Kota Ramana, PhD, MS

  • 3942 Citations
  • 36 h-Index
19962020
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Research Output 1996 2019

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Article
2019

Aldose reductase regulates hyperglycemia-induced huvec death via SIRT1/AMPK-α1/mTOR pathway

Pal, P. B., Sonowal, H., Shukla, K., Srivastava, S. K. & Ramana, K., Jan 1 2019, In : Journal of Molecular Endocrinology. 63, 1, p. 11-25 15 p.

Research output: Contribution to journalArticle

Aldehyde Reductase
AMP-Activated Protein Kinases
Human Umbilical Vein Endothelial Cells
Hyperglycemia
Glucose
2 Citations (Scopus)

Didymin by suppressing NF-κB activation prevents VEGF-induced angiogenesis in vitro and in vivo

Shukla, K., Sonowal, H., Saxena, A. & Ramana, K., Jan 1 2019, (Accepted/In press) In : Vascular Pharmacology.

Research output: Contribution to journalArticle

Vascular Endothelial Growth Factor A
Human Umbilical Vein Endothelial Cells
Neoplasms
E-Selectin
Vascular Cell Adhesion Molecule-1
2018
2 Citations (Scopus)

Aldose reductase inhibitor, fidarestat prevents doxorubicin-induced endothelial cell death and dysfunction

Sonowal, H., Pal, P., Shukla, K., Saxena, A., Srivastava, S. K. & Ramana, K., Apr 1 2018, In : Biochemical Pharmacology. 150, p. 181-190 10 p.

Research output: Contribution to journalArticle

Aldehyde Reductase
Endothelial cells
Cell death
Doxorubicin
Cell Death

Aldose reductase inhibitor, fidarestat prevents high-fat diet-induced intestinal polyps in APCmin/+ mice

Saxena, A., Tammali, R., Ramana, K. & Srivastava, S., Jan 1 2018, In : Current Cancer Drug Targets. 18, 9, p. 905-911 7 p.

Research output: Contribution to journalArticle

Intestinal Polyps
Aldehyde Reductase
High Fat Diet
Large Intestine
Polyps
9 Citations (Scopus)

Didymin prevents hyperglycemia-induced human umbilical endothelial cells dysfunction and death

Shukla, K., Sonowal, H., Saxena, A. & Ramana, K., Jun 1 2018, In : Biochemical Pharmacology. 152, p. 1-10 10 p.

Research output: Contribution to journalArticle

Umbilicus
Endothelial cells
Hyperglycemia
Cell Death
Endothelial Cells
1 Citation (Scopus)

Vialinin A, an Edible Mushroom-Derived p-Terphenyl Antioxidant, Prevents VEGF-Induced Neovascularization in Vitro and in Vivo

Sonowal, H., Shukla, K., Kota, S., Saxena, A. & Ramana, K., Jan 1 2018, In : Oxidative Medicine and Cellular Longevity. 2018, 1052102.

Research output: Contribution to journalArticle

Agaricales
Vascular Endothelial Growth Factor A
Antioxidants
Umbilicus
Endothelial cells
2017
10 Citations (Scopus)

Aldose reductase inhibitor, fidarestat regulates mitochondrial biogenesis via Nrf2/HO-1/AMPK pathway in colon cancer cells

Shukla, K., Sonowal, H., Saxena, A., Ramana, K. & Srivastava, S., Dec 28 2017, In : Cancer Letters. 411, p. 57-63 7 p.

Research output: Contribution to journalArticle

Aldehyde Reductase
AMP-Activated Protein Kinases
Organelle Biogenesis
Colonic Neoplasms
Epidermal Growth Factor
13 Citations (Scopus)

Aldose reductase inhibitor increases doxorubicin-sensitivity of colon cancer cells and decreases cardiotoxicity

Sonowal, H., Pal, P. B., Wen, J. J., Awasthi, S., Ramana, K. & Srivastava, S., Dec 1 2017, In : Scientific Reports. 7, 1, 3182.

Research output: Contribution to journalArticle

Aldehyde Reductase
Doxorubicin
Colonic Neoplasms
Colorectal Neoplasms
Anthracyclines
2 Citations (Scopus)

Aldose Reductase Inhibitor Protects against Hyperglycemic Stress by Activating Nrf2-Dependent Antioxidant Proteins

Shukla, K., Pal, P. B., Sonowal, H., Srivastava, S. & Ramana, K., 2017, In : Journal of Diabetes Research. 2017, 6785852.

Research output: Contribution to journalArticle

Aldehyde Reductase
Antioxidants
Monocytes
Proteins
Heme Oxygenase-1
5 Citations (Scopus)

Aldose reductase mediates NLRP3 inflammasome-initiated innate immune response in hyperglycemia-induced thp1 monocytes and male mice

Pal, P. B., Sonowal, H., Shukla, K., Srivastava, S. & Ramana, K., Oct 1 2017, In : Endocrinology. 158, 10, p. 3661-3675 15 p.

Research output: Contribution to journalArticle

Inflammasomes
Aldehyde Reductase
Innate Immunity
Hyperglycemia
Monocytes
6 Citations (Scopus)
Endothelial cells
Vascular Endothelial Growth Factor A
Lipid Peroxidation
Endothelial Cells
Lipids
2016

Corrigendum to "Aldose reductase inhibition suppresses oxidative stress-induced inflammatory disorders" [Chem. Biol. Interact. (2011) 330-338]

Srivastava, S., Yadav, U. C. S., Reddy, A. B. M., Mishra, R., Saxena, A., Tammali, R., Shoeb, M., Ansari, N., Bhatnagar, A., Petrash, M. J., Srivastava, S. & Ramana, K., 2016, (Accepted/In press) In : Chemico-Biological Interactions.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Regulatory roles of glutathione-S-transferases and 4-hydroxynonenal in stress-mediated signaling and toxicity

Awasthi, Y. C., Ramana, K., Chaudhary, P., Srivastava, S. & Awasthi, S., Sep 15 2016, (Accepted/In press) In : Free Radical Biology and Medicine.

Research output: Contribution to journalArticle

Glutathione Transferase
Toxicity
Oxidative stress
Oxidative Stress
Modulation
2014
53 Citations (Scopus)

4-hydroxynonenal in the pathogenesis and progression of human diseases

Shoeb, M., Ansari, N., Srivastava, S. & Ramana, K., Jan 2014, In : Current Medicinal Chemistry. 21, 2, p. 230-237 8 p.

Research output: Contribution to journalArticle

Disease Progression
Oxidative stress
Poisons
Lipid Peroxidation
Oxidative Stress
8 Citations (Scopus)

Aldose reductase inhibition suppresses azoxymethane-induced colonic premalignant lesions in C57BL/KsJ-db/db mice

Saxena, A., Shoeb, M., Tammali, R., Ramana, K. & Srivastava, S., Dec 1 2014, In : Cancer Letters. 355, 1, p. 141-147 7 p.

Research output: Contribution to journalArticle

Azoxymethane
Aldehyde Reductase
Obese Mice
Colonic Neoplasms
Obesity
6 Citations (Scopus)

Lipid peroxidation products in human health and disease 2014

Ramana, K. V., Srivastava, S. & Singhal, S. S., 2014, In : Oxidative Medicine and Cellular Longevity. 2014, p. 162414 1 p.

Research output: Contribution to journalArticle

Animals
Health
Lipids
6 Citations (Scopus)

Lipid peroxidation products in human health and disease 2014.

Ramana, K. V., Sanjay, S. & Sharad, S. S., Sep 14 2014, In : Oxidative Medicine and Cellular Longivity.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Therapeutic potential of natural pharmacological agents in the treatment of human diseases

Ramana, K., Singhal, S. S. & Reddy, A. B., Dec 28 2014, In : BioMed Research International. 2014, 573452.

Research output: Contribution to journalArticle

Pharmacognosy
Traditional Medicine
Pharmacology
Therapeutics
2013

Aldose Reductase: A Potential Drug Target for the Treatment of Sepsis Complications.

Mohammad, S. & Ramana, K. V., 2013, In : J Biochem Pharm Res. 1, p. 168-175

Research output: Contribution to journalArticle

18 Citations (Scopus)
TNF-Related Apoptosis-Inducing Ligand
Aldehyde Reductase
Death Domain Receptors
Colonic Neoplasms
Up-Regulation
27 Citations (Scopus)

Aldose Reductase Inhibition Prevents Allergic Airway Remodeling through PI3K/AKT/GSK3β Pathway in Mice

Yadav, U. C. S., Naura, A. S., Aguilera-Aguirre, L., Boldogh, I., Boulares, H. A., Calhoun, W., Ramana, K. & Srivastava, S., Feb 27 2013, In : PLoS One. 8, 2, e57442.

Research output: Contribution to journalArticle

aldehyde reductase
Airway Remodeling
Aldehyde Reductase
phosphatidylinositol 3-kinase
Phosphatidylinositol 3-Kinases
20 Citations (Scopus)

Aldose reductase inhibition prevents colon cancer growth by restoring phosphatase and tensin homolog through modulation of miR-21 and FOXO3a

Saxena, A., Tammali, R., Ramana, K. & Srivastava, S., Apr 10 2013, In : Antioxidants and Redox Signaling. 18, 11, p. 1249-1262 14 p.

Research output: Contribution to journalArticle

Aldehyde Reductase
Phosphoric Monoester Hydrolases
Colonic Neoplasms
Modulation
Acids
20 Citations (Scopus)

Aldose reductase inhibition suppresses colon cancer cell viability by modulating microRNA-21 mediated programmed cell death 4 (PDCD4) expression

Saxena, A., Shoeb, M., Ramana, K. & Srivastava, S., Oct 2013, In : European Journal of Cancer. 49, 15, p. 3311-3319 9 p.

Research output: Contribution to journalArticle

Aldehyde Reductase
MicroRNAs
Colonic Neoplasms
Cell Survival
Cell Death
12 Citations (Scopus)

Aldose reductase regulates acrolein-induced cytotoxicity in human small airway epithelial cells

Yadav, U. C. S., Ramana, K. & Srivastava, S., 2013, In : Free Radical Biology and Medicine. 65, p. 15-25 11 p.

Research output: Contribution to journalArticle

Acrolein
Aldehyde Reductase
Cytotoxicity
Epithelial Cells
Mitochondria
22 Citations (Scopus)

Lipid peroxidation products in human health and disease

Ramana, K., Srivastava, S. & Singhal, S. S., 2013, In : Oxidative Medicine and Cellular Longevity. 583438.

Research output: Contribution to journalArticle

Oxidative stress
Malondialdehyde
Aldehydes
Rats
Animals
10 Citations (Scopus)

Piceatannol suppresses endotoxin-induced ocular inflammation in rats

Kalariya, N. M., Shoeb, M., Reddy, A. B. M., Sawhney, R. & Ramana, K., 2013, In : International Immunopharmacology. 17, 2, p. 439-446 8 p.

Research output: Contribution to journalArticle

Endotoxins
Inflammation
Uveitis
Anti-Inflammatory Agents
Nitric Oxide Synthase Type II
6 Citations (Scopus)

Prevention of allergic rhinitis by aldose reductase inhibition in a murine model.

Yadav, U. C. S., Mishra, R., Aguilera-Aguirre, L., Sur, S., Bolodgh, I., Ramana, K. & Srivatsava, S. K., Jun 2013, In : Inflammation & allergy drug targets. 12, 3, p. 178-186 9 p.

Research output: Contribution to journalArticle

Aldehyde Reductase
Nose
Cell Degranulation
Tryptases
Cytokines
71 Citations (Scopus)
Aldehydes
Lipid Peroxidation
Lipids
Oxidation-Reduction
Poisons
2012
27 Citations (Scopus)

Antidiabetic drug metformin suppresses endotoxin-induced uveitis in rats

Kalariya, N. M., Shoeb, M., Ansari, N., Srivastava, S. & Ramana, K., Jun 2012, In : Investigative Ophthalmology and Visual Science. 53, 7, p. 3431-3440 10 p.

Research output: Contribution to journalArticle

Metformin
Uveitis
Hypoglycemic Agents
Endotoxins
AMP-Activated Protein Kinases
25 Citations (Scopus)
Macrophages
Arachidonic Acid
Anti-Inflammatory Agents
Lipopolysaccharides
Epoprostenol
23 Citations (Scopus)

A potential therapeutic role for aldose reductase inhibitors in the treatment of endotoxin-related inflammatory diseases

Pandey, S., Srivastava, S. & Ramana, K., Mar 2012, In : Expert Opinion on Investigational Drugs. 21, 3, p. 329-339 11 p.

Research output: Contribution to journalArticle

Aldehyde Reductase
Endotoxins
Diabetes Complications
Therapeutics
Endotoxemia
4 Citations (Scopus)

Focus on Molecules: Lutein

Kalariya, N. M., Ramana, K. & vanKuijk, F. J. G. M., Sep 2012, In : Experimental Eye Research. 102, p. 107-108 2 p.

Research output: Contribution to journalArticle

Lutein
Macular Degeneration
Retina

How Does Oxidative Stress Affect Inflammasome Activation?

Mohammad, S. & Ramana, K. V., 2012, In : J Clin Cell Immunol. 3, p. 107

Research output: Contribution to journalArticle

20 Citations (Scopus)

Prevention of VEGF-induced growth and tube formation in human retinal endothelial cells by aldose reductase inhibition

Yadav, U. C. S., Srivastava, S. & Ramana, K., Sep 2012, In : Journal of Diabetes and its Complications. 26, 5, p. 369-377 9 p.

Research output: Contribution to journalArticle

Aldehyde Reductase
Vascular Endothelial Growth Factor A
Endothelial Cells
Growth
p38 Mitogen-Activated Protein Kinases

What is the role of 4-hydroxynonenal in inflammation?

Ramana, K. V., 2012, In : Biochem AnaBiochem. 1

Research output: Contribution to journalArticle

2011
81 Citations (Scopus)

Aldose reductase: New insights for an old enzyme

Ramana, K. V., Apr 1 2011, In : Biomolecular Concepts. 2, 1-2, p. 103-114 12 p.

Research output: Contribution to journalArticle

Aldehyde Reductase
Oxidative stress
Diabetes Complications
Aldehydes
Chemical activation
81 Citations (Scopus)

Aldose reductase: New insights for an old enzyme

Ramana, K. V., 2011, In : Biomol Concepts. 2, p. 103-114

Research output: Contribution to journalArticle

7 Citations (Scopus)

Aldose reductase deficiency in mice protects from ragweed pollen extract (RWE)-induced allergic asthma

Yadav, U. C. S., Aguilera-Aguirre, L., Boldogh, I., Ramana, K. & Srivastava, S., Nov 3 2011, In : Respiratory Research. 12, 145.

Research output: Contribution to journalArticle

Aldehyde Reductase
Asthma
Respiratory Hypersensitivity
Eosinophils
Therapeutic Irrigation
18 Citations (Scopus)

Aldose reductase deficiency protects from autoimmune- and endotoxin-induced uveitis in mice

Yadav, U. C. S., Shoeb, M., Srivastava, S. & Ramana, K., Oct 2011, In : Investigative Ophthalmology and Visual Science. 52, 11, p. 8076-8085 10 p.

Research output: Contribution to journalArticle

Aldehyde Reductase
Uveitis
Endotoxins
T-Lymphocytes
Chemokines
20 Citations (Scopus)

Aldose reductase deficiency protects sugar-induced lens opacification in rats

Reddy, A. B. M., Tammali, R., Mishra, R., Srivastava, S., Srivastava, S. & Ramana, K., May 30 2011, In : Chemico-Biological Interactions. 191, 1-3, p. 346-350 5 p.

Research output: Contribution to journalArticle

Aldehyde Reductase
Sugars
Lenses
Rats
Cataract
25 Citations (Scopus)
Hypoxia-Inducible Factor 1
Aldehyde Reductase
Proteasome Endopeptidase Complex
Colonic Neoplasms
Vascular Endothelial Growth Factor A
19 Citations (Scopus)

Aldose reductase inhibition suppresses airway inflammation

Yadav, U. C. S., Ramana, K. & Srivastava, S., May 30 2011, In : Chemico-Biological Interactions. 191, 1-3, p. 339-345 7 p.

Research output: Contribution to journalArticle

Aldehyde Reductase
Inflammation
Reactive Oxygen Species
Asthma
Epithelial Cells
90 Citations (Scopus)

Aldose reductase inhibition suppresses oxidative stress-induced inflammatory disorders

Srivastava, S., Yadav, U. C. S., Reddy, A. B. M., Saxena, A., Tammali, R., Shoeb, M., Ansari, N., Bhatnagar, A., Petrash, M. J., Srivastava, S. & Ramana, K., May 30 2011, In : Chemico-Biological Interactions. 191, 1-3, p. 330-338 9 p.

Research output: Contribution to journalArticle

Aldehyde Reductase
Oxidative stress
Oxidative Stress
Reactive Oxygen Species
Intercellular Signaling Peptides and Proteins
8 Citations (Scopus)

Amelioration of experimental autoimmune uveoretinitis by aldose reductase inhibition in lewis Rats

Yadav, U. C. S., Shoeb, M., Srivastava, S. & Ramana, K., Oct 2011, In : Investigative Ophthalmology and Visual Science. 52, 11, p. 8033-8041 9 p.

Research output: Contribution to journalArticle

Aldehyde Reductase
Uveitis
Retinoids
Aqueous Humor
Peptides
6 Citations (Scopus)

Current prospective of aldose reductase inhibition in the therapy of allergic airway inflammation in asthma

Ramana, K., Yadav, U. C. S., Calhoun, W. & Srivastava, S., 2011, In : Current Molecular Medicine. 11, 7, p. 599-608 10 p.

Research output: Contribution to journalArticle

Aldehyde Reductase
Asthma
Inflammation
Steroids
Phase III Clinical Trials
34 Citations (Scopus)

Emerging role of antioxidants in the protection of uveitis complications

Yadav, U. C. S., Kalariya, N. M. & Ramana, K., Feb 2011, In : Current Medicinal Chemistry. 18, 6, p. 931-942 12 p.

Research output: Contribution to journalArticle

Uveitis
Antioxidants
Oxidative stress
Eye Diseases
Oxidative Stress
44 Citations (Scopus)

Inhibition of aldose reductase prevents angiogenesis in vitro and in vivo

Tammali, R., Reddy, A. B. M., Srivastava, S. & Ramana, K., May 2011, In : Angiogenesis. 14, 2, p. 209-221 13 p.

Research output: Contribution to journalArticle

Aldehyde Reductase
Endothelial cells
Human Umbilical Vein Endothelial Cells
Vascular Endothelial Growth Factor A
Colonic Neoplasms
34 Citations (Scopus)

Inhibition of aldose reductase prevents colon cancer metastasis

Tammali, R., Reddy, A. B. M., Saxena, A., Rychahou, P. G., Evers, B. M., Qiu, S., Awasthi, S., Ramana, K. & Srivastava, S., 2011, In : Carcinogenesis. 32, 8, p. 1259-1267 9 p.

Research output: Contribution to journalArticle

Aldehyde Reductase
Colonic Neoplasms
Neoplasm Metastasis
Nude Mice
HT29 Cells
28 Citations (Scopus)

Inhibition of aldose reductase prevents endotoxin-induced inflammation by regulating the arachidonic acid pathway in murine macrophages

Shoeb, M., Yadav, U. C. S., Srivastava, S. & Ramana, K., Nov 1 2011, In : Free Radical Biology and Medicine. 51, 9, p. 1686-1696 11 p.

Research output: Contribution to journalArticle

Aldehyde Reductase
Macrophages
Arachidonic Acid
Endotoxins
Inflammation