Kota Ramana, PhD, MS

  • 3973 Citations
  • 36 h-Index
19962020
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Research Output 1996 2019

2006
34 Citations (Scopus)

Inhibition of aldose reductase prevents lipopolysaccharide-induced inflammatory response in human lens epithelial cells

Pladzyk, A., Reddy, A. B. M., Yadav, U. C. S., Tammali, R., Ramana, K. & Srivastava, S., Dec 2006, In : Investigative Ophthalmology and Visual Science. 47, 12, p. 5395-5403 9 p.

Research output: Contribution to journalArticle

Aldehyde Reductase
Lenses
Lipopolysaccharides
Epithelial Cells
Matrix Metalloproteinases
48 Citations (Scopus)

Mediation of aldose reductase in lipopolysaccharide-induced inflammatory signals in mouse peritoneal macrophages

Ramana, K. & Srivastava, S., Nov 2006, In : Cytokine. 36, 3-4, p. 115-122 8 p.

Research output: Contribution to journalArticle

Aldehyde Reductase
Macrophages
Peritoneal Macrophages
Lipopolysaccharides
Cytokines
115 Citations (Scopus)

Mitogenic responses of vascular smooth muscle cells to lipid peroxidation-derived aldehyde 4-hydroxy-trans-2-nonenal (HNE): Role of aldose reductase-catalyzed reduction of the HNE-glutathione conjugates in regulating cell growth

Ramana, K., Bhatnagar, A., Srivastava, S., Yadav, U. C., Awasthi, S., Awasthi, Y. C. & Srivastava, S., Jun 30 2006, In : Journal of Biological Chemistry. 281, 26, p. 17652-17660 9 p.

Research output: Contribution to journalArticle

Aldehyde Reductase
Cell growth
Vascular Smooth Muscle
Aldehydes
Lipid Peroxidation
28 Citations (Scopus)

Structure of a glutathione conjugate bound to the active site of aldose reductase

Singh, R., White, M., Ramana, K., Petrash, J. M., Watowich, S., Bhatnagar, A. & Srivastava, S., Jul 1 2006, In : Proteins: Structure, Function and Genetics. 64, 1, p. 101-110 10 p.

Research output: Contribution to journalArticle

Aldehyde Reductase
Glutathione
Catalytic Domain
Aldehydes
S-(1,2-dicarboxyethyl)glutathione
2005
6 Citations (Scopus)

Regulation of lens aldose reductase activity by nitric oxide

Srivastava, S., Tammali, R., Chandra, D., Greer, D. A., Ramana, K., Bhatnagar, A. & Srivastava, S., Dec 2005, In : Experimental Eye Research. 81, 6, p. 664-672 9 p.

Research output: Contribution to journalArticle

Aldehyde Reductase
Lenses
Nitric Oxide
Sorbitol
S-Nitroso-N-Acetylpenicillamine
96 Citations (Scopus)

Requirement of aldose reductase for the hyperglycemic activation of protein kinase C and formation of diacylglycerol in vascular smooth muscle cells

Ramana, K., Friedrich, B., Tammali, R., West, M. B., Bhatnagar, A. & Srivastava, S., Mar 2005, In : Diabetes. 54, 3, p. 818-829 12 p.

Research output: Contribution to journalArticle

Aldehyde Reductase
Diglycerides
Vascular Smooth Muscle
Protein Kinase C
Smooth Muscle Myocytes
344 Citations (Scopus)

Role of aldose reductase and oxidative damage in diabetes and the consequent potential for therapeutic options

Srivastava, S., Ramana, K. & Bhatnagar, A., May 2005, In : Endocrine Reviews. 26, 3, p. 380-392 13 p.

Research output: Contribution to journalArticle

Aldehyde Reductase
Diabetes Complications
Aldehydes
Therapeutics
Glucose
2004
126 Citations (Scopus)

Activation of nulcear factor-κB by hyperglycemia in vascular smooth muscle cells is regulated by aldose reductase

Ramana, K., Friedrich, B., Srivastava, S., Bhatnagar, A. & Srivastava, S., Nov 2004, In : Diabetes. 53, 11, p. 2910-2920 11 p.

Research output: Contribution to journalArticle

Aldehyde Reductase
Vascular Smooth Muscle
Hyperglycemia
Smooth Muscle Myocytes
Protein Kinase C
40 Citations (Scopus)

Aldose reductase regulates TNF-α-induced cell signaling and apoptosis in vascular endothelial cells

Ramana, K., Bhatnagar, A. & Srivastava, S., Jul 16 2004, In : FEBS Letters. 570, 1-3, p. 189-194 6 p.

Research output: Contribution to journalArticle

Cell signaling
Aldehyde Reductase
Endothelial cells
Endothelial Cells
Apoptosis
64 Citations (Scopus)

Inhibition of aldose reductase attenuates TNF-α-induced expression of adhesion molecules in endothelial cells

Ramana, K., Bhatnagar, A. & Srivastava, S., Aug 2004, In : FASEB Journal. 18, 11, p. 1209-1218 10 p.

Research output: Contribution to journalArticle

aldehyde reductase
Aldehyde Reductase
Endothelial cells
endothelial cells
adhesion
15 Citations (Scopus)

Oxidative stress-induced up-regulation of the chloride channel and Na +/Ca2+ exchanger during cataractogenesis in diabetic rats

Ramana, K., Chandra, D., Wills, N. K., Bhatnagar, A. & Srivastava, S., May 2004, In : Journal of Diabetes and its Complications. 18, 3, p. 177-182 6 p.

Research output: Contribution to journalArticle

Chloride Channels
Oxidative Stress
Up-Regulation
Proteins
Lenses
2003
1 Citation (Scopus)

Aldose reductase and the stress response

Bhatnagar, A., Liu, S. Q., Srivastava, S., Ramana, K. & Srivastava, S., 2003, In : ACS Symposium Series. 865, p. 199-210 12 p.

Research output: Contribution to journalArticle

Aldehyde Reductase
Oxidoreductases
2 Citations (Scopus)

Aldose reductase detoxifies lipid aldehydes and their glutathione conjugates

Srivastava, S., Ramana, K., Srivastava, S. & Bhatnagar, A., 2003, In : ACS Symposium Series. 865, p. 37-48 12 p.

Research output: Contribution to journalArticle

Aldehyde Reductase
Aldehydes
Glutathione
Lipids
79 Citations (Scopus)
Aldehyde Reductase
Hyperglycemia
Lenses
Tumor Necrosis Factor-alpha
Epithelial Cells
21 Citations (Scopus)

Aldose reductase mediates the mitogenic signals of cytokines

Ramana, K., Chandra, D., Srivastava, S., Bhatnagar, A. & Srivastava, S., Feb 1 2003, In : Chemico-Biological Interactions. 143-144, p. 587-596 10 p.

Research output: Contribution to journalArticle

Aldehyde Reductase
Cytokines
Chemical activation
Vascular Smooth Muscle
Smooth Muscle Myocytes

Aldose reductase regulates reactive oxygen species mediated-inflammatory signals

Ramana, K., Chandra, D., Srivastava, S., Bhatnagar, A., Aggarwal, B. B. & Srivastava, S., 2003, In : ACS Symposium Series. 865, p. 213-223 11 p.

Research output: Contribution to journalArticle

Aldehyde Reductase
Reactive Oxygen Species
42 Citations (Scopus)

Nitric oxide regulates the polyol pathway of glucose metabolism in vascular smooth muscle cells

Ramana, K., Chandra, D., Srivastava, S., Bhatnagar, A. & Srivastava, S., Mar 1 2003, In : FASEB Journal. 17, 3, p. 417-425 9 p.

Research output: Contribution to journalArticle

aldehyde reductase
Aldehyde Reductase
polyols
Vascular Smooth Muscle
blood vessels
27 Citations (Scopus)

Regulation of aldose reductase and the polyol pathway activity by nitric oxide

Srivastava, S., Ramana, K., Chandra, D., Srivastava, S. & Bhatnagar, A., Feb 1 2003, In : Chemico-Biological Interactions. 143-144, p. 333-340 8 p.

Research output: Contribution to journalArticle

Aldehyde Reductase
Nitric Oxide
Nitric Oxide Donors
Sorbitol
Diabetes Complications
2 Citations (Scopus)

Role of aldose reductase in the detoxification of oxidized phospholipids

Srivastava, S., Ramana, K., Srivastava, S. K., D'Souza, S. E. & Bhatnagar, A., 2003, In : ACS Symposium Series. 865, p. 49-64 16 p.

Research output: Contribution to journalArticle

Aldehyde Reductase
Detoxification
Phospholipids
Oxidoreductases
15 Citations (Scopus)

Role of aldose reductase in TNF-α-induced apoptosis of vascular endothelial cells

Chandra, D., Ramana, K., Friedrich, B., Srivastava, S., Bhatnagar, A. & Srivastava, S., Feb 1 2003, In : Chemico-Biological Interactions. 143-144, p. 605-612 8 p.

Research output: Contribution to journalArticle

Aldehyde Reductase
Endothelial cells
Endothelial Cells
Tumor Necrosis Factor-alpha
Apoptosis
2002
99 Citations (Scopus)

Aldose reductase mediates mitogenic signaling in vascular smooth muscle cells

Ramana, K., Chandra, D., Srivastava, S., Bhatnagar, A., Aggarwal, B. B. & Srivastava, S., Aug 30 2002, In : Journal of Biological Chemistry. 277, 35, p. 32063-32070 8 p.

Research output: Contribution to journalArticle

Aldehyde Reductase
Vascular Smooth Muscle
Smooth Muscle Myocytes
Muscle
Cells
1 Citation (Scopus)

Estimation of oxygen free radicals and nonenzymatic antioxidants in living-related donor kidney transplantation

Minz, M., Ramana, K., Sakhuja, V. K. & Ganguly, N. K., Sep 2002, In : Transplantation Proceedings. 34, 6, p. 2029 1 p.

Research output: Contribution to journalArticle

Living Donors
Malondialdehyde
Vitamin A
Vitamin E
Kidney Transplantation
38 Citations (Scopus)

Inhibition of fiber cell globulization and hyperglycemia-induced lens opacification by aminopeptidase inhibitor bestatin

Chandra, D., Ramana, K., Wang, L., Christensen, B. N., Bhatnagar, A. & Srivastava, S., 2002, In : Investigative Ophthalmology and Visual Science. 43, 7, p. 2285-2292 8 p.

Research output: Contribution to journalArticle

Aminopeptidases
Hyperglycemia
Lenses
leucylmethionine
Calpain
58 Citations (Scopus)

Nitric oxide prevents aldose reductase activation and sorbitol accumulation during diabetes

Chandra, D., Jackson, E. B., Ramana, K., Kelley, R., Srivastava, S. & Bhatnagar, A., Oct 1 2002, In : Diabetes. 51, 10, p. 3095-3101 7 p.

Research output: Contribution to journalArticle

Aldehyde Reductase
Sorbitol
Nitric Oxide
NG-Nitroarginine Methyl Ester
Nitric Oxide Donors
2001
18 Citations (Scopus)

Characterization of the glutathione binding site of aldose reductase

Ramana, K., Dixit, B. L., Srivastava, S., Bhatnagar, A., Balendiran, G. K., Watowich, S., Petrash, J. M. & Srivastava, S., Jan 30 2001, In : Chemico-Biological Interactions. 130-132, p. 537-548 12 p.

Research output: Contribution to journalArticle

Aldehyde Reductase
Aldehydes
Glutathione
Binding Sites
Catalytic Domain
8 Citations (Scopus)

Metabolic regulation of aldose reductase activity by nitric oxide donors

Dixit, B. L., Ramana, K., Chandra, D., Jackson, E. B., Srivastava, S., Bhatnagar, A. & Srivastava, S., Jan 30 2001, In : Chemico-Biological Interactions. 130-132, p. 573-581 9 p.

Research output: Contribution to journalArticle

Aldehyde Reductase
Penicillamine
Nitric Oxide Donors
Nitrosation
Enzyme activity
32 Citations (Scopus)

Structural and kinetic modifications of aldose reductase by S-nitrosothiols

Srivastava, S., Dixit, B. L., Ramana, K., Chandra, A., Chandra, D., Zacarias, A., Petrash, J. M., Bhatnagar, A. & Srivastava, S., Aug 15 2001, In : Biochemical Journal. 358, 1, p. 111-118 8 p.

Research output: Contribution to journalArticle

S-Nitrosothiols
Aldehyde Reductase
Kinetics
Penicillamine
Nitric Oxide
2000
76 Citations (Scopus)

Kinetic and structural characterization of the glutathione-binding site of aldose reductase

Dixit, B. L., Balendiran, G. K., Watowich, S., Srivastava, S., Ramana, K., Petrash, J. M., Bhatnagar, A. & Srivastava, S., Jul 14 2000, In : Journal of Biological Chemistry. 275, 28, p. 21587-21595 9 p.

Research output: Contribution to journalArticle

Aldehyde Reductase
Glutathione
Binding Sites
Kinetics
Catalytic Domain
84 Citations (Scopus)

Selective recognition of glutathiolated aldehydes by aldose reductase

Ramana, K., Dixit, B. L., Srivastava, S., Balendiran, G. K., Srivastava, S. & Bhatnagar, A., Oct 10 2000, In : Biochemistry. 39, 40, p. 12172-12180 9 p.

Research output: Contribution to journalArticle

Aldehyde Reductase
Aldehydes
glutamyl-cysteinyl-alanine
Mutation
Aminobutyrates
1999
2 Citations (Scopus)
Rifampin
Oxidative Stress
Pyrazinamide
Liver
Enzymes
6 Citations (Scopus)
Aminopyrine
Phenobarbital
Macaca mulatta
Isoenzymes
Purification
1998
3 Citations (Scopus)

Differential effects of phenobarbitone on the hepatic and renal glutathione-S-transferases in the rhesus monkey

Ramana, K. & Kohli, K. K., Feb 1998, In : Indian Journal of Pharmacology. 30, 1, p. 34-37 4 p.

Research output: Contribution to journalArticle

Phenobarbital
Glutathione Transferase
Macaca mulatta
Kidney
Ethacrynic Acid
14 Citations (Scopus)

Gene regulation of cytochrome P450 - An overview

Ramana, K. & Kohli, K. K., May 1998, In : Indian Journal of Experimental Biology. 36, 5, p. 437-446 10 p.

Research output: Contribution to journalArticle

Gene expression
Cytochrome P-450 Enzyme System
Transcription Factors
Genes
Eukaryota
NADPH-Ferrihemoprotein Reductase
Mixed Function Oxygenases
Macaca mulatta
Purification
Cytochromes b5
1996
5 Citations (Scopus)

Induction of hepatic cytochrome P450 by phenobarbitone in rhesus monkey (Macaca mulatta)

Ramana, K. & Kohli, K. K., 1996, In : Drug and Chemical Toxicology. 19, 1-2, p. 97-107 11 p.

Research output: Contribution to journalArticle

Phenobarbital
Macaca mulatta
Cytochrome P-450 Enzyme System
Aminopyrine N-Demethylase
Proteins

Methods for Treating COPD

Ramana, K. V., 1800, Patent No. US 8785483B2

Research output: Patent

Methods involving aldose reductase inhibitors

Ramana, K. V., 1800, Patent No. US 8273746

Research output: Patent