Kota Ramana, PhD, MS

  • 3973 Citations
  • 36 h-Index
19962020
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Research Output 1996 2019

2011
20 Citations (Scopus)

Aldose reductase deficiency protects sugar-induced lens opacification in rats

Reddy, A. B. M., Tammali, R., Mishra, R., Srivastava, S., Srivastava, S. & Ramana, K., May 30 2011, In : Chemico-Biological Interactions. 191, 1-3, p. 346-350 5 p.

Research output: Contribution to journalArticle

Aldehyde Reductase
Sugars
Lenses
Rats
Cataract
26 Citations (Scopus)
Hypoxia-Inducible Factor 1
Aldehyde Reductase
Proteasome Endopeptidase Complex
Colonic Neoplasms
Vascular Endothelial Growth Factor A
19 Citations (Scopus)

Aldose reductase inhibition suppresses airway inflammation

Yadav, U. C. S., Ramana, K. & Srivastava, S., May 30 2011, In : Chemico-Biological Interactions. 191, 1-3, p. 339-345 7 p.

Research output: Contribution to journalArticle

Aldehyde Reductase
Inflammation
Reactive Oxygen Species
Asthma
Epithelial Cells
91 Citations (Scopus)

Aldose reductase inhibition suppresses oxidative stress-induced inflammatory disorders

Srivastava, S., Yadav, U. C. S., Reddy, A. B. M., Saxena, A., Tammali, R., Shoeb, M., Ansari, N., Bhatnagar, A., Petrash, M. J., Srivastava, S. & Ramana, K., May 30 2011, In : Chemico-Biological Interactions. 191, 1-3, p. 330-338 9 p.

Research output: Contribution to journalArticle

Aldehyde Reductase
Oxidative stress
Oxidative Stress
Reactive Oxygen Species
Intercellular Signaling Peptides and Proteins
8 Citations (Scopus)

Amelioration of experimental autoimmune uveoretinitis by aldose reductase inhibition in lewis Rats

Yadav, U. C. S., Shoeb, M., Srivastava, S. & Ramana, K., Oct 2011, In : Investigative Ophthalmology and Visual Science. 52, 11, p. 8033-8041 9 p.

Research output: Contribution to journalArticle

Aldehyde Reductase
Uveitis
Retinoids
Aqueous Humor
Peptides
6 Citations (Scopus)

Current prospective of aldose reductase inhibition in the therapy of allergic airway inflammation in asthma

Ramana, K., Yadav, U. C. S., Calhoun, W. & Srivastava, S., 2011, In : Current Molecular Medicine. 11, 7, p. 599-608 10 p.

Research output: Contribution to journalArticle

Aldehyde Reductase
Asthma
Inflammation
Steroids
Phase III Clinical Trials
34 Citations (Scopus)

Emerging role of antioxidants in the protection of uveitis complications

Yadav, U. C. S., Kalariya, N. M. & Ramana, K., Feb 2011, In : Current Medicinal Chemistry. 18, 6, p. 931-942 12 p.

Research output: Contribution to journalArticle

Uveitis
Antioxidants
Oxidative stress
Eye Diseases
Oxidative Stress
44 Citations (Scopus)

Inhibition of aldose reductase prevents angiogenesis in vitro and in vivo

Tammali, R., Reddy, A. B. M., Srivastava, S. & Ramana, K., May 2011, In : Angiogenesis. 14, 2, p. 209-221 13 p.

Research output: Contribution to journalArticle

Aldehyde Reductase
Endothelial cells
Human Umbilical Vein Endothelial Cells
Vascular Endothelial Growth Factor A
Colonic Neoplasms
34 Citations (Scopus)

Inhibition of aldose reductase prevents colon cancer metastasis

Tammali, R., Reddy, A. B. M., Saxena, A., Rychahou, P. G., Evers, B. M., Qiu, S., Awasthi, S., Ramana, K. & Srivastava, S., 2011, In : Carcinogenesis. 32, 8, p. 1259-1267 9 p.

Research output: Contribution to journalArticle

Aldehyde Reductase
Colonic Neoplasms
Neoplasm Metastasis
Nude Mice
HT29 Cells
28 Citations (Scopus)

Inhibition of aldose reductase prevents endotoxin-induced inflammation by regulating the arachidonic acid pathway in murine macrophages

Shoeb, M., Yadav, U. C. S., Srivastava, S. & Ramana, K., Nov 1 2011, In : Free Radical Biology and Medicine. 51, 9, p. 1686-1696 11 p.

Research output: Contribution to journalArticle

Aldehyde Reductase
Macrophages
Arachidonic Acid
Endotoxins
Inflammation
4 Citations (Scopus)

Post-translational protein modification by carotenoid cleavage products

Kalariya, N. M., Ramana, K., Srivastava, S. & van Kuijk, F. J. G. M., Mar 2011, In : BioFactors. 37, 2, p. 104-116 13 p.

Research output: Contribution to journalArticle

Carotenoids
Post Translational Protein Processing
Aldehydes
Proteins
Sulfides
17 Citations (Scopus)

Preventive effects of ethyl pyruvate on endotoxin-induced uveitis in rats

Kalariya, N. M., Reddy, A. B. M., Ansari, N., VanKuijk, F. J. G. M. & Ramana, K., Jul 2011, In : Investigative Ophthalmology and Visual Science. 52, 8, p. 5144-5152 9 p.

Research output: Contribution to journalArticle

Uveitis
Endotoxins
Aqueous Humor
Lipopolysaccharides
NF-kappa B
43 Citations (Scopus)

Targeting aldose reductase for the treatment of cancer

Tammali, R., Srivastava, S. & Ramana, K., Jun 2011, In : Current Cancer Drug Targets. 11, 5, p. 560-571 12 p.

Research output: Contribution to journalArticle

Aldehyde Reductase
Inflammation
Oxidative Stress
Neoplasms
Cytokines
2010
104 Citations (Scopus)

Aldose reductase: A novel therapeutic target for inflammatory pathologies

Ramana, K. & Srivastava, S., Jan 2010, In : International Journal of Biochemistry and Cell Biology. 42, 1, p. 17-20 4 p.

Research output: Contribution to journalArticle

Aldehyde Reductase
Pathology
Diabetes Complications
Glucose
Sorbitol
16 Citations (Scopus)

Aldose reductase inhibition: Emerging drug target for the treatment of cardiovascular complications

Reddy, A. B. M. & Ramana, K., Jan 2010, In : Recent Patents on Cardiovascular Drug Discovery. 5, 1, p. 25-32 8 p.

Research output: Contribution to journalArticle

Aldehyde Reductase
Pharmaceutical Preparations
Blood Vessels
Mortality
Hyperglycemia
12 Citations (Scopus)
Aldehyde Reductase
Facilitative Glucose Transport Proteins
Macrophages
Lipopolysaccharides
Glucose
26 Citations (Scopus)

Aldose Reductase Inhibition Prevents Metaplasia of Airway Epithelial Cells

Yadav, U. C. S., Aguilera-Aguirre, L., Ramana, K., Boldogh, I. & Srivastava, S., 2010, In : PLoS One. 5, 12, e14440.

Research output: Contribution to journalArticle

aldehyde reductase
metaplasia
Aldehyde Reductase
Goblet Cells
goblet cells
27 Citations (Scopus)

Aldose reductase regulates vascular smooth muscle cell proliferation by modulating G1/S phase transition of cell cycle

Tammali, R., Saxena, A., Srivastava, S. & Ramana, K., May 2010, In : Endocrinology. 151, 5, p. 2140-2150 11 p.

Research output: Contribution to journalArticle

Aldehyde Reductase
Phase Transition
G1 Phase
S Phase
Vascular Smooth Muscle
4 Citations (Scopus)

Editorial: Aldose reductase inhibition for the treatment of asthma

Srivastava, S. & Ramana, K., 2010, In : Expert Review of Clinical Immunology. 6, 1, p. 1-4 4 p.

Research output: Contribution to journalArticle

Anti-Asthmatic Agents
Aldehyde Reductase
Enzyme Inhibitors
Anti-Inflammatory Agents
Asthma
6 Citations (Scopus)

Inhibition of aldose reductase attenuates endotoxin signals in human non-pigmented ciliary epithelial cells

Yadav, U. C. S., Srivastava, S. & Ramana, K., May 2010, In : Experimental Eye Research. 90, 5, p. 555-563 9 p.

Research output: Contribution to journalArticle

Aldehyde Reductase
Endotoxins
Epithelial Cells
Aqueous Humor
Homeostasis
33 Citations (Scopus)
Aldehyde Reductase
1-Phosphatidylinositol 4-Kinase
Phase Transition
Colonic Neoplasms
Intercellular Signaling Peptides and Proteins
26 Citations (Scopus)

Measurement and identification of S-glutathiolated proteins.

Hill, B. G., Ramana, K., Cai, J., Bhatnagar, A. & Srivastava, S., 2010, In : Methods in Enzymology. 473, p. 179-197 19 p.

Research output: Contribution to journalArticle

Protein S
Proteins
Post Translational Protein Processing
Sulfhydryl Compounds
Oxidation-Reduction
24 Citations (Scopus)

Prevention of endotoxin-induced uveitis in rats by plant sterol guggulsterone

Kalariya, N. M., Shoeb, M., Reddy, A. B. M., Zhang, M., van Kuijk, F. J. G. M. & Ramana, K., Oct 2010, In : Investigative Ophthalmology and Visual Science. 51, 10, p. 5105-5113 9 p.

Research output: Contribution to journalArticle

Phytosterols
Uveitis
Endotoxins
Aqueous Humor
Matrix Metalloproteinase 2
26 Citations (Scopus)

Protective role of benfotiamine, a fat-soluble vitamin B1 analogue, in lipopolysaccharide-induced cytotoxic signals in murine macrophages

Yadav, U. C. S., Kalariya, N. M., Srivastava, S. & Ramana, K., May 2010, In : Free Radical Biology and Medicine. 48, 10, p. 1423-1434 12 p.

Research output: Contribution to journalArticle

Macrophages
Thiamine
Lipopolysaccharides
Fats
Chemical activation
10 Citations (Scopus)

Synthesis, quantification, characterization, and signaling properties of glutathionyl conjugates of enals.

Srivastava, S., Ramana, K., Bhatnagar, A. & Srivastava, S., 2010, In : Methods in Enzymology. 474, p. 297-313 17 p.

Research output: Contribution to journalArticle

Metabolism
Cell signaling
Lipids
Detoxification
Pathology
7 Citations (Scopus)
Eye Diseases
Tumor Necrosis Factor-alpha
Pathology
Enzymes
Immunology
28 Citations (Scopus)

Understanding the role of aldose reductase in ocular inflammation

Yadav, U. C. S., Srivastava, S. & Ramana, K., 2010, In : Current Molecular Medicine. 10, 6, p. 540-549 10 p.

Research output: Contribution to journalArticle

Aldehyde Reductase
Oxidative stress
Inflammation
Oxidative Stress
Lipids
2009
33 Citations (Scopus)

Aldose reductase deficiency in mice prevents azoxymethane-induced colonic preneoplastic aberrant crypt foci formation

Tammali, R., Reddy, A. B. M., Ramana, K., Petrash, M. J. & Srivastava, S., 2009, In : Carcinogenesis. 30, 5, p. 799-807 9 p.

Research output: Contribution to journalArticle

Aberrant Crypt Foci
Azoxymethane
Aldehyde Reductase
Colonic Neoplasms
Colon
36 Citations (Scopus)

Aldose reductase inhibition suppresses the expression of Th2 cytokines and airway inflammation in ovalbumin-induced asthma in mice

Yadav, U. C. S., Naura, A. S., Aguilera-Aguirre, L., Ramana, K., Boldogh, I., Sur, S., Boulares, H. A. & Srivastava, S., Oct 1 2009, In : Journal of Immunology. 183, 7, p. 4723-4732 10 p.

Research output: Contribution to journalArticle

Aldehyde Reductase
Ovalbumin
Asthma
Cytokines
Inflammation
35 Citations (Scopus)

Aldose reductase regulates high glucose-induced ectodomain shedding of tumor necrosis factor (TNF)-α via protein kinase C-δ and TNF-α converting enzyme in vascular smooth muscle cells

Reddy, A. B. M., Ramana, K., Srivastava, S., Bhatnagar, A. & Srivastava, S., Jan 2009, In : Endocrinology. 150, 1, p. 63-74 12 p.

Research output: Contribution to journalArticle

Aldehyde Reductase
Vascular Smooth Muscle
Protein Kinase C
Smooth Muscle Myocytes
Tumor Necrosis Factor-alpha
26 Citations (Scopus)

Anti-inflammatory effect of aldose reductase inhibition in murine polymicrobial sepsis

Reddy, A. B. M., Srivastava, S. & Ramana, K., Dec 2009, In : Cytokine. 48, 3, p. 170-176 7 p.

Research output: Contribution to journalArticle

Aldehyde Reductase
Sepsis
Anti-Inflammatory Agents
Cecum
Punctures
43 Citations (Scopus)

Cadmium-induced apoptotic death of human retinal pigment epithelial cells is mediated by MAPK pathway

Kalariya, N. M., Wills, N. K., Ramana, K., Srivastava, S. & van Kuijk, F. J. G. M., Oct 2009, In : Experimental Eye Research. 89, 4, p. 494-502 9 p.

Research output: Contribution to journalArticle

Retinal Pigments
Mitogen-Activated Protein Kinases
Cadmium
Epithelial Cells
Macular Degeneration
50 Citations (Scopus)

Focus on Molecules: Nuclear factor-kappaB

Srivastava, S. & Ramana, K., Jan 5 2009, In : Experimental Eye Research. 88, 1, p. 2-3 2 p.

Research output: Contribution to journalArticle

Eye Diseases
NF-kappa B
Uveitis
Autoimmune Diseases
Signal Transduction
21 Citations (Scopus)

Genotoxic effects of carotenoid breakdown products in human retinal pigment epithelial cells

Kalariya, N. M., Ramana, K., Srivastava, S. & Van Kuijk, F. J. G. M., 2009, In : Current Eye Research. 34, 9, p. 737-747 11 p.

Research output: Contribution to journalArticle

Retinal Pigments
Carotenoids
DNA Damage
Epithelial Cells
Dithionitrobenzoic Acid
40 Citations (Scopus)

Inhibition of aldose reductase prevents experimental allergic airway inflammation in mice

Yadav, U. C. S., Ramana, K., Aguilera-Aguirre, L., Boldogh, I., Boulares, H. A. & Srivastava, S., Aug 6 2009, In : PLoS One. 4, 8, e6535.

Research output: Contribution to journalArticle

aldehyde reductase
Aldehyde Reductase
inflammation
Inflammation
mice
31 Citations (Scopus)

Molecular cloning and oxidative modification of human lens ALDH1A1: Implication in impaired detoxification of lipid aldehydes

Xiao, T., Shoeb, M., Siddiqui, M. S., Zhang, M., Ramana, K., Srivastava, S., Vasiliou, V. & Ansari, N., 2009, In : Journal of Toxicology and Environmental Health - Part A: Current Issues. 72, 9, p. 577-584 8 p.

Research output: Contribution to journalArticle

Detoxification
Cloning
Molecular Cloning
Aldehydes
Lenses
36 Citations (Scopus)

Prevention of endotoxin-induced uveitis in rats by benfotiamine, a lipophilic analogue of vitamin B1

Yadav, U. C. S., Subramanyam, S. & Ramana, K., 2009, In : Investigative Ophthalmology and Visual Science. 50, 5, p. 2276-2282 7 p.

Research output: Contribution to journalArticle

Thiamine
Uveitis
Endotoxins
NF-kappa B
Ciliary Body
25 Citations (Scopus)

Prevention of posterior capsular opacification through aldose reductase inhibition

Yadav, U. C. S., Ighani-Hosseinabad, F., Van Kuijk, F. J. G. M., Srivastava, S. & Ramana, K., Feb 2009, In : Investigative Ophthalmology and Visual Science. 50, 2, p. 752-759 8 p.

Research output: Contribution to journalArticle

Aldehyde Reductase
Lenses
Epithelial Cells
Crystallins
Fibroblast Growth Factor 2
2008
56 Citations (Scopus)

Carotenoid derived aldehydes-induced oxidative stress causes apoptotic cell death in human retinal pigment epithelial cells

Kalariya, N. M., Ramana, K., Srivastava, S. & van Kuijk, F. J. G. M., Jan 2008, In : Experimental Eye Research. 86, 1, p. 70-80 11 p.

Research output: Contribution to journalArticle

Retinal Pigments
Carotenoids
Aldehydes
Oxidative Stress
Cell Death
44 Citations (Scopus)

Glutathione level regulates HNE-induced genotoxicity in human erythroleukemia cells

Yadav, U. C. S., Ramana, K., Awasthi, Y. C. & Srivastava, S., Mar 1 2008, In : Toxicology and Applied Pharmacology. 227, 2, p. 257-264 8 p.

Research output: Contribution to journalArticle

Leukemia, Erythroblastic, Acute
Glutathione
DNA Damage
K562 Cells
DNA
19 Citations (Scopus)

l-Arginine prevents metabolic effects of high glucose in diabetic mice

West, M. B., Ramana, K., Kaiserova, K., Srivastava, S. & Bhatnagar, A., Jul 23 2008, In : FEBS Letters. 582, 17, p. 2609-2614 6 p.

Research output: Contribution to journalArticle

Medical problems
Protein Kinase C
Arginine
Glucose
Aldehyde Reductase
2007
68 Citations (Scopus)

Aldose reductase inhibition prevents endotoxin-induced uveitis in rats

Yadav, U. C. S., Srivastava, S. & Ramana, K., Oct 2007, In : Investigative Ophthalmology and Visual Science. 48, 10, p. 4634-4642 9 p.

Research output: Contribution to journalArticle

Aldehyde Reductase
Uveitis
Endotoxins
Lipopolysaccharides
Aqueous Humor
45 Citations (Scopus)

Aldose reductase mediates endotoxin-induced production of nitric oxide and cytotoxicity in murine macrophages

Ramana, K., Reddy, A. B. M., Tammali, R. & Srivastava, S., Apr 15 2007, In : Free Radical Biology and Medicine. 42, 8, p. 1290-1302 13 p.

Research output: Contribution to journalArticle

Aldehyde Reductase
Macrophages
Cytotoxicity
Endotoxins
Nitric Oxide
41 Citations (Scopus)

Aldose reductase-regulated tumor necrosis factor-α production is essential for high glucose-induced vascular smooth muscle cell growth

Ramana, K., Tammali, R., Reddy, A. B. M., Bhatnagar, A. & Srivastava, S., Sep 2007, In : Endocrinology. 148, 9, p. 4371-4384 14 p.

Research output: Contribution to journalArticle

Aldehyde Reductase
Vascular Smooth Muscle
Smooth Muscle Myocytes
Tumor Necrosis Factor-alpha
Glucose
48 Citations (Scopus)

Aldose reductase regulates TNF-α-induced PGE2 production in human colon cancer cells

Tammali, R., Ramana, K. & Srivastava, S., Jul 18 2007, In : Cancer Letters. 252, 2, p. 299-306 8 p.

Research output: Contribution to journalArticle

Aldehyde Reductase
Dinoprostone
Colonic Neoplasms
Caco-2 Cells
Cyclooxygenase 2
2006
109 Citations (Scopus)

Aldose reductase mediates the lipopolysaccharide-induced release of inflammatory mediators in RAW264.7 murine macrophages

Ramana, K., Fadl, A. A., Tammali, R., Reddy, A. B. M., Chopra, A. & Srivastava, S., Nov 3 2006, In : Journal of Biological Chemistry. 281, 44, p. 33019-33029 11 p.

Research output: Contribution to journalArticle

Aldehyde Reductase
Macrophages
Lipopolysaccharides
Type C Phospholipases
Ablation
15 Citations (Scopus)

Aldose reductase prevents aldehyde toxicity in cultured human lens epithelial cells

Pladzyk, A., Ramana, K., Ansari, N. & Srivastava, S., Aug 2006, In : Experimental Eye Research. 83, 2, p. 408-416 9 p.

Research output: Contribution to journalArticle

Aldehyde Reductase
Aldehydes
Lenses
Epithelial Cells
Lipids
77 Citations (Scopus)

Aldose reductase regulates growth factor-induced cyclooxygenase-2 expression and prostaglandin E2 production in human colon cancer cells

Tammali, R., Ramana, K., Singhal, S. S., Awasthi, S. & Srivastava, S., Oct 1 2006, In : Cancer Research. 66, 19, p. 9705-9713 9 p.

Research output: Contribution to journalArticle

Aldehyde Reductase
Cyclooxygenase 2
Caco-2 Cells
Dinoprostone
Colonic Neoplasms
54 Citations (Scopus)

Contribution of aldose reductase to diabetic hyperproliferation of vascular smooth muscle cells

Srivastava, S., Ramana, K., Tammali, R., Srivastava, S. & Bhatnagar, A., 2006, In : Diabetes. 55, 4, p. 901-910 10 p.

Research output: Contribution to journalArticle

Aldehyde Reductase
Vascular Smooth Muscle
Smooth Muscle Myocytes
Tunica Intima
Growth
75 Citations (Scopus)

Endotoxin-induced cardiomyopathy and systemic inflammation in mice is prevented by aldose reductase inhibition

Ramana, K., Willis, M. S., White, M. D., Horton, J. W., Dimaio, J. M., Srivastava, D., Bhatnagar, A. & Srivastava, S., Oct 2006, In : Circulation. 114, 17, p. 1838-1846 9 p.

Research output: Contribution to journalArticle

Aldehyde Reductase
Cardiomyopathies
Endotoxins
Inflammation
Cytokines