Larry Denner, PhD

Director, Research Discovery and Translation

  • 3294 Citations
  • 33 h-Index
1978 …2019

Research output per year

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Research Output

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Article
2019
Open Access
2 Scopus citations
2017

Central insulin dysregulation and energy dyshomeostasis in two mouse models of Alzheimer's disease

Velazquez, R., Tran, A., Ishimwe, E., Denner, L., Dave, N., Oddo, S. & Dineley, K., Oct 1 2017, In : Neurobiology of Aging. 58, p. 1-13 13 p.

Research output: Contribution to journalArticle

24 Scopus citations

PPARgamma agonists rescue increased phosphorylation of FGF14 at S226 in the Tg2576 mouse model of Alzheimer's disease

Hsu, W. C. J., Wildburger, N. C., Haidacher, S. J., Nenov, M. N., Folorunso, O., Singh, A. K., Chesson, B. C., Franklin, W. F., Cortez, I., Sadygov, R., Dineley, K., Rudra, J. S., Taglialatela, G., Lichti, C. F., Denner, L. & Laezza, F., Sep 1 2017, In : Experimental Neurology. 295, p. 1-17 17 p.

Research output: Contribution to journalArticle

15 Scopus citations

The progestin receptor interactome in the female mouse hypothalamus: Interactions with synaptic proteins are isoform specific and ligand dependent

Acharya, K. D., Nettles, S. A., Sellers, K. J., Im, D. D., Harling, M., Pattanayak, C., Vardar-Ulu, D., Lichti, C. F., Huang, S., Edwards, D. P., Srivastava, D. P., Denner, L. & Tetel, M. J., Sep 1 2017, In : eNeuro. 4, 5, e0272-17.2017.

Research output: Contribution to journalArticle

2 Scopus citations
2016

PPARγ agonism attenuates cocaine cue reactivity

Miller, W. R., Fox, R. G., Stutz, S. J., Lane, S. D., Denner, L., Cunningham, K. & Dineley, K., 2016, (Accepted/In press) In : Addiction Biology.

Research output: Contribution to journalArticle

8 Scopus citations
2015

Impaired firing properties of dentate granule neurons in an Alzheimer’s disease animal model are rescued by PPARγ agonism

Nenov, M. N., Tempia, F., Denner, L., Dineley, K. & Laezza, F., Mar 15 2015, In : Journal of Neurophysiology. 113, 6, p. 1712-1726 15 p.

Research output: Contribution to journalArticle

15 Scopus citations

Targeted proteomics for biomarker discovery and validation of hepatocellular carcinoma in hepatitis C infected patients

Mustafa, G. M., Denner, L., Petersen, J. R. & Elferink, C., 2015, In : World Journal of Hepatology. 7, 10, p. 1312-1324 13 p.

Research output: Contribution to journalArticle

13 Scopus citations
2014

Cognitive enhancing treatment with a PPARγ agonist normalizes dentate granule cell presynaptic function in Tg2576 APP mice

Nenov, M. N., Laezza, F., Haidacher, S. J., Zhao, Y., Sadygov, R. G., Starkey, J. M., Spratt, H., Luxon, B. A., Dineley, K. T. & Denner, L., Jan 20 2014, In : Journal of Neuroscience. 34, 3, p. 1028-1036 9 p.

Research output: Contribution to journalArticle

39 Scopus citations

PPARγ recruitment to active ERK during memory consolidation is required for alzheimer's disease-related cognitive enhancement

Jahrling, J. B., Hernandez, C. M., Denner, L. & Dineley, K. T., Jan 1 2014, In : Journal of Neuroscience. 34, 11, p. 4054-4063 10 p.

Research output: Contribution to journalArticle

39 Scopus citations
2013

Biomarker discovery for early detection of hepatocellular carcinoma in hepatitis C-Infected patients

Mustafa, M. G., Petersen, J. R., Ju, H., Cicalese, L., Snyder, N., Haidacher, S. J., Denner, L. & Elferink, C., Dec 1 2013, In : Molecular and Cellular Proteomics. 12, 12, p. 3640-3652 13 p.

Research output: Contribution to journalArticle

31 Scopus citations

Detection of structural and metabolic changes in traumatically injured hippocampus by quantitative differential proteomics

Wu, P., Zhao, Y., Haidacher, S. J., Wang, E., Parsley, M. O., Gao, J., Sadygov, R. G., Starkey, J. M., Luxon, B. A., Spratt, H., Dewitt, D. S., Prough, D. S. & Denner, L., May 1 2013, In : Journal of neurotrauma. 30, 9, p. 775-788 14 p.

Research output: Contribution to journalArticle

16 Scopus citations
2012

Cognitive enhancement with rosiglitazone links the hippocampal PPARγ and ERK MAPK signaling pathways

Denner, L. A., Rodriguez-Rivera, J., Haidacher, S. J., Jahrling, J. B., Carmical, J. R., Hernandez, C. M., Zhao, Y., Sadygov, R. G., Starkey, J. M., Spratt, H., Luxon, B. A., Wood, T. G. & Dineley, K. T., Nov 21 2012, In : Journal of Neuroscience. 32, 47, p. 16725-16735 11 p.

Research output: Contribution to journalArticle

76 Scopus citations

Development of a novel protocol for isolation and purification of human granulosa cells

Chilvers, R. A., Bodenburg, Y. H., Denner, L. A. & Urban, R. J., Jun 1 2012, In : Journal of Assisted Reproduction and Genetics. 29, 6, p. 547-556 10 p.

Research output: Contribution to journalArticle

7 Scopus citations

Molecular mechanisms underlying effects of neural stem cells against traumatic axonal injury

Wang, E., Gao, J., Yang, Q., Parsley, M. O., Dunn, T. J., Zhang, L., Dewitt, D. S., Denner, L., Prough, D. S. & Wu, P., Jan 20 2012, In : Journal of neurotrauma. 29, 2, p. 295-312 18 p.

Research output: Contribution to journalArticle

22 Scopus citations
2011

Rosiglitazone reversal of Tg2576 cognitive deficits is independent of peripheral gluco-regulatory status

Rodriguez-Rivera, J., Denner, L. & Dineley, K. T., Jan 1 2011, In : Behavioural Brain Research. 216, 1, p. 255-261 7 p.

Research output: Contribution to journalArticle

64 Scopus citations

The simplest method for in vitro Β-cell production from human adult stem cells

Bhandari, D. R., Seo, K. W., Sun, B., Seo, M. S., Kim, H. S., Seo, Y. J., Marcin, J., Forraz, N., Roy, H. L., Larry, D., Colin, M. & Kang, K. S., Oct 1 2011, In : Differentiation. 82, 3, p. 144-152 9 p.

Research output: Contribution to journalArticle

27 Scopus citations
2010

Altered retinoic acid metabolism in diabetic mouse kidney identified by 18O isotopic labeling and 2D mass spectrometry

Starkey, J. M., Zhao, Y., Sadygov, R. G., Haidacher, S. J., S.LeJeune, W., Dey, N., Luxon, B. A., Kane, M. A., Napoli, J. L., Denner, L. & Tilton, R. G., Aug 10 2010, In : PloS one. 5, 6, e11095.

Research output: Contribution to journalArticle

33 Scopus citations

Insulin-like growth factor-I activates extracellularly regulated kinase to regulate the P450 side-chain cleavage insulin-like response element in granulosa cells

Denner, L., Bodenburg, Y. H., Jiang, J., Pagès, G. & Urban, R. J., Jun 1 2010, In : Endocrinology. 151, 6, p. 2819-2825 7 p.

Research output: Contribution to journalArticle

11 Scopus citations

Steroid receptor coactivator-2 expression in brain and physical associations with steroid receptors

Yore, M. A., Im, D., Webb, L. K., Zhao, Y., Chadwick, J. G., Molenda-Figueira, H. A., Haidacher, S. J., Denner, L. & Tetel, M. J., Sep 1 2010, In : Neuroscience. 169, 3, p. 1017-1028 12 p.

Research output: Contribution to journalArticle

22 Scopus citations
8 Scopus citations

Using power spectrum analysis to evaluate 18o-water labeling data acquired from low resolution mass spectrometers

Sadygov, R. G., Zhao, Y., Haidacher, S. J., Starkey, J. M., Tilton, R. G. & Denner, L., Aug 6 2010, In : Journal of Proteome Research. 9, 8, p. 4306-4312 7 p.

Research output: Contribution to journalArticle

17 Scopus citations
2009

Blockage of receptor for advanced glycation end products prevents development of cardiac dysfunction in db/db type 2 diabetic mice

Nielsen, J. M., Kristiansen, S. B., Nørregaard, R., Andersen, C. L., Denner, L., Nielsen, T. T., Flyvbjerg, A. & Bøtker, H. E., Jul 2009, In : European Journal of Heart Failure. 11, 7, p. 638-647 10 p.

Research output: Contribution to journalArticle

39 Scopus citations

Oct-4A isoform is expressed in human cord blood-derived CD133 stem cells and differentiated progeny

Howe, M., Zhao, J., Bodenburg, Y., McGuckin, C. P., Forraz, N., Tilton, R. G., Urban, R. J. & Denner, L., Jun 1 2009, In : Cell Proliferation. 42, 3, p. 265-275 11 p.

Research output: Contribution to journalArticle

6 Scopus citations
2008

A neutralizing antibody against receptor for advanced glycation end products (RAGE) reduces atherosclerosis in uremic mice

Bro, S., Flyvbjerg, A., Binder, C. J., Bang, C. A., Denner, L., Olgaard, K. & Nielsen, L. B., Dec 1 2008, In : Atherosclerosis. 201, 2, p. 274-280 7 p.

Research output: Contribution to journalArticle

33 Scopus citations

Comprehensive analysis of the mouse renal cortex using two-dimensional HPLC - Tandem mass spectrometry

Zhao, Y., Denner, L., Haidacher, S. J., LeJeune, W. S. & Tilton, R. G., May 23 2008, In : Proteome Science. 6, 15.

Research output: Contribution to journalArticle

19 Scopus citations

Identification of ERK and JNK as signaling mediators on protein kinase C activation in cultured granulosa cells

Sriraman, V., Modi, S. R., Bodenburg, Y., Denner, L. A. & Urban, R. J., Nov 6 2008, In : Molecular and Cellular Endocrinology. 294, 1-2, p. 52-60 9 p.

Research output: Contribution to journalArticle

20 Scopus citations

Steroid receptor coactivator-1 from brain physically interacts differentially with steroid receptor subtypes

Molenda-Figueira, H. A., Murphy, S. D., Shea, K. L., Siegal, N. K., Zhao, Y., Chadwick, J. G., Denner, L. A. & Tetel, M. J., Oct 1 2008, In : Endocrinology. 149, 10, p. 5272-5279 8 p.

Research output: Contribution to journalArticle

34 Scopus citations
2007

Diabetes-induced changes in the renal cortical proteome assessed with two-dimensional gel electrophoresis and mass spectrometry

Tilton, R. G., Haidacher, S. J., LeJeune, W. S., Zhang, X., Zhao, Y., Kurosky, A., Brasier, A. R. & Denner, L., May 1 2007, In : Proteomics. 7, 10, p. 1729-1742 14 p.

Research output: Contribution to journalArticle

48 Scopus citations

Directed engineering of umbilical cord blood stem cells to produce C-peptide and insulin

Denner, L., Bodenburg, Y., Zhao, J. G., Howe, M., Cappo, J., Tilton, R. G., Copland, J. A., Forraz, N., McGuckin, C. & Urban, R., Jun 1 2007, In : Cell Proliferation. 40, 3, p. 367-380 14 p.

Research output: Contribution to journalArticle

64 Scopus citations
2006

Diabetes-induced activation of canonical and noncanonical nuclear factor-κB pathways in renal cortex

Starkey, J. M., Haidacher, S. J., LeJeune, W. S., Zhang, X., Tieu, B. C., Choudhary, S., Brasier, A. R., Denner, L. A. & Tilton, R. G., Aug 15 2006, In : Diabetes. 55, 5, p. 1252-1259 8 p.

Research output: Contribution to journalArticle

44 Scopus citations

Functional analysis of the nuclear proteome of human A549 alveolar epithelial cells by HPLC-high resolution 2-D gel electrophoresis

Forbus, J., Spratt, H., Wiktorowicz, J., Wu, Z., Boldogh, I., Denner, L., Kurosky, A., Brasier, R. C., Luxon, B. & Brasier, A. R., May 1 2006, In : Proteomics. 6, 9, p. 2656-2672 17 p.

Research output: Contribution to journalArticle

35 Scopus citations

Renal effects of a neutralising RAGE-antibody in long term streptozotocin-diabetic mice

Jensen, L. J. N., Denner, L., Schrijvers, B. F., Tilton, R. G., Rasch, R. & Flyvbjerg, A., Mar 1 2006, In : Journal of Endocrinology. 188, 3, p. 493-501 9 p.

Research output: Contribution to journalArticle

61 Scopus citations
2005

Inhibition of vascular endothelial growth factor (VEGF) does not affect early renal changes in a rat model of lean type 2 diabetes

Schrijvers, B. F., De Vriese, A. S., Tilton, R. G., Van De Voorde, J., Denner, L., Lameire, N. H. & Flyvbjerg, A., Jan 1 2005, In : Hormone and Metabolic Research. 37, 1, p. 21-25 5 p.

Research output: Contribution to journalArticle

23 Scopus citations

Production of stem cells with embryonic characteristics from human umbilical cord blood

McGuckin, C. P., Forraz, N., Baradez, M. O., Navran, S., Zhao, J., Urban, R., Tilton, R. & Denner, L., Aug 1 2005, In : Cell Proliferation. 38, 4, p. 245-255 11 p.

Research output: Contribution to journalArticle

178 Scopus citations
2004

Long-Term Renal Effects of a Neutralizing RAGE Antibody in Obese Type 2 Diabetic Mice

Flyvbjerg, A., Denner, L., Schrijvers, B. F., Tilton, R. G., Mogensen, T. H., Paludan, S. R. & Rasch, R., Jan 1 2004, In : Diabetes. 53, 1, p. 166-172 7 p.

Research output: Contribution to journalArticle

149 Scopus citations

Protein kinase Cι enhances the transcriptional activity of the porcine P-450 side-chain cleavage insulin-like response element

Urban, R. J., Bodenburg, Y. H., Jiang, J., Denner, L. & Chedrese, J., Jun 1 2004, In : American Journal of Physiology - Endocrinology and Metabolism. 286, 6 49-6, p. E975-E979

Research output: Contribution to journalArticle

8 Scopus citations
2003

A murine vascular endothelial growth factor antibody inhibits in vivo growth of human Caki-I renal adenocarcinoma

Dagnaes-Hansen, F., Rasmussen, L. M., Tilton, R., Denner, L. & Flyvbjerg, A., Mar 1 2003, In : Anticancer Research. 23, 2 B, p. 1625-1630 6 p.

Research output: Contribution to journalArticle

7 Scopus citations
2002

Double blockade of cell cycle at G1-S transition and M phase by 3-iodoacetamido benzoyl ethyl ester, a new type of tubulin ligand

Jiang, J. D., Denner, L., Ling, Y. H., Li, J. N., Davis, A., Wang, Y., Li, Y., Roboz, J., Wang, L. G., Perez-Soler, R., Marcelli, M., Bekesi, G. & Holland, J. F., Jan 1 2002, In : Cancer Research. 62, 21, p. 6080-6088 9 p.

Research output: Contribution to journalArticle

31 Scopus citations

Monogene and polygene therapy for the treatment of experimental prostate cancers by use of apoptotic genes bax and bad driven by the prostate-specific promoter ARR2PB

Zhang, Y., Yu, J., Unni, E., Shao, T. C., Nan, B., Snabboon, T., Kasper, S., Andriani, F., Denner, L. & Marcelli, M., Jan 1 2002, In : Human Gene Therapy. 13, 17, p. 2051-2064 14 p.

Research output: Contribution to journalArticle

19 Scopus citations
2001

Adenovirus-mediated bax overexpression for the induction of therapeutic apoptosis in prostate cancer

Li, X., Marani, M., Yu, J., Nan, B., Roth, J. A., Kagawa, S., Fang, B., Denner, L. & Marcelli, M., Jan 1 2001, In : Cancer Research. 61, 1, p. 186-191 6 p.

Research output: Contribution to journalArticle

87 Scopus citations

Overexpression of BCL-XLunderlies the molecular basis for resistance to staurosporine-induced apoptosis in PC-3 cells

Li, X. Y., Marani, M., Mannucci, R., Kinsey, B., Andriani, F., Nicoletti, I., Denner, L. & Marcelli, M., Feb 15 2001, In : Cancer Research. 61, 4, p. 1699-1706 8 p.

Research output: Contribution to journalArticle

102 Scopus citations

Requirement for p38 and p44/p42 mitogen-activated protein kinases in RAGE-mediated nuclear factor-κB transcriptional activation and cytokine secretion

Yeh, C. H., Sturgis, L., Haidacher, J., Zhang, X. N., Sherwood, S. J., Bjercke, R. J., Juhasz, O., Crow, M. T., Tilton, R. G. & Denner, L., Jan 1 2001, In : Diabetes. 50, 6, p. 1495-1504 10 p.

Research output: Contribution to journalArticle

Open Access
263 Scopus citations

Use of the probasin promoter ARR2PB to express bax in androgen receptor-positive prostate cancer cells

Andriani, F., Nan, B., Yu, J., Li, X., Weigel, N. L., McPhaul, M. J., Kasper, S., Kagawa, S., Fang, B., Matusik, R. J., Denner, L. & Marcelli, M., Sep 5 2001, In : Journal of the National Cancer Institute. 93, 17, p. 1314-1324 11 p.

Research output: Contribution to journalArticle

Open Access
34 Scopus citations
2000

3-m-bromoacetylamino benzoic acid ethyl ester: A new cancericidal agent that activates the apoptotic pathway through caspase-9

Schlesinger, M., Jiang, J. D., Roboz, J. P., Denner, L., Ling, Y. H., Holland, J. F. & Bekesi, J. G., Dec 1 2000, In : Biochemical Pharmacology. 60, 11, p. 1693-1702 10 p.

Research output: Contribution to journalArticle

10 Scopus citations

Heterogeneous apoptotic responses of prostate cancer cell lines identify an association between sensitivity to staurosporine-induced apoptosis, expression of Bcl-2 family members, and caspase activation

Marcelli, M., Marani, M., Li, X., Sturgis, L., Haidacher, S. J., Trial, J. A., Mannucci, R., Nicoletti, I. & Denner, L., Mar 1 2000, In : Prostate. 42, 4, p. 260-273 14 p.

Research output: Contribution to journalArticle

54 Scopus citations

Induction of apoptosis in BPH stromal cells by adenoviral-mediated overexpression of caspase-7

Marcelli, M., Shao, T. C., Li, X., Yin, H., Marani, M., Denner, L., Teng, B. & Cunningham, G. R., Aug 2000, In : Journal of Urology. 164, 2, p. 518-525 8 p.

Research output: Contribution to journalArticle

17 Scopus citations
1999

Alzheimer's disease and stroke

Dineley, K. & Denner, L., Feb 10 1999, In : IDrugs. 2, 1, p. 7-8 2 p.

Research output: Contribution to journalArticle

1 Scopus citations

Nuclear factor-κB and cell death after experimental intracerebral hemorrhage in rats

Hickenbottom, S. L., Grotta, J. C., Strong, R., Denner, L. A. & Aronowski, J., Nov 1999, In : Stroke. 30, 11, p. 2472-2478 7 p.

Research output: Contribution to journalArticle

Open Access
142 Scopus citations

Signaling pathway activated during apoptosis of the prostate cancer celt line LNCaP: Overexpression of caspase-7 as a new gene therapy strategy for prostate cancer

Marcelli, M., Cunningham, G. R., Walkup, M., He, Z., Sturgis, L., Kagan, C., Mannucci, R., Nicoletti, I., Teng, B. B. & Denner, L., Jan 16 1999, In : Cancer Research. 59, 2, p. 382-390 9 p.

Research output: Contribution to journalArticle

115 Scopus citations
1998

Caspase-7 is activated during lovastatin-induced apoptosis of the prostate cancer cell line LNCaP

Marcelli, M., Cunningham, G. R., Haidacher, S. J., Padayatty, S. J., Sturgis, L., Kagan, C. & Denner, L., Jan 1 1998, In : Cancer Research. 58, 1, p. 76-83 8 p.

Research output: Contribution to journalArticle

198 Scopus citations