Larry Denner, PhD

Director, Research Discovery and Translation

  • 3280 Citations
  • 32 h-Index
1978 …2019
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Research Output 1978 2019

  • 3280 Citations
  • 32 h-Index
  • 72 Article
  • 2 Chapter
  • 2 Comment/debate
  • 1 Review article
2019
2 Citations (Scopus)
Open Access
Aryl Hydrocarbon Receptors
White Adipose Tissue
Brown Adipose Tissue
Thermogenesis
respiration
2018
Publications
Actins
Alzheimer Disease
Ointments
Insulin

Glutamate decarboxylase

Wu, J. Y., Denner, L., Lin, C. T. & Hwang, B., Jan 1 2018, Glutamine and Glutamate Mammals: Volume I. CRC Press, p. 101-122 22 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Glutamate Decarboxylase
Neuroglia
gamma-Aminobutyric Acid
GABAergic Neurons
Aminobutyrates
4 Citations (Scopus)

Targeting Insulin for Alzheimer's Disease: Mechanisms, Status and Potential Directions

Lee, J. H., Jahrling, J. B., Denner, L. & Dineley, K., Jan 1 2018, In : Journal of Alzheimer's Disease. 64, s1, p. S427-S453

Research output: Contribution to journalReview article

Alzheimer Disease
Insulin
Insulin Resistance
Brain
Direction compound
2017
24 Citations (Scopus)

Central insulin dysregulation and energy dyshomeostasis in two mouse models of Alzheimer's disease

Velazquez, R., Tran, A., Ishimwe, E., Denner, L., Dave, N., Oddo, S. & Dineley, K., Oct 1 2017, In : Neurobiology of Aging. 58, p. 1-13 13 p.

Research output: Contribution to journalArticle

Alzheimer Disease
Insulin
Insulin Resistance
Central Nervous System
Vascular Resistance
Ointments
Alzheimer Disease
Insulin
corrigendum
15 Citations (Scopus)

PPARgamma agonists rescue increased phosphorylation of FGF14 at S226 in the Tg2576 mouse model of Alzheimer's disease

Hsu, W. C. J., Wildburger, N. C., Haidacher, S. J., Nenov, M. N., Folorunso, O., Singh, A. K., Chesson, B. C., Franklin, W. F., Cortez, I., Sadygov, R., Dineley, K., Rudra, J. S., Taglialatela, G., Lichti, C. F., Denner, L. & Laezza, F., Sep 1 2017, In : Experimental Neurology. 295, p. 1-17 17 p.

Research output: Contribution to journalArticle

rosiglitazone
PPAR gamma
Alzheimer Disease
Dentate Gyrus
Phosphorylation
2 Citations (Scopus)

The progestin receptor interactome in the female mouse hypothalamus: Interactions with synaptic proteins are isoform specific and ligand dependent

Acharya, K. D., Nettles, S. A., Sellers, K. J., Im, D. D., Harling, M., Pattanayak, C., Vardar-Ulu, D., Lichti, C. F., Huang, S., Edwards, D. P., Srivastava, D. P., Denner, L. & Tetel, M. J., Sep 1 2017, In : eNeuro. 4, 5, e0272-17.2017.

Research output: Contribution to journalArticle

Progesterone Receptors
Hypothalamus
Protein Isoforms
Ligands
Synapsins
2016
8 Citations (Scopus)

PPARγ agonism attenuates cocaine cue reactivity

Miller, W. R., Fox, R. G., Stutz, S. J., Lane, S. D., Denner, L., Cunningham, K. & Dineley, K., 2016, (Accepted/In press) In : Addiction Biology.

Research output: Contribution to journalArticle

Peroxisome Proliferator-Activated Receptors
Cocaine
Cues
Recurrence
Rodentia
2015
15 Citations (Scopus)

Impaired firing properties of dentate granule neurons in an Alzheimer’s disease animal model are rescued by PPARγ agonism

Nenov, M. N., Tempia, F., Denner, L., Dineley, K. & Laezza, F., Mar 15 2015, In : Journal of Neurophysiology. 113, 6, p. 1712-1726 15 p.

Research output: Contribution to journalArticle

rosiglitazone
Peroxisomes
Dentate Gyrus
Alzheimer Disease
Animal Models
13 Citations (Scopus)

Targeted proteomics for biomarker discovery and validation of hepatocellular carcinoma in hepatitis C infected patients

Mustafa, G. M., Denner, L., Petersen, J. R. & Elferink, C., 2015, In : World Journal of Hepatology. 7, 10, p. 1312-1324 13 p.

Research output: Contribution to journalArticle

Hepatitis C
Proteomics
Hepatocellular Carcinoma
Biomarkers
Body Fluids
2014
39 Citations (Scopus)

Cognitive enhancing treatment with a PPARγ agonist normalizes dentate granule cell presynaptic function in Tg2576 APP mice

Nenov, M. N., Laezza, F., Haidacher, S. J., Zhao, Y., Sadygov, R., Starkey, J., Spratt, H., Luxon, B. A., Dineley, K. & Denner, L., 2014, In : Journal of Neuroscience. 34, 3, p. 1028-1036 9 p.

Research output: Contribution to journalArticle

PPAR gamma
Dentate Gyrus
Alzheimer Disease
Therapeutics
SNARE Proteins
52 Citations (Scopus)

Insulin resistance in Alzheimer's disease

Dineley, K., Jahrling, J. B. & Denner, L., Dec 1 2014, In : Neurobiology of Disease. 72, PA, p. 92-103 12 p.

Research output: Contribution to journalArticle

Insulin Resistance
Alzheimer Disease
Insulin
Disease Resistance
Animal Models
39 Citations (Scopus)

PPARγ recruitment to active ERK during memory consolidation is required for alzheimer's disease-related cognitive enhancement

Jahrling, J. B., Hernandez, C. M., Denner, L. & Dineley, K., 2014, In : Journal of Neuroscience. 34, 11, p. 4054-4063 10 p.

Research output: Contribution to journalArticle

Peroxisome Proliferator-Activated Receptors
Alzheimer Disease
rosiglitazone
Cognitive Reserve
Memory Consolidation
2013
31 Citations (Scopus)

Biomarker discovery for early detection of hepatocellular carcinoma in hepatitis C-Infected patients

Mustafa, M. G., Petersen, J. R., Ju, H., Cicalese, L., Snyder, N., Haidacher, S. J., Denner, L. & Elferink, C., Dec 2013, In : Molecular and Cellular Proteomics. 12, 12, p. 3640-3652 13 p.

Research output: Contribution to journalArticle

Biomarkers
Hepatitis C
Viruses
Hepatocellular Carcinoma
Hepacivirus
16 Citations (Scopus)

Detection of structural and metabolic changes in traumatically injured hippocampus by quantitative differential proteomics

Wu, P., Zhao, Y., Haidacher, S. J., Wang, E., Parsley, M. O., Gao, J., Sadygov, R., Starkey, J., Luxon, B. A., Spratt, H., Dewitt, D., Prough, D. & Denner, L., May 1 2013, In : Journal of Neurotrauma. 30, 9, p. 775-788 14 p.

Research output: Contribution to journalArticle

Proteomics
Hippocampus
Calcineurin
Down-Regulation
Knowledge Bases
2012
75 Citations (Scopus)

Cognitive enhancement with rosiglitazone links the hippocampal PPARγ and ERK MAPK signaling pathways

Denner, L., Rodriguez-Rivera, J., Haidacher, S. J., Jahrling, J. B., Carmical, J. R., Hernandez, C. M., Zhao, Y., Sadygov, R., Starkey, J., Spratt, H., Luxon, B. A., Wood, T. & Dineley, K., Nov 21 2012, In : Journal of Neuroscience. 32, 47, p. 16725-16735 11 p.

Research output: Contribution to journalArticle

rosiglitazone
Peroxisome Proliferator-Activated Receptors
Extracellular Signal-Regulated MAP Kinases
Mitogen-Activated Protein Kinases
Protein Kinases

Corrigendum to "The simplest method for in vitro Β-cell production from human adult stem cells" [Differentiation 82 (2011) 144-152]

Bhandari, D. R., Seo, K. W., Sun, B., Seo, M. S., Kim, H. S., Seo, Y. J., Jurga, M., Forraz, N., Le Roy, H., Denner, L., McGuckin, C. P. & Kang, K. S., Apr 2012, In : Differentiation. 83, 4, p. 232 1 p.

Research output: Contribution to journalArticle

Adult Stem Cells
Cell Differentiation
corrigendum
In Vitro Techniques
7 Citations (Scopus)

Development of a novel protocol for isolation and purification of human granulosa cells

Chilvers, R. A., Bodenburg, Y. H., Denner, L. & Urban, R., Jun 2012, In : Journal of Assisted Reproduction and Genetics. 29, 6, p. 547-556 10 p.

Research output: Contribution to journalArticle

Granulosa Cells
Follicular Fluid
Density Gradient Centrifugation
Antibodies
Oocyte Retrieval
22 Citations (Scopus)

Molecular mechanisms underlying effects of neural stem cells against traumatic axonal injury

Wang, E., Gao, J., Yang, Q., Parsley, M. O., Dunn, T. J., Zhang, L., Dewitt, D., Denner, L., Prough, D. & Wu, P., Jan 20 2012, In : Journal of Neurotrauma. 29, 2, p. 295-312 18 p.

Research output: Contribution to journalArticle

Glial Cell Line-Derived Neurotrophic Factor
Neural Stem Cells
Wounds and Injuries
Actins
Amyloid beta-Protein Precursor
2011
64 Citations (Scopus)

Rosiglitazone reversal of Tg2576 cognitive deficits is independent of peripheral gluco-regulatory status

Rodriguez-Rivera, J., Denner, L. & Dineley, K., Jan 1 2011, In : Behavioural Brain Research. 216, 1, p. 255-261 7 p.

Research output: Contribution to journalArticle

rosiglitazone
PPAR gamma
Alzheimer Disease
Reversal Learning
Memory Disorders
27 Citations (Scopus)

The simplest method for in vitro Β-cell production from human adult stem cells

Bhandari, D. R., Seo, K. W., Sun, B., Seo, M. S., Kim, H. S., Seo, Y. J., Marcin, J., Forraz, N., Roy, H. L., Denner, L., Colin, M. & Kang, K. S., Oct 2011, In : Differentiation. 82, 3, p. 144-152 9 p.

Research output: Contribution to journalArticle

Adult Stem Cells
Insulin
Endoderm
C-Peptide
Mesenchymal Stromal Cells
2010
33 Citations (Scopus)

Altered retinoic acid metabolism in diabetic mouse kidney identified by 18O isotopic labeling and 2D mass spectrometry

Starkey, J., Zhao, Y., Sadygov, R., Haidacher, S. J., S.LeJeune, W., Dey, N., Luxon, B. A., Kane, M. A., Napoli, J. L., Denner, L. & Tilton, R., 2010, In : PLoS One. 5, 6, e11095.

Research output: Contribution to journalArticle

retinoic acid
Tretinoin
Metabolism
Labeling
Mass spectrometry
11 Citations (Scopus)

Insulin-like growth factor-I activates extracellularly regulated kinase to regulate the P450 side-chain cleavage insulin-like response element in granulosa cells

Denner, L., Bodenburg, Y. H., Jiang, J., Pagès, G. & Urban, R., Jun 2010, In : Endocrinology. 151, 6, p. 2819-2825 7 p.

Research output: Contribution to journalArticle

Protein Splicing
Granulosa Cells
Response Elements
Insulin-Like Growth Factor I
Phosphotransferases

Signaling pathways regulating growth and differentiation of adult stem cells

Denner, L., Howe, M. & Urban, R., 2010, Handbook of Cell Signaling, 2/e. Elsevier Inc., Vol. 3. p. 2743-2751 9 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Glycogen Synthase Kinase 3
Adult Stem Cells
Stem cells
Protein Isoforms
Phosphorylation
21 Citations (Scopus)

Steroid receptor coactivator-2 expression in brain and physical associations with steroid receptors

Yore, M. A., Im, D., Webb, L. K., Zhao, Y., Chadwick, J. G., Molenda-Figueira, H. A., Haidacher, S. J., Denner, L. & Tetel, M. J., Sep 2010, In : Neuroscience. 169, 3, p. 1017-1028 12 p.

Research output: Contribution to journalArticle

Nuclear Receptor Coactivator 2
Steroid Receptors
Estrogen Receptors
Brain
Progesterone Receptors
8 Citations (Scopus)
Type 2 Diabetes Mellitus
Chronic Disease
Cytokines
Interleukin 1 Receptor Antagonist Protein
Social Adjustment
16 Citations (Scopus)

Using power spectrum analysis to evaluate 18o-water labeling data acquired from low resolution mass spectrometers

Sadygov, R., Zhao, Y., Haidacher, S. J., Starkey, J., Tilton, R. & Denner, L., Aug 6 2010, In : Journal of Proteome Research. 9, 8, p. 4306-4312 7 p.

Research output: Contribution to journalArticle

Mass spectrometers
Power spectrum
Spectrum analysis
Labeling
Spectrum Analysis
2009
38 Citations (Scopus)

Blockage of receptor for advanced glycation end products prevents development of cardiac dysfunction in db/db type 2 diabetic mice

Nielsen, J. M., Kristiansen, S. B., Nørregaard, R., Andersen, C. L., Denner, L., Nielsen, T. T., Flyvbjerg, A. & Bøtker, H. E., Jul 2009, In : European Journal of Heart Failure. 11, 7, p. 638-647 10 p.

Research output: Contribution to journalArticle

Myocardium
Protein Isoforms
Gene Expression
Diabetes Complications
Myosins
6 Citations (Scopus)

Oct-4A isoform is expressed in human cord blood-derived CD133 stem cells and differentiated progeny

Howe, M., Zhao, J., Bodenburg, Y., McGuckin, C. P., Forraz, N., Tilton, R., Urban, R. & Denner, L., Jun 2009, In : Cell Proliferation. 42, 3, p. 265-275 11 p.

Research output: Contribution to journalArticle

Fetal Blood
Protein Isoforms
Stem Cells
Embryonic Stem Cells
Flow Cytometry
2008
32 Citations (Scopus)

A neutralizing antibody against receptor for advanced glycation end products (RAGE) reduces atherosclerosis in uremic mice

Bro, S., Flyvbjerg, A., Binder, C. J., Bang, C. A., Denner, L., Olgaard, K. & Nielsen, L. B., Dec 2008, In : Atherosclerosis. 201, 2, p. 274-280 7 p.

Research output: Contribution to journalArticle

Neutralizing Antibodies
Atherosclerosis
Uremia
Apolipoproteins E
Antibodies
19 Citations (Scopus)

Comprehensive analysis of the mouse renal cortex using two-dimensional HPLC - Tandem mass spectrometry

Zhao, Y., Denner, L., Haidacher, S. J., LeJeune, W. S. & Tilton, R., May 23 2008, In : Proteome Science. 6, 15.

Research output: Contribution to journalArticle

Tandem Mass Spectrometry
Mass spectrometry
High Pressure Liquid Chromatography
Kidney
Proteome
2 Citations (Scopus)

Critical issues for engineering cord blood stem cells to produce insulin

Denner, L. & Urban, R., Sep 2008, In : Expert Opinion on Biological Therapy. 8, 9, p. 1251-1254 4 p.

Research output: Contribution to journalArticle

Stem cells
Fetal Blood
Blood Cells
Blood
Stem Cells
19 Citations (Scopus)

Identification of ERK and JNK as signaling mediators on protein kinase C activation in cultured granulosa cells

Sriraman, V., Modi, S. R., Bodenburg, Y., Denner, L. & Urban, R., Nov 6 2008, In : Molecular and Cellular Endocrinology. 294, 1-2, p. 52-60 9 p.

Research output: Contribution to journalArticle

Granulosa Cells
Protein Kinase C
Cultured Cells
Acetates
Chemical activation
32 Citations (Scopus)

Steroid receptor coactivator-1 from brain physically interacts differentially with steroid receptor subtypes

Molenda-Figueira, H. A., Murphy, S. D., Shea, K. L., Siegal, N. K., Zhao, Y., Chadwick, J. G., Denner, L. & Tetel, M. J., Oct 2008, In : Endocrinology. 149, 10, p. 5272-5279 8 p.

Research output: Contribution to journalArticle

Nuclear Receptor Coactivator 1
Steroid Receptors
Progesterone Receptors
Estrogens
Brain
2007
48 Citations (Scopus)

Diabetes-induced changes in the renal cortical proteome assessed with two-dimensional gel electrophoresis and mass spectrometry

Tilton, R., Haidacher, S. J., LeJeune, W. S., Zhang, X., Zhao, Y., Kurosky, A., Brasier, A. R. & Denner, L., May 2007, In : Proteomics. 7, 10, p. 1729-1742 14 p.

Research output: Contribution to journalArticle

Electrophoresis, Gel, Two-Dimensional
Proteome
Medical problems
Electrophoresis
Mass spectrometry
64 Citations (Scopus)

Directed engineering of umbilical cord blood stem cells to produce C-peptide and insulin

Denner, L., Bodenburg, Y., Zhao, J. G., Howe, M., Cappo, J., Tilton, R., Copland, J. A., Forraz, N., McGuckin, C. & Urban, R., Jun 2007, In : Cell Proliferation. 40, 3, p. 367-380 14 p.

Research output: Contribution to journalArticle

C-Peptide
Fetal Blood
Blood Cells
Stem Cells
Embryonic Stem Cells
2006
44 Citations (Scopus)

Diabetes-induced activation of canonical and noncanonical nuclear factor-κB pathways in renal cortex

Starkey, J., Haidacher, S. J., LeJeune, W. S., Zhang, X., Tieu, B. C., Choudhary, S., Brasier, A. R., Denner, L. & Tilton, R., 2006, In : Diabetes. 55, 5, p. 1252-1259 8 p.

Research output: Contribution to journalArticle

Kidney
Proteins
Phosphotransferases
Cytokines
DNA-Binding Proteins
35 Citations (Scopus)

Functional analysis of the nuclear proteome of human A549 alveolar epithelial cells by HPLC-high resolution 2-D gel electrophoresis

Forbus, J., Spratt, H., Wiktorowicz, J., Wu, Z., Boldogh, I., Denner, L., Kurosky, A., Brasier, R. C., Luxon, B. & Brasier, A. R., May 2006, In : Proteomics. 6, 9, p. 2656-2672 17 p.

Research output: Contribution to journalArticle

Alveolar Epithelial Cells
Functional analysis
Electrophoresis, Gel, Two-Dimensional
Proteome
Electrophoresis
60 Citations (Scopus)

Renal effects of a neutralising RAGE-antibody in long term streptozotocin-diabetic mice

Jensen, L. J. N., Denner, L., Schrijvers, B. F., Tilton, R., Rasch, R. & Flyvbjerg, A., Mar 2006, In : Journal of Endocrinology. 188, 3, p. 493-501 9 p.

Research output: Contribution to journalArticle

Streptozocin
Neutralizing Antibodies
Kidney
Antibodies
Type 1 Diabetes Mellitus
2005
23 Citations (Scopus)

Inhibition of vascular endothelial growth factor (VEGF) does not affect early renal changes in a rat model of lean type 2 diabetes

Schrijvers, B. F., De Vriese, A. S., Tilton, R., Van De Voorde, J., Denner, L., Lameire, N. H. & Flyvbjerg, A., Jan 2005, In : Hormone and Metabolic Research. 37, 1, p. 21-25 5 p.

Research output: Contribution to journalArticle

Medical problems
Type 2 Diabetes Mellitus
Vascular Endothelial Growth Factor A
Rats
Kidney
177 Citations (Scopus)

Production of stem cells with embryonic characteristics from human umbilical cord blood

McGuckin, C. P., Forraz, N., Baradez, M. O., Navran, S., Zhao, J., Urban, R., Tilton, R. & Denner, L., Aug 2005, In : Cell Proliferation. 38, 4, p. 245-255 11 p.

Research output: Contribution to journalArticle

Embryonic Stem Cells
Fetal Blood
Stem Cell Factor
Stem Cells
CD15 Antigens
2004
149 Citations (Scopus)

Long-Term Renal Effects of a Neutralizing RAGE Antibody in Obese Type 2 Diabetic Mice

Flyvbjerg, A., Denner, L., Schrijvers, B. F., Tilton, R., Mogensen, T. H., Paludan, S. R. & Rasch, R., Jan 2004, In : Diabetes. 53, 1, p. 166-172 7 p.

Research output: Contribution to journalArticle

Kidney
Antibodies
Type 2 Diabetes Mellitus
Albumins
Creatinine
7 Citations (Scopus)
Response Elements
Protein Kinase C
Swine
Insulin
Phosphotransferases
2003
7 Citations (Scopus)

A murine vascular endothelial growth factor antibody inhibits in vivo growth of human Caki-I renal adenocarcinoma

Dagnaes-Hansen, F., Rasmussen, L. M., Tilton, R., Denner, L. & Flyvbjerg, A., Mar 2003, In : Anticancer Research. 23, 2 B, p. 1625-1630 6 p.

Research output: Contribution to journalArticle

Renal Cell Carcinoma
Vascular Endothelial Growth Factor A
Antibodies
Growth
Nude Mice
2002
31 Citations (Scopus)

Double blockade of cell cycle at G1-S transition and M phase by 3-iodoacetamido benzoyl ethyl ester, a new type of tubulin ligand

Jiang, J. D., Denner, L., Ling, Y. H., Li, J. N., Davis, A., Wang, Y., Li, Y., Roboz, J., Wang, L. G., Perez-Soler, R., Marcelli, M., Bekesi, G. & Holland, J. F., Nov 1 2002, In : Cancer Research. 62, 21, p. 6080-6088 9 p.

Research output: Contribution to journalArticle

Tubulin
S Phase
Cell Division
Cell Cycle
Ligands
19 Citations (Scopus)

Monogene and polygene therapy for the treatment of experimental prostate cancers by use of apoptotic genes bax and bad driven by the prostate-specific promoter ARR2PB

Zhang, Y., Yu, J., Unni, E., Shao, T. C., Nan, B., Snabboon, T., Kasper, S., Andriani, F., Denner, L. & Marcelli, M., 2002, In : Human Gene Therapy. 13, 17, p. 2051-2064 14 p.

Research output: Contribution to journalArticle

Investigational Therapies
Prostate
Prostatic Neoplasms
Androgens
Genes
2001
87 Citations (Scopus)

Adenovirus-mediated bax overexpression for the induction of therapeutic apoptosis in prostate cancer

Li, X., Marani, M., Yu, J., Nan, B., Roth, J. A., Kagawa, S., Fang, B., Denner, L. & Marcelli, M., Jan 1 2001, In : Cancer Research. 61, 1, p. 186-191 6 p.

Research output: Contribution to journalArticle

Adenoviridae
Prostatic Neoplasms
Caspase 7
Apoptosis
Caspases
102 Citations (Scopus)

Overexpression of BCL-XL underlies the molecular basis for resistance to staurosporine-induced apoptosis in PC-3 cells

Li, X. Y., Marani, M., Mannucci, R., Kinsey, B., Andriani, F., Nicoletti, I., Denner, L. & Marcelli, M., Feb 15 2001, In : Cancer Research. 61, 4, p. 1699-1706 8 p.

Research output: Contribution to journalArticle

Staurosporine
Apoptosis
Cell Line
Cytochromes c
Green Fluorescent Proteins
262 Citations (Scopus)

Requirement for p38 and p44/p42 mitogen-activated protein kinases in RAGE-mediated nuclear factor-κB transcriptional activation and cytokine secretion

Yeh, C. H., Sturgis, L., Haidacher, J., Zhang, X. N., Sherwood, S. J., Bjercke, R. J., Juhasz, O., Crow, M. T., Tilton, R. & Denner, L., 2001, In : Diabetes. 50, 6, p. 1495-1504 10 p.

Research output: Contribution to journalArticle

Mitogen-Activated Protein Kinase 1
Transcriptional Activation
p38 Mitogen-Activated Protein Kinases
Cytokines
Advanced Glycosylation End Products