Kota Ramana, PhD, MS

  • 3973 Citations
  • 36 h-Index
19962020
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Research Output 1996 2019

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1996
5 Citations (Scopus)

Induction of hepatic cytochrome P450 by phenobarbitone in rhesus monkey (Macaca mulatta)

Ramana, K. & Kohli, K. K., 1996, In : Drug and Chemical Toxicology. 19, 1-2, p. 97-107 11 p.

Research output: Contribution to journalArticle

Phenobarbital
Macaca mulatta
Cytochrome P-450 Enzyme System
Aminopyrine N-Demethylase
Proteins
1998
3 Citations (Scopus)

Differential effects of phenobarbitone on the hepatic and renal glutathione-S-transferases in the rhesus monkey

Ramana, K. & Kohli, K. K., Feb 1998, In : Indian Journal of Pharmacology. 30, 1, p. 34-37 4 p.

Research output: Contribution to journalArticle

Phenobarbital
Glutathione Transferase
Macaca mulatta
Kidney
Ethacrynic Acid
14 Citations (Scopus)

Gene regulation of cytochrome P450 - An overview

Ramana, K. & Kohli, K. K., May 1998, In : Indian Journal of Experimental Biology. 36, 5, p. 437-446 10 p.

Research output: Contribution to journalArticle

Gene expression
Cytochrome P-450 Enzyme System
Transcription Factors
Genes
Eukaryota
NADPH-Ferrihemoprotein Reductase
Mixed Function Oxygenases
Macaca mulatta
Purification
Cytochromes b5
1999
2 Citations (Scopus)
Rifampin
Oxidative Stress
Pyrazinamide
Liver
Enzymes
6 Citations (Scopus)
Aminopyrine
Phenobarbital
Macaca mulatta
Isoenzymes
Purification
2000
76 Citations (Scopus)

Kinetic and structural characterization of the glutathione-binding site of aldose reductase

Dixit, B. L., Balendiran, G. K., Watowich, S., Srivastava, S., Ramana, K., Petrash, J. M., Bhatnagar, A. & Srivastava, S., Jul 14 2000, In : Journal of Biological Chemistry. 275, 28, p. 21587-21595 9 p.

Research output: Contribution to journalArticle

Aldehyde Reductase
Glutathione
Binding Sites
Kinetics
Catalytic Domain
84 Citations (Scopus)

Selective recognition of glutathiolated aldehydes by aldose reductase

Ramana, K., Dixit, B. L., Srivastava, S., Balendiran, G. K., Srivastava, S. & Bhatnagar, A., Oct 10 2000, In : Biochemistry. 39, 40, p. 12172-12180 9 p.

Research output: Contribution to journalArticle

Aldehyde Reductase
Aldehydes
glutamyl-cysteinyl-alanine
Mutation
Aminobutyrates
2001
18 Citations (Scopus)

Characterization of the glutathione binding site of aldose reductase

Ramana, K., Dixit, B. L., Srivastava, S., Bhatnagar, A., Balendiran, G. K., Watowich, S., Petrash, J. M. & Srivastava, S., Jan 30 2001, In : Chemico-Biological Interactions. 130-132, p. 537-548 12 p.

Research output: Contribution to journalArticle

Aldehyde Reductase
Aldehydes
Glutathione
Binding Sites
Catalytic Domain
8 Citations (Scopus)

Metabolic regulation of aldose reductase activity by nitric oxide donors

Dixit, B. L., Ramana, K., Chandra, D., Jackson, E. B., Srivastava, S., Bhatnagar, A. & Srivastava, S., Jan 30 2001, In : Chemico-Biological Interactions. 130-132, p. 573-581 9 p.

Research output: Contribution to journalArticle

Aldehyde Reductase
Penicillamine
Nitric Oxide Donors
Nitrosation
Enzyme activity
32 Citations (Scopus)

Structural and kinetic modifications of aldose reductase by S-nitrosothiols

Srivastava, S., Dixit, B. L., Ramana, K., Chandra, A., Chandra, D., Zacarias, A., Petrash, J. M., Bhatnagar, A. & Srivastava, S., Aug 15 2001, In : Biochemical Journal. 358, 1, p. 111-118 8 p.

Research output: Contribution to journalArticle

S-Nitrosothiols
Aldehyde Reductase
Kinetics
Penicillamine
Nitric Oxide
2002
99 Citations (Scopus)

Aldose reductase mediates mitogenic signaling in vascular smooth muscle cells

Ramana, K., Chandra, D., Srivastava, S., Bhatnagar, A., Aggarwal, B. B. & Srivastava, S., Aug 30 2002, In : Journal of Biological Chemistry. 277, 35, p. 32063-32070 8 p.

Research output: Contribution to journalArticle

Aldehyde Reductase
Vascular Smooth Muscle
Smooth Muscle Myocytes
Muscle
Cells
1 Citation (Scopus)

Estimation of oxygen free radicals and nonenzymatic antioxidants in living-related donor kidney transplantation

Minz, M., Ramana, K., Sakhuja, V. K. & Ganguly, N. K., Sep 2002, In : Transplantation Proceedings. 34, 6, p. 2029 1 p.

Research output: Contribution to journalArticle

Living Donors
Malondialdehyde
Vitamin A
Vitamin E
Kidney Transplantation
38 Citations (Scopus)

Inhibition of fiber cell globulization and hyperglycemia-induced lens opacification by aminopeptidase inhibitor bestatin

Chandra, D., Ramana, K., Wang, L., Christensen, B. N., Bhatnagar, A. & Srivastava, S., 2002, In : Investigative Ophthalmology and Visual Science. 43, 7, p. 2285-2292 8 p.

Research output: Contribution to journalArticle

Aminopeptidases
Hyperglycemia
Lenses
leucylmethionine
Calpain
58 Citations (Scopus)

Nitric oxide prevents aldose reductase activation and sorbitol accumulation during diabetes

Chandra, D., Jackson, E. B., Ramana, K., Kelley, R., Srivastava, S. & Bhatnagar, A., Oct 1 2002, In : Diabetes. 51, 10, p. 3095-3101 7 p.

Research output: Contribution to journalArticle

Aldehyde Reductase
Sorbitol
Nitric Oxide
NG-Nitroarginine Methyl Ester
Nitric Oxide Donors
2003
1 Citation (Scopus)

Aldose reductase and the stress response

Bhatnagar, A., Liu, S. Q., Srivastava, S., Ramana, K. & Srivastava, S., 2003, In : ACS Symposium Series. 865, p. 199-210 12 p.

Research output: Contribution to journalArticle

Aldehyde Reductase
Oxidoreductases
2 Citations (Scopus)

Aldose reductase detoxifies lipid aldehydes and their glutathione conjugates

Srivastava, S., Ramana, K., Srivastava, S. & Bhatnagar, A., 2003, In : ACS Symposium Series. 865, p. 37-48 12 p.

Research output: Contribution to journalArticle

Aldehyde Reductase
Aldehydes
Glutathione
Lipids
79 Citations (Scopus)
Aldehyde Reductase
Hyperglycemia
Lenses
Tumor Necrosis Factor-alpha
Epithelial Cells
21 Citations (Scopus)

Aldose reductase mediates the mitogenic signals of cytokines

Ramana, K., Chandra, D., Srivastava, S., Bhatnagar, A. & Srivastava, S., Feb 1 2003, In : Chemico-Biological Interactions. 143-144, p. 587-596 10 p.

Research output: Contribution to journalArticle

Aldehyde Reductase
Cytokines
Chemical activation
Vascular Smooth Muscle
Smooth Muscle Myocytes

Aldose reductase regulates reactive oxygen species mediated-inflammatory signals

Ramana, K., Chandra, D., Srivastava, S., Bhatnagar, A., Aggarwal, B. B. & Srivastava, S., 2003, In : ACS Symposium Series. 865, p. 213-223 11 p.

Research output: Contribution to journalArticle

Aldehyde Reductase
Reactive Oxygen Species
42 Citations (Scopus)

Nitric oxide regulates the polyol pathway of glucose metabolism in vascular smooth muscle cells

Ramana, K., Chandra, D., Srivastava, S., Bhatnagar, A. & Srivastava, S., Mar 1 2003, In : FASEB Journal. 17, 3, p. 417-425 9 p.

Research output: Contribution to journalArticle

aldehyde reductase
Aldehyde Reductase
polyols
Vascular Smooth Muscle
blood vessels
27 Citations (Scopus)

Regulation of aldose reductase and the polyol pathway activity by nitric oxide

Srivastava, S., Ramana, K., Chandra, D., Srivastava, S. & Bhatnagar, A., Feb 1 2003, In : Chemico-Biological Interactions. 143-144, p. 333-340 8 p.

Research output: Contribution to journalArticle

Aldehyde Reductase
Nitric Oxide
Nitric Oxide Donors
Sorbitol
Diabetes Complications
2 Citations (Scopus)

Role of aldose reductase in the detoxification of oxidized phospholipids

Srivastava, S., Ramana, K., Srivastava, S. K., D'Souza, S. E. & Bhatnagar, A., 2003, In : ACS Symposium Series. 865, p. 49-64 16 p.

Research output: Contribution to journalArticle

Aldehyde Reductase
Detoxification
Phospholipids
Oxidoreductases
15 Citations (Scopus)

Role of aldose reductase in TNF-α-induced apoptosis of vascular endothelial cells

Chandra, D., Ramana, K., Friedrich, B., Srivastava, S., Bhatnagar, A. & Srivastava, S., Feb 1 2003, In : Chemico-Biological Interactions. 143-144, p. 605-612 8 p.

Research output: Contribution to journalArticle

Aldehyde Reductase
Endothelial cells
Endothelial Cells
Tumor Necrosis Factor-alpha
Apoptosis
2004
126 Citations (Scopus)

Activation of nulcear factor-κB by hyperglycemia in vascular smooth muscle cells is regulated by aldose reductase

Ramana, K., Friedrich, B., Srivastava, S., Bhatnagar, A. & Srivastava, S., Nov 2004, In : Diabetes. 53, 11, p. 2910-2920 11 p.

Research output: Contribution to journalArticle

Aldehyde Reductase
Vascular Smooth Muscle
Hyperglycemia
Smooth Muscle Myocytes
Protein Kinase C
40 Citations (Scopus)

Aldose reductase regulates TNF-α-induced cell signaling and apoptosis in vascular endothelial cells

Ramana, K., Bhatnagar, A. & Srivastava, S., Jul 16 2004, In : FEBS Letters. 570, 1-3, p. 189-194 6 p.

Research output: Contribution to journalArticle

Cell signaling
Aldehyde Reductase
Endothelial cells
Endothelial Cells
Apoptosis
64 Citations (Scopus)

Inhibition of aldose reductase attenuates TNF-α-induced expression of adhesion molecules in endothelial cells

Ramana, K., Bhatnagar, A. & Srivastava, S., Aug 2004, In : FASEB Journal. 18, 11, p. 1209-1218 10 p.

Research output: Contribution to journalArticle

aldehyde reductase
Aldehyde Reductase
Endothelial cells
endothelial cells
adhesion
15 Citations (Scopus)

Oxidative stress-induced up-regulation of the chloride channel and Na +/Ca2+ exchanger during cataractogenesis in diabetic rats

Ramana, K., Chandra, D., Wills, N. K., Bhatnagar, A. & Srivastava, S., May 2004, In : Journal of Diabetes and its Complications. 18, 3, p. 177-182 6 p.

Research output: Contribution to journalArticle

Chloride Channels
Oxidative Stress
Up-Regulation
Proteins
Lenses
2005
6 Citations (Scopus)

Regulation of lens aldose reductase activity by nitric oxide

Srivastava, S., Tammali, R., Chandra, D., Greer, D. A., Ramana, K., Bhatnagar, A. & Srivastava, S., Dec 2005, In : Experimental Eye Research. 81, 6, p. 664-672 9 p.

Research output: Contribution to journalArticle

Aldehyde Reductase
Lenses
Nitric Oxide
Sorbitol
S-Nitroso-N-Acetylpenicillamine
96 Citations (Scopus)

Requirement of aldose reductase for the hyperglycemic activation of protein kinase C and formation of diacylglycerol in vascular smooth muscle cells

Ramana, K., Friedrich, B., Tammali, R., West, M. B., Bhatnagar, A. & Srivastava, S., Mar 2005, In : Diabetes. 54, 3, p. 818-829 12 p.

Research output: Contribution to journalArticle

Aldehyde Reductase
Diglycerides
Vascular Smooth Muscle
Protein Kinase C
Smooth Muscle Myocytes
344 Citations (Scopus)

Role of aldose reductase and oxidative damage in diabetes and the consequent potential for therapeutic options

Srivastava, S., Ramana, K. & Bhatnagar, A., May 2005, In : Endocrine Reviews. 26, 3, p. 380-392 13 p.

Research output: Contribution to journalArticle

Aldehyde Reductase
Diabetes Complications
Aldehydes
Therapeutics
Glucose
2006
109 Citations (Scopus)

Aldose reductase mediates the lipopolysaccharide-induced release of inflammatory mediators in RAW264.7 murine macrophages

Ramana, K., Fadl, A. A., Tammali, R., Reddy, A. B. M., Chopra, A. & Srivastava, S., Nov 3 2006, In : Journal of Biological Chemistry. 281, 44, p. 33019-33029 11 p.

Research output: Contribution to journalArticle

Aldehyde Reductase
Macrophages
Lipopolysaccharides
Type C Phospholipases
Ablation
15 Citations (Scopus)

Aldose reductase prevents aldehyde toxicity in cultured human lens epithelial cells

Pladzyk, A., Ramana, K., Ansari, N. & Srivastava, S., Aug 2006, In : Experimental Eye Research. 83, 2, p. 408-416 9 p.

Research output: Contribution to journalArticle

Aldehyde Reductase
Aldehydes
Lenses
Epithelial Cells
Lipids
77 Citations (Scopus)

Aldose reductase regulates growth factor-induced cyclooxygenase-2 expression and prostaglandin E2 production in human colon cancer cells

Tammali, R., Ramana, K., Singhal, S. S., Awasthi, S. & Srivastava, S., Oct 1 2006, In : Cancer Research. 66, 19, p. 9705-9713 9 p.

Research output: Contribution to journalArticle

Aldehyde Reductase
Cyclooxygenase 2
Caco-2 Cells
Dinoprostone
Colonic Neoplasms
54 Citations (Scopus)

Contribution of aldose reductase to diabetic hyperproliferation of vascular smooth muscle cells

Srivastava, S., Ramana, K., Tammali, R., Srivastava, S. & Bhatnagar, A., 2006, In : Diabetes. 55, 4, p. 901-910 10 p.

Research output: Contribution to journalArticle

Aldehyde Reductase
Vascular Smooth Muscle
Smooth Muscle Myocytes
Tunica Intima
Growth
75 Citations (Scopus)

Endotoxin-induced cardiomyopathy and systemic inflammation in mice is prevented by aldose reductase inhibition

Ramana, K., Willis, M. S., White, M. D., Horton, J. W., Dimaio, J. M., Srivastava, D., Bhatnagar, A. & Srivastava, S., Oct 2006, In : Circulation. 114, 17, p. 1838-1846 9 p.

Research output: Contribution to journalArticle

Aldehyde Reductase
Cardiomyopathies
Endotoxins
Inflammation
Cytokines
34 Citations (Scopus)

Inhibition of aldose reductase prevents lipopolysaccharide-induced inflammatory response in human lens epithelial cells

Pladzyk, A., Reddy, A. B. M., Yadav, U. C. S., Tammali, R., Ramana, K. & Srivastava, S., Dec 2006, In : Investigative Ophthalmology and Visual Science. 47, 12, p. 5395-5403 9 p.

Research output: Contribution to journalArticle

Aldehyde Reductase
Lenses
Lipopolysaccharides
Epithelial Cells
Matrix Metalloproteinases
48 Citations (Scopus)

Mediation of aldose reductase in lipopolysaccharide-induced inflammatory signals in mouse peritoneal macrophages

Ramana, K. & Srivastava, S., Nov 2006, In : Cytokine. 36, 3-4, p. 115-122 8 p.

Research output: Contribution to journalArticle

Aldehyde Reductase
Macrophages
Peritoneal Macrophages
Lipopolysaccharides
Cytokines
115 Citations (Scopus)

Mitogenic responses of vascular smooth muscle cells to lipid peroxidation-derived aldehyde 4-hydroxy-trans-2-nonenal (HNE): Role of aldose reductase-catalyzed reduction of the HNE-glutathione conjugates in regulating cell growth

Ramana, K., Bhatnagar, A., Srivastava, S., Yadav, U. C., Awasthi, S., Awasthi, Y. C. & Srivastava, S., Jun 30 2006, In : Journal of Biological Chemistry. 281, 26, p. 17652-17660 9 p.

Research output: Contribution to journalArticle

Aldehyde Reductase
Cell growth
Vascular Smooth Muscle
Aldehydes
Lipid Peroxidation
28 Citations (Scopus)

Structure of a glutathione conjugate bound to the active site of aldose reductase

Singh, R., White, M., Ramana, K., Petrash, J. M., Watowich, S., Bhatnagar, A. & Srivastava, S., Jul 1 2006, In : Proteins: Structure, Function and Genetics. 64, 1, p. 101-110 10 p.

Research output: Contribution to journalArticle

Aldehyde Reductase
Glutathione
Catalytic Domain
Aldehydes
S-(1,2-dicarboxyethyl)glutathione
2007
68 Citations (Scopus)

Aldose reductase inhibition prevents endotoxin-induced uveitis in rats

Yadav, U. C. S., Srivastava, S. & Ramana, K., Oct 2007, In : Investigative Ophthalmology and Visual Science. 48, 10, p. 4634-4642 9 p.

Research output: Contribution to journalArticle

Aldehyde Reductase
Uveitis
Endotoxins
Lipopolysaccharides
Aqueous Humor
45 Citations (Scopus)

Aldose reductase mediates endotoxin-induced production of nitric oxide and cytotoxicity in murine macrophages

Ramana, K., Reddy, A. B. M., Tammali, R. & Srivastava, S., Apr 15 2007, In : Free Radical Biology and Medicine. 42, 8, p. 1290-1302 13 p.

Research output: Contribution to journalArticle

Aldehyde Reductase
Macrophages
Cytotoxicity
Endotoxins
Nitric Oxide
41 Citations (Scopus)

Aldose reductase-regulated tumor necrosis factor-α production is essential for high glucose-induced vascular smooth muscle cell growth

Ramana, K., Tammali, R., Reddy, A. B. M., Bhatnagar, A. & Srivastava, S., Sep 2007, In : Endocrinology. 148, 9, p. 4371-4384 14 p.

Research output: Contribution to journalArticle

Aldehyde Reductase
Vascular Smooth Muscle
Smooth Muscle Myocytes
Tumor Necrosis Factor-alpha
Glucose
48 Citations (Scopus)

Aldose reductase regulates TNF-α-induced PGE2 production in human colon cancer cells

Tammali, R., Ramana, K. & Srivastava, S., Jul 18 2007, In : Cancer Letters. 252, 2, p. 299-306 8 p.

Research output: Contribution to journalArticle

Aldehyde Reductase
Dinoprostone
Colonic Neoplasms
Caco-2 Cells
Cyclooxygenase 2
2008
56 Citations (Scopus)

Carotenoid derived aldehydes-induced oxidative stress causes apoptotic cell death in human retinal pigment epithelial cells

Kalariya, N. M., Ramana, K., Srivastava, S. & van Kuijk, F. J. G. M., Jan 2008, In : Experimental Eye Research. 86, 1, p. 70-80 11 p.

Research output: Contribution to journalArticle

Retinal Pigments
Carotenoids
Aldehydes
Oxidative Stress
Cell Death
44 Citations (Scopus)

Glutathione level regulates HNE-induced genotoxicity in human erythroleukemia cells

Yadav, U. C. S., Ramana, K., Awasthi, Y. C. & Srivastava, S., Mar 1 2008, In : Toxicology and Applied Pharmacology. 227, 2, p. 257-264 8 p.

Research output: Contribution to journalArticle

Leukemia, Erythroblastic, Acute
Glutathione
DNA Damage
K562 Cells
DNA
19 Citations (Scopus)

l-Arginine prevents metabolic effects of high glucose in diabetic mice

West, M. B., Ramana, K., Kaiserova, K., Srivastava, S. & Bhatnagar, A., Jul 23 2008, In : FEBS Letters. 582, 17, p. 2609-2614 6 p.

Research output: Contribution to journalArticle

Medical problems
Protein Kinase C
Arginine
Glucose
Aldehyde Reductase
2009
33 Citations (Scopus)

Aldose reductase deficiency in mice prevents azoxymethane-induced colonic preneoplastic aberrant crypt foci formation

Tammali, R., Reddy, A. B. M., Ramana, K., Petrash, M. J. & Srivastava, S., 2009, In : Carcinogenesis. 30, 5, p. 799-807 9 p.

Research output: Contribution to journalArticle

Aberrant Crypt Foci
Azoxymethane
Aldehyde Reductase
Colonic Neoplasms
Colon
36 Citations (Scopus)

Aldose reductase inhibition suppresses the expression of Th2 cytokines and airway inflammation in ovalbumin-induced asthma in mice

Yadav, U. C. S., Naura, A. S., Aguilera-Aguirre, L., Ramana, K., Boldogh, I., Sur, S., Boulares, H. A. & Srivastava, S., Oct 1 2009, In : Journal of Immunology. 183, 7, p. 4723-4732 10 p.

Research output: Contribution to journalArticle

Aldehyde Reductase
Ovalbumin
Asthma
Cytokines
Inflammation
35 Citations (Scopus)

Aldose reductase regulates high glucose-induced ectodomain shedding of tumor necrosis factor (TNF)-α via protein kinase C-δ and TNF-α converting enzyme in vascular smooth muscle cells

Reddy, A. B. M., Ramana, K., Srivastava, S., Bhatnagar, A. & Srivastava, S., Jan 2009, In : Endocrinology. 150, 1, p. 63-74 12 p.

Research output: Contribution to journalArticle

Aldehyde Reductase
Vascular Smooth Muscle
Protein Kinase C
Smooth Muscle Myocytes
Tumor Necrosis Factor-alpha