Kota Ramana, PhD, MS

  • 3973 Citations
  • 36 h-Index
19962020
If you made any changes in Pure, your changes will be visible here soon.

Research Output 1996 2019

54 Citations (Scopus)

4-hydroxynonenal in the pathogenesis and progression of human diseases

Shoeb, M., Ansari, N., Srivastava, S. & Ramana, K., Jan 2014, In : Current Medicinal Chemistry. 21, 2, p. 230-237 8 p.

Research output: Contribution to journalArticle

Disease Progression
Oxidative stress
Poisons
Lipid Peroxidation
Oxidative Stress
126 Citations (Scopus)

Activation of nulcear factor-κB by hyperglycemia in vascular smooth muscle cells is regulated by aldose reductase

Ramana, K., Friedrich, B., Srivastava, S., Bhatnagar, A. & Srivastava, S., Nov 2004, In : Diabetes. 53, 11, p. 2910-2920 11 p.

Research output: Contribution to journalArticle

Aldehyde Reductase
Vascular Smooth Muscle
Hyperglycemia
Smooth Muscle Myocytes
Protein Kinase C
82 Citations (Scopus)

Aldose reductase: New insights for an old enzyme

Ramana, K. V., Apr 1 2011, In : Biomolecular Concepts. 2, 1-2, p. 103-114 12 p.

Research output: Contribution to journalArticle

Aldehyde Reductase
Oxidative stress
Diabetes Complications
Aldehydes
Chemical activation
104 Citations (Scopus)

Aldose reductase: A novel therapeutic target for inflammatory pathologies

Ramana, K. & Srivastava, S., Jan 2010, In : International Journal of Biochemistry and Cell Biology. 42, 1, p. 17-20 4 p.

Research output: Contribution to journalArticle

Aldehyde Reductase
Pathology
Diabetes Complications
Glucose
Sorbitol

Aldose Reductase: A Potential Drug Target for the Treatment of Sepsis Complications.

Mohammad, S. & Ramana, K. V., 2013, In : J Biochem Pharm Res. 1, p. 168-175

Research output: Contribution to journalArticle

82 Citations (Scopus)

Aldose reductase: New insights for an old enzyme

Ramana, K. V., 2011, In : Biomol Concepts. 2, p. 103-114

Research output: Contribution to journalArticle

1 Citation (Scopus)

Aldose reductase and the stress response

Bhatnagar, A., Liu, S. Q., Srivastava, S., Ramana, K. & Srivastava, S., 2003, In : ACS Symposium Series. 865, p. 199-210 12 p.

Research output: Contribution to journalArticle

Aldehyde Reductase
Oxidoreductases
33 Citations (Scopus)

Aldose reductase deficiency in mice prevents azoxymethane-induced colonic preneoplastic aberrant crypt foci formation

Tammali, R., Reddy, A. B. M., Ramana, K., Petrash, M. J. & Srivastava, S., 2009, In : Carcinogenesis. 30, 5, p. 799-807 9 p.

Research output: Contribution to journalArticle

Aberrant Crypt Foci
Azoxymethane
Aldehyde Reductase
Colonic Neoplasms
Colon
7 Citations (Scopus)

Aldose reductase deficiency in mice protects from ragweed pollen extract (RWE)-induced allergic asthma

Yadav, U. C. S., Aguilera-Aguirre, L., Boldogh, I., Ramana, K. & Srivastava, S., Nov 3 2011, In : Respiratory Research. 12, 145.

Research output: Contribution to journalArticle

Aldehyde Reductase
Asthma
Respiratory Hypersensitivity
Eosinophils
Therapeutic Irrigation
18 Citations (Scopus)

Aldose reductase deficiency protects from autoimmune- and endotoxin-induced uveitis in mice

Yadav, U. C. S., Shoeb, M., Srivastava, S. & Ramana, K., Oct 2011, In : Investigative Ophthalmology and Visual Science. 52, 11, p. 8076-8085 10 p.

Research output: Contribution to journalArticle

Aldehyde Reductase
Uveitis
Endotoxins
T-Lymphocytes
Chemokines
20 Citations (Scopus)

Aldose reductase deficiency protects sugar-induced lens opacification in rats

Reddy, A. B. M., Tammali, R., Mishra, R., Srivastava, S., Srivastava, S. & Ramana, K., May 30 2011, In : Chemico-Biological Interactions. 191, 1-3, p. 346-350 5 p.

Research output: Contribution to journalArticle

Aldehyde Reductase
Sugars
Lenses
Rats
Cataract
2 Citations (Scopus)

Aldose reductase detoxifies lipid aldehydes and their glutathione conjugates

Srivastava, S., Ramana, K., Srivastava, S. & Bhatnagar, A., 2003, In : ACS Symposium Series. 865, p. 37-48 12 p.

Research output: Contribution to journalArticle

Aldehyde Reductase
Aldehydes
Glutathione
Lipids
16 Citations (Scopus)

Aldose reductase inhibition: Emerging drug target for the treatment of cardiovascular complications

Reddy, A. B. M. & Ramana, K., Jan 2010, In : Recent Patents on Cardiovascular Drug Discovery. 5, 1, p. 25-32 8 p.

Research output: Contribution to journalArticle

Aldehyde Reductase
Pharmaceutical Preparations
Blood Vessels
Mortality
Hyperglycemia
19 Citations (Scopus)
TNF-Related Apoptosis-Inducing Ligand
Aldehyde Reductase
Death Domain Receptors
Colonic Neoplasms
Up-Regulation
27 Citations (Scopus)

Aldose Reductase Inhibition Prevents Allergic Airway Remodeling through PI3K/AKT/GSK3β Pathway in Mice

Yadav, U. C. S., Naura, A. S., Aguilera-Aguirre, L., Boldogh, I., Boulares, H. A., Calhoun, W., Ramana, K. & Srivastava, S., Feb 27 2013, In : PLoS One. 8, 2, e57442.

Research output: Contribution to journalArticle

aldehyde reductase
Airway Remodeling
Aldehyde Reductase
phosphatidylinositol 3-kinase
Phosphatidylinositol 3-Kinases
21 Citations (Scopus)

Aldose reductase inhibition prevents colon cancer growth by restoring phosphatase and tensin homolog through modulation of miR-21 and FOXO3a

Saxena, A., Tammali, R., Ramana, K. & Srivastava, S., Apr 10 2013, In : Antioxidants and Redox Signaling. 18, 11, p. 1249-1262 14 p.

Research output: Contribution to journalArticle

Aldehyde Reductase
Phosphoric Monoester Hydrolases
Colonic Neoplasms
Modulation
Acids
68 Citations (Scopus)

Aldose reductase inhibition prevents endotoxin-induced uveitis in rats

Yadav, U. C. S., Srivastava, S. & Ramana, K., Oct 2007, In : Investigative Ophthalmology and Visual Science. 48, 10, p. 4634-4642 9 p.

Research output: Contribution to journalArticle

Aldehyde Reductase
Uveitis
Endotoxins
Lipopolysaccharides
Aqueous Humor
26 Citations (Scopus)
Hypoxia-Inducible Factor 1
Aldehyde Reductase
Proteasome Endopeptidase Complex
Colonic Neoplasms
Vascular Endothelial Growth Factor A
12 Citations (Scopus)
Aldehyde Reductase
Facilitative Glucose Transport Proteins
Macrophages
Lipopolysaccharides
Glucose
26 Citations (Scopus)

Aldose Reductase Inhibition Prevents Metaplasia of Airway Epithelial Cells

Yadav, U. C. S., Aguilera-Aguirre, L., Ramana, K., Boldogh, I. & Srivastava, S., 2010, In : PLoS One. 5, 12, e14440.

Research output: Contribution to journalArticle

aldehyde reductase
metaplasia
Aldehyde Reductase
Goblet Cells
goblet cells
19 Citations (Scopus)

Aldose reductase inhibition suppresses airway inflammation

Yadav, U. C. S., Ramana, K. & Srivastava, S., May 30 2011, In : Chemico-Biological Interactions. 191, 1-3, p. 339-345 7 p.

Research output: Contribution to journalArticle

Aldehyde Reductase
Inflammation
Reactive Oxygen Species
Asthma
Epithelial Cells
8 Citations (Scopus)

Aldose reductase inhibition suppresses azoxymethane-induced colonic premalignant lesions in C57BL/KsJ-db/db mice

Saxena, A., Shoeb, M., Tammali, R., Ramana, K. & Srivastava, S., Dec 1 2014, In : Cancer Letters. 355, 1, p. 141-147 7 p.

Research output: Contribution to journalArticle

Azoxymethane
Aldehyde Reductase
Obese Mice
Colonic Neoplasms
Obesity
22 Citations (Scopus)

Aldose reductase inhibition suppresses colon cancer cell viability by modulating microRNA-21 mediated programmed cell death 4 (PDCD4) expression

Saxena, A., Shoeb, M., Ramana, K. & Srivastava, S., Oct 2013, In : European Journal of Cancer. 49, 15, p. 3311-3319 9 p.

Research output: Contribution to journalArticle

Aldehyde Reductase
MicroRNAs
Colonic Neoplasms
Cell Survival
Cell Death
91 Citations (Scopus)

Aldose reductase inhibition suppresses oxidative stress-induced inflammatory disorders

Srivastava, S., Yadav, U. C. S., Reddy, A. B. M., Saxena, A., Tammali, R., Shoeb, M., Ansari, N., Bhatnagar, A., Petrash, M. J., Srivastava, S. & Ramana, K., May 30 2011, In : Chemico-Biological Interactions. 191, 1-3, p. 330-338 9 p.

Research output: Contribution to journalArticle

Aldehyde Reductase
Oxidative stress
Oxidative Stress
Reactive Oxygen Species
Intercellular Signaling Peptides and Proteins
36 Citations (Scopus)

Aldose reductase inhibition suppresses the expression of Th2 cytokines and airway inflammation in ovalbumin-induced asthma in mice

Yadav, U. C. S., Naura, A. S., Aguilera-Aguirre, L., Ramana, K., Boldogh, I., Sur, S., Boulares, H. A. & Srivastava, S., Oct 1 2009, In : Journal of Immunology. 183, 7, p. 4723-4732 10 p.

Research output: Contribution to journalArticle

Aldehyde Reductase
Ovalbumin
Asthma
Cytokines
Inflammation
4 Citations (Scopus)

Aldose reductase inhibitor, fidarestat prevents doxorubicin-induced endothelial cell death and dysfunction

Sonowal, H., Pal, P., Shukla, K., Saxena, A., Srivastava, S. K. & Ramana, K., Apr 1 2018, In : Biochemical Pharmacology. 150, p. 181-190 10 p.

Research output: Contribution to journalArticle

Aldehyde Reductase
Endothelial cells
Cell death
Doxorubicin
Cell Death
1 Citation (Scopus)

Aldose reductase inhibitor, fidarestat prevents high-fat diet-induced intestinal polyps in APCmin/+ mice

Saxena, A., Tammali, R., Ramana, K. & Srivastava, S., Jan 1 2018, In : Current Cancer Drug Targets. 18, 9, p. 905-911 7 p.

Research output: Contribution to journalArticle

Intestinal Polyps
Aldehyde Reductase
High Fat Diet
Large Intestine
Polyps
12 Citations (Scopus)

Aldose reductase inhibitor, fidarestat regulates mitochondrial biogenesis via Nrf2/HO-1/AMPK pathway in colon cancer cells

Shukla, K., Sonowal, H., Saxena, A., Ramana, K. & Srivastava, S., Dec 28 2017, In : Cancer Letters. 411, p. 57-63 7 p.

Research output: Contribution to journalArticle

Aldehyde Reductase
AMP-Activated Protein Kinases
Organelle Biogenesis
Colonic Neoplasms
Epidermal Growth Factor
13 Citations (Scopus)

Aldose reductase inhibitor increases doxorubicin-sensitivity of colon cancer cells and decreases cardiotoxicity

Sonowal, H., Pal, P. B., Wen, J. J., Awasthi, S., Ramana, K. & Srivastava, S., Dec 1 2017, In : Scientific Reports. 7, 1, 3182.

Research output: Contribution to journalArticle

Aldehyde Reductase
Doxorubicin
Colonic Neoplasms
Colorectal Neoplasms
Anthracyclines
2 Citations (Scopus)

Aldose Reductase Inhibitor Protects against Hyperglycemic Stress by Activating Nrf2-Dependent Antioxidant Proteins

Shukla, K., Pal, P. B., Sonowal, H., Srivastava, S. & Ramana, K., 2017, In : Journal of Diabetes Research. 2017, 6785852.

Research output: Contribution to journalArticle

Aldehyde Reductase
Antioxidants
Monocytes
Proteins
Heme Oxygenase-1
79 Citations (Scopus)
Aldehyde Reductase
Hyperglycemia
Lenses
Tumor Necrosis Factor-alpha
Epithelial Cells
45 Citations (Scopus)

Aldose reductase mediates endotoxin-induced production of nitric oxide and cytotoxicity in murine macrophages

Ramana, K., Reddy, A. B. M., Tammali, R. & Srivastava, S., Apr 15 2007, In : Free Radical Biology and Medicine. 42, 8, p. 1290-1302 13 p.

Research output: Contribution to journalArticle

Aldehyde Reductase
Macrophages
Cytotoxicity
Endotoxins
Nitric Oxide
99 Citations (Scopus)

Aldose reductase mediates mitogenic signaling in vascular smooth muscle cells

Ramana, K., Chandra, D., Srivastava, S., Bhatnagar, A., Aggarwal, B. B. & Srivastava, S., Aug 30 2002, In : Journal of Biological Chemistry. 277, 35, p. 32063-32070 8 p.

Research output: Contribution to journalArticle

Aldehyde Reductase
Vascular Smooth Muscle
Smooth Muscle Myocytes
Muscle
Cells
5 Citations (Scopus)

Aldose reductase mediates NLRP3 inflammasome-initiated innate immune response in hyperglycemia-induced thp1 monocytes and male mice

Pal, P. B., Sonowal, H., Shukla, K., Srivastava, S. & Ramana, K., Oct 1 2017, In : Endocrinology. 158, 10, p. 3661-3675 15 p.

Research output: Contribution to journalArticle

Inflammasomes
Aldehyde Reductase
Innate Immunity
Hyperglycemia
Monocytes
109 Citations (Scopus)

Aldose reductase mediates the lipopolysaccharide-induced release of inflammatory mediators in RAW264.7 murine macrophages

Ramana, K., Fadl, A. A., Tammali, R., Reddy, A. B. M., Chopra, A. & Srivastava, S., Nov 3 2006, In : Journal of Biological Chemistry. 281, 44, p. 33019-33029 11 p.

Research output: Contribution to journalArticle

Aldehyde Reductase
Macrophages
Lipopolysaccharides
Type C Phospholipases
Ablation
21 Citations (Scopus)

Aldose reductase mediates the mitogenic signals of cytokines

Ramana, K., Chandra, D., Srivastava, S., Bhatnagar, A. & Srivastava, S., Feb 1 2003, In : Chemico-Biological Interactions. 143-144, p. 587-596 10 p.

Research output: Contribution to journalArticle

Aldehyde Reductase
Cytokines
Chemical activation
Vascular Smooth Muscle
Smooth Muscle Myocytes
15 Citations (Scopus)

Aldose reductase prevents aldehyde toxicity in cultured human lens epithelial cells

Pladzyk, A., Ramana, K., Ansari, N. & Srivastava, S., Aug 2006, In : Experimental Eye Research. 83, 2, p. 408-416 9 p.

Research output: Contribution to journalArticle

Aldehyde Reductase
Aldehydes
Lenses
Epithelial Cells
Lipids
41 Citations (Scopus)

Aldose reductase-regulated tumor necrosis factor-α production is essential for high glucose-induced vascular smooth muscle cell growth

Ramana, K., Tammali, R., Reddy, A. B. M., Bhatnagar, A. & Srivastava, S., Sep 2007, In : Endocrinology. 148, 9, p. 4371-4384 14 p.

Research output: Contribution to journalArticle

Aldehyde Reductase
Vascular Smooth Muscle
Smooth Muscle Myocytes
Tumor Necrosis Factor-alpha
Glucose
12 Citations (Scopus)

Aldose reductase regulates acrolein-induced cytotoxicity in human small airway epithelial cells

Yadav, U. C. S., Ramana, K. & Srivastava, S., 2013, In : Free Radical Biology and Medicine. 65, p. 15-25 11 p.

Research output: Contribution to journalArticle

Acrolein
Aldehyde Reductase
Cytotoxicity
Epithelial Cells
Mitochondria
77 Citations (Scopus)

Aldose reductase regulates growth factor-induced cyclooxygenase-2 expression and prostaglandin E2 production in human colon cancer cells

Tammali, R., Ramana, K., Singhal, S. S., Awasthi, S. & Srivastava, S., Oct 1 2006, In : Cancer Research. 66, 19, p. 9705-9713 9 p.

Research output: Contribution to journalArticle

Aldehyde Reductase
Cyclooxygenase 2
Caco-2 Cells
Dinoprostone
Colonic Neoplasms
35 Citations (Scopus)

Aldose reductase regulates high glucose-induced ectodomain shedding of tumor necrosis factor (TNF)-α via protein kinase C-δ and TNF-α converting enzyme in vascular smooth muscle cells

Reddy, A. B. M., Ramana, K., Srivastava, S., Bhatnagar, A. & Srivastava, S., Jan 2009, In : Endocrinology. 150, 1, p. 63-74 12 p.

Research output: Contribution to journalArticle

Aldehyde Reductase
Vascular Smooth Muscle
Protein Kinase C
Smooth Muscle Myocytes
Tumor Necrosis Factor-alpha

Aldose reductase regulates hyperglycemia-induced huvec death via SIRT1/AMPK-α1/mTOR pathway

Pal, P. B., Sonowal, H., Shukla, K., Srivastava, S. K. & Ramana, K., Jan 1 2019, In : Journal of Molecular Endocrinology. 63, 1, p. 11-25 15 p.

Research output: Contribution to journalArticle

Aldehyde Reductase
AMP-Activated Protein Kinases
Human Umbilical Vein Endothelial Cells
Hyperglycemia
Glucose

Aldose reductase regulates reactive oxygen species mediated-inflammatory signals

Ramana, K., Chandra, D., Srivastava, S., Bhatnagar, A., Aggarwal, B. B. & Srivastava, S., 2003, In : ACS Symposium Series. 865, p. 213-223 11 p.

Research output: Contribution to journalArticle

Aldehyde Reductase
Reactive Oxygen Species
40 Citations (Scopus)

Aldose reductase regulates TNF-α-induced cell signaling and apoptosis in vascular endothelial cells

Ramana, K., Bhatnagar, A. & Srivastava, S., Jul 16 2004, In : FEBS Letters. 570, 1-3, p. 189-194 6 p.

Research output: Contribution to journalArticle

Cell signaling
Aldehyde Reductase
Endothelial cells
Endothelial Cells
Apoptosis
48 Citations (Scopus)

Aldose reductase regulates TNF-α-induced PGE2 production in human colon cancer cells

Tammali, R., Ramana, K. & Srivastava, S., Jul 18 2007, In : Cancer Letters. 252, 2, p. 299-306 8 p.

Research output: Contribution to journalArticle

Aldehyde Reductase
Dinoprostone
Colonic Neoplasms
Caco-2 Cells
Cyclooxygenase 2
27 Citations (Scopus)

Aldose reductase regulates vascular smooth muscle cell proliferation by modulating G1/S phase transition of cell cycle

Tammali, R., Saxena, A., Srivastava, S. & Ramana, K., May 2010, In : Endocrinology. 151, 5, p. 2140-2150 11 p.

Research output: Contribution to journalArticle

Aldehyde Reductase
Phase Transition
G1 Phase
S Phase
Vascular Smooth Muscle
8 Citations (Scopus)

Amelioration of experimental autoimmune uveoretinitis by aldose reductase inhibition in lewis Rats

Yadav, U. C. S., Shoeb, M., Srivastava, S. & Ramana, K., Oct 2011, In : Investigative Ophthalmology and Visual Science. 52, 11, p. 8033-8041 9 p.

Research output: Contribution to journalArticle

Aldehyde Reductase
Uveitis
Retinoids
Aqueous Humor
Peptides
27 Citations (Scopus)

Antidiabetic drug metformin suppresses endotoxin-induced uveitis in rats

Kalariya, N. M., Shoeb, M., Ansari, N., Srivastava, S. & Ramana, K., Jun 2012, In : Investigative Ophthalmology and Visual Science. 53, 7, p. 3431-3440 10 p.

Research output: Contribution to journalArticle

Metformin
Uveitis
Hypoglycemic Agents
Endotoxins
AMP-Activated Protein Kinases
26 Citations (Scopus)

Anti-inflammatory effect of aldose reductase inhibition in murine polymicrobial sepsis

Reddy, A. B. M., Srivastava, S. & Ramana, K., Dec 2009, In : Cytokine. 48, 3, p. 170-176 7 p.

Research output: Contribution to journalArticle

Aldehyde Reductase
Sepsis
Anti-Inflammatory Agents
Cecum
Punctures
25 Citations (Scopus)
Macrophages
Arachidonic Acid
Anti-Inflammatory Agents
Lipopolysaccharides
Epoprostenol