Leticia Castillo

2018

Secondary hemophagocytic lymphohistiocytosis, macrophage activation syndrome, and hyperferritinemic sepsis-induced multiple-organ dysfunction syndrome in the pediatric ICU

Carcillo, J. A., Shakoory, B. & Castillo, L., Dec 10 2018, Pediatric Critical Care: Current Controversies. Springer International Publishing, p. 245-255 11 p.

Research output: Chapter in Book/Report/Conference proceeding › Chapter

3 Scopus citations

2017

A multifaceted approach to reduction of catheter-associated urinary tract infections in the intensive care unit with an emphasis on stewardship of culturing

Mullin, K. M., Kovacs, C. S., Fatica, C., Einloth, C., Neuner, E. A., Guzman, J. A., Kaiser, E., Menon, V., Castillo, L., Popovich, M. J., Manno, E. M., Gordon, S. M. & Fraser, T. G., Feb 1 2017, In: Infection control and hospital epidemiology. 38, 2, p. 186-188 3 p.

Research output: Contribution to journal › Article › peer-review

Open Access

54 Scopus citations

Insulin therapy for glycaemic control in critically ill children

Lyons, J., Foster, B., Castillo, L. & Lyons, B. E., Feb 14 2017, In: Cochrane Database of Systematic Reviews. 2017, 2, CD009983.

Research output: Contribution to journal › Article › peer-review

Open Access

2012

Arginine, citrulline, and nitric oxide

Luiking, Y. C., Castillo, L. & Deutz, N. E. P., Dec 22 2012, Modern Nutrition in Health and Disease: Eleventh Edition. Wolters Kluwer Health Adis (ESP), p. 477-486 10 p.

Research output: Chapter in Book/Report/Conference proceeding › Chapter

4 Scopus citations

Impact of resident duty hour limits on safety in the intensive care unit: A national survey of pediatric and neonatal intensivists

Typpo, K. V., Tcharmtchi, M. H., Thomas, E. J., Kelly, P. A., Castillo, L. D. & Singh, H., Sep 2012, In: Pediatric Critical Care Medicine. 13, 5, p. 578-582 5 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

21 Scopus citations

2011

Albumin synthesis rates in post-surgical infants and septic adolescents; influence of amino acids, energy, and insulin

Verbruggen, S. C., Schierbeek, H., Coss-Bu, J., Joosten, K. F. M., Castillo, L. & van Goudoever, J. B., Aug 2011, In: Clinical Nutrition. 30, 4, p. 469-477 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

29 Scopus citations

Current recommended parenteral protein intakes do not support protein synthesis in critically ill septic, insulin-resistant adolescents with tight glucose control

Verbruggen, S. C. A. T., Coss-Bu, J., Wu, M., Schierbeek, H., Joosten, K. F. M., Dhar, A., Van Goudoever, J. B. & Castillo, L., Nov 2011, In: Critical care medicine. 39, 11, p. 2518-2525 8 p.

Research output: Contribution to journal › Article › peer-review

45 Scopus citations

Enteral arginase II provides ornithine for citrulline synthesis

Marini, J. C., Keller, B., Didelija, I. C., Castillo, L. & Lee, B., Jan 2011, In: American Journal of Physiology - Endocrinology and Metabolism. 300, 1, p. E188-E194

Research output: Contribution to journal › Article › peer-review

Open Access

16 Scopus citations

Insulin resistance in critical illness

Dhar, A. & Castillo, L., Jun 2011, In: Current Opinion in Pediatrics. 23, 3, p. 269-274 6 p.

Research output: Contribution to journal › Review article › peer-review

33 Scopus citations

The Accreditation Council for Graduate Medical Education proposed work hour regulations

Goodman, D. M., Winkler, M. K., Fiser, R. T., Abd-Allah, S., Mathur, M., Rivero, N., Weiss, I. K., Peterson, B., Cornfield, D. N., Mink, R., Nozik Grayck, E., McCabe, M. E., Schuette, J., Nares, M. A., Totapally, B., Petrillo-Albarano, T., Wolfson, R. K., Moreland, J. G., Potter, K. E. & Fackler, J. & 34 others, Garber, N., Burns, J. P., Shanley, T. P., Lieh-Lai, M. W., Steiner, M., Tieves, K. S., Goldsmith, M., Asuncion, A., Ross, S. L. P., Howell, J. D., Biagas, K., Ognibene, K., Joshi, P., Rubenstein, J. S., Kocis, K. C., Cheifetz, I. M., Turner, D. A., Doughty, L., Hall, M. W., Mason, K., Penfil, S., Morrison, W., Hoehn, K. S., Watson, R. S., Garcia, R. L., Storgion, S. A., Fleming, G. M., Castillo, L., Tcharmtchi, M. H., Taylor, R. P., Ul Haque, I., Crain, N., Baden, H. P. & Lee, K. J., Jan 2011, In: Pediatric Critical Care Medicine. 12, 1, p. 120-121 2 p.

Research output: Contribution to journal › Letter › peer-review

2010

Arginine utilization for citrulline synthesis in arginase II knockout mice

Marini, J. C., Didelija, I. C., Castillo, L. & Lee, B., 2010, In: EAAP Scientific Series. 127, 1, p. 135-136 2 p.

Research output: Contribution to journal › Article › peer-review

Associations of four circulating chemokines with multiple atherosclerosis phenotypes in a large population-based sample: Results from the Dallas heart study

Castillo, L., Rohatgi, A., Ayers, C. R., Owens, A. W., Das, S. R., Khera, A., Mcguire, D. K. & De Lemos, J. A., May 1 2010, In: Journal of Interferon and Cytokine Research. 30, 5, p. 339-347 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

33 Scopus citations

Glutamine: Precursor or nitrogen donor for citrulline synthesis?

Marini, J. C., Didelija, I. C., Castillo, L. & Lee, B., Jul 2010, In: American Journal of Physiology - Endocrinology and Metabolism. 299, 1, p. E69-E79

Research output: Contribution to journal › Article › peer-review

Open Access

50 Scopus citations

Glutamine: Precursor or nitrogen donor for the synthesis of citrulline?

Marini, J. C., Didelija, I. C., Castillo, L. & Lee, B., 2010, In: EAAP Scientific Series. 127, 1, p. 123-124 2 p.

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Parenteral amino acid intakes in critically Ill children: A matter of convenience

Verbruggen, S., Sy, J., Arrivillaga, A., Joosten, K., Van Goudoever, J. & Castillo, L., May 2010, In: Journal of Parenteral and Enteral Nutrition. 34, 3, p. 329-340 12 p.

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Plasma arginine and ornithine are the main citrulline precursors in mice infused with arginine-free diets

Marini, J. C., Didelija, I. C., Castillo, L. & Lee, B., Aug 2010, In: Journal of Nutrition. 140, 8, p. 1432-1437 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

20 Scopus citations

Precursors for the synthesis of citrulline in mice fed arginine free diets

Marini, J. C., Didelija, I. C., Castillo, L. & Lee, B., 2010, In: EAAP Scientific Series. 127, 1, p. 133-134 2 p.

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

2009

Arginine, citrulline and nitric oxide metabolism in sepsis

Kao, C. C., Bandi, V., Guntupalli, K. K., Wu, M., Castillo, L. & Jahoor, F., 2009, In: Clinical Science. 117, 1, p. 23-30 8 p.

Research output: Contribution to journal › Article › peer-review

103 Scopus citations

Continuous renal replacement therapy amino acid, trace metal and folate clearance in critically ill children

Zappitelli, M., Juarez, M., Castillo, L., Coss-Bu, J. & Goldstein, S. L., Apr 2009, In: Intensive care medicine. 35, 4, p. 698-706 9 p.

Research output: Contribution to journal › Article › peer-review

73 Scopus citations

Ontogeny of methionine utilization and splanchnic uptake in critically ill children

Verbruggen, S., Sy, J., Gordon, W. E., Hsu, J., Wu, M., Chacko, S., Zurakowski, D., Burrin, D. & Castillo, L., Nov 2009, In: American Journal of Physiology - Endocrinology and Metabolism. 297, 5, p. E1046-E1055

Research output: Contribution to journal › Article › peer-review

Open Access

6 Scopus citations

Recognizing, understanding, and treating critical community acquired methicillin-resistant Staphylococcus aureus infection in children

Carcillo, J. A., Castillo, L., Thomas, J. & Kissoon, N., May 1 2009, In: Pediatric Critical Care Medicine. 10, 3, p. 405-407 3 p.

Research output: Contribution to journal › Editorial › peer-review

3 Scopus citations

Secondary hemophagocytic lymphohistiocytosis and severe sepsis/systemic inflammatory response syndrome/multiorgan dysfunction syndrome/macrophage activation syndrome share common intermediate phenotypes on a spectrum of inflammation

Castillo, L. & Carcillo, J., May 1 2009, In: Pediatric Critical Care Medicine. 10, 3, p. 387-392 6 p.

Research output: Contribution to journal › Article › peer-review

226 Scopus citations

2008

Adaptation to a long term (4 weeks) arginine- and precursor (glutamate, proline and aspartate)-free diet

Tharakan, J. F., Yu, Y. M., Zurakowski, D., Roth, R. M., Young, V. R. & Castillo, L., Aug 2008, In: Clinical Nutrition. 27, 4, p. 513-522 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

19 Scopus citations

Bicarbonate kinetics and predicted energy expenditure in critically ill children

Sy, J., Gourishankar, A., Gordon, W. E., Griffin, D., Zurakowski, D., Roth, R. M., Coss-Bu, J., Jefferson, L., Heird, W. & Castillo, L., Aug 1 2008, In: American Journal of Clinical Nutrition. 88, 2, p. 340-347 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

19 Scopus citations

High elevated ferritin levels and the diagnosis of HLH/sepsis/SIRS/MODS/MAS

Castillo, L., Nov 2008, In: Pediatric Blood and Cancer. 51, 5, p. 710 1 p.

Research output: Contribution to journal › Letter › peer-review

12 Scopus citations

Nutrition of Critically Ill Children with Acute Renal Failure

Zappitelli, M., Maxvold, N. J. & Castillo, L., Jan 1 2008, Critical Care Nephrology, Second Edition. Elsevier, p. 1613-1617 5 p.

Research output: Chapter in Book/Report/Conference proceeding › Chapter

2007

Insulin therapy in the pediatric intensive care unit

Verbruggen, S. C. A. T., Joosten, K. F. M., Castillo, L. & van Goudoever, J. B., Dec 2007, In: Clinical Nutrition. 26, 6, p. 677-690 14 p.

Research output: Contribution to journal › Review article › peer-review

38 Scopus citations

Interaction between murine spf-ash mutation and genetic background yields different metabolic phenotypes

Marini, J. C., Erez, A., Castillo, L. & Lee, B., Dec 2007, In: American Journal of Physiology - Endocrinology and Metabolism. 293, 6, p. E1764-E1771

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

2006

Nutrition in the Critically Ill Child

Mehta, N. & Castillo, L., 2006, Pediatric Critical Care. Mosby Inc., p. 1068-1084 17 p.

Research output: Chapter in Book/Report/Conference proceeding › Chapter

1 Scopus citations

2005

Hyperglycemia, asymmetric dimethylarginine, and patient survival: Dysregulation of complex networks and the metabolic basis of disease

Castillo, L. & Al-Khadra, E., Mar 2005, In: Critical care medicine. 33, 3, p. 674-676 3 p.

Research output: Contribution to journal › Editorial › peer-review

2003

Arginine and nitric oxide metabolism in critically ill septic pediatric patients

Argaman, Z., Young, V. R., Noviski, N., Castillo-Rosas, L., Lu, X. M., Zurakowski, D., Cooper, M., Davison, C., Tharakan, J. F., Ajami, A. & Castillo, L., Feb 1 2003, In: Critical care medicine. 31, 2, p. 591-597 7 p.

Research output: Contribution to journal › Article › peer-review

111 Scopus citations

2002

L-arginine-nitric oxide pathway in endstage reneal disease: Authors' reply

Owen, W., Young, V. R., Ajami, A. & Castillo, L., 2002, In: American Journal of Kidney Diseases. 39, 1, p. 198-202 5 p.

Research output: Contribution to journal › Comment/debate › peer-review

Plasma L-5-oxoproline kinetics and whole blood glutathione synthesis rates in severely burned adult humans

Yu, Y. M., Ryan, C. M., Fei, Z. W., Lu, X. M., Castillo, L., Schultz, J. T., Tompkins, R. G. & Young, V. R., 2002, In: American Journal of Physiology - Endocrinology and Metabolism. 282, 2 45-2, p. E247-E258

Research output: Contribution to journal › Article › peer-review

49 Scopus citations

2001

Arginine and ornithine kinetics in severely burned patients: Increased rate of arginine disposal

Yu, Y. M., Ryan, C. M., Castillo, L., Lu, X. M., Beaumier, L., Tompkins, R. G. & Young, V. R., Mar 2001, In: American Journal of Physiology - Endocrinology and Metabolism. 280, 3 43-3, p. E509-E517

Research output: Contribution to journal › Article › peer-review

Open Access

95 Scopus citations

Cysteine metabolism and whole blood glutathione synthesis in septic pediatric patients

Lyons, J., Rauh-Pfeiffer, A., Ming-Yu, Y., Lu, X. M., Zurakowski, D., Curley, M., Collier, S., Duggan, C., Nurko, S., Thompson, J., Ajami, A., Borgonha, S., Young, V. R. & Castillo, L., 2001, In: Critical care medicine. 29, 4, p. 870-877 8 p.

Research output: Contribution to journal › Article › peer-review

121 Scopus citations

2000

Arginine, citrulline, and nitric oxide metabolism in end-stage renal disease patients

Lau, T., Owen, W., Yu, Y. M., Noviski, N., Lyons, J., Zurakowski, D., Tsay, R., Ajami, A., Young, V. R. & Castillo, L., May 2000, In: Journal of Clinical Investigation. 105, 9, p. 1217-1225 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

115 Scopus citations

Blood glutathione synthesis rates in healthy adults receiving a sulfur amino acid-free diet

Lyons, J., Rauh-Pfeiffer, A., Yu, Y. M., Lu, X. M., Zurakowski, D., Tompkins, R. G., Ajami, A. M., Young, V. R. & Castillo, L., May 9 2000, In: Proceedings of the National Academy of Sciences of the United States of America. 97, 10, p. 5071-5076 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

146 Scopus citations

1998

Human arginine metabolism during end stage renal disease

Castillo, L., Law, T., Owen, W. & Young, V. R., Mar 20 1998, In: FASEB Journal. 12, 5, p. A969

Research output: Contribution to journal › Article › peer-review

Nutrition and shock in pediatric patients

Curley, M. A. Q. & Castillo, L., 1998, In: New Horizons: Science and Practice of Acute Medicine. 6, 2, p. 212-225 14 p.

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

1997

Adaptation to a long term (4 WKS) arginine-precursor-free diet in adult humans

Castillo, L., Bedri, S., Beaumier, L., Ajami, A. & Young, V. R., 1997, In: FASEB Journal. 11, 3, p. A439

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Estimation of arginine oxidation and de novo synthesis in healthy adult men, using L-[5-¹³C]arginine

Beaumier, L., Bedri, S., Castillo, L., Ajami, A. M. & Young, V. R., 1997, In: FASEB Journal. 11, 3, p. A439

Research output: Contribution to journal › Article › peer-review

Metabolism of L-arginine and the no pathway in septic children

Argaman, Z., Noviski, N., Castillo-Rosas, L., Ritz, R., Rigatti, V., Ajami, A., Young, V. R. & Castillo, L., 1997, In: FASEB Journal. 11, 3, p. A438

Research output: Contribution to journal › Article › peer-review

1996

Splanchnic uptake and oxidation of proljne in healthy subjects

Castillo, L., Beaumier, L., Yu, Y. M. & Yjaing, V. R., 1996, In: FASEB Journal. 10, 3, p. A284

Research output: Contribution to journal › Article › peer-review

Twenty-four-hour intravenous and oral tracer studies with L-[1-¹³C]phenylalanine and L-[3,3-²H₂]tyrosine at a tyrosine-free, generous phenylalanine intake in adults

Sánchez, M., El-Khoury, A. E., Castillo, L., Chapman, T. E., Basile Filho, A., Beaumier, L. & Young, V. R., Apr 1996, In: American Journal of Clinical Nutrition. 63, 4, p. 532-545 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

34 Scopus citations

Whole body nitric oxide synthesis in healthy men determined from [¹⁵N]arginine-to-[¹⁵N]citrulline labeling

Castillo, L., Beaumier, L., Ajami, A. M. & Young, V. R., Oct 15 1996, In: Proceedings of the National Academy of Sciences of the United States of America. 93, 21, p. 11460-11465 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

192 Scopus citations

1995

Inhaled nitric oxide does not alter endotoxin-induced nitric oxide synthase activity during rat lung perfusion

Kurrek, M. M., Castillo, L., Bloch, K. D., Tannenbaum, S. R. & Zapol, W. M., 1995, In: Journal of Applied Physiology. 79, 4, p. 1088-1092 5 p.

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Phenylalanine and tyrosine kinetics in young men throughout a continuous 24-h period, at a low phenylalanine intake

Sánchez, M., El-Khoury, A. E., Castillo, L., Chapman, T. E. & Young, V. R., Mar 1995, In: American Journal of Clinical Nutrition. 61, 3, p. 555-570 16 p.

Research output: Contribution to journal › Article › peer-review

Open Access

39 Scopus citations

Plasma arginine, citrulline, and ornithine kinetics in adults, with observations on nitric oxide synthesis

Castillo, L., Sanchez, M., Vogt, J., Chapman, T. E., Derojas-Walker, T. C., Tannenbaum, S. R., Ajami, A. M. & Young, V. R., 1995, In: American Journal of Physiology - Endocrinology and Metabolism. 268, 2 31-2, p. E360-E367

Research output: Contribution to journal › Article › peer-review

118 Scopus citations

Plasma arginine and leucine kinetics and urea production rates in burn patients

Yu, Y. M., Young, V. R., Castillo, L., Chapman, T. E., Tompkins, R. G., Ryan, C. M. & Burke, J. F., May 1995, In: Metabolism. 44, 5, p. 659-666 8 p.

Research output: Contribution to journal › Article › peer-review

60 Scopus citations

Urea cycle intermediate kinetics and nitrate excretion at normal and 'therapeutic' intakes of arginine in humans

Beaumier, L., Castillo, L., Ajami, A. M. & Young, V. R., 1995, In: American Journal of Physiology - Endocrinology and Metabolism. 269, 5 32-5, p. E884-E896

Research output: Contribution to journal › Article › peer-review

83 Scopus citations

Leticia Castillo, MD

Research output

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