 production in human colon cancer cells

Tammali, R., Ramana, K. V., Singhal, S. S., Awasthi, S. & Srivastava, S. K., Oct 1 2006, In : Cancer Research. 66, 19, p. 9705-9713 9 p.

Research output: Contribution to journalArticle

79 Scopus citations

Contribution of aldose reductase to diabetic hyperproliferation of vascular smooth muscle cells

Srivastava, S., Ramana, K. V., Tammali, R., Srivastava, S. K. & Bhatnagar, A., Jul 27 2006, In : Diabetes. 55, 4, p. 901-910 10 p.

Research output: Contribution to journalArticle

54 Scopus citations

Endotoxin-induced cardiomyopathy and systemic inflammation in mice is prevented by aldose reductase inhibition

Ramana, K. V., Willis, M. S., White, M. D., Horton, J. W., Dimaio, J. M., Srivastava, D., Bhatnagar, A. & Srivastava, S. K., Oct 1 2006, In : Circulation. 114, 17, p. 1838-1846 9 p.

Research output: Contribution to journalArticle

75 Scopus citations

Inhibition of aldose reductase prevents lipopolysaccharide-induced inflammatory response in human lens epithelial cells

Pladzyk, A., Reddy, A. B. M., Yadav, U. C. S., Tammali, R., Ramana, K. V. & Srivastava, S. K., Dec 1 2006, In : Investigative Ophthalmology and Visual Science. 47, 12, p. 5395-5403 9 p.

Research output: Contribution to journalArticle

34 Scopus citations

Mediation of aldose reductase in lipopolysaccharide-induced inflammatory signals in mouse peritoneal macrophages

Ramana, K. V. & Srivastava, S. K., Nov 1 2006, In : Cytokine. 36, 3-4, p. 115-122 8 p.

Research output: Contribution to journalArticle

48 Scopus citations

Mitogenic responses of vascular smooth muscle cells to lipid peroxidation-derived aldehyde 4-hydroxy-trans-2-nonenal (HNE): Role of aldose reductase-catalyzed reduction of the HNE-glutathione conjugates in regulating cell growth

Ramana, K. V., Bhatnagar, A., Srivastava, S., Yadav, U. C., Awasthi, S., Awasthi, Y. C. & Srivastava, S. K., Jun 30 2006, In : Journal of Biological Chemistry. 281, 26, p. 17652-17660 9 p.

Research output: Contribution to journalArticle

118 Scopus citations

Structure of a glutathione conjugate bound to the active site of aldose reductase

Singh, R., White, M. A., Ramana, K. V., Petrash, J. M., Watowich, S. J., Bhatnagar, A. & Srivastava, S. K., Jul 1 2006, In : Proteins: Structure, Function and Genetics. 64, 1, p. 101-110 10 p.

Research output: Contribution to journalArticle

29 Scopus citations
2007

Aldose reductase inhibition prevents endotoxin-induced uveitis in rats

Yadav, U. C. S., Srivastava, S. K. & Ramana, K. V., Oct 1 2007, In : Investigative Ophthalmology and Visual Science. 48, 10, p. 4634-4642 9 p.

Research output: Contribution to journalArticle

68 Scopus citations

Aldose reductase mediates endotoxin-induced production of nitric oxide and cytotoxicity in murine macrophages

Ramana, K. V., Reddy, A. B. M., Tammali, R. & Srivastava, S. K., Apr 15 2007, In : Free Radical Biology and Medicine. 42, 8, p. 1290-1302 13 p.

Research output: Contribution to journalArticle

45 Scopus citations

Aldose reductase-regulated tumor necrosis factor-α production is essential for high glucose-induced vascular smooth muscle cell growth

Ramana, K. V., Tammali, R., Reddy, A. B. M., Bhatnagar, A. & Srivastava, S. K., Sep 1 2007, In : Endocrinology. 148, 9, p. 4371-4384 14 p.

Research output: Contribution to journalArticle

41 Scopus citations

Aldose reductase regulates TNF-α-induced PGE2 production in human colon cancer cells

Tammali, R., Ramana, K. V. & Srivastava, S. K., Jul 18 2007, In : Cancer Letters. 252, 2, p. 299-306 8 p.

Research output: Contribution to journalArticle

48 Scopus citations
2008

Carotenoid derived aldehydes-induced oxidative stress causes apoptotic cell death in human retinal pigment epithelial cells

Kalariya, N. M., Ramana, K. V., Srivastava, S. K. & van Kuijk, F. J. G. M., Jan 1 2008, In : Experimental Eye Research. 86, 1, p. 70-80 11 p.

Research output: Contribution to journalArticle

58 Scopus citations

Glutathione level regulates HNE-induced genotoxicity in human erythroleukemia cells

Yadav, U. C. S., Ramana, K. V., Awasthi, Y. C. & Srivastava, S. K., Mar 1 2008, In : Toxicology and Applied Pharmacology. 227, 2, p. 257-264 8 p.

Research output: Contribution to journalArticle

46 Scopus citations