Kota Ramana, PhD, MS

  • 4106 Citations
  • 36 h-Index
19962021

Research output per year

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Research Output

4-hydroxynonenal in the pathogenesis and progression of human diseases

Shoeb, M., Ansari, N. H., Srivastava, S. K. & Ramana, K. V., Jan 1 2014, In : Current Medicinal Chemistry. 21, 2, p. 230-237 8 p.

Research output: Contribution to journalArticle

62 Scopus citations

4-Hydroxy-Trans-2-Nonenal in the Regulation of Anti-Oxidative and Pro-Inflammatory Signaling Pathways

Sonowal, H. & Ramana, K. V., Jan 1 2019, In : Oxidative medicine and cellular longevity. 2019, 5937326.

Research output: Contribution to journalReview article

Open Access

Activation of nulcear factor-κB by hyperglycemia in vascular smooth muscle cells is regulated by aldose reductase

Ramana, K. V., Friedrich, B., Srivastava, S., Bhatnagar, A. & Srivastava, S. K., Nov 1 2004, In : Diabetes. 53, 11, p. 2910-2920 11 p.

Research output: Contribution to journalArticle

131 Scopus citations

Aldose reductase: New insights for an old enzyme

Ramana, K. V., Apr 1 2011, In : Biomolecular Concepts. 2, 1-2, p. 103-114 12 p.

Research output: Contribution to journalReview article

88 Scopus citations

Aldose reductase: A novel therapeutic target for inflammatory pathologies

Ramana, K. V. & Srivastava, S. K., Jan 1 2010, In : International Journal of Biochemistry and Cell Biology. 42, 1, p. 17-20 4 p.

Research output: Contribution to journalShort survey

109 Scopus citations

Aldose Reductase: A Potential Drug Target for the Treatment of Sepsis Complications.

Mohammad, S. & Ramana, K. V., 2013, In : J Biochem Pharm Res. 1, p. 168-175

Research output: Contribution to journalArticle

Aldose reductase: New insights for an old enzyme

Ramana, K. V., 2011, In : Biomol Concepts. 2, p. 103-114

Research output: Contribution to journalArticle

88 Scopus citations

Aldose reductase and the stress response

Bhatnagar, A., Liu, S. Q., Srivastava, S., Ramana, K. V. & Srivastava, S. K., Dec 1 2003, In : ACS Symposium Series. 865, p. 199-210 12 p.

Research output: Contribution to journalArticle

1 Scopus citations

Aldose reductase deficiency in mice prevents azoxymethane-induced colonic preneoplastic aberrant crypt foci formation

Tammali, R., Reddy, A. B. M., Ramana, K. V., Petrash, M. J. & Srivastava, S. K., May 13 2009, In : Carcinogenesis. 30, 5, p. 799-807 9 p.

Research output: Contribution to journalArticle

33 Scopus citations

Aldose reductase deficiency in mice protects from ragweed pollen extract (RWE)-induced allergic asthma

Yadav, U. C. S., Aguilera-Aguirre, L., Boldogh, I., Ramana, K. V. & Srivastava, S. K., Nov 3 2011, In : Respiratory Research. 12, 145.

Research output: Contribution to journalArticle

7 Scopus citations

Aldose reductase deficiency protects from autoimmune- and endotoxin-induced uveitis in mice

Yadav, U. C. S., Shoeb, M., Srivastava, S. K. & Ramana, K. V., Oct 1 2011, In : Investigative Ophthalmology and Visual Science. 52, 11, p. 8076-8085 10 p.

Research output: Contribution to journalArticle

18 Scopus citations

Aldose reductase deficiency protects sugar-induced lens opacification in rats

Reddy, A. B. M., Tammali, R., Mishra, R., Srivastava, S., Srivastava, S. K. & Ramana, K. V., May 30 2011, In : Chemico-Biological Interactions. 191, 1-3, p. 346-350 5 p.

Research output: Contribution to journalArticle

20 Scopus citations

Aldose reductase detoxifies lipid aldehydes and their glutathione conjugates

Srivastava, S. K., Ramana, K. V., Srivastava, S. & Bhatnagar, A., Dec 1 2003, In : ACS Symposium Series. 865, p. 37-48 12 p.

Research output: Contribution to journalArticle

2 Scopus citations

Aldose reductase inhibition: Emerging drug target for the treatment of cardiovascular complications

Reddy, A. B. M. & Ramana, K. V., Jan 1 2010, In : Recent patents on cardiovascular drug discovery. 5, 1, p. 25-32 8 p.

Research output: Contribution to journalReview article

16 Scopus citations
19 Scopus citations

Aldose Reductase Inhibition Prevents Allergic Airway Remodeling through PI3K/AKT/GSK3β Pathway in Mice

Yadav, U. C. S., Naura, A. S., Aguilera-Aguirre, L., Boldogh, I., Boulares, H. A., Calhoun, W. J., Ramana, K. V. & Srivastava, S. K., Feb 27 2013, In : PloS one. 8, 2, e57442.

Research output: Contribution to journalArticle

27 Scopus citations

Aldose reductase inhibition prevents colon cancer growth by restoring phosphatase and tensin homolog through modulation of miR-21 and FOXO3a

Saxena, A., Tammali, R., Ramana, K. V. & Srivastava, S. K., Apr 10 2013, In : Antioxidants and Redox Signaling. 18, 11, p. 1249-1262 14 p.

Research output: Contribution to journalArticle

21 Scopus citations

Aldose reductase inhibition prevents endotoxin-induced uveitis in rats

Yadav, U. C. S., Srivastava, S. K. & Ramana, K. V., Oct 1 2007, In : Investigative Ophthalmology and Visual Science. 48, 10, p. 4634-4642 9 p.

Research output: Contribution to journalArticle

68 Scopus citations
12 Scopus citations

Aldose Reductase Inhibition Prevents Metaplasia of Airway Epithelial Cells

Yadav, U. C. S., Aguilera-Aguirre, L., Ramana, K. V., Boldogh, I. & Srivastava, S. K., Dec 1 2010, In : PloS one. 5, 12, e14440.

Research output: Contribution to journalArticle

26 Scopus citations

Aldose reductase inhibition suppresses airway inflammation

Yadav, U. C. S., Ramana, K. V. & Srivastava, S. K., May 30 2011, In : Chemico-Biological Interactions. 191, 1-3, p. 339-345 7 p.

Research output: Contribution to journalArticle

19 Scopus citations

Aldose reductase inhibition suppresses azoxymethane-induced colonic premalignant lesions in C57BL/KsJ-db/db mice

Saxena, A., Shoeb, M., Tammali, R., Ramana, K. V. & Srivastava, S. K., Dec 1 2014, In : Cancer Letters. 355, 1, p. 141-147 7 p.

Research output: Contribution to journalArticle

8 Scopus citations

Aldose reductase inhibition suppresses colon cancer cell viability by modulating microRNA-21 mediated programmed cell death 4 (PDCD4) expression

Saxena, A., Shoeb, M., Ramana, K. V. & Srivastava, S. K., Oct 1 2013, In : European Journal of Cancer. 49, 15, p. 3311-3319 9 p.

Research output: Contribution to journalArticle

22 Scopus citations

Aldose reductase inhibition suppresses oxidative stress-induced inflammatory disorders

Srivastava, S. K., Yadav, U. C. S., Reddy, A. B. M., Saxena, A., Tammali, R., Shoeb, M., Ansari, N. H., Bhatnagar, A., Petrash, M. J., Srivastava, S. & Ramana, K. V., May 30 2011, In : Chemico-Biological Interactions. 191, 1-3, p. 330-338 9 p.

Research output: Contribution to journalArticle

96 Scopus citations

Aldose reductase inhibition suppresses the expression of Th2 cytokines and airway inflammation in ovalbumin-induced asthma in mice

Yadav, U. C. S., Naura, A. S., Aguilera-Aguirre, L., Ramana, K. V., Boldogh, I., Sur, S., Boulares, H. A. & Srivastava, S. K., Oct 1 2009, In : Journal of Immunology. 183, 7, p. 4723-4732 10 p.

Research output: Contribution to journalArticle

36 Scopus citations

Aldose reductase inhibitor, fidarestat prevents doxorubicin-induced endothelial cell death and dysfunction

Sonowal, H., Pal, P., Shukla, K., Saxena, A., Srivastava, S. K. & Ramana, K., Apr 1 2018, In : Biochemical Pharmacology. 150, p. 181-190 10 p.

Research output: Contribution to journalArticle

5 Scopus citations

Aldose reductase inhibitor, fidarestat prevents high-fat diet-induced intestinal polyps in APCmin/+ mice

Saxena, A., Tammali, R., Ramana, K. & Srivastava, S., Jan 1 2018, In : Current Cancer Drug Targets. 18, 9, p. 905-911 7 p.

Research output: Contribution to journalArticle

1 Scopus citations

Aldose reductase inhibitor, fidarestat regulates mitochondrial biogenesis via Nrf2/HO-1/AMPK pathway in colon cancer cells

Shukla, K., Sonowal, H., Saxena, A., Ramana, K. & Srivastava, S., Dec 28 2017, In : Cancer Letters. 411, p. 57-63 7 p.

Research output: Contribution to journalArticle

16 Scopus citations

Aldose reductase inhibitor increases doxorubicin-sensitivity of colon cancer cells and decreases cardiotoxicity

Sonowal, H., Pal, P. B., Wen, J. J., Awasthi, S., Ramana, K. & Srivastava, S., Dec 1 2017, In : Scientific Reports. 7, 1, 3182.

Research output: Contribution to journalArticle

14 Scopus citations

Aldose Reductase Inhibitor Protects against Hyperglycemic Stress by Activating Nrf2-Dependent Antioxidant Proteins

Shukla, K., Pal, P. B., Sonowal, H., Srivastava, S. & Ramana, K., 2017, In : Journal of Diabetes Research. 2017, 6785852.

Research output: Contribution to journalArticle

2 Scopus citations
80 Scopus citations

Aldose reductase mediates endotoxin-induced production of nitric oxide and cytotoxicity in murine macrophages

Ramana, K. V., Reddy, A. B. M., Tammali, R. & Srivastava, S. K., Apr 15 2007, In : Free Radical Biology and Medicine. 42, 8, p. 1290-1302 13 p.

Research output: Contribution to journalArticle

45 Scopus citations

Aldose reductase mediates mitogenic signaling in vascular smooth muscle cells

Ramana, K. V., Chandra, D., Srivastava, S., Bhatnagar, A., Aggarwal, B. B. & Srivastava, S. K., Aug 30 2002, In : Journal of Biological Chemistry. 277, 35, p. 32063-32070 8 p.

Research output: Contribution to journalArticle

99 Scopus citations

Aldose reductase mediates NLRP3 inflammasome-initiated innate immune response in hyperglycemia-induced thp1 monocytes and male mice

Pal, P. B., Sonowal, H., Shukla, K., Srivastava, S. & Ramana, K., Oct 1 2017, In : Endocrinology. 158, 10, p. 3661-3675 15 p.

Research output: Contribution to journalArticle

6 Scopus citations

Aldose reductase mediates the lipopolysaccharide-induced release of inflammatory mediators in RAW264.7 murine macrophages

Ramana, K. V., Fadl, A. A., Tammali, R., Reddy, A. B. M., Chopra, A. K. & Srivastava, S. K., Nov 3 2006, In : Journal of Biological Chemistry. 281, 44, p. 33019-33029 11 p.

Research output: Contribution to journalArticle

114 Scopus citations

Aldose reductase mediates the mitogenic signals of cytokines

Ramana, K. V., Chandra, D., Srivastava, S., Bhatnagar, A. & Srivastava, S. K., Feb 1 2003, In : Chemico-Biological Interactions. 143-144, p. 587-596 10 p.

Research output: Contribution to journalArticle

21 Scopus citations

Aldose reductase prevents aldehyde toxicity in cultured human lens epithelial cells

Pladzyk, A., Ramana, K. V., Ansari, N. H. & Srivastava, S. K., Aug 1 2006, In : Experimental Eye Research. 83, 2, p. 408-416 9 p.

Research output: Contribution to journalArticle

17 Scopus citations

Aldose reductase-regulated tumor necrosis factor-α production is essential for high glucose-induced vascular smooth muscle cell growth

Ramana, K. V., Tammali, R., Reddy, A. B. M., Bhatnagar, A. & Srivastava, S. K., Sep 1 2007, In : Endocrinology. 148, 9, p. 4371-4384 14 p.

Research output: Contribution to journalArticle

41 Scopus citations

Aldose reductase regulates acrolein-induced cytotoxicity in human small airway epithelial cells

Yadav, U. C. S., Ramana, K. V. & Srivastava, S. K., Sep 30 2013, In : Free Radical Biology and Medicine. 65, p. 15-25 11 p.

Research output: Contribution to journalArticle

13 Scopus citations

Aldose reductase regulates growth factor-induced cyclooxygenase-2 expression and prostaglandin E2 production in human colon cancer cells

Tammali, R., Ramana, K. V., Singhal, S. S., Awasthi, S. & Srivastava, S. K., Oct 1 2006, In : Cancer Research. 66, 19, p. 9705-9713 9 p.

Research output: Contribution to journalArticle

79 Scopus citations

Aldose reductase regulates high glucose-induced ectodomain shedding of tumor necrosis factor (TNF)-α via protein kinase C-δ and TNF-α converting enzyme in vascular smooth muscle cells

Reddy, A. B. M., Ramana, K. V., Srivastava, S., Bhatnagar, A. & Srivastava, S. K., Jan 1 2009, In : Endocrinology. 150, 1, p. 63-74 12 p.

Research output: Contribution to journalArticle

38 Scopus citations

Aldose reductase regulates hyperglycemia-induced huvec death via SIRT1/AMPK-α1/mTOR pathway

Pal, P. B., Sonowal, H., Shukla, K., Srivastava, S. K. & Ramana, K., Jan 1 2019, In : Journal of Molecular Endocrinology. 63, 1, p. 11-25 15 p.

Research output: Contribution to journalArticle

1 Scopus citations

Aldose reductase regulates reactive oxygen species mediated-inflammatory signals

Ramana, K. V., Chandra, D., Srivastava, S., Bhatnagar, A., Aggarwal, B. B. & Srivastava, S. K., Dec 1 2003, In : ACS Symposium Series. 865, p. 213-223 11 p.

Research output: Contribution to journalArticle

Aldose reductase regulates TNF-α-induced cell signaling and apoptosis in vascular endothelial cells

Ramana, K. V., Bhatnagar, A. & Srivastava, S. K., Jul 16 2004, In : FEBS Letters. 570, 1-3, p. 189-194 6 p.

Research output: Contribution to journalArticle

40 Scopus citations

Aldose reductase regulates TNF-α-induced PGE2 production in human colon cancer cells

Tammali, R., Ramana, K. V. & Srivastava, S. K., Jul 18 2007, In : Cancer Letters. 252, 2, p. 299-306 8 p.

Research output: Contribution to journalArticle

48 Scopus citations

Aldose reductase regulates vascular smooth muscle cell proliferation by modulating G1/S phase transition of cell cycle

Tammali, R., Saxena, A., Srivastava, S. K. & Ramana, K. V., May 1 2010, In : Endocrinology. 151, 5, p. 2140-2150 11 p.

Research output: Contribution to journalArticle

28 Scopus citations

Amelioration of experimental autoimmune uveoretinitis by aldose reductase inhibition in lewis Rats

Yadav, U. C. S., Shoeb, M., Srivastava, S. K. & Ramana, K. V., Oct 1 2011, In : Investigative Ophthalmology and Visual Science. 52, 11, p. 8033-8041 9 p.

Research output: Contribution to journalArticle

8 Scopus citations

Antidiabetic drug metformin suppresses endotoxin-induced uveitis in rats

Kalariya, N. M., Shoeb, M., Ansari, N. H., Srivastava, S. K. & Ramana, K. V., Jun 1 2012, In : Investigative Ophthalmology and Visual Science. 53, 7, p. 3431-3440 10 p.

Research output: Contribution to journalArticle

28 Scopus citations

Anti-inflammatory effect of aldose reductase inhibition in murine polymicrobial sepsis

Reddy, A. B. M., Srivastava, S. K. & Ramana, K. V., Dec 1 2009, In : Cytokine. 48, 3, p. 170-176 7 p.

Research output: Contribution to journalArticle

26 Scopus citations