Kota Ramana

Article

54 Citations (Scopus)

4-hydroxynonenal in the pathogenesis and progression of human diseases

Shoeb, M., Ansari, N., Srivastava, S. & Ramana, K., Jan 2014, In : Current Medicinal Chemistry. 21, 2, p. 230-237 8 p.

Research output: Contribution to journal › Article

Disease Progression

Oxidative stress

Poisons

Lipid Peroxidation

Oxidative Stress

126 Citations (Scopus)

Activation of nulcear factor-κB by hyperglycemia in vascular smooth muscle cells is regulated by aldose reductase

Ramana, K., Friedrich, B., Srivastava, S., Bhatnagar, A. & Srivastava, S., Nov 2004, In : Diabetes. 53, 11, p. 2910-2920 11 p.

Research output: Contribution to journal › Article

Aldehyde Reductase

Vascular Smooth Muscle

Hyperglycemia

Smooth Muscle Myocytes

Protein Kinase C

82 Citations (Scopus)

Aldose reductase: New insights for an old enzyme

Ramana, K. V., Apr 1 2011, In : Biomolecular Concepts. 2, 1-2, p. 103-114 12 p.

Research output: Contribution to journal › Article

Aldehyde Reductase

Oxidative stress

Diabetes Complications

Aldehydes

Chemical activation

104 Citations (Scopus)

Aldose reductase: A novel therapeutic target for inflammatory pathologies

Ramana, K. & Srivastava, S., Jan 2010, In : International Journal of Biochemistry and Cell Biology. 42, 1, p. 17-20 4 p.

Research output: Contribution to journal › Article

Aldehyde Reductase

Pathology

Diabetes Complications

Glucose

Sorbitol

Aldose Reductase: A Potential Drug Target for the Treatment of Sepsis Complications.

Mohammad, S. & Ramana, K. V., 2013, In : J Biochem Pharm Res. 1, p. 168-175

Research output: Contribution to journal › Article

82 Citations (Scopus)

Aldose reductase: New insights for an old enzyme

Ramana, K. V., 2011, In : Biomol Concepts. 2, p. 103-114

Research output: Contribution to journal › Article

1 Citation (Scopus)

Aldose reductase and the stress response

Bhatnagar, A., Liu, S. Q., Srivastava, S., Ramana, K. & Srivastava, S., 2003, In : ACS Symposium Series. 865, p. 199-210 12 p.

Research output: Contribution to journal › Article

Aldehyde Reductase

Oxidoreductases

33 Citations (Scopus)

Aldose reductase deficiency in mice prevents azoxymethane-induced colonic preneoplastic aberrant crypt foci formation

Tammali, R., Reddy, A. B. M., Ramana, K., Petrash, M. J. & Srivastava, S., 2009, In : Carcinogenesis. 30, 5, p. 799-807 9 p.

Research output: Contribution to journal › Article

Aberrant Crypt Foci

Azoxymethane

Aldehyde Reductase

Colonic Neoplasms

Colon

7 Citations (Scopus)

Aldose reductase deficiency in mice protects from ragweed pollen extract (RWE)-induced allergic asthma

Yadav, U. C. S., Aguilera-Aguirre, L., Boldogh, I., Ramana, K. & Srivastava, S., Nov 3 2011, In : Respiratory Research. 12, 145.

Research output: Contribution to journal › Article

Aldehyde Reductase

Asthma

Respiratory Hypersensitivity

Eosinophils

Therapeutic Irrigation

18 Citations (Scopus)

Aldose reductase deficiency protects from autoimmune- and endotoxin-induced uveitis in mice

Yadav, U. C. S., Shoeb, M., Srivastava, S. & Ramana, K., Oct 2011, In : Investigative Ophthalmology and Visual Science. 52, 11, p. 8076-8085 10 p.

Research output: Contribution to journal › Article

Aldehyde Reductase

Uveitis

Endotoxins

T-Lymphocytes

Chemokines

20 Citations (Scopus)

Aldose reductase deficiency protects sugar-induced lens opacification in rats

Reddy, A. B. M., Tammali, R., Mishra, R., Srivastava, S., Srivastava, S. & Ramana, K., May 30 2011, In : Chemico-Biological Interactions. 191, 1-3, p. 346-350 5 p.

Research output: Contribution to journal › Article

Aldehyde Reductase

Sugars

Lenses

Rats

Cataract

2 Citations (Scopus)

Aldose reductase detoxifies lipid aldehydes and their glutathione conjugates

Srivastava, S., Ramana, K., Srivastava, S. & Bhatnagar, A., 2003, In : ACS Symposium Series. 865, p. 37-48 12 p.

Research output: Contribution to journal › Article

Aldehyde Reductase

Aldehydes

Glutathione

Lipids

16 Citations (Scopus)

Aldose reductase inhibition: Emerging drug target for the treatment of cardiovascular complications

Reddy, A. B. M. & Ramana, K., Jan 2010, In : Recent Patents on Cardiovascular Drug Discovery. 5, 1, p. 25-32 8 p.

Research output: Contribution to journal › Article

Aldehyde Reductase

Pharmaceutical Preparations

Blood Vessels

Mortality

Hyperglycemia

19 Citations (Scopus)

Aldose reductase inhibition enhances TRAIL-induced human colon cancer cell apoptosis through AKT/FOXO₃a-dependent upregulation of death receptors

Shoeb, M., Ramana, K. & Srivastava, S., 2013, In : Free Radical Biology and Medicine. 63, p. 280-290 11 p.

Research output: Contribution to journal › Article

TNF-Related Apoptosis-Inducing Ligand

Aldehyde Reductase

Death Domain Receptors

Colonic Neoplasms

Up-Regulation

27 Citations (Scopus)

Aldose Reductase Inhibition Prevents Allergic Airway Remodeling through PI3K/AKT/GSK3β Pathway in Mice

Yadav, U. C. S., Naura, A. S., Aguilera-Aguirre, L., Boldogh, I., Boulares, H. A., Calhoun, W., Ramana, K. & Srivastava, S., Feb 27 2013, In : PLoS One. 8, 2, e57442.

Research output: Contribution to journal › Article

aldehyde reductase

Airway Remodeling

Aldehyde Reductase

phosphatidylinositol 3-kinase

Phosphatidylinositol 3-Kinases

21 Citations (Scopus)

Aldose reductase inhibition prevents colon cancer growth by restoring phosphatase and tensin homolog through modulation of miR-21 and FOXO3a

Saxena, A., Tammali, R., Ramana, K. & Srivastava, S., Apr 10 2013, In : Antioxidants and Redox Signaling. 18, 11, p. 1249-1262 14 p.

Research output: Contribution to journal › Article

Aldehyde Reductase

Phosphoric Monoester Hydrolases

Colonic Neoplasms

Modulation

Acids

68 Citations (Scopus)

Aldose reductase inhibition prevents endotoxin-induced uveitis in rats

Yadav, U. C. S., Srivastava, S. & Ramana, K., Oct 2007, In : Investigative Ophthalmology and Visual Science. 48, 10, p. 4634-4642 9 p.

Research output: Contribution to journal › Article

Aldehyde Reductase

Uveitis

Endotoxins

Lipopolysaccharides

Aqueous Humor

26 Citations (Scopus)

Aldose reductase inhibition prevents hypoxia-induced increase in hypoxia-inducible factor-1α (HIF-1α) and vascular endothelial growth factor (VEGF) by regulating 26 S proteasome-mediated protein degradation in human colon cancer cells

Tammali, R., Saxena, A., Srivastava, S. & Ramana, K., Jul 8 2011, In : Journal of Biological Chemistry. 286, 27, p. 24089-24100 12 p.

Research output: Contribution to journal › Article

Hypoxia-Inducible Factor 1

Aldehyde Reductase

Proteasome Endopeptidase Complex

Colonic Neoplasms

Vascular Endothelial Growth Factor A

12 Citations (Scopus)

Aldose reductase inhibition prevents lipopolysaccharide-induced glucose uptake and glucose transporter 3 expression in RAW264.7 macrophages

Reddy, A. B. M., Srivastava, S. & Ramana, K., Jun 2010, In : International Journal of Biochemistry and Cell Biology. 42, 6, p. 1039-1045 7 p.

Research output: Contribution to journal › Article

Aldehyde Reductase

Facilitative Glucose Transport Proteins

Macrophages

Lipopolysaccharides

Glucose

26 Citations (Scopus)

Aldose Reductase Inhibition Prevents Metaplasia of Airway Epithelial Cells

Yadav, U. C. S., Aguilera-Aguirre, L., Ramana, K., Boldogh, I. & Srivastava, S., 2010, In : PLoS One. 5, 12, e14440.

Research output: Contribution to journal › Article

aldehyde reductase

metaplasia

Aldehyde Reductase

Goblet Cells

goblet cells

19 Citations (Scopus)

Aldose reductase inhibition suppresses airway inflammation

Yadav, U. C. S., Ramana, K. & Srivastava, S., May 30 2011, In : Chemico-Biological Interactions. 191, 1-3, p. 339-345 7 p.

Research output: Contribution to journal › Article

Aldehyde Reductase

Inflammation

Reactive Oxygen Species

Asthma

Epithelial Cells

8 Citations (Scopus)

Aldose reductase inhibition suppresses azoxymethane-induced colonic premalignant lesions in C57BL/KsJ-db/db mice

Saxena, A., Shoeb, M., Tammali, R., Ramana, K. & Srivastava, S., Dec 1 2014, In : Cancer Letters. 355, 1, p. 141-147 7 p.

Research output: Contribution to journal › Article

Azoxymethane

Aldehyde Reductase

Obese Mice

Colonic Neoplasms

Obesity

22 Citations (Scopus)

Aldose reductase inhibition suppresses colon cancer cell viability by modulating microRNA-21 mediated programmed cell death 4 (PDCD4) expression

Saxena, A., Shoeb, M., Ramana, K. & Srivastava, S., Oct 2013, In : European Journal of Cancer. 49, 15, p. 3311-3319 9 p.

Research output: Contribution to journal › Article

Aldehyde Reductase

MicroRNAs

Colonic Neoplasms

Cell Survival

Cell Death

91 Citations (Scopus)

Aldose reductase inhibition suppresses oxidative stress-induced inflammatory disorders

Srivastava, S., Yadav, U. C. S., Reddy, A. B. M., Saxena, A., Tammali, R., Shoeb, M., Ansari, N., Bhatnagar, A., Petrash, M. J., Srivastava, S. & Ramana, K., May 30 2011, In : Chemico-Biological Interactions. 191, 1-3, p. 330-338 9 p.

Research output: Contribution to journal › Article

Aldehyde Reductase

Oxidative stress

Oxidative Stress

Reactive Oxygen Species

Intercellular Signaling Peptides and Proteins

36 Citations (Scopus)

Aldose reductase inhibition suppresses the expression of Th2 cytokines and airway inflammation in ovalbumin-induced asthma in mice

Yadav, U. C. S., Naura, A. S., Aguilera-Aguirre, L., Ramana, K., Boldogh, I., Sur, S., Boulares, H. A. & Srivastava, S., Oct 1 2009, In : Journal of Immunology. 183, 7, p. 4723-4732 10 p.

Research output: Contribution to journal › Article

Aldehyde Reductase

Ovalbumin

Asthma

Cytokines

Inflammation

4 Citations (Scopus)

Aldose reductase inhibitor, fidarestat prevents doxorubicin-induced endothelial cell death and dysfunction

Sonowal, H., Pal, P., Shukla, K., Saxena, A., Srivastava, S. K. & Ramana, K., Apr 1 2018, In : Biochemical Pharmacology. 150, p. 181-190 10 p.

Research output: Contribution to journal › Article

Aldehyde Reductase

Endothelial cells

Cell death

Doxorubicin

Cell Death

1 Citation (Scopus)

Aldose reductase inhibitor, fidarestat prevents high-fat diet-induced intestinal polyps in APC^min/+ mice

Saxena, A., Tammali, R., Ramana, K. & Srivastava, S., Jan 1 2018, In : Current Cancer Drug Targets. 18, 9, p. 905-911 7 p.

Research output: Contribution to journal › Article

Intestinal Polyps

Aldehyde Reductase

High Fat Diet

Large Intestine

Polyps

12 Citations (Scopus)

Aldose reductase inhibitor, fidarestat regulates mitochondrial biogenesis via Nrf2/HO-1/AMPK pathway in colon cancer cells

Shukla, K., Sonowal, H., Saxena, A., Ramana, K. & Srivastava, S., Dec 28 2017, In : Cancer Letters. 411, p. 57-63 7 p.

Research output: Contribution to journal › Article

Aldehyde Reductase

AMP-Activated Protein Kinases

Organelle Biogenesis

Colonic Neoplasms

Epidermal Growth Factor

13 Citations (Scopus)

Aldose reductase inhibitor increases doxorubicin-sensitivity of colon cancer cells and decreases cardiotoxicity

Sonowal, H., Pal, P. B., Wen, J. J., Awasthi, S., Ramana, K. & Srivastava, S., Dec 1 2017, In : Scientific Reports. 7, 1, 3182.

Research output: Contribution to journal › Article

Aldehyde Reductase

Doxorubicin

Colonic Neoplasms

Colorectal Neoplasms

Anthracyclines

2 Citations (Scopus)

Aldose Reductase Inhibitor Protects against Hyperglycemic Stress by Activating Nrf2-Dependent Antioxidant Proteins

Shukla, K., Pal, P. B., Sonowal, H., Srivastava, S. & Ramana, K., 2017, In : Journal of Diabetes Research. 2017, 6785852.

Research output: Contribution to journal › Article

Aldehyde Reductase

Antioxidants

Monocytes

Proteins

Heme Oxygenase-1

79 Citations (Scopus)

Aldose reductase mediates cytotoxic signals of hyperglycemia and TNF-alpha in human lens epithelial cells.

Ramana, K., Friedrich, B., Bhatnagar, A. & Srivastava, S., 2003, In : The FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 17, 2, p. 315-317 3 p.

Research output: Contribution to journal › Article

Aldehyde Reductase

Hyperglycemia

Lenses

Tumor Necrosis Factor-alpha

Epithelial Cells

45 Citations (Scopus)

Aldose reductase mediates endotoxin-induced production of nitric oxide and cytotoxicity in murine macrophages

Ramana, K., Reddy, A. B. M., Tammali, R. & Srivastava, S., Apr 15 2007, In : Free Radical Biology and Medicine. 42, 8, p. 1290-1302 13 p.

Research output: Contribution to journal › Article

Aldehyde Reductase

Macrophages

Cytotoxicity

Endotoxins

Nitric Oxide

99 Citations (Scopus)

Aldose reductase mediates mitogenic signaling in vascular smooth muscle cells

Ramana, K., Chandra, D., Srivastava, S., Bhatnagar, A., Aggarwal, B. B. & Srivastava, S., Aug 30 2002, In : Journal of Biological Chemistry. 277, 35, p. 32063-32070 8 p.

Research output: Contribution to journal › Article

Aldehyde Reductase

Vascular Smooth Muscle

Smooth Muscle Myocytes

Muscle

Cells

5 Citations (Scopus)

Aldose reductase mediates NLRP3 inflammasome-initiated innate immune response in hyperglycemia-induced thp1 monocytes and male mice

Pal, P. B., Sonowal, H., Shukla, K., Srivastava, S. & Ramana, K., Oct 1 2017, In : Endocrinology. 158, 10, p. 3661-3675 15 p.

Research output: Contribution to journal › Article

Inflammasomes

Aldehyde Reductase

Innate Immunity

Hyperglycemia

Monocytes

109 Citations (Scopus)

Aldose reductase mediates the lipopolysaccharide-induced release of inflammatory mediators in RAW264.7 murine macrophages

Ramana, K., Fadl, A. A., Tammali, R., Reddy, A. B. M., Chopra, A. & Srivastava, S., Nov 3 2006, In : Journal of Biological Chemistry. 281, 44, p. 33019-33029 11 p.

Research output: Contribution to journal › Article

Aldehyde Reductase

Macrophages

Lipopolysaccharides

Type C Phospholipases

Ablation

21 Citations (Scopus)

Aldose reductase mediates the mitogenic signals of cytokines

Ramana, K., Chandra, D., Srivastava, S., Bhatnagar, A. & Srivastava, S., Feb 1 2003, In : Chemico-Biological Interactions. 143-144, p. 587-596 10 p.

Research output: Contribution to journal › Article

Aldehyde Reductase

Cytokines

Chemical activation

Vascular Smooth Muscle

Smooth Muscle Myocytes

15 Citations (Scopus)

Aldose reductase prevents aldehyde toxicity in cultured human lens epithelial cells

Pladzyk, A., Ramana, K., Ansari, N. & Srivastava, S., Aug 2006, In : Experimental Eye Research. 83, 2, p. 408-416 9 p.

Research output: Contribution to journal › Article

Aldehyde Reductase

Aldehydes

Lenses

Epithelial Cells

Lipids

41 Citations (Scopus)

Aldose reductase-regulated tumor necrosis factor-α production is essential for high glucose-induced vascular smooth muscle cell growth

Ramana, K., Tammali, R., Reddy, A. B. M., Bhatnagar, A. & Srivastava, S., Sep 2007, In : Endocrinology. 148, 9, p. 4371-4384 14 p.

Research output: Contribution to journal › Article

Aldehyde Reductase

Vascular Smooth Muscle

Smooth Muscle Myocytes

Tumor Necrosis Factor-alpha

Glucose

12 Citations (Scopus)

Aldose reductase regulates acrolein-induced cytotoxicity in human small airway epithelial cells

Yadav, U. C. S., Ramana, K. & Srivastava, S., 2013, In : Free Radical Biology and Medicine. 65, p. 15-25 11 p.

Research output: Contribution to journal › Article

Acrolein

Aldehyde Reductase

Cytotoxicity

Epithelial Cells

Mitochondria

77 Citations (Scopus)

Aldose reductase regulates growth factor-induced cyclooxygenase-2 expression and prostaglandin E2 production in human colon cancer cells

Tammali, R., Ramana, K., Singhal, S. S., Awasthi, S. & Srivastava, S., Oct 1 2006, In : Cancer Research. 66, 19, p. 9705-9713 9 p.

Research output: Contribution to journal › Article

Aldehyde Reductase

Cyclooxygenase 2

Caco-2 Cells

Dinoprostone

Colonic Neoplasms

35 Citations (Scopus)

Aldose reductase regulates high glucose-induced ectodomain shedding of tumor necrosis factor (TNF)-α via protein kinase C-δ and TNF-α converting enzyme in vascular smooth muscle cells

Reddy, A. B. M., Ramana, K., Srivastava, S., Bhatnagar, A. & Srivastava, S., Jan 2009, In : Endocrinology. 150, 1, p. 63-74 12 p.

Research output: Contribution to journal › Article

Aldehyde Reductase

Vascular Smooth Muscle

Protein Kinase C

Smooth Muscle Myocytes

Tumor Necrosis Factor-alpha

Aldose reductase regulates hyperglycemia-induced huvec death via SIRT1/AMPK-α1/mTOR pathway

Pal, P. B., Sonowal, H., Shukla, K., Srivastava, S. K. & Ramana, K., Jan 1 2019, In : Journal of Molecular Endocrinology. 63, 1, p. 11-25 15 p.

Research output: Contribution to journal › Article

Aldehyde Reductase

AMP-Activated Protein Kinases

Human Umbilical Vein Endothelial Cells

Hyperglycemia

Glucose

Aldose reductase regulates reactive oxygen species mediated-inflammatory signals

Ramana, K., Chandra, D., Srivastava, S., Bhatnagar, A., Aggarwal, B. B. & Srivastava, S., 2003, In : ACS Symposium Series. 865, p. 213-223 11 p.

Research output: Contribution to journal › Article

Aldehyde Reductase

Reactive Oxygen Species

40 Citations (Scopus)

Aldose reductase regulates TNF-α-induced cell signaling and apoptosis in vascular endothelial cells

Ramana, K., Bhatnagar, A. & Srivastava, S., Jul 16 2004, In : FEBS Letters. 570, 1-3, p. 189-194 6 p.

Research output: Contribution to journal › Article

Cell signaling

Aldehyde Reductase

Endothelial cells

Endothelial Cells

Apoptosis

48 Citations (Scopus)

Aldose reductase regulates TNF-α-induced PGE2 production in human colon cancer cells

Tammali, R., Ramana, K. & Srivastava, S., Jul 18 2007, In : Cancer Letters. 252, 2, p. 299-306 8 p.

Research output: Contribution to journal › Article

Aldehyde Reductase

Dinoprostone

Colonic Neoplasms

Caco-2 Cells

Cyclooxygenase 2

27 Citations (Scopus)

Aldose reductase regulates vascular smooth muscle cell proliferation by modulating G1/S phase transition of cell cycle

Tammali, R., Saxena, A., Srivastava, S. & Ramana, K., May 2010, In : Endocrinology. 151, 5, p. 2140-2150 11 p.

Research output: Contribution to journal › Article

Aldehyde Reductase

Phase Transition

G1 Phase

S Phase

Vascular Smooth Muscle

8 Citations (Scopus)

Amelioration of experimental autoimmune uveoretinitis by aldose reductase inhibition in lewis Rats

Yadav, U. C. S., Shoeb, M., Srivastava, S. & Ramana, K., Oct 2011, In : Investigative Ophthalmology and Visual Science. 52, 11, p. 8033-8041 9 p.

Research output: Contribution to journal › Article

Aldehyde Reductase

Uveitis

Retinoids

Aqueous Humor

Peptides

27 Citations (Scopus)

Antidiabetic drug metformin suppresses endotoxin-induced uveitis in rats

Kalariya, N. M., Shoeb, M., Ansari, N., Srivastava, S. & Ramana, K., Jun 2012, In : Investigative Ophthalmology and Visual Science. 53, 7, p. 3431-3440 10 p.

Research output: Contribution to journal › Article

Metformin

Uveitis

Hypoglycemic Agents

Endotoxins

AMP-Activated Protein Kinases

26 Citations (Scopus)

Anti-inflammatory effect of aldose reductase inhibition in murine polymicrobial sepsis

Reddy, A. B. M., Srivastava, S. & Ramana, K., Dec 2009, In : Cytokine. 48, 3, p. 170-176 7 p.

Research output: Contribution to journal › Article

Aldehyde Reductase

Sepsis

Anti-Inflammatory Agents

Cecum

Punctures

25 Citations (Scopus)

Anti-inflammatory effects of benfotiamine are mediated through the regulation of the arachidonic acid pathway in macrophages

Shoeb, M. & Ramana, K., Jan 1 2012, In : Free Radical Biology and Medicine. 52, 1, p. 182-190 9 p.

Research output: Contribution to journal › Article

Macrophages

Arachidonic Acid

Anti-Inflammatory Agents

Lipopolysaccharides

Epoprostenol

Kota Ramana, PhD, MS